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The map label for this gene is mmsB [H]

Identifier: 77456924

GI number: 77456924

Start: 822733

End: 823620

Strand: Direct

Name: mmsB [H]

Synonym: Pfl01_0696

Alternate gene names: 77456924

Gene position: 822733-823620 (Clockwise)

Preceding gene: 77456923

Following gene: 77456926

Centisome position: 12.78

GC content: 65.09

Gene sequence:

>888_bases
ATGAAAATCGCATTTATCGGTCTGGGCAACATGGGCGCGCCGATGGCGCGCAACCTGATCAAGGCCGGGCATTCGCTGAA
TCTGGTGGACCTGAACAAAACCGTGCTCGCGGAGCTCGAGCAACTGGGTGGCACCATCCGCGCTTCGGCTCGCGAAGCGG
CTGAAGATGCAGAACTGGTGATCACTATGCTGCCCGCCGCCGTGCATGTACGCAGCGTCTGGCTCGGTGAGGACGGTGTG
CTGGCCGGGATCGGCAAAGGCGTGCCGGCGGTGGATTGCAGCACCATCGATCCGCAGACGGCGCGCGATGTGGCGGCGGC
GGCCGCCAAGCAAGGCGTGGCCATGGCCGATGCCCCGGTGTCCGGTGGTACCGGCGGCGCCACCGCAGGTACATTGACCT
TCATGGTCGGCACCACTCCTGAACTGTTCGCCACCCTGCAACCGGTGCTGGCGCAGATGGGCCGCAACATCGTGCATTGC
GGTGAGGTCGGCACCGGTCAGATCGCCAAGATCTGCAACAACCTGTTGCTCGCCATTTCGATGGTCGGCGTCAGCGAGGC
GATGGCCCTGGGCGATGCGCTGGGGATCGACACCACGGTGCTCGCCGGGATCATCAACAGCTCGACCGGCCGTTGCTGGA
GTTCGGAAATGTACAACCCGTGGCCGGGCATCGTCGAAACGGCACCGGCCTCGCGCGGCTACACGGGTGGCTTCGGCGCC
GAACTGATGCTCAAGGATCTGGGGCTGGCCACCGAGGCGGCGCGTCAGGCCCATCAGCCGGTGGTGCTGGGCGCGGTGGC
GCAGCAGTTGTATCAGGCGATGAGTCAGCGCGGGGAAGGGGGCAAGGACTTCTCGGCGATCATCAACAGCTATCGCAAGC
CGCAGTAA

Upstream 100 bases:

>100_bases
GTTCTACACCCAGACCAAAACGGTCACGGCGCGCTGGTTCGATGACGACAGCGTCAACGACGGCGTGAACACCACCATCA
ACCTGCGCTGAGGAATGGCC

Downstream 100 bases:

>100_bases
TCGTCGTCAGGCCTGTGCTCGTCGCAGGTCTGCAATTCAGATGCAGTAGGTGTTGCCGGGAAATCACGTCGGGTGGTTTC
CCGGCTTTTTTGTATCAGGC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKIAFIGLGNMGAPMARNLIKAGHSLNLVDLNKTVLAELEQLGGTIRASAREAAEDAELVITMLPAAVHVRSVWLGEDGV
LAGIGKGVPAVDCSTIDPQTARDVAAAAAKQGVAMADAPVSGGTGGATAGTLTFMVGTTPELFATLQPVLAQMGRNIVHC
GEVGTGQIAKICNNLLLAISMVGVSEAMALGDALGIDTTVLAGIINSSTGRCWSSEMYNPWPGIVETAPASRGYTGGFGA
ELMLKDLGLATEAARQAHQPVVLGAVAQQLYQAMSQRGEGGKDFSAIINSYRKPQ

Sequences:

>Translated_295_residues
MKIAFIGLGNMGAPMARNLIKAGHSLNLVDLNKTVLAELEQLGGTIRASAREAAEDAELVITMLPAAVHVRSVWLGEDGV
LAGIGKGVPAVDCSTIDPQTARDVAAAAAKQGVAMADAPVSGGTGGATAGTLTFMVGTTPELFATLQPVLAQMGRNIVHC
GEVGTGQIAKICNNLLLAISMVGVSEAMALGDALGIDTTVLAGIINSSTGRCWSSEMYNPWPGIVETAPASRGYTGGFGA
ELMLKDLGLATEAARQAHQPVVLGAVAQQLYQAMSQRGEGGKDFSAIINSYRKPQ
>Mature_295_residues
MKIAFIGLGNMGAPMARNLIKAGHSLNLVDLNKTVLAELEQLGGTIRASAREAAEDAELVITMLPAAVHVRSVWLGEDGV
LAGIGKGVPAVDCSTIDPQTARDVAAAAAKQGVAMADAPVSGGTGGATAGTLTFMVGTTPELFATLQPVLAQMGRNIVHC
GEVGTGQIAKICNNLLLAISMVGVSEAMALGDALGIDTTVLAGIINSSTGRCWSSEMYNPWPGIVETAPASRGYTGGFGA
ELMLKDLGLATEAARQAHQPVVLGAVAQQLYQAMSQRGEGGKDFSAIINSYRKPQ

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=293, Percent_Identity=47.098976109215, Blast_Score=290, Evalue=9e-79,
Organism=Homo sapiens, GI40556376, Length=290, Percent_Identity=24.4827586206897, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=34.1296928327645, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1790315, Length=292, Percent_Identity=36.6438356164384, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786719, Length=297, Percent_Identity=31.986531986532, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=30.7167235494881, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=291, Percent_Identity=46.3917525773196, Blast_Score=257, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=46.5986394557823, Blast_Score=274, Evalue=5e-74,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=46.5986394557823, Blast_Score=274, Evalue=5e-74,
Organism=Drosophila melanogaster, GI28574115, Length=295, Percent_Identity=22.3728813559322, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24655240, Length=63, Percent_Identity=52.3809523809524, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30256; Mature: 30256

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGLGNMGAPMARNLIKAGHSLNLVDLNKTVLAELEQLGGTIRASAREAAEDAELV
CEEEEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ITMLPAAVHVRSVWLGEDGVLAGIGKGVPAVDCSTIDPQTARDVAAAAAKQGVAMADAPV
HHHHHHHHHHHHEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCC
SGGTGGATAGTLTFMVGTTPELFATLQPVLAQMGRNIVHCGEVGTGQIAKICNNLLLAIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
MVGVSEAMALGDALGIDTTVLAGIINSSTGRCWSSEMYNPWPGIVETAPASRGYTGGFGA
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHH
ELMLKDLGLATEAARQAHQPVVLGAVAQQLYQAMSQRGEGGKDFSAIINSYRKPQ
HHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKIAFIGLGNMGAPMARNLIKAGHSLNLVDLNKTVLAELEQLGGTIRASAREAAEDAELV
CEEEEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ITMLPAAVHVRSVWLGEDGVLAGIGKGVPAVDCSTIDPQTARDVAAAAAKQGVAMADAPV
HHHHHHHHHHHHEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCC
SGGTGGATAGTLTFMVGTTPELFATLQPVLAQMGRNIVHCGEVGTGQIAKICNNLLLAIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
MVGVSEAMALGDALGIDTTVLAGIINSSTGRCWSSEMYNPWPGIVETAPASRGYTGGFGA
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHH
ELMLKDLGLATEAARQAHQPVVLGAVAQQLYQAMSQRGEGGKDFSAIINSYRKPQ
HHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]