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The map label for this gene is hutH [H]

Identifier: 77456661

GI number: 77456661

Start: 492038

End: 493582

Strand: Reverse

Name: hutH [H]

Synonym: Pfl01_0433

Alternate gene names: 77456661

Gene position: 493582-492038 (Counterclockwise)

Preceding gene: 77456662

Following gene: 77456660

Centisome position: 7.67

GC content: 65.44

Gene sequence:

>1545_bases
ATGACAACGCCAACTCCTGAGCCGGTCACCTTCGGCGAACGCCCTCTGCGCATCGAAGACGTGCTGGCTCTGGCCAACCG
TCAGGCGCCCGTGCAGTTGCAGAGCGACGCGCCTTATCGCGAACGCATCGCCAAGGGCGCGCGGTTCCTCGATTCGCTGC
TGGACAAGGAAGGTGTGATCTACGGCGTGACCACCGGTTACGGAGACTCCTGCGTGGTTGCGGTGCCGTTGCATCACGTC
GAGGCGCTGCCGCGTCATCTCTACACGTTCCACGGTTGCGGGCTGGGCAAACTGCTCGACGCCCAGGCCACCCGCGCGGT
GCTGGCGGCGCGTTTGCAGTCGTTGTGCCACGGCGTATCCGGGGTGCGCATCGAGTTGCTGGAACGCCTGCATGCCTTCC
TTGAACACGACATTTTGCCGCTGATTCCTGAAGAGGGTTCGGTGGGCGCCAGCGGCGACCTGACGCCGCTGTCCTACGTC
GCCGCAACCCTGTCCGGCGAGCGTGAAGTGATGTTCCGTGGCGAACGCCGCCAGGCTGCGGACGTGCACCGTGAACTGGG
CTGGACACCATTGGTGCTGCGTCCGAAAGAAGCGCTGGCGCTGATGAACGGCACCGCCGTGATGACCGGTCTGGCGTGCC
TGGCTTACGCCCGCGCCGACTACCTGCTGCAACTGGCCACCCGCATCACTGCGTTGAACGTGGTGGCGCTGCAAGGCAAT
CCGGAACACTTCGACGAGCGCCTGTTCGCCGCCAAGCCGCATCCGGGTCAGATGCAGGTGGCCGCGTGGCTGCGCAAGGA
TCTGGCAATCGACGCGCCGACCGCGCCGCTGCACCGCTTGCAGGATCGCTACTCGCTGCGCTGTGCACCGCACGTGCTTG
GCGTATTGGCCGACAGCCTGAACTGGCTGCGCTCGTTCATCGAAACCGAACTCAACAGCGCCAACGACAACCCGATCATC
GACGCCGAAGCCGAGCGCGTGCTGCACGGCGGACACTTCTACGGCGGGCATATCGCGTTCGCCATGGACAGCCTGAAAAA
CCTCGTGGCCAACGTCGCCGACCTGCTCGACCGACAACTCGCGCTGCTGGTCGACGAGCGTTACAACCACGGTTTGCCGA
GCAACCTGTCCGGCGCCAGCGCCGACCGCGCGATGCTCAACCACGGCTTCAAGGCCGTGCAAATCGGCGCCAGTGCCTGG
ACTGCCGAAGCGCTGAAAAACACCATGCCGGCCAGCGTGTTCTCACGCTCCACCGAGTGCCACAACCAGGACAAGGTGAG
CATGGGCACCATCGCCGCCCGCGACGCCATTCGCGTGCTGGAGCTGACCGAACAGGTCGCCGCCGCCACGTTGCTCGCGG
CCAATCAAGGCGTGTGGCTGCGCGGCCGCGATGAAGACGCTCGCCCACTGCCACCGTCGCTGGCCGCCATGCATGAACAA
CTGGCCCAAGACTTCCCGCCAGTGATCGAAGACCGCGCCCTGGAAGGCGAACTGCGCCTGTGCCTGCAACGCATCGCCGA
GCAACACTGGAGGCTGCATGCGTAG

Upstream 100 bases:

>100_bases
GTCATTCATCAGTGGGCCACCCGCTACGCCGAACGCCTGAGTCACTATTGCCTCGAAGCACCGTGCCAATGGTTCAACTT
TTACCCATTCTGGAAAACCG

Downstream 100 bases:

>100_bases
CGCCGGAGTGCTTCACGCCGATACGGAAATCCTCGTGCCGTTCTTTGACGTCGACACCATGCACGTCGTCTGGCACGGCC
ATTACGTGAAATACCTGGAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTTPTPEPVTFGERPLRIEDVLALANRQAPVQLQSDAPYRERIAKGARFLDSLLDKEGVIYGVTTGYGDSCVVAVPLHHV
EALPRHLYTFHGCGLGKLLDAQATRAVLAARLQSLCHGVSGVRIELLERLHAFLEHDILPLIPEEGSVGASGDLTPLSYV
AATLSGEREVMFRGERRQAADVHRELGWTPLVLRPKEALALMNGTAVMTGLACLAYARADYLLQLATRITALNVVALQGN
PEHFDERLFAAKPHPGQMQVAAWLRKDLAIDAPTAPLHRLQDRYSLRCAPHVLGVLADSLNWLRSFIETELNSANDNPII
DAEAERVLHGGHFYGGHIAFAMDSLKNLVANVADLLDRQLALLVDERYNHGLPSNLSGASADRAMLNHGFKAVQIGASAW
TAEALKNTMPASVFSRSTECHNQDKVSMGTIAARDAIRVLELTEQVAAATLLAANQGVWLRGRDEDARPLPPSLAAMHEQ
LAQDFPPVIEDRALEGELRLCLQRIAEQHWRLHA

Sequences:

>Translated_514_residues
MTTPTPEPVTFGERPLRIEDVLALANRQAPVQLQSDAPYRERIAKGARFLDSLLDKEGVIYGVTTGYGDSCVVAVPLHHV
EALPRHLYTFHGCGLGKLLDAQATRAVLAARLQSLCHGVSGVRIELLERLHAFLEHDILPLIPEEGSVGASGDLTPLSYV
AATLSGEREVMFRGERRQAADVHRELGWTPLVLRPKEALALMNGTAVMTGLACLAYARADYLLQLATRITALNVVALQGN
PEHFDERLFAAKPHPGQMQVAAWLRKDLAIDAPTAPLHRLQDRYSLRCAPHVLGVLADSLNWLRSFIETELNSANDNPII
DAEAERVLHGGHFYGGHIAFAMDSLKNLVANVADLLDRQLALLVDERYNHGLPSNLSGASADRAMLNHGFKAVQIGASAW
TAEALKNTMPASVFSRSTECHNQDKVSMGTIAARDAIRVLELTEQVAAATLLAANQGVWLRGRDEDARPLPPSLAAMHEQ
LAQDFPPVIEDRALEGELRLCLQRIAEQHWRLHA
>Mature_513_residues
TTPTPEPVTFGERPLRIEDVLALANRQAPVQLQSDAPYRERIAKGARFLDSLLDKEGVIYGVTTGYGDSCVVAVPLHHVE
ALPRHLYTFHGCGLGKLLDAQATRAVLAARLQSLCHGVSGVRIELLERLHAFLEHDILPLIPEEGSVGASGDLTPLSYVA
ATLSGEREVMFRGERRQAADVHRELGWTPLVLRPKEALALMNGTAVMTGLACLAYARADYLLQLATRITALNVVALQGNP
EHFDERLFAAKPHPGQMQVAAWLRKDLAIDAPTAPLHRLQDRYSLRCAPHVLGVLADSLNWLRSFIETELNSANDNPIID
AEAERVLHGGHFYGGHIAFAMDSLKNLVANVADLLDRQLALLVDERYNHGLPSNLSGASADRAMLNHGFKAVQIGASAWT
AEALKNTMPASVFSRSTECHNQDKVSMGTIAARDAIRVLELTEQVAAATLLAANQGVWLRGRDEDARPLPPSLAAMHEQL
AQDFPPVIEDRALEGELRLCLQRIAEQHWRLHA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=516, Percent_Identity=35.077519379845, Blast_Score=268, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17567831, Length=504, Percent_Identity=35.7142857142857, Blast_Score=244, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56260; Mature: 56129

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTPEPVTFGERPLRIEDVLALANRQAPVQLQSDAPYRERIAKGARFLDSLLDKEGVI
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEE
YGVTTGYGDSCVVAVPLHHVEALPRHLYTFHGCGLGKLLDAQATRAVLAARLQSLCHGVS
EEEECCCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GVRIELLERLHAFLEHDILPLIPEEGSVGASGDLTPLSYVAATLSGEREVMFRGERRQAA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHH
DVHRELGWTPLVLRPKEALALMNGTAVMTGLACLAYARADYLLQLATRITALNVVALQGN
HHHHHCCCCCEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
PEHFDERLFAAKPHPGQMQVAAWLRKDLAIDAPTAPLHRLQDRYSLRCAPHVLGVLADSL
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
NWLRSFIETELNSANDNPIIDAEAERVLHGGHFYGGHIAFAMDSLKNLVANVADLLDRQL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHH
ALLVDERYNHGLPSNLSGASADRAMLNHGFKAVQIGASAWTAEALKNTMPASVFSRSTEC
HHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHCCCHHHHHCCHHH
HNQDKVSMGTIAARDAIRVLELTEQVAAATLLAANQGVWLRGRDEDARPLPPSLAAMHEQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHH
LAQDFPPVIEDRALEGELRLCLQRIAEQHWRLHA
HHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTPTPEPVTFGERPLRIEDVLALANRQAPVQLQSDAPYRERIAKGARFLDSLLDKEGVI
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEE
YGVTTGYGDSCVVAVPLHHVEALPRHLYTFHGCGLGKLLDAQATRAVLAARLQSLCHGVS
EEEECCCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GVRIELLERLHAFLEHDILPLIPEEGSVGASGDLTPLSYVAATLSGEREVMFRGERRQAA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHH
DVHRELGWTPLVLRPKEALALMNGTAVMTGLACLAYARADYLLQLATRITALNVVALQGN
HHHHHCCCCCEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
PEHFDERLFAAKPHPGQMQVAAWLRKDLAIDAPTAPLHRLQDRYSLRCAPHVLGVLADSL
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
NWLRSFIETELNSANDNPIIDAEAERVLHGGHFYGGHIAFAMDSLKNLVANVADLLDRQL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHH
ALLVDERYNHGLPSNLSGASADRAMLNHGFKAVQIGASAWTAEALKNTMPASVFSRSTEC
HHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHCCCHHHHHCCHHH
HNQDKVSMGTIAARDAIRVLELTEQVAAATLLAANQGVWLRGRDEDARPLPPSLAAMHEQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHH
LAQDFPPVIEDRALEGELRLCLQRIAEQHWRLHA
HHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]