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The map label for this gene is msrA [H]

Identifier: 77456687

GI number: 77456687

Start: 526067

End: 526732

Strand: Reverse

Name: msrA [H]

Synonym: Pfl01_0459

Alternate gene names: 77456687

Gene position: 526732-526067 (Counterclockwise)

Preceding gene: 77456688

Following gene: 77456685

Centisome position: 8.18

GC content: 58.86

Gene sequence:

>666_bases
ATGGTTCTGCGCTCGGAAATTCTGGTGAACAAAAACGTGCTACCGACTAAAGAACAAGCTCTGCCTGGCCGCGAAACACC
GATGGCCCTGCCTGAAAAACACTTTGTTTTCACCGAAACGCCGTTGCTGGGTCCGTTCTTTCAGGACGTCGACTTCGCAA
TCTTCGGGCTGGGCTGCTTCTGGGGTGCCGAGCGCCGCTTCTGGCAGCGCGAAGGCGTGGTCAGCACCGTGGTCGGTTAC
GCCGGCGGTTTCACGCCGAACCCGACCTACGAAGAAGTCTGCTCGGGCCTGACCGGCCACGCTGAAGTGGTGCTGGTGGT
GTTCGACAAGGCCAAGGTCAGCTACGAAGAGCTGCTGGCGATGTTCTGGGAATTGCACAACCCGACGCAGGGCATGCGTC
AGGGCAATGACATCGGCACCCAGTACCGTTCGGTGATCTACGCGACCCATCCGGAGCAACTGGATGCGGCGCTGAAGAGC
AAAGCCGTTTATCAGGCTGAGCTGTCGAAGGCGGGTCTGGGTGAAATCAGCACCGAGATTGAACAGGCCCCGACGGTTTA
CTTCGCCGAGACCTATCACCAGCAGTATCTGGCGAAAAACCCGGAAGGCTATTGCGGGATTGGCGGCACTGGCGTGTGCA
TGCCACCGAGTCTGGCAGGTAACTAA

Upstream 100 bases:

>100_bases
CGGACACTATCCGCACATTTTGCCTGGTGATTAACCGGGCATCATTGGGCACACTGTGGGTCAGCTTATAGACATCCCAT
CCTGACTGAGAGGAACGATC

Downstream 100 bases:

>100_bases
GCCCGCCTTGATCGCTCCCGCGCTTAGCGTGGGAGCGATTGACGGTTGATCAGCTTTCGGCGATCAACCAATCCATCTGC
CACCCACCCTGGGTCTGGCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MVLRSEILVNKNVLPTKEQALPGRETPMALPEKHFVFTETPLLGPFFQDVDFAIFGLGCFWGAERRFWQREGVVSTVVGY
AGGFTPNPTYEEVCSGLTGHAEVVLVVFDKAKVSYEELLAMFWELHNPTQGMRQGNDIGTQYRSVIYATHPEQLDAALKS
KAVYQAELSKAGLGEISTEIEQAPTVYFAETYHQQYLAKNPEGYCGIGGTGVCMPPSLAGN

Sequences:

>Translated_221_residues
MVLRSEILVNKNVLPTKEQALPGRETPMALPEKHFVFTETPLLGPFFQDVDFAIFGLGCFWGAERRFWQREGVVSTVVGY
AGGFTPNPTYEEVCSGLTGHAEVVLVVFDKAKVSYEELLAMFWELHNPTQGMRQGNDIGTQYRSVIYATHPEQLDAALKS
KAVYQAELSKAGLGEISTEIEQAPTVYFAETYHQQYLAKNPEGYCGIGGTGVCMPPSLAGN
>Mature_221_residues
MVLRSEILVNKNVLPTKEQALPGRETPMALPEKHFVFTETPLLGPFFQDVDFAIFGLGCFWGAERRFWQREGVVSTVVGY
AGGFTPNPTYEEVCSGLTGHAEVVLVVFDKAKVSYEELLAMFWELHNPTQGMRQGNDIGTQYRSVIYATHPEQLDAALKS
KAVYQAELSKAGLGEISTEIEQAPTVYFAETYHQQYLAKNPEGYCGIGGTGVCMPPSLAGN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=198, Percent_Identity=58.5858585858586, Blast_Score=242, Evalue=2e-64,
Organism=Homo sapiens, GI208609995, Length=171, Percent_Identity=63.1578947368421, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI208609993, Length=118, Percent_Identity=63.5593220338983, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1790665, Length=210, Percent_Identity=55.7142857142857, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=38.1944444444444, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=39.2405063291139, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=38.8888888888889, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=38.1944444444444, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=37.8571428571429, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24362; Mature: 24362

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRSEILVNKNVLPTKEQALPGRETPMALPEKHFVFTETPLLGPFFQDVDFAIFGLGCF
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WGAERRFWQREGVVSTVVGYAGGFTPNPTYEEVCSGLTGHAEVVLVVFDKAKVSYEELLA
HHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHH
MFWELHNPTQGMRQGNDIGTQYRSVIYATHPEQLDAALKSKAVYQAELSKAGLGEISTEI
HHHHHCCCHHHHHCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EQAPTVYFAETYHQQYLAKNPEGYCGIGGTGVCMPPSLAGN
HHCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVLRSEILVNKNVLPTKEQALPGRETPMALPEKHFVFTETPLLGPFFQDVDFAIFGLGCF
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WGAERRFWQREGVVSTVVGYAGGFTPNPTYEEVCSGLTGHAEVVLVVFDKAKVSYEELLA
HHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHH
MFWELHNPTQGMRQGNDIGTQYRSVIYATHPEQLDAALKSKAVYQAELSKAGLGEISTEI
HHHHHCCCHHHHHCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EQAPTVYFAETYHQQYLAKNPEGYCGIGGTGVCMPPSLAGN
HHCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA