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The map label for this gene is hflC [H]

Identifier: 77456754

GI number: 77456754

Start: 608889

End: 609758

Strand: Direct

Name: hflC [H]

Synonym: Pfl01_0526

Alternate gene names: 77456754

Gene position: 608889-609758 (Clockwise)

Preceding gene: 77456753

Following gene: 77456755

Centisome position: 9.46

GC content: 59.08

Gene sequence:

>870_bases
ATGAGCAATAAATCGCTGATCGCCCTGATCGTTGGCGTTGTTGTGGTACTGGTTGGCTGGAACTGCTTCTACATCGTCGC
TCAGACCGAGCGCGCGGTGTTGCTGCAATTCGGTCGCGTGGTTCAGGCTGACGTTCAGCCGGGTCTGCATGTGAAGGTGC
CTTACGTTAACCAGGTGCGTAAATTCGACGCACGTCTGATGACGCTGGATGCGCCGACGCAACGCTTCCTGACGCTGGAA
AAGAAAGCCGTGATGGTCGATGCCTACGCCAAGTGGCGCGTGAAGGATGCCGAGCGCTTCTACACCGCAACGTCCGGCCT
CAAGCAGATCGCCGACGAGCGTCTGTCCCGTCGTCTGGAATCGGGTCTGCGTGACCAGTTCGGTAAGCGCACCCTGCACG
AAGTGGTGTCGGGTGAGCGCGATGCGCTGATGGCCGATATCACCGCGTCGCTGAACAAGATGGCGGAAAAAGAGCTGGGT
ATCGAAGTGGTCGATGTCCGGGTCAAGGCCATCGATCTGCCGAAAGAAGTGAACCGCAGCGTGTTCGAGCGCATGAGCAC
CGAGCGTGAGCGTGAAGCTCGCGAGCACCGCGCCAAGGGTAACGAGCTGGCCGAAGGCATCCGTGCCGACGCCGATCGTC
AACGCCGTGTGCTGCTGGCTGAAGCCTATCGTGAATCCGAAGAGATTCGCGGTGACGGTGATGCCCAGGCCGCTGCGATC
TACTCCAAGGCCTACGGTCAGGATCAGGAGTTCTACGGTTTCTACCGTAGCCTGCGTGCCTACCGTGAAAGCTTTGCGAA
CAAATCCGACGTCCTGGTCCTCGACCCAAGCAGCGACTTCTTCCGTTACCTGGAAAAGTCCAAGCCTTGA

Upstream 100 bases:

>100_bases
GCAATGCACCGGTCACCGGTTCGGCTGCCGCCAGCAACAACACGGACGCTACGCCGCATGTCACTGACCTGCCACAGTCG
CGTACAAGGGAGACCCGCTG

Downstream 100 bases:

>100_bases
TACGACGTTGACCTGAATCATTCCGCCCGGCGGCTAAAACCTCGGGCGGGGTGATCCTTTGGGAAAACGTGTGTATGATG
CGGCAGCCGGGAAATTCCCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSNKSLIALIVGVVVVLVGWNCFYIVAQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVRKFDARLMTLDAPTQRFLTLE
KKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLESGLRDQFGKRTLHEVVSGERDALMADITASLNKMAEKELG
IEVVDVRVKAIDLPKEVNRSVFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEIRGDGDAQAAAI
YSKAYGQDQEFYGFYRSLRAYRESFANKSDVLVLDPSSDFFRYLEKSKP

Sequences:

>Translated_289_residues
MSNKSLIALIVGVVVVLVGWNCFYIVAQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVRKFDARLMTLDAPTQRFLTLE
KKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLESGLRDQFGKRTLHEVVSGERDALMADITASLNKMAEKELG
IEVVDVRVKAIDLPKEVNRSVFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEIRGDGDAQAAAI
YSKAYGQDQEFYGFYRSLRAYRESFANKSDVLVLDPSSDFFRYLEKSKP
>Mature_288_residues
SNKSLIALIVGVVVVLVGWNCFYIVAQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVRKFDARLMTLDAPTQRFLTLEK
KAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLESGLRDQFGKRTLHEVVSGERDALMADITASLNKMAEKELGI
EVVDVRVKAIDLPKEVNRSVFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEIRGDGDAQAAAIY
SKAYGQDQEFYGFYRSLRAYRESFANKSDVLVLDPSSDFFRYLEKSKP

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI21686995, Length=181, Percent_Identity=29.8342541436464, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI38016911, Length=161, Percent_Identity=27.9503105590062, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI221316744, Length=181, Percent_Identity=29.8342541436464, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1790617, Length=312, Percent_Identity=38.1410256410256, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1786697, Length=222, Percent_Identity=28.3783783783784, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790616, Length=207, Percent_Identity=28.5024154589372, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17569497, Length=203, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17569499, Length=206, Percent_Identity=29.6116504854369, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71989955, Length=163, Percent_Identity=29.4478527607362, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71989948, Length=163, Percent_Identity=29.4478527607362, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25153583, Length=169, Percent_Identity=28.4023668639053, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987612, Length=169, Percent_Identity=28.4023668639053, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987621, Length=172, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17569493, Length=183, Percent_Identity=28.4153005464481, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193209764, Length=183, Percent_Identity=28.4153005464481, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32566490, Length=159, Percent_Identity=28.9308176100629, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17570161, Length=160, Percent_Identity=27.5, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193210507, Length=160, Percent_Identity=27.5, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17570459, Length=222, Percent_Identity=27.027027027027, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI18860517, Length=171, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI62484448, Length=240, Percent_Identity=29.5833333333333, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281365664, Length=238, Percent_Identity=29.8319327731092, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI62484274, Length=240, Percent_Identity=29.5833333333333, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24657857, Length=238, Percent_Identity=29.8319327731092, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45556022, Length=182, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550506, Length=214, Percent_Identity=25.2336448598131, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32978; Mature: 32847

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKSLIALIVGVVVVLVGWNCFYIVAQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVR
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHH
KFDARLMTLDAPTQRFLTLEKKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLE
HHHHHEEEECCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLRDQFGKRTLHEVVSGERDALMADITASLNKMAEKELGIEVVDVRVKAIDLPKEVNRS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHH
VFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEIRGDGDAQAAAI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YSKAYGQDQEFYGFYRSLRAYRESFANKSDVLVLDPSSDFFRYLEKSKP
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCC
>Mature Secondary Structure 
SNKSLIALIVGVVVVLVGWNCFYIVAQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVR
CCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHH
KFDARLMTLDAPTQRFLTLEKKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLE
HHHHHEEEECCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLRDQFGKRTLHEVVSGERDALMADITASLNKMAEKELGIEVVDVRVKAIDLPKEVNRS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHH
VFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEIRGDGDAQAAAI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YSKAYGQDQEFYGFYRSLRAYRESFANKSDVLVLDPSSDFFRYLEKSKP
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]