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The map label for this gene is yedX [H]

Identifier: 77456428

GI number: 77456428

Start: 239753

End: 240163

Strand: Reverse

Name: yedX [H]

Synonym: Pfl01_0200

Alternate gene names: 77456428

Gene position: 240163-239753 (Counterclockwise)

Preceding gene: 77456429

Following gene: 77456426

Centisome position: 3.73

GC content: 58.88

Gene sequence:

>411_bases
ATGACCCCACTGCGCATCACTTTCGCCGCGCTCGGCCTGAGCGCCTTTTCGAGCCTGGCGCTGGCCGCCGGCAACCCGCT
GAGCGTACACGTGCTCAATCTGGAAAACGGCCTGCCGTCGCCGGGCATCAACGTGACGCTGGAACGTCATGTCGGCCAGA
ACTGGCAGCCGCTGGCGCAGGGCACCACCAATGAACAGGGACGGATCGCCGAATTGTTCCCGGCGAACAAACCGTTCGAG
GCCGGTGAGTATCGAGTGGTGTTCAAGACCGGTGAGTACTTCGAGAAGACGAAGCACGAGACGTTTTTTCCGGAGATTCC
GGTGATCTTTAAAGTGCAGCAGACGGATCAGCACTATCACATTCCGTTGCTGCTGAGTCCGTATGGCTTCTCCACTTATC
GCGGTTCGTAA

Upstream 100 bases:

>100_bases
GCCGGTTCCGGTGGCGGTGAACAGGACGAAAGCTGTGCGACGAAGGCGGCCGAAGCTGGCGGTCTTTCCATCAACCGAAT
TTGAACCCAGGAGCATCACC

Downstream 100 bases:

>100_bases
AAACAACATCGATCCAATGTGGGAGCGGGCAAGCCTGCTCCCATAGGGGAACCCGTATTCTTCAGAGGGTCGCCAGTGCC
CGCAATCGCGCGGCGTCAAG

Product: transthyretin

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP; Transthyretin-related protein; TRP [H]

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MTPLRITFAALGLSAFSSLALAAGNPLSVHVLNLENGLPSPGINVTLERHVGQNWQPLAQGTTNEQGRIAELFPANKPFE
AGEYRVVFKTGEYFEKTKHETFFPEIPVIFKVQQTDQHYHIPLLLSPYGFSTYRGS

Sequences:

>Translated_136_residues
MTPLRITFAALGLSAFSSLALAAGNPLSVHVLNLENGLPSPGINVTLERHVGQNWQPLAQGTTNEQGRIAELFPANKPFE
AGEYRVVFKTGEYFEKTKHETFFPEIPVIFKVQQTDQHYHIPLLLSPYGFSTYRGS
>Mature_135_residues
TPLRITFAALGLSAFSSLALAAGNPLSVHVLNLENGLPSPGINVTLERHVGQNWQPLAQGTTNEQGRIAELFPANKPFEA
GEYRVVFKTGEYFEKTKHETFFPEIPVIFKVQQTDQHYHIPLLLSPYGFSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=133, Percent_Identity=47.3684210526316, Blast_Score=128, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115532920, Length=110, Percent_Identity=35.4545454545455, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115532922, Length=110, Percent_Identity=35.4545454545455, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115534555, Length=110, Percent_Identity=36.3636363636364, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24652571, Length=110, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 15116; Mature: 14985

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLRITFAALGLSAFSSLALAAGNPLSVHVLNLENGLPSPGINVTLERHVGQNWQPLAQ
CCCEEEHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCC
GTTNEQGRIAELFPANKPFEAGEYRVVFKTGEYFEKTKHETFFPEIPVIFKVQQTDQHYH
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCEEEEEECCCCEEE
IPLLLSPYGFSTYRGS
EEEEECCCCCCCCCCC
>Mature Secondary Structure 
TPLRITFAALGLSAFSSLALAAGNPLSVHVLNLENGLPSPGINVTLERHVGQNWQPLAQ
CCEEEHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCC
GTTNEQGRIAELFPANKPFEAGEYRVVFKTGEYFEKTKHETFFPEIPVIFKVQQTDQHYH
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCEEEEEECCCCEEE
IPLLLSPYGFSTYRGS
EEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9723926 [H]