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The map label for this gene is aceE [H]

Identifier: 77456691

GI number: 77456691

Start: 533418

End: 536063

Strand: Reverse

Name: aceE [H]

Synonym: Pfl01_0463

Alternate gene names: 77456691

Gene position: 536063-533418 (Counterclockwise)

Preceding gene: 77456707

Following gene: 77456690

Centisome position: 8.33

GC content: 59.45

Gene sequence:

>2646_bases
ATGCAAGACCTCGATCCCGTCGAAACCCAGGAATGGCTGGACGCCCTGGAATCGGTTCTCGACAAAGAAGGCGAAGACCG
TGCTCACTATCTGATGACCCGTATGGGTGAACTGGCAACCCGCAGCGGTTCGCAGCTCCCTTACGCCATCACCACGCCTT
ACCGCAACACGATCCCCGTTACCCACGAAGCACGCATGCCTGGCGACCTGTTCATGGAACGCCGCATTCGCTCGCTGGTA
CGCTGGAACGCGATGGCCATGGTAATGCGTACGAACCTGAAAGATTCTGACCTGGGTGGTCACATCTCCAGCTTCGCTTC
CAGTGCGACCCTGTACGACATCGGCTTCAACTACTTCTTCCAGGCCCCGACCGACGAACACGGCGGCGACCTGATCTACT
TCCAGGGCCACACCTCGCCAGGCGTTTATGCCCGTGCATTCATGGAAGGCCGCATCACCGAAGACCAGATGAACAACTTC
CGCCAGGAAGTCGACGGTCAGGGCCTGTCGTCCTACCCGCACCCTTGGCTGATGCCTGACTTCTGGCAGTTCCCGACCGT
TTCGATGGGGCTGGGCCCGATCCAGGCGATCTACCAGGCTCGCTTCATGAAGTACCTGGAACACCGCGGTTTCATTCAGC
CGGGCAAACAGAAAGTCTGGTGCTTCCTGGGCGACGGCGAGTGCGACGAGCCGGAATCCCTGGGCGCCATCTCCCTGGCC
GGCCGCGAGAAGCTGGACAACCTGATCTTCGTCATCAACTGCAACCTGCAGCGCCTCGACGGCCCGGTTCGCGGCAACGG
CAAGATCATCCAGGAACTCGAAGGCGTGTTCCGCGGTGCTCAGTGGAACGTGACCAAAGTCATCTGGGGCCGTTTCTGGG
ACCCACTGCTGGCCAAAGACGTCGACGGCATCCTGCAACGTCGCATGGACGAAGTCATCGACGGCGAGTACCAGAACTAC
AAAGCCAAAGACGGCGCATTCGTGCGCGAACACTTCTTCAACACGCCAGAACTCAAGGCGATGGTTGCAGACCTGTCCGA
CGACGAGATCTGGAAACTCAACCGTGGCGGCCACGACCCGTACAAGGTCTACGCGGCATACCACGAAGCGGTCAACCACA
AAGAACAACCGACCGTCATCCTGGCCAAGACCATCAAGGGTTACGGTACCGGTGCGGGCGAAGCGAAGAACACCGCGCAC
AACACCAAGAAAGTCGACGTCGACAGCCTGAAGCTGTTCCGCGACCGCTTCGACATCCCGGTGAAAGACGAAGAGCTGGA
AAACCTGCCGTTCTTCAAGCCAGAGCCAAACAGCGCCGAAGCCCGTTACCTGGCCGAGCGTCGCGCCGCATTGGGTGGTT
TCGTGCCTCAGCGTCGCGCCCAGAGCTTCAGCGTACCGACTCCGGATCTGGACACCCTCAAGGCGATCCTCGACGGTTCC
GGCGACCGTGAAATTTCCACCACCATGGCCTTCGTGCGGATCCTCGCGCAACTGGTCAAGGACAAGGAAATCGGCCCGCG
CATCGTTCCGATCATCCCGGACGAAGCCCGTACCTTCGGTATGGAAGGCATGTTCCGCCAACTGGGCATCTACTCGTCCG
TCGGCCAGCTCTACGAGCCAGTCGATAAAGACCAGGTGATGTTCTACAAGGAAGACCAGAAAGGTCAGATCCTTGAAGAA
GGCATCAACGAAGCAGGCGCCATGAGTTCCTTCATCGCCGCCGGTACTTCGTACTCCAGCCACAACCAGCCAATGCTGCC
GTTCTACATCTTCTACTCGATGTTCGGCTTCCAGCGTATCGGCGATCTGGCCTGGGCTGCCGGCGACAGCCGCACCCGTG
GCTTCCTGATCGGCGGCACCGCCGGCCGTACCACCCTGAACGGTGAAGGCCTGCAGCACGAAGACGGTCACAGCCACCTG
CTGGCTGCCACCATCCCGAACTGCCGCACCTACGATCCGACCTACGGCTACGAGCTGGCGGTGATCATTCAGGACGGCAT
GAAGAAGATGACCGAAGAGCAACAGGACATCTTCTATTACATCACCGTGATGAACGAGTCCTACCAGCAGCCAGCCATGC
CGGCCGGTGCCGAAGAAGGCATCAAGAAAGGCATGTACCTGCTCGAAGAAGACACCCGCGATGCGGCGCATCACGTACAG
CTGATGGGCTCCGGCACCATCCTGCGTGAAGTCCGTGAAGCGGCGAAGATTCTGCGTGAAGAGTTCAACATCGGCGCCGA
TGTGTGGAGCGTCACCAGCTTCAACGAACTGCGTCGCGACGGCCTGGCCGTAGAGCGAAGCAACCGTCTGAAACCTGGCC
AGAAGCCTAAGCGCAGCTACGTCGAAGAATGCCTGAGCGGCCGTAAGGGTCCGGTCATCGCCTCTACCGACTACATGAAA
CTGTTCGCCGAGCAGATCCGTCAGTGGGTACCGTCCAAGGAATTCAAAGTCCTGGGCACCGACGGTTTCGGCCGTAGCGA
CAGCCGCAAGAAACTGCGTCATTTCTTCGAAGTCGACCGTCATTTCGTGGTGTTGGCAGCCCTGGAAGCACTGGCTGACC
GTGGTGATATCGAACCTAAAGTCGTGGCCGAGGCCATTACCAAGTTCGGCATCGACCCGGAAAAACGCAACCCACTGGAC
TGCTGA

Upstream 100 bases:

>100_bases
CAACCTGTCGGCAATCCAAGAATTTTAAATCGTCTGCCCACAAGGCCAGTCGCAAACTCAGGCAACCGATTCTGGAAGCC
TTTCCGCCCTGGAGCAAGCC

Downstream 100 bases:

>100_bases
GGAGAAACTCTGTGAGCGAACTCATTCGCGTACCTGACATCGGCAGCGGTGAAGGTGAAGTAATCGAACTGTTTGTGAAG
GTCGGCGACCGTATCGAAGC

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 881; Mature: 881

Protein sequence:

>881_residues
MQDLDPVETQEWLDALESVLDKEGEDRAHYLMTRMGELATRSGSQLPYAITTPYRNTIPVTHEARMPGDLFMERRIRSLV
RWNAMAMVMRTNLKDSDLGGHISSFASSATLYDIGFNYFFQAPTDEHGGDLIYFQGHTSPGVYARAFMEGRITEDQMNNF
RQEVDGQGLSSYPHPWLMPDFWQFPTVSMGLGPIQAIYQARFMKYLEHRGFIQPGKQKVWCFLGDGECDEPESLGAISLA
GREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAQWNVTKVIWGRFWDPLLAKDVDGILQRRMDEVIDGEYQNY
KAKDGAFVREHFFNTPELKAMVADLSDDEIWKLNRGGHDPYKVYAAYHEAVNHKEQPTVILAKTIKGYGTGAGEAKNTAH
NTKKVDVDSLKLFRDRFDIPVKDEELENLPFFKPEPNSAEARYLAERRAALGGFVPQRRAQSFSVPTPDLDTLKAILDGS
GDREISTTMAFVRILAQLVKDKEIGPRIVPIIPDEARTFGMEGMFRQLGIYSSVGQLYEPVDKDQVMFYKEDQKGQILEE
GINEAGAMSSFIAAGTSYSSHNQPMLPFYIFYSMFGFQRIGDLAWAAGDSRTRGFLIGGTAGRTTLNGEGLQHEDGHSHL
LAATIPNCRTYDPTYGYELAVIIQDGMKKMTEEQQDIFYYITVMNESYQQPAMPAGAEEGIKKGMYLLEEDTRDAAHHVQ
LMGSGTILREVREAAKILREEFNIGADVWSVTSFNELRRDGLAVERSNRLKPGQKPKRSYVEECLSGRKGPVIASTDYMK
LFAEQIRQWVPSKEFKVLGTDGFGRSDSRKKLRHFFEVDRHFVVLAALEALADRGDIEPKVVAEAITKFGIDPEKRNPLD
C

Sequences:

>Translated_881_residues
MQDLDPVETQEWLDALESVLDKEGEDRAHYLMTRMGELATRSGSQLPYAITTPYRNTIPVTHEARMPGDLFMERRIRSLV
RWNAMAMVMRTNLKDSDLGGHISSFASSATLYDIGFNYFFQAPTDEHGGDLIYFQGHTSPGVYARAFMEGRITEDQMNNF
RQEVDGQGLSSYPHPWLMPDFWQFPTVSMGLGPIQAIYQARFMKYLEHRGFIQPGKQKVWCFLGDGECDEPESLGAISLA
GREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAQWNVTKVIWGRFWDPLLAKDVDGILQRRMDEVIDGEYQNY
KAKDGAFVREHFFNTPELKAMVADLSDDEIWKLNRGGHDPYKVYAAYHEAVNHKEQPTVILAKTIKGYGTGAGEAKNTAH
NTKKVDVDSLKLFRDRFDIPVKDEELENLPFFKPEPNSAEARYLAERRAALGGFVPQRRAQSFSVPTPDLDTLKAILDGS
GDREISTTMAFVRILAQLVKDKEIGPRIVPIIPDEARTFGMEGMFRQLGIYSSVGQLYEPVDKDQVMFYKEDQKGQILEE
GINEAGAMSSFIAAGTSYSSHNQPMLPFYIFYSMFGFQRIGDLAWAAGDSRTRGFLIGGTAGRTTLNGEGLQHEDGHSHL
LAATIPNCRTYDPTYGYELAVIIQDGMKKMTEEQQDIFYYITVMNESYQQPAMPAGAEEGIKKGMYLLEEDTRDAAHHVQ
LMGSGTILREVREAAKILREEFNIGADVWSVTSFNELRRDGLAVERSNRLKPGQKPKRSYVEECLSGRKGPVIASTDYMK
LFAEQIRQWVPSKEFKVLGTDGFGRSDSRKKLRHFFEVDRHFVVLAALEALADRGDIEPKVVAEAITKFGIDPEKRNPLD
C
>Mature_881_residues
MQDLDPVETQEWLDALESVLDKEGEDRAHYLMTRMGELATRSGSQLPYAITTPYRNTIPVTHEARMPGDLFMERRIRSLV
RWNAMAMVMRTNLKDSDLGGHISSFASSATLYDIGFNYFFQAPTDEHGGDLIYFQGHTSPGVYARAFMEGRITEDQMNNF
RQEVDGQGLSSYPHPWLMPDFWQFPTVSMGLGPIQAIYQARFMKYLEHRGFIQPGKQKVWCFLGDGECDEPESLGAISLA
GREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAQWNVTKVIWGRFWDPLLAKDVDGILQRRMDEVIDGEYQNY
KAKDGAFVREHFFNTPELKAMVADLSDDEIWKLNRGGHDPYKVYAAYHEAVNHKEQPTVILAKTIKGYGTGAGEAKNTAH
NTKKVDVDSLKLFRDRFDIPVKDEELENLPFFKPEPNSAEARYLAERRAALGGFVPQRRAQSFSVPTPDLDTLKAILDGS
GDREISTTMAFVRILAQLVKDKEIGPRIVPIIPDEARTFGMEGMFRQLGIYSSVGQLYEPVDKDQVMFYKEDQKGQILEE
GINEAGAMSSFIAAGTSYSSHNQPMLPFYIFYSMFGFQRIGDLAWAAGDSRTRGFLIGGTAGRTTLNGEGLQHEDGHSHL
LAATIPNCRTYDPTYGYELAVIIQDGMKKMTEEQQDIFYYITVMNESYQQPAMPAGAEEGIKKGMYLLEEDTRDAAHHVQ
LMGSGTILREVREAAKILREEFNIGADVWSVTSFNELRRDGLAVERSNRLKPGQKPKRSYVEECLSGRKGPVIASTDYMK
LFAEQIRQWVPSKEFKVLGTDGFGRSDSRKKLRHFFEVDRHFVVLAALEALADRGDIEPKVVAEAITKFGIDPEKRNPLD
C

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=882, Percent_Identity=59.9773242630385, Blast_Score=1098, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99526; Mature: 99526

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDLDPVETQEWLDALESVLDKEGEDRAHYLMTRMGELATRSGSQLPYAITTPYRNTIPV
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
THEARMPGDLFMERRIRSLVRWNAMAMVMRTNLKDSDLGGHISSFASSATLYDIGFNYFF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCEEEE
QAPTDEHGGDLIYFQGHTSPGVYARAFMEGRITEDQMNNFRQEVDGQGLSSYPHPWLMPD
ECCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FWQFPTVSMGLGPIQAIYQARFMKYLEHRGFIQPGKQKVWCFLGDGECDEPESLGAISLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHCCEEEEC
GREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAQWNVTKVIWGRFWDPLLAKD
CHHCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHH
VDGILQRRMDEVIDGEYQNYKAKDGAFVREHFFNTPELKAMVADLSDDEIWKLNRGGHDP
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCEEECCCCCCCH
YKVYAAYHEAVNHKEQPTVILAKTIKGYGTGAGEAKNTAHNTKKVDVDSLKLFRDRFDIP
HHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
VKDEELENLPFFKPEPNSAEARYLAERRAALGGFVPQRRAQSFSVPTPDLDTLKAILDGS
CCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHCCC
GDREISTTMAFVRILAQLVKDKEIGPRIVPIIPDEARTFGMEGMFRQLGIYSSVGQLYEP
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCHHHHHHHHHHHHHHHHHHCC
VDKDQVMFYKEDQKGQILEEGINEAGAMSSFIAAGTSYSSHNQPMLPFYIFYSMFGFQRI
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
GDLAWAAGDSRTRGFLIGGTAGRTTLNGEGLQHEDGHSHLLAATIPNCRTYDPTYGYELA
HHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEE
VIIQDGMKKMTEEQQDIFYYITVMNESYQQPAMPAGAEEGIKKGMYLLEEDTRDAAHHVQ
EEEHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHEE
LMGSGTILREVREAAKILREEFNIGADVWSVTSFNELRRDGLAVERSNRLKPGQKPKRSY
EECCCHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCEEECCCCCCCCCCHHHHH
VEECLSGRKGPVIASTDYMKLFAEQIRQWVPSKEFKVLGTDGFGRSDSRKKLRHFFEVDR
HHHHHCCCCCCEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
HFVVLAALEALADRGDIEPKVVAEAITKFGIDPEKRNPLDC
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQDLDPVETQEWLDALESVLDKEGEDRAHYLMTRMGELATRSGSQLPYAITTPYRNTIPV
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
THEARMPGDLFMERRIRSLVRWNAMAMVMRTNLKDSDLGGHISSFASSATLYDIGFNYFF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCEEEE
QAPTDEHGGDLIYFQGHTSPGVYARAFMEGRITEDQMNNFRQEVDGQGLSSYPHPWLMPD
ECCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FWQFPTVSMGLGPIQAIYQARFMKYLEHRGFIQPGKQKVWCFLGDGECDEPESLGAISLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHCCEEEEC
GREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAQWNVTKVIWGRFWDPLLAKD
CHHCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHH
VDGILQRRMDEVIDGEYQNYKAKDGAFVREHFFNTPELKAMVADLSDDEIWKLNRGGHDP
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCEEECCCCCCCH
YKVYAAYHEAVNHKEQPTVILAKTIKGYGTGAGEAKNTAHNTKKVDVDSLKLFRDRFDIP
HHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
VKDEELENLPFFKPEPNSAEARYLAERRAALGGFVPQRRAQSFSVPTPDLDTLKAILDGS
CCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHCCC
GDREISTTMAFVRILAQLVKDKEIGPRIVPIIPDEARTFGMEGMFRQLGIYSSVGQLYEP
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCHHHHHHHHHHHHHHHHHHCC
VDKDQVMFYKEDQKGQILEEGINEAGAMSSFIAAGTSYSSHNQPMLPFYIFYSMFGFQRI
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
GDLAWAAGDSRTRGFLIGGTAGRTTLNGEGLQHEDGHSHLLAATIPNCRTYDPTYGYELA
HHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEE
VIIQDGMKKMTEEQQDIFYYITVMNESYQQPAMPAGAEEGIKKGMYLLEEDTRDAAHHVQ
EEEHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHEE
LMGSGTILREVREAAKILREEFNIGADVWSVTSFNELRRDGLAVERSNRLKPGQKPKRSY
EECCCHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCEEECCCCCCCCCCHHHHH
VEECLSGRKGPVIASTDYMKLFAEQIRQWVPSKEFKVLGTDGFGRSDSRKKLRHFFEVDR
HHHHHCCCCCCEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
HFVVLAALEALADRGDIEPKVVAEAITKFGIDPEKRNPLDC
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]