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The map label for this gene is mutY [H]

Identifier: 77456548

GI number: 77456548

Start: 364048

End: 365115

Strand: Reverse

Name: mutY [H]

Synonym: Pfl01_0320

Alternate gene names: 77456548

Gene position: 365115-364048 (Counterclockwise)

Preceding gene: 77456549

Following gene: 77456547

Centisome position: 5.67

GC content: 65.26

Gene sequence:

>1068_bases
ATGAGAGCAGAGCAGTTTTCCACGGCGGTACTGGAATGGTTCGACCGCCACGGTCGCCATGACTTGCCCTGGCAACAGAA
CATCAACCCATATCGGGTGTGGGTGTCCGAGATCATGTTGCAGCAGACCCAGGTCAGCACCGTGCTCAATTACTTCGACC
GGTTCATGGCCGCACTGCCGACGGTCGAAGCCCTGGCCGCAGCGCCGGAAGACGAAGTGCTGCACCTGTGGACGGGCCTG
GGTTACTACACCCGCGCGCGCAATCTGCAGAAGACCGCGAAGATCGTCGTCAGCCAGTACGGTGGCGAGTTCCCCCGGGA
TGTCGAGAAGCTCACCGAGCTGCCGGGCATCGGCCTGTCCACCGCCGGCGCGATCGGCAGCATCAGCATGGGCCTGCGCG
CGCCGATCCTCGACGGCAACGTCAAACGGGTGCTGGCGCGCTTTACCGCGCAGGAGGGCTATCCCGGCGAGCCGAAGGTC
GCCAAGCAACTGTGGGCCAACGCCGAGCGCTTCACGCCGCAGGATCGGGTCAACGCCTACACCCAGGCGATGATGGATCT
GGGCGCCACGCTCTGCACCCGCAGCAAGCCGAGCTGCCTGCTGTGTCCGCTGGAAAAGGGCTGCGAAGCGCACATGCTGG
GCCTGGAGACACGCTATCCGATCCCCAAGCCGCGCAAAGCCATCCCGCAGAAGCGCACGCTGATGCCGCTGCTGGCCAAC
GAGGATGGCGCGATTTTGCTTTATCGCCGCCCGTCCAGCGGATTGTGGGGCGGTTTGTGGAGCCTGCCGGAACTCGACGA
CCTCGACGACCTGCAACACCTCGCCGCGCAGCACTCGCTGGAACTGGGCGAGCAGCAGGCGCTGCCGAGCCTTGTCCACA
CCTTCAGCCACTTCCAGCTGTCCATCGAACCCTGGCTGGTTCAGGTTCAGGAAGCCGGCGGTCACGTGGCCGAGGCCGAC
TGGCTCTGGTATAACCTCGCCACCCCGCCGCGCCTGGGCCTCGCCGCCCCGGTAAAGACCTTGCTCGAACGCGCGGCCGC
CGTCTTGAATGCAGGAGAGTCGACATGA

Upstream 100 bases:

>100_bases
GCAAACTGGCCGGCGACAAGCTCAGCGAAAAAATCGACGAAAAACTGGGTGATAAAGTCAGCCCGGAACTGAAAAACGCA
TTGAAGGGGCTGTTCAAGCG

Downstream 100 bases:

>100_bases
CCCGCACCGTAATGTGCCGCAAGTACAAAGAACAACTCGAAGGTCTGGAGCGCCCACCGTACCCGGGTGCCAAGGGCCAG
GATATTTTCGAACACGTCTC

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRAEQFSTAVLEWFDRHGRHDLPWQQNINPYRVWVSEIMLQQTQVSTVLNYFDRFMAALPTVEALAAAPEDEVLHLWTGL
GYYTRARNLQKTAKIVVSQYGGEFPRDVEKLTELPGIGLSTAGAIGSISMGLRAPILDGNVKRVLARFTAQEGYPGEPKV
AKQLWANAERFTPQDRVNAYTQAMMDLGATLCTRSKPSCLLCPLEKGCEAHMLGLETRYPIPKPRKAIPQKRTLMPLLAN
EDGAILLYRRPSSGLWGGLWSLPELDDLDDLQHLAAQHSLELGEQQALPSLVHTFSHFQLSIEPWLVQVQEAGGHVAEAD
WLWYNLATPPRLGLAAPVKTLLERAAAVLNAGEST

Sequences:

>Translated_355_residues
MRAEQFSTAVLEWFDRHGRHDLPWQQNINPYRVWVSEIMLQQTQVSTVLNYFDRFMAALPTVEALAAAPEDEVLHLWTGL
GYYTRARNLQKTAKIVVSQYGGEFPRDVEKLTELPGIGLSTAGAIGSISMGLRAPILDGNVKRVLARFTAQEGYPGEPKV
AKQLWANAERFTPQDRVNAYTQAMMDLGATLCTRSKPSCLLCPLEKGCEAHMLGLETRYPIPKPRKAIPQKRTLMPLLAN
EDGAILLYRRPSSGLWGGLWSLPELDDLDDLQHLAAQHSLELGEQQALPSLVHTFSHFQLSIEPWLVQVQEAGGHVAEAD
WLWYNLATPPRLGLAAPVKTLLERAAAVLNAGEST
>Mature_355_residues
MRAEQFSTAVLEWFDRHGRHDLPWQQNINPYRVWVSEIMLQQTQVSTVLNYFDRFMAALPTVEALAAAPEDEVLHLWTGL
GYYTRARNLQKTAKIVVSQYGGEFPRDVEKLTELPGIGLSTAGAIGSISMGLRAPILDGNVKRVLARFTAQEGYPGEPKV
AKQLWANAERFTPQDRVNAYTQAMMDLGATLCTRSKPSCLLCPLEKGCEAHMLGLETRYPIPKPRKAIPQKRTLMPLLAN
EDGAILLYRRPSSGLWGGLWSLPELDDLDDLQHLAAQHSLELGEQQALPSLVHTFSHFQLSIEPWLVQVQEAGGHVAEAD
WLWYNLATPPRLGLAAPVKTLLERAAAVLNAGEST

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=366, Percent_Identity=37.1584699453552, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI115298648, Length=366, Percent_Identity=37.1584699453552, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI115298650, Length=366, Percent_Identity=37.1584699453552, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI115298654, Length=366, Percent_Identity=37.1584699453552, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI115298652, Length=366, Percent_Identity=37.1584699453552, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI6912520, Length=366, Percent_Identity=37.1584699453552, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI1789331, Length=344, Percent_Identity=52.9069767441861, Blast_Score=365, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39498; Mature: 39498

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAEQFSTAVLEWFDRHGRHDLPWQQNINPYRVWVSEIMLQQTQVSTVLNYFDRFMAALP
CCHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TVEALAAAPEDEVLHLWTGLGYYTRARNLQKTAKIVVSQYGGEFPRDVEKLTELPGIGLS
HHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
TAGAIGSISMGLRAPILDGNVKRVLARFTAQEGYPGEPKVAKQLWANAERFTPQDRVNAY
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHCCCHHHHHHH
TQAMMDLGATLCTRSKPSCLLCPLEKGCEAHMLGLETRYPIPKPRKAIPQKRTLMPLLAN
HHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCHHHCCCHHCCCCEEEC
EDGAILLYRRPSSGLWGGLWSLPELDDLDDLQHLAAQHSLELGEQQALPSLVHTFSHFQL
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEE
SIEPWLVQVQEAGGHVAEADWLWYNLATPPRLGLAAPVKTLLERAAAVLNAGEST
EECHHHEEEHHCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRAEQFSTAVLEWFDRHGRHDLPWQQNINPYRVWVSEIMLQQTQVSTVLNYFDRFMAALP
CCHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TVEALAAAPEDEVLHLWTGLGYYTRARNLQKTAKIVVSQYGGEFPRDVEKLTELPGIGLS
HHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
TAGAIGSISMGLRAPILDGNVKRVLARFTAQEGYPGEPKVAKQLWANAERFTPQDRVNAY
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHCCCHHHHHHH
TQAMMDLGATLCTRSKPSCLLCPLEKGCEAHMLGLETRYPIPKPRKAIPQKRTLMPLLAN
HHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCHHHCCCHHCCCCEEEC
EDGAILLYRRPSSGLWGGLWSLPELDDLDDLQHLAAQHSLELGEQQALPSLVHTFSHFQL
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEE
SIEPWLVQVQEAGGHVAEADWLWYNLATPPRLGLAAPVKTLLERAAAVLNAGEST
EECHHHEEEHHCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]