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The map label for this gene is gabP [H]

Identifier: 77456541

GI number: 77456541

Start: 359105

End: 360496

Strand: Direct

Name: gabP [H]

Synonym: Pfl01_0313

Alternate gene names: 77456541

Gene position: 359105-360496 (Clockwise)

Preceding gene: 77456534

Following gene: 77456545

Centisome position: 5.58

GC content: 61.21

Gene sequence:

>1392_bases
ATGAGCAGTACCCAAAGCTCCAATGGCCTCGAACAGGGGCTCAAACCGCGTCATGTGACCATGCTGTCGATCGCCGGGGT
GATCGGTGCAGGTCTGTTCGTCGGCTCCGGCCACGCCATCGCCGCTGCCGGTCCCGCTGTTCTGCTGGCTTACGCCGCTG
CTGGCGCGCTGGTTGTGTTGGTGATGCGCATGCTCGGCGAAATGGCGGTTGCCTCGCCTGACACTGGCTCGTTCTCGACT
TACGCCGACCGCGCTATCGGTCACTGGGCCGGTTTCACCATCGGCTGGCTGTACTGGTGGTTCTGGGTTTTGGTGATTCC
GCTGGAAGCCAACGCCGCCGCAACCATCCTGCATGCGTGGTTCCCGGGTGTGGATATCTGGGCGTTCGCCCTGATCATCA
CCATGCTGCTGACCGTGACCAACCTGTTCAGCGTGAAAAACTACGGTGAGTTCGAATTCTGGTTCGCCCTGCTCAAAGTC
GTGGCGATCATCGGTTTCATCATTCTTGGCGTCGCGGCCATTTTCGGTTTCCTGCCGAACAGCCAGGTCAGCGGCGTTTC
GCACATCTTCGACACCCAGGGCTTCCTGCCGAACGGCATGGGCGCGGTGCTGGGCGCGATCCTGACCACCATGTTCTCCT
TCATGGGTACCGAGATCGTGACCATCGCGGCCGCCGAATCGAAGAACCCGGGCAAGCAGATCTCCAAGGCCACCAACTCG
GTGATCTGGCGGATCGGCCTGTTCTACCTCGTTTCGATCTTCATCGTTGTGGCCCTGGTGCCATGGAACGACCCGGTTCT
GGCCAGCGTCGGTTCCTACCAGACCGTGCTTGAGCGCATGGGTATCCCGAACGCCAAGATGATCGTCGATATCGTGGTTC
TGGTTGCGGTGACCAGCTGTCTGAACTCGGCGCTGTACACCTCGTCGCGCATGCTGTTCTCCCTCGGCAAGCGTGGTGAC
GCCCCGGTCATGTCGACCCGCACCAACAAGAGCGGCACCCCTTACTGGGCGGTGATGCTGTCCACTGGCGCGGCATTCCT
GTGCACCTTCGCCAACTACGTGGCCCCGGCTGCGGTGTTCGAGTTCCTGCTGGCCAGTTCGGGCGCCATCGCGCTGCTGG
TGTATCTGGTGATCGCGATTTCGCAACTGCGCATGCGTAAACAACGCATGGCTCGCGGCGAGAAAATCGTCTTCAGCATG
TGGCTGTTCCCGGGCCTGACCTACGCGGTGATCGCCTTCATCGTGGCAGCCCTGACCATCATGCTGTTCCAGGACGCCCA
CCGCGTGGAAATCCTCGCGACCGGCCTGCTGAGTCTGGTGGTTGTGGCGACCGGCCTGTTGGTGGCTCGTCGTCGTAAAA
TGGAAAACCGTGGTGCGGCAGTTCTGAACTGA

Upstream 100 bases:

>100_bases
TTATTGCGTGCAGAATCCGGAACGCCCCGTTGGATTCTTTTTACGAGAAGGAACGCCAGACGGGCCGGACGCAATCGCTT
TCCTCGCAAAGGTAGTTCCA

Downstream 100 bases:

>100_bases
TCCGCAACGCATAACGCAAAACGGCCGCTGTCAGTGATGACAAGCGGCCGTTTTTGTTACTGCGAGCGGTTTATTCGCTC
TTCTCTTCCTGCGCTTCCAC

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSSTQSSNGLEQGLKPRHVTMLSIAGVIGAGLFVGSGHAIAAAGPAVLLAYAAAGALVVLVMRMLGEMAVASPDTGSFST
YADRAIGHWAGFTIGWLYWWFWVLVIPLEANAAATILHAWFPGVDIWAFALIITMLLTVTNLFSVKNYGEFEFWFALLKV
VAIIGFIILGVAAIFGFLPNSQVSGVSHIFDTQGFLPNGMGAVLGAILTTMFSFMGTEIVTIAAAESKNPGKQISKATNS
VIWRIGLFYLVSIFIVVALVPWNDPVLASVGSYQTVLERMGIPNAKMIVDIVVLVAVTSCLNSALYTSSRMLFSLGKRGD
APVMSTRTNKSGTPYWAVMLSTGAAFLCTFANYVAPAAVFEFLLASSGAIALLVYLVIAISQLRMRKQRMARGEKIVFSM
WLFPGLTYAVIAFIVAALTIMLFQDAHRVEILATGLLSLVVVATGLLVARRRKMENRGAAVLN

Sequences:

>Translated_463_residues
MSSTQSSNGLEQGLKPRHVTMLSIAGVIGAGLFVGSGHAIAAAGPAVLLAYAAAGALVVLVMRMLGEMAVASPDTGSFST
YADRAIGHWAGFTIGWLYWWFWVLVIPLEANAAATILHAWFPGVDIWAFALIITMLLTVTNLFSVKNYGEFEFWFALLKV
VAIIGFIILGVAAIFGFLPNSQVSGVSHIFDTQGFLPNGMGAVLGAILTTMFSFMGTEIVTIAAAESKNPGKQISKATNS
VIWRIGLFYLVSIFIVVALVPWNDPVLASVGSYQTVLERMGIPNAKMIVDIVVLVAVTSCLNSALYTSSRMLFSLGKRGD
APVMSTRTNKSGTPYWAVMLSTGAAFLCTFANYVAPAAVFEFLLASSGAIALLVYLVIAISQLRMRKQRMARGEKIVFSM
WLFPGLTYAVIAFIVAALTIMLFQDAHRVEILATGLLSLVVVATGLLVARRRKMENRGAAVLN
>Mature_462_residues
SSTQSSNGLEQGLKPRHVTMLSIAGVIGAGLFVGSGHAIAAAGPAVLLAYAAAGALVVLVMRMLGEMAVASPDTGSFSTY
ADRAIGHWAGFTIGWLYWWFWVLVIPLEANAAATILHAWFPGVDIWAFALIITMLLTVTNLFSVKNYGEFEFWFALLKVV
AIIGFIILGVAAIFGFLPNSQVSGVSHIFDTQGFLPNGMGAVLGAILTTMFSFMGTEIVTIAAAESKNPGKQISKATNSV
IWRIGLFYLVSIFIVVALVPWNDPVLASVGSYQTVLERMGIPNAKMIVDIVVLVAVTSCLNSALYTSSRMLFSLGKRGDA
PVMSTRTNKSGTPYWAVMLSTGAAFLCTFANYVAPAAVFEFLLASSGAIALLVYLVIAISQLRMRKQRMARGEKIVFSMW
LFPGLTYAVIAFIVAALTIMLFQDAHRVEILATGLLSLVVVATGLLVARRRKMENRGAAVLN

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=454, Percent_Identity=65.8590308370044, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786302, Length=422, Percent_Identity=37.2037914691943, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.5291375291375, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87081708, Length=400, Percent_Identity=39, Blast_Score=268, Evalue=8e-73,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=36.7245657568238, Blast_Score=261, Evalue=9e-71,
Organism=Escherichia coli, GI48994972, Length=438, Percent_Identity=35.8447488584475, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=30.9210526315789, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI87081915, Length=386, Percent_Identity=36.5284974093264, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1786602, Length=456, Percent_Identity=32.8947368421053, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87081869, Length=409, Percent_Identity=23.4718826405868, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=335, Percent_Identity=22.3880597014925, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=436, Percent_Identity=33.9449541284404, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6324061, Length=459, Percent_Identity=30.0653594771242, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322892, Length=400, Percent_Identity=34.5, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=442, Percent_Identity=32.3529411764706, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=402, Percent_Identity=32.3383084577114, Blast_Score=192, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=413, Percent_Identity=31.7191283292978, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=30.8068459657702, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6321053, Length=404, Percent_Identity=31.1881188118812, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324924, Length=434, Percent_Identity=29.7235023041475, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=436, Percent_Identity=31.8807339449541, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321629, Length=403, Percent_Identity=31.0173697270471, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6319543, Length=404, Percent_Identity=27.7227722772277, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=29.3670886075949, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=409, Percent_Identity=28.8508557457213, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=400, Percent_Identity=31, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=414, Percent_Identity=28.743961352657, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=439, Percent_Identity=25.9681093394077, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320364, Length=470, Percent_Identity=23.4042553191489, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49627; Mature: 49496

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTQSSNGLEQGLKPRHVTMLSIAGVIGAGLFVGSGHAIAAAGPAVLLAYAAAGALVVL
CCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHH
VMRMLGEMAVASPDTGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPLEANAAATILHAW
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FPGVDIWAFALIITMLLTVTNLFSVKNYGEFEFWFALLKVVAIIGFIILGVAAIFGFLPN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SQVSGVSHIFDTQGFLPNGMGAVLGAILTTMFSFMGTEIVTIAAAESKNPGKQISKATNS
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHH
VIWRIGLFYLVSIFIVVALVPWNDPVLASVGSYQTVLERMGIPNAKMIVDIVVLVAVTSC
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LNSALYTSSRMLFSLGKRGDAPVMSTRTNKSGTPYWAVMLSTGAAFLCTFANYVAPAAVF
HHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHH
EFLLASSGAIALLVYLVIAISQLRMRKQRMARGEKIVFSMWLFPGLTYAVIAFIVAALTI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
MLFQDAHRVEILATGLLSLVVVATGLLVARRRKMENRGAAVLN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSTQSSNGLEQGLKPRHVTMLSIAGVIGAGLFVGSGHAIAAAGPAVLLAYAAAGALVVL
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHH
VMRMLGEMAVASPDTGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPLEANAAATILHAW
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FPGVDIWAFALIITMLLTVTNLFSVKNYGEFEFWFALLKVVAIIGFIILGVAAIFGFLPN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SQVSGVSHIFDTQGFLPNGMGAVLGAILTTMFSFMGTEIVTIAAAESKNPGKQISKATNS
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHH
VIWRIGLFYLVSIFIVVALVPWNDPVLASVGSYQTVLERMGIPNAKMIVDIVVLVAVTSC
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LNSALYTSSRMLFSLGKRGDAPVMSTRTNKSGTPYWAVMLSTGAAFLCTFANYVAPAAVF
HHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHH
EFLLASSGAIALLVYLVIAISQLRMRKQRMARGEKIVFSMWLFPGLTYAVIAFIVAALTI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
MLFQDAHRVEILATGLLSLVVVATGLLVARRRKMENRGAAVLN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]