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The map label for this gene is prlC [H]

Identifier: 77456316

GI number: 77456316

Start: 93738

End: 95780

Strand: Reverse

Name: prlC [H]

Synonym: Pfl01_0088

Alternate gene names: 77456316

Gene position: 95780-93738 (Counterclockwise)

Preceding gene: 77456317

Following gene: 77456314

Centisome position: 1.49

GC content: 61.28

Gene sequence:

>2043_bases
ATGCCCGACACCAATCCCCTCCTGCAACACTGGACGCTGCCACCGTGGCCAGCGATTCACGCCGAGCATTTACTGCCGGC
CGTCAACAGCATCATTGCCGATAACCGACGCATCATCGCCCAGGTGATCGCCAGTCAGACCGAACATCCCGGCTGGGATG
ATCTGGTGCTGAGCATCGACGAGGCCGACGCGCGCCTCGGCGAAGTCCGCTCGATTCTCGAAACGTTGTCGATGGTCAGA
TCCGACGATCCGGTCTGGCTCGTGGAAAGCGCCAAGGCGCATCTGGCGATCAATCAGTATCGCTCTGAAAAAGCCCACAA
TCGCCGGTTGTACGAGACCTATCAGCGTTTGGCGCAGAGCTCGATCGCCGGCAGTTTCGATGAGGCGCGCAACATCGCAC
TGTCGCGAATTCTGCGCCGATTCAAGCAGTCGGGCATTGAGCTTCCCACTGAACAGCAGCAGGAGCTGGCGCGGTTGAAC
CGCGAGATCGGAGGCTTGGAATTCGTATTTCTGGACAACCTCGAGCGCTGGGCCGAGGCGTGGAGCAAACGTGTTGACGA
TGTGGCACTGCTTACGGGCCTGCCGCCGGCGATGAAGGATCGGCTGGCACTCGCCGCACGCCAGACCGGCCATGACGGCT
GGTTGATCCGCCTGGACCAGAACACCTTCCAGCACATCCTTAAATACGCCGAGAACCGCGCCTTGCGGGAGGAATGCTAT
GTGGCCTACATGACCCGTGCCTCCGATCGAGGGCCGCTGGCCGGCCGCTTCGACAACGCCCCGGTACTGAAGAAGCTGCT
CGCCTTGCGTCAGCAGAAAGCCCGTTTGCTCGGTCATGAAAACGCCGCGCAACTGAGTCTTGCCAAAAACAGCGCCGGGA
CAACGGCATGGGTTAGTGGTTTTCTACAGCGTCAGGCGGCGCAACTGGCACCTACCCTCGCGCAGGATGCAGAACAACTG
ACAGACTTCGCGCAGCAACGCGGGATCGACCGGGTCCAGCCGTGGGATGAAGACTTCCTCGCCGAACAATGGCGCCAGCA
GCAGTTTCCCGGTGCGCTTGAAAACCTGCGGGATTACTTCCCGCTCGAGGGCACCCTGCGCAGGCTCTTGCTGTTTTGCG
AGCGAATGTTCGGGATCCGCATCGTCGAGCAATCCGGCGGTGGGCACTTGCACGACGATGTGCGCCTGCTGGAAATCAGC
GAGGATGAGCAGGTCATCGGCTACATCTACCTCGATCCGTTTCACCGCGATGGCGCTGCGGATTTCCCCGGCACCTTCAC
GCTGCGCAACCGCCGGATCAATGCCGAAGGCCGCCCGGCGCTGCCGATTGCCCTGCTCTACAGCAATTTCACACCGGCCA
GCGATACCCATCCGTGCCGGCTCGAGCTCCACGATCTGCGGGTGCTGTTTCATGAATTCGGCCATTGCCTCCAGCACGTG
CTGACGCGCTCGCCCCATCACAGCCTGTCCGGCATCCTTCAATTGGGCCATGAAGCGGCGGAGTTTTCCGGGCAATTGTT
CGAGCAGTGGTGTCTGTCGCGTGAGTTTTTGCTGTGGCTGGGTGCTCATTTTCAGACGGGCAAACGATTGAGCGCAGCAA
GGGTCGACGCGGCATTGTCAGCCAGTCAGGCCCATTCCGCCCGGCAACAGGCCTTTTTGCTGATGGGGGCGATGATCGAT
TTCGAGCTGCACCTGACCCACGGCGATGGGCGCTCGGTCGAGGAGACTTGCACCGATGTGCAGCGCAGCCTGGGTCATCT
GCAACTGCCGGACGATCATCGCTTCGCCAATGGATTCGATTACATGGTGACCCAGTACGACGCCTCGGTTTACGCCTACG
TCTGGTCGGGCGTGCTGGCTCAGGAAGCGTTCAAGCGCTTCAGCCAGGACTGGGTGTTCAACGCGCAAACCGGCCGTGAG
TTTCGTGCAACGTTCTTTGCGCCGGGTGCGGGGCGTCCATTGCTGGACGCGGTGGAAGCGTTCATCGGCCGGCCGGTCGC
CGGCCTCGTTGACGGAGAGGCCGGACGAGTTACTTCAGATTGA

Upstream 100 bases:

>100_bases
TTCCACGATTCGTCGGTGGAAGGTGGTATTGGCTTACCACCTGTCCCCCGCACTTGCTTCGTAGGCTGGCCTTTTGCGCC
ACGCCTCGAAGGAAGCTGCC

Downstream 100 bases:

>100_bases
CCGTCTGAAACCAGCTCTTCATCGAGCACGTGGCAAACGCGCTGGTGCTGCAATCGCCATTGGCCAGCGCGGTGCGCAAC
TTGTCGACATCGGCCTGCAT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MPDTNPLLQHWTLPPWPAIHAEHLLPAVNSIIADNRRIIAQVIASQTEHPGWDDLVLSIDEADARLGEVRSILETLSMVR
SDDPVWLVESAKAHLAINQYRSEKAHNRRLYETYQRLAQSSIAGSFDEARNIALSRILRRFKQSGIELPTEQQQELARLN
REIGGLEFVFLDNLERWAEAWSKRVDDVALLTGLPPAMKDRLALAARQTGHDGWLIRLDQNTFQHILKYAENRALREECY
VAYMTRASDRGPLAGRFDNAPVLKKLLALRQQKARLLGHENAAQLSLAKNSAGTTAWVSGFLQRQAAQLAPTLAQDAEQL
TDFAQQRGIDRVQPWDEDFLAEQWRQQQFPGALENLRDYFPLEGTLRRLLLFCERMFGIRIVEQSGGGHLHDDVRLLEIS
EDEQVIGYIYLDPFHRDGAADFPGTFTLRNRRINAEGRPALPIALLYSNFTPASDTHPCRLELHDLRVLFHEFGHCLQHV
LTRSPHHSLSGILQLGHEAAEFSGQLFEQWCLSREFLLWLGAHFQTGKRLSAARVDAALSASQAHSARQQAFLLMGAMID
FELHLTHGDGRSVEETCTDVQRSLGHLQLPDDHRFANGFDYMVTQYDASVYAYVWSGVLAQEAFKRFSQDWVFNAQTGRE
FRATFFAPGAGRPLLDAVEAFIGRPVAGLVDGEAGRVTSD

Sequences:

>Translated_680_residues
MPDTNPLLQHWTLPPWPAIHAEHLLPAVNSIIADNRRIIAQVIASQTEHPGWDDLVLSIDEADARLGEVRSILETLSMVR
SDDPVWLVESAKAHLAINQYRSEKAHNRRLYETYQRLAQSSIAGSFDEARNIALSRILRRFKQSGIELPTEQQQELARLN
REIGGLEFVFLDNLERWAEAWSKRVDDVALLTGLPPAMKDRLALAARQTGHDGWLIRLDQNTFQHILKYAENRALREECY
VAYMTRASDRGPLAGRFDNAPVLKKLLALRQQKARLLGHENAAQLSLAKNSAGTTAWVSGFLQRQAAQLAPTLAQDAEQL
TDFAQQRGIDRVQPWDEDFLAEQWRQQQFPGALENLRDYFPLEGTLRRLLLFCERMFGIRIVEQSGGGHLHDDVRLLEIS
EDEQVIGYIYLDPFHRDGAADFPGTFTLRNRRINAEGRPALPIALLYSNFTPASDTHPCRLELHDLRVLFHEFGHCLQHV
LTRSPHHSLSGILQLGHEAAEFSGQLFEQWCLSREFLLWLGAHFQTGKRLSAARVDAALSASQAHSARQQAFLLMGAMID
FELHLTHGDGRSVEETCTDVQRSLGHLQLPDDHRFANGFDYMVTQYDASVYAYVWSGVLAQEAFKRFSQDWVFNAQTGRE
FRATFFAPGAGRPLLDAVEAFIGRPVAGLVDGEAGRVTSD
>Mature_679_residues
PDTNPLLQHWTLPPWPAIHAEHLLPAVNSIIADNRRIIAQVIASQTEHPGWDDLVLSIDEADARLGEVRSILETLSMVRS
DDPVWLVESAKAHLAINQYRSEKAHNRRLYETYQRLAQSSIAGSFDEARNIALSRILRRFKQSGIELPTEQQQELARLNR
EIGGLEFVFLDNLERWAEAWSKRVDDVALLTGLPPAMKDRLALAARQTGHDGWLIRLDQNTFQHILKYAENRALREECYV
AYMTRASDRGPLAGRFDNAPVLKKLLALRQQKARLLGHENAAQLSLAKNSAGTTAWVSGFLQRQAAQLAPTLAQDAEQLT
DFAQQRGIDRVQPWDEDFLAEQWRQQQFPGALENLRDYFPLEGTLRRLLLFCERMFGIRIVEQSGGGHLHDDVRLLEISE
DEQVIGYIYLDPFHRDGAADFPGTFTLRNRRINAEGRPALPIALLYSNFTPASDTHPCRLELHDLRVLFHEFGHCLQHVL
TRSPHHSLSGILQLGHEAAEFSGQLFEQWCLSREFLLWLGAHFQTGKRLSAARVDAALSASQAHSARQQAFLLMGAMIDF
ELHLTHGDGRSVEETCTDVQRSLGHLQLPDDHRFANGFDYMVTQYDASVYAYVWSGVLAQEAFKRFSQDWVFNAQTGREF
RATFFAPGAGRPLLDAVEAFIGRPVAGLVDGEAGRVTSD

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=657, Percent_Identity=23.5920852359209, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI14149738, Length=665, Percent_Identity=22.1052631578947, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI156105687, Length=629, Percent_Identity=23.8473767885533, Blast_Score=123, Evalue=7e-28,
Organism=Escherichia coli, GI1789913, Length=671, Percent_Identity=31.892697466468, Blast_Score=327, Evalue=2e-90,
Organism=Escherichia coli, GI1787819, Length=671, Percent_Identity=25.6333830104322, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319793, Length=679, Percent_Identity=20.4712812960236, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322715, Length=556, Percent_Identity=23.5611510791367, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356111, Length=583, Percent_Identity=23.4991423670669, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20129717, Length=537, Percent_Identity=24.0223463687151, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76839; Mature: 76707

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDTNPLLQHWTLPPWPAIHAEHLLPAVNSIIADNRRIIAQVIASQTEHPGWDDLVLSID
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEC
EADARLGEVRSILETLSMVRSDDPVWLVESAKAHLAINQYRSEKAHNRRLYETYQRLAQS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SIAGSFDEARNIALSRILRRFKQSGIELPTEQQQELARLNREIGGLEFVFLDNLERWAEA
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHH
WSKRVDDVALLTGLPPAMKDRLALAARQTGHDGWLIRLDQNTFQHILKYAENRALREECY
HHHHCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
VAYMTRASDRGPLAGRFDNAPVLKKLLALRQQKARLLGHENAAQLSLAKNSAGTTAWVSG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCHHHHHHH
FLQRQAAQLAPTLAQDAEQLTDFAQQRGIDRVQPWDEDFLAEQWRQQQFPGALENLRDYF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCC
PLEGTLRRLLLFCERMFGIRIVEQSGGGHLHDDVRLLEISEDEQVIGYIYLDPFHRDGAA
CCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
DFPGTFTLRNRRINAEGRPALPIALLYSNFTPASDTHPCRLELHDLRVLFHEFGHCLQHV
CCCCEEEEECCEECCCCCCCCCCEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
LTRSPHHSLSGILQLGHEAAEFSGQLFEQWCLSREFLLWLGAHFQTGKRLSAARVDAALS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHHH
ASQAHSARQQAFLLMGAMIDFELHLTHGDGRSVEETCTDVQRSLGHLQLPDDHRFANGFD
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
YMVTQYDASVYAYVWSGVLAQEAFKRFSQDWVFNAQTGREFRATFFAPGAGRPLLDAVEA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCHHHHHHHH
FIGRPVAGLVDGEAGRVTSD
HHCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
PDTNPLLQHWTLPPWPAIHAEHLLPAVNSIIADNRRIIAQVIASQTEHPGWDDLVLSID
CCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEC
EADARLGEVRSILETLSMVRSDDPVWLVESAKAHLAINQYRSEKAHNRRLYETYQRLAQS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SIAGSFDEARNIALSRILRRFKQSGIELPTEQQQELARLNREIGGLEFVFLDNLERWAEA
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHH
WSKRVDDVALLTGLPPAMKDRLALAARQTGHDGWLIRLDQNTFQHILKYAENRALREECY
HHHHCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
VAYMTRASDRGPLAGRFDNAPVLKKLLALRQQKARLLGHENAAQLSLAKNSAGTTAWVSG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCHHHHHHH
FLQRQAAQLAPTLAQDAEQLTDFAQQRGIDRVQPWDEDFLAEQWRQQQFPGALENLRDYF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCC
PLEGTLRRLLLFCERMFGIRIVEQSGGGHLHDDVRLLEISEDEQVIGYIYLDPFHRDGAA
CCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCC
DFPGTFTLRNRRINAEGRPALPIALLYSNFTPASDTHPCRLELHDLRVLFHEFGHCLQHV
CCCCEEEEECCEECCCCCCCCCCEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
LTRSPHHSLSGILQLGHEAAEFSGQLFEQWCLSREFLLWLGAHFQTGKRLSAARVDAALS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHHH
ASQAHSARQQAFLLMGAMIDFELHLTHGDGRSVEETCTDVQRSLGHLQLPDDHRFANGFD
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
YMVTQYDASVYAYVWSGVLAQEAFKRFSQDWVFNAQTGREFRATFFAPGAGRPLLDAVEA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCCHHHHHHHH
FIGRPVAGLVDGEAGRVTSD
HHCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]