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The map label for this gene is hutC [H]

Identifier: 77456586

GI number: 77456586

Start: 408472

End: 409221

Strand: Direct

Name: hutC [H]

Synonym: Pfl01_0358

Alternate gene names: 77456586

Gene position: 408472-409221 (Clockwise)

Preceding gene: 77456584

Following gene: 77456587

Centisome position: 6.34

GC content: 61.47

Gene sequence:

>750_bases
GTGCCGACTCCGCCTCCAGTCTCCCCGTTGGCCGCGAACATGGGCGACAGTCCGGCGCCCTTGTACGCCCGCGTCAAACA
GATGATCACCCAGCAGATCGACAGCGGTAACTGGCCGCCGCATTACCGCGTGCCGTCGGAAAGCGAGCTGGTCAGCCAGC
TGGGTTTCAGCCGCATGACCATCAACCGCGCGTTGCGGGAAATGACCGCCGACGGTCTGCTGGTGCGTATGCAAGGCGTC
GGCACTTTCGTTGCTGAGCCGAAGAGCCAGTCCGCGCTGTTCGAAGTGCACAACATCGCCGACGAAATCGCCTCCCGTGG
CCATCGCCACACTTGCCAGGTGATCACCCTGGAAGAAGAGGCTGCCGGTTCCGAGCGCGCGCTGGCGCTGGACATGCGCG
AAGGGCAGAAGGTCTTTCACTCGCTGATCGTGCACTACGAAAACGATGTTCCGGTGCAAATCGAAGACCGTTTCGTCAAT
GCGCTGGTCGCCCCGGAATACCTCAAGCAGGACTTCACCCTGCAAACGCCTTACGCCTATCTGAACCAGGTCGCGCCGCT
GACCGAAGGCGAGCACGTGGTCGAAGCGATCCTTGCCGAAGCGTCCGAATGCAAATTGCTGCAGATCGAAAAAGGCGAGC
CTTGCCTTTTGATCCGTCGTCGTACCTGGTCGGGTCGTCAGCCGGTGACGGCGGCGCGCCTGATCCACCCCGGTTCCCGT
CATCGTCTGGAAGGTCGGTTTCATAAATGA

Upstream 100 bases:

>100_bases
CACCCCATCGTGTGTTATTTGTATATACATATACAGACGTTTGCCTGCCCGGTAAACTCCGGCAAGCTAGCAACTTTCAT
CCAATGAACAGGGATCCACC

Downstream 100 bases:

>100_bases
GTGAAGTGAAGGTTTTACGCGCTGAGGGCTACCCGCGCATGCCGTGGAAAAACGGCGGCGGCAGCACCGAGGAAATCACC
CGTGACGCCGGCGCCGGCCT

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MPTPPPVSPLAANMGDSPAPLYARVKQMITQQIDSGNWPPHYRVPSESELVSQLGFSRMTINRALREMTADGLLVRMQGV
GTFVAEPKSQSALFEVHNIADEIASRGHRHTCQVITLEEEAAGSERALALDMREGQKVFHSLIVHYENDVPVQIEDRFVN
ALVAPEYLKQDFTLQTPYAYLNQVAPLTEGEHVVEAILAEASECKLLQIEKGEPCLLIRRRTWSGRQPVTAARLIHPGSR
HRLEGRFHK

Sequences:

>Translated_249_residues
MPTPPPVSPLAANMGDSPAPLYARVKQMITQQIDSGNWPPHYRVPSESELVSQLGFSRMTINRALREMTADGLLVRMQGV
GTFVAEPKSQSALFEVHNIADEIASRGHRHTCQVITLEEEAAGSERALALDMREGQKVFHSLIVHYENDVPVQIEDRFVN
ALVAPEYLKQDFTLQTPYAYLNQVAPLTEGEHVVEAILAEASECKLLQIEKGEPCLLIRRRTWSGRQPVTAARLIHPGSR
HRLEGRFHK
>Mature_248_residues
PTPPPVSPLAANMGDSPAPLYARVKQMITQQIDSGNWPPHYRVPSESELVSQLGFSRMTINRALREMTADGLLVRMQGVG
TFVAEPKSQSALFEVHNIADEIASRGHRHTCQVITLEEEAAGSERALALDMREGQKVFHSLIVHYENDVPVQIEDRFVNA
LVAPEYLKQDFTLQTPYAYLNQVAPLTEGEHVVEAILAEASECKLLQIEKGEPCLLIRRRTWSGRQPVTAARLIHPGSRH
RLEGRFHK

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=226, Percent_Identity=26.5486725663717, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786950, Length=203, Percent_Identity=24.6305418719212, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27876; Mature: 27745

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPPPVSPLAANMGDSPAPLYARVKQMITQQIDSGNWPPHYRVPSESELVSQLGFSRMT
CCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHHHH
INRALREMTADGLLVRMQGVGTFVAEPKSQSALFEVHNIADEIASRGHRHTCQVITLEEE
HHHHHHHHCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEHH
AAGSERALALDMREGQKVFHSLIVHYENDVPVQIEDRFVNALVAPEYLKQDFTLQTPYAY
CCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCHHHHHCCCCCCCCHHH
LNQVAPLTEGEHVVEAILAEASECKLLQIEKGEPCLLIRRRTWSGRQPVTAARLIHPGSR
HHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
HRLEGRFHK
CCCCCCCCC
>Mature Secondary Structure 
PTPPPVSPLAANMGDSPAPLYARVKQMITQQIDSGNWPPHYRVPSESELVSQLGFSRMT
CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHHHH
INRALREMTADGLLVRMQGVGTFVAEPKSQSALFEVHNIADEIASRGHRHTCQVITLEEE
HHHHHHHHCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEHH
AAGSERALALDMREGQKVFHSLIVHYENDVPVQIEDRFVNALVAPEYLKQDFTLQTPYAY
CCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCHHHHHCCCCCCCCHHH
LNQVAPLTEGEHVVEAILAEASECKLLQIEKGEPCLLIRRRTWSGRQPVTAARLIHPGSR
HHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
HRLEGRFHK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]