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The map label for this gene is ubiE [H]

Identifier: 77456615

GI number: 77456615

Start: 440677

End: 441447

Strand: Reverse

Name: ubiE [H]

Synonym: Pfl01_0387

Alternate gene names: 77456615

Gene position: 441447-440677 (Counterclockwise)

Preceding gene: 77456619

Following gene: 77456614

Centisome position: 6.86

GC content: 60.83

Gene sequence:

>771_bases
ATGACTGATCAGCGCAAAGGCAGCGATGCCGAACCCACCACTCACTTCGGCTTCAAAAACGTTCCGGAAAGCCAGAAAGC
GGAAAAAGTCGCTGAGGTGTTCCACTCCGTGGCCGCCAAGTACGACCTGATGAACGACCTTCTGTCGGGCGGCATGCACC
GTCTGTGGAAGCGTTTCGCGATCGAACTGTCGGGCGTACGCGCCGGCAATCGCGTGCTGGACATCGCCGGCGGCACGGGC
GATCTGACCAAGAAGTTCTCGCACCTGGTCGGCCCGACCGGTCAGGTGGTGCTGGCCGACATCAACGAATCCATGCTCAA
GGTCGGTCGTGACCGCCTGCTGGATGTCGGCGTGTCGGGCAATGTCGAGTTCGTTCAGGCCGACGCTGAAAAGCTGCCGT
TCCCGGACAACCACTTTGACTGCGTGACCATCGCCTTCGGCCTGCGCAACGTGACGCACAAGGAAGACGCCCTGCGTTCG
ATGCTGCGCGTCCTCAAGCCGGGCGGCCGCCTGCTGGTGCTGGAATTCTCCAAGCCGACCAACGCGCTGATGTCCAAGGC
CTACGACGCCTACTCGTTCGCCTTCATGCCGCTGATGGGCAAGCTGATCACCAATGACTCGGAAAGCTATCGCTACCTGG
CCGAATCGATCCGCATGCACCCGAATCAAGAAACCCTGAAGTCGATGATGGTCGACGCCGGTTTCGACCGCGTGACCTAT
CACAACATGACCGCAGGCATCGTCGCCCTGCACCGCGGCATCAAACCCTGA

Upstream 100 bases:

>100_bases
CAAATCGTCCCGAAGGTTGCCCATCTTACCTTTAGCCATTCCAAGACAAAGCATGGCTTGGGGATTAGAATGTCGCGCAT
TCTCTTTTGGTGACAGCGAT

Downstream 100 bases:

>100_bases
TGCTGCTGACCGGGCTGCTCGCCAGCGTCGAACTCGGCCTCAACCGTGTGCTGCGTCTCGACAGCACGGCGCTGCCGCGA
CTGGCGCATCTGACCGGCAA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTDQRKGSDAEPTTHFGFKNVPESQKAEKVAEVFHSVAAKYDLMNDLLSGGMHRLWKRFAIELSGVRAGNRVLDIAGGTG
DLTKKFSHLVGPTGQVVLADINESMLKVGRDRLLDVGVSGNVEFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKEDALRS
MLRVLKPGGRLLVLEFSKPTNALMSKAYDAYSFAFMPLMGKLITNDSESYRYLAESIRMHPNQETLKSMMVDAGFDRVTY
HNMTAGIVALHRGIKP

Sequences:

>Translated_256_residues
MTDQRKGSDAEPTTHFGFKNVPESQKAEKVAEVFHSVAAKYDLMNDLLSGGMHRLWKRFAIELSGVRAGNRVLDIAGGTG
DLTKKFSHLVGPTGQVVLADINESMLKVGRDRLLDVGVSGNVEFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKEDALRS
MLRVLKPGGRLLVLEFSKPTNALMSKAYDAYSFAFMPLMGKLITNDSESYRYLAESIRMHPNQETLKSMMVDAGFDRVTY
HNMTAGIVALHRGIKP
>Mature_255_residues
TDQRKGSDAEPTTHFGFKNVPESQKAEKVAEVFHSVAAKYDLMNDLLSGGMHRLWKRFAIELSGVRAGNRVLDIAGGTGD
LTKKFSHLVGPTGQVVLADINESMLKVGRDRLLDVGVSGNVEFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKEDALRSM
LRVLKPGGRLLVLEFSKPTNALMSKAYDAYSFAFMPLMGKLITNDSESYRYLAESIRMHPNQETLKSMMVDAGFDRVTYH
NMTAGIVALHRGIKP

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=275, Percent_Identity=45.8181818181818, Blast_Score=247, Evalue=9e-66,
Organism=Escherichia coli, GI48994983, Length=246, Percent_Identity=71.5447154471545, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17557039, Length=255, Percent_Identity=45.0980392156863, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6323526, Length=259, Percent_Identity=42.8571428571429, Blast_Score=182, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24641702, Length=261, Percent_Identity=47.8927203065134, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28360; Mature: 28229

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQRKGSDAEPTTHFGFKNVPESQKAEKVAEVFHSVAAKYDLMNDLLSGGMHRLWKRFA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IELSGVRAGNRVLDIAGGTGDLTKKFSHLVGPTGQVVLADINESMLKVGRDRLLDVGVSG
HHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHCHHHEEEECCCC
NVEFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKEDALRSMLRVLKPGGRLLVLEFSKPT
CEEEEECCHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCH
NALMSKAYDAYSFAFMPLMGKLITNDSESYRYLAESIRMHPNQETLKSMMVDAGFDRVTY
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
HNMTAGIVALHRGIKP
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDQRKGSDAEPTTHFGFKNVPESQKAEKVAEVFHSVAAKYDLMNDLLSGGMHRLWKRFA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IELSGVRAGNRVLDIAGGTGDLTKKFSHLVGPTGQVVLADINESMLKVGRDRLLDVGVSG
HHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHCHHHEEEECCCC
NVEFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKEDALRSMLRVLKPGGRLLVLEFSKPT
CEEEEECCHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCH
NALMSKAYDAYSFAFMPLMGKLITNDSESYRYLAESIRMHPNQETLKSMMVDAGFDRVTY
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
HNMTAGIVALHRGIKP
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA