Click here to switch to the map view.

The map label for this gene is hslU [H]

Identifier: 77456624

GI number: 77456624

Start: 449262

End: 450599

Strand: Reverse

Name: hslU [H]

Synonym: Pfl01_0396

Alternate gene names: 77456624

Gene position: 450599-449262 (Counterclockwise)

Preceding gene: 255961281

Following gene: 77456623

Centisome position: 7.0

GC content: 61.06

Gene sequence:

>1338_bases
ATGTCCATGACTCCCCGCGAAATCGTCCACGAACTCAACCGCCACATCATCGGCCAGGACGATGCCAAACGCGCCGTCGC
GATTGCCCTGCGCAACCGCTGGCGCCGCATGCAGCTGCCTGAAGAGCTGCGCGTTGAAGTGACCCCGAAGAACATCCTGA
TGATCGGCCCGACCGGTGTCGGTAAAACCGAGATCGCCCGTCGCCTGGCCAAACTGGCCAACGCGCCGTTCATCAAGGTC
GAAGCGACCAAATTCACCGAAGTCGGCTACGTCGGCCGTGACGTCGAATCGATCATCCGTGATCTGGCCGACGCCGCGAT
CAAGATGCTGCGCGAGCAGGAAATGACCCGCGTTCGCCACCGTGCCGAAGACGCCGCCGAGGACCGTATTCTCGACGCCC
TGCTGCCACCGGCACGCATGGGCTTCAGCAATGAAGAAGCGCCGACCCAGGATTCCAATACTCGCCAACTGTTCCGCAAG
CGCCTGCGCGAAGGTCAGCTGGACGACAAGGAAATCGAGATCGAAGTCGCCGAAATGGCCGGCATCGAAATCGCCACGCC
TCCGGGCATGGAAGAAATGACCAACCAGTTGCAGAACCTGTTCGCCAACATGGGCAAGGGCAAGAAGAAGGCCCGCAAGC
TCAAGGTCAAGGAAGCGCTGAAGCTGGTACGCGACGAAGAAGCCGGTCGCCTGGTCAACGAAGAAGAGTTGAAGGCCAAG
GCCCTGGAAGCAGTCGAGCAGCACGGCATCGTATTCATCGACGAGATCGACAAGGTCGCCAAGCGCGGCAATGTCGGCGG
CGCCGATGTGTCCCGCGAGGGCGTGCAACGTGACCTGCTGCCGCTGATCGAAGGCTGCACCGTCAACACCAAGCTGGGCA
TGGTCAAGACCGACCACATCCTGTTCATCGCCTCCGGTGCGTTCCACCTGAGCAAGCCGAGCGATCTGGTGCCGGAACTG
CAAGGTCGTCTGCCGATCCGCGTTGAACTCAAGGCCCTGAGCCCGCAGGACTTCGAACGCATTCTCAGCGAACCGCACGC
CTCGCTCACCGAGCAATACTGCGCGCTGCTGAAAACCGAAGGCCTGAACATCCAGTTCCAGCCGGAAGGCATCAAGCGTC
TGGCGGAAATCGCCTGGCAGGTCAACGAGAAGACCGAGAACATCGGTGCCCGTCGCCTGCACACACTGCTCGAGCGTCTG
CTGGAAGAGGTGTCGTTCAGTGCCGGCGATCTGGCCAGCGCCCACGACGACAAAGCGATCCAGATCGACGCCGAGTACGT
CAACAGCCACCTGGGCGAATTGGCGCAGAACGAAGACCTGTCCCGTTATATCCTGTAA

Upstream 100 bases:

>100_bases
ACCAACCACACCCAGACCATTGAGGAGCAGGATCTCGCTGAATGAGCCTGACGCGGCCCCTGTGCCACGGCTTGTTTCTG
CTTGAGGACCGTCAATTATT

Downstream 100 bases:

>100_bases
GCCATACTTACAGTGGTCGTGAAACTGTGGGAGCCATCGGCTCCCACAATTTTTTTCACCTGACGGAACGCCGGCAATGA
CCCAACTCCCCACCGACATC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKV
EATKFTEVGYVGRDVESIIRDLADAAIKMLREQEMTRVRHRAEDAAEDRILDALLPPARMGFSNEEAPTQDSNTRQLFRK
RLREGQLDDKEIEIEVAEMAGIEIATPPGMEEMTNQLQNLFANMGKGKKKARKLKVKEALKLVRDEEAGRLVNEEELKAK
ALEAVEQHGIVFIDEIDKVAKRGNVGGADVSREGVQRDLLPLIEGCTVNTKLGMVKTDHILFIASGAFHLSKPSDLVPEL
QGRLPIRVELKALSPQDFERILSEPHASLTEQYCALLKTEGLNIQFQPEGIKRLAEIAWQVNEKTENIGARRLHTLLERL
LEEVSFSAGDLASAHDDKAIQIDAEYVNSHLGELAQNEDLSRYIL

Sequences:

>Translated_445_residues
MSMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKV
EATKFTEVGYVGRDVESIIRDLADAAIKMLREQEMTRVRHRAEDAAEDRILDALLPPARMGFSNEEAPTQDSNTRQLFRK
RLREGQLDDKEIEIEVAEMAGIEIATPPGMEEMTNQLQNLFANMGKGKKKARKLKVKEALKLVRDEEAGRLVNEEELKAK
ALEAVEQHGIVFIDEIDKVAKRGNVGGADVSREGVQRDLLPLIEGCTVNTKLGMVKTDHILFIASGAFHLSKPSDLVPEL
QGRLPIRVELKALSPQDFERILSEPHASLTEQYCALLKTEGLNIQFQPEGIKRLAEIAWQVNEKTENIGARRLHTLLERL
LEEVSFSAGDLASAHDDKAIQIDAEYVNSHLGELAQNEDLSRYIL
>Mature_444_residues
SMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVE
ATKFTEVGYVGRDVESIIRDLADAAIKMLREQEMTRVRHRAEDAAEDRILDALLPPARMGFSNEEAPTQDSNTRQLFRKR
LREGQLDDKEIEIEVAEMAGIEIATPPGMEEMTNQLQNLFANMGKGKKKARKLKVKEALKLVRDEEAGRLVNEEELKAKA
LEAVEQHGIVFIDEIDKVAKRGNVGGADVSREGVQRDLLPLIEGCTVNTKLGMVKTDHILFIASGAFHLSKPSDLVPELQ
GRLPIRVELKALSPQDFERILSEPHASLTEQYCALLKTEGLNIQFQPEGIKRLAEIAWQVNEKTENIGARRLHTLLERLL
EEVSFSAGDLASAHDDKAIQIDAEYVNSHLGELAQNEDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=444, Percent_Identity=71.3963963963964, Blast_Score=646, Evalue=0.0,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=47, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49993; Mature: 49862

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGV
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEECCCCC
GKTEIARRLAKLANAPFIKVEATKFTEVGYVGRDVESIIRDLADAAIKMLREQEMTRVRH
CHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEDAAEDRILDALLPPARMGFSNEEAPTQDSNTRQLFRKRLREGQLDDKEIEIEVAEMA
HHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHC
GIEIATPPGMEEMTNQLQNLFANMGKGKKKARKLKVKEALKLVRDEEAGRLVNEEELKAK
CEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ALEAVEQHGIVFIDEIDKVAKRGNVGGADVSREGVQRDLLPLIEGCTVNTKLGMVKTDHI
HHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCE
LFIASGAFHLSKPSDLVPELQGRLPIRVELKALSPQDFERILSEPHASLTEQYCALLKTE
EEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCC
GLNIQFQPEGIKRLAEIAWQVNEKTENIGARRLHTLLERLLEEVSFSAGDLASAHDDKAI
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
QIDAEYVNSHLGELAQNEDLSRYIL
EEEHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
SMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEECCCCC
GKTEIARRLAKLANAPFIKVEATKFTEVGYVGRDVESIIRDLADAAIKMLREQEMTRVRH
CHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEDAAEDRILDALLPPARMGFSNEEAPTQDSNTRQLFRKRLREGQLDDKEIEIEVAEMA
HHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHC
GIEIATPPGMEEMTNQLQNLFANMGKGKKKARKLKVKEALKLVRDEEAGRLVNEEELKAK
CEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ALEAVEQHGIVFIDEIDKVAKRGNVGGADVSREGVQRDLLPLIEGCTVNTKLGMVKTDHI
HHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCE
LFIASGAFHLSKPSDLVPELQGRLPIRVELKALSPQDFERILSEPHASLTEQYCALLKTE
EEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCC
GLNIQFQPEGIKRLAEIAWQVNEKTENIGARRLHTLLERLLEEVSFSAGDLASAHDDKAI
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
QIDAEYVNSHLGELAQNEDLSRYIL
EEEHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA