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The map label for this gene is fmt [H]

Identifier: 77456244

GI number: 77456244

Start: 18485

End: 19444

Strand: Reverse

Name: fmt [H]

Synonym: Pfl01_0016

Alternate gene names: 77456244

Gene position: 19444-18485 (Counterclockwise)

Preceding gene: 77456245

Following gene: 77456243

Centisome position: 0.3

GC content: 64.69

Gene sequence:

>960_bases
ATGACTGAGCCACTGCGCATCGTTTTTGCCGGCACCCCGGAATTCGCCGCCGAACACCTCAAGGCCCTGCTGGACAGCCC
TTACGAGATCGTTGCGGTCTACACCCAACCGGATCGCCCGGCCGGGCGTGGGCAAAAACTGATGCCGAGCCCGGTCAAAC
AGCTCGCCCTGGAAAACAATATTCAGGTGTTGCAGCCGCCGACCCTGCGCAACGCCGACGCTCAGGCCGAGCTCGCTGCG
CTCAAGCCGGATTTGATGGTGGTGGTTGCCTACGGCCTGATTCTGCCGCAAGCGGTGCTGGATATTCCGCGCCTGGGTTG
CATCAACAGTCACGCCTCGCTGCTGCCGCGCTGGCGCGGTGCGGCGCCGATCCAGCGCGCCGTGGAAGCGGGCGACGCCG
AGAGCGGCGTGACCGTGATGCGCATGGAAGCCGGTCTCGATACCGGGCCGATGCTGCTTAAAGTCGTGACCCCGATCAGC
GCCGAAGACACCGGCGGCAGCCTCCACGATCGCTTGGCCGAAATGGGCCCGCCCGCCGTGGTTCAAGCGATTGCCGGTCT
GGCCGCCGGCACCCTGGAAGGCGAAGTGCAGAACGACGAGCTCGCCACCTACGCGCACAAACTGAACAAAGATGAAGCAC
GCATCGACTGGAGCCGCCCGGCCGTTGAGCTGGAACGTCTGGTCCGTGCCTTCAATCCATGGCCGATCACCCACAGCACG
CTCAACGGCGAAGCGCTGAAAGTGTTGGCGGCGACACTGGCCGAAGGCAAAGGCGCACCGGGCACCATCCTCGGCGCCAG
CAAGGACGGTCTGATCGTCGCCTGTGGCGAACAGGCGCTGTGCCTGACCCGTCTGCAATTGCCCGGCGGCAAGGCGCTGA
ACTTCAGCGATCTGTTCAACAGCCGTCGTGAGAAATTCGCCACCGGCATCGTGCTGGGTGCAGCGGTGGACGCTCAATGA

Upstream 100 bases:

>100_bases
GGATCAAGAAGAAACTGGAAAAGCAGCACCGCCAGAACGCTTGATGCCCCTCTCCAAAGGCTTGCTGCGGCAAGCCTTTT
TCTTTTTATGAGACTCCCCC

Downstream 100 bases:

>100_bases
ACCCGCGTCTGGCCGCCGCCAAGGCACTCGCCGCTGTTCTCAGTGGCAAGGCTTCGCTCAACAGCTCCCTGCCGACGCAA
CTGGACAAGGTCGAAGATCG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTEPLRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSPVKQLALENNIQVLQPPTLRNADAQAELAA
LKPDLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPIS
AEDTGGSLHDRLAEMGPPAVVQAIAGLAAGTLEGEVQNDELATYAHKLNKDEARIDWSRPAVELERLVRAFNPWPITHST
LNGEALKVLAATLAEGKGAPGTILGASKDGLIVACGEQALCLTRLQLPGGKALNFSDLFNSRREKFATGIVLGAAVDAQ

Sequences:

>Translated_319_residues
MTEPLRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSPVKQLALENNIQVLQPPTLRNADAQAELAA
LKPDLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPIS
AEDTGGSLHDRLAEMGPPAVVQAIAGLAAGTLEGEVQNDELATYAHKLNKDEARIDWSRPAVELERLVRAFNPWPITHST
LNGEALKVLAATLAEGKGAPGTILGASKDGLIVACGEQALCLTRLQLPGGKALNFSDLFNSRREKFATGIVLGAAVDAQ
>Mature_318_residues
TEPLRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSPVKQLALENNIQVLQPPTLRNADAQAELAAL
KPDLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISA
EDTGGSLHDRLAEMGPPAVVQAIAGLAAGTLEGEVQNDELATYAHKLNKDEARIDWSRPAVELERLVRAFNPWPITHSTL
NGEALKVLAATLAEGKGAPGTILGASKDGLIVACGEQALCLTRLQLPGGKALNFSDLFNSRREKFATGIVLGAAVDAQ

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=313, Percent_Identity=28.7539936102236, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI21614513, Length=314, Percent_Identity=28.0254777070064, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI164663775, Length=319, Percent_Identity=28.5266457680251, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1789683, Length=311, Percent_Identity=58.8424437299035, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1788589, Length=303, Percent_Identity=28.0528052805281, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI133930964, Length=303, Percent_Identity=27.0627062706271, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550868, Length=305, Percent_Identity=29.5081967213115, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28571984, Length=224, Percent_Identity=32.5892857142857, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24585660, Length=331, Percent_Identity=27.4924471299094, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33787; Mature: 33656

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPLRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSPVKQLALENN
CCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCC
IQVLQPPTLRNADAQAELAALKPDLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRG
CEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
AAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDTGGSLHDRLAEMGPPAV
CCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHH
VQAIAGLAAGTLEGEVQNDELATYAHKLNKDEARIDWSRPAVELERLVRAFNPWPITHST
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHCCCCCCCCCC
LNGEALKVLAATLAEGKGAPGTILGASKDGLIVACGEQALCLTRLQLPGGKALNFSDLFN
CCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCEEEEEEEECCCCCCCCHHHHHH
SRREKFATGIVLGAAVDAQ
HHHHHHHHHEEEEEEECCC
>Mature Secondary Structure 
TEPLRIVFAGTPEFAAEHLKALLDSPYEIVAVYTQPDRPAGRGQKLMPSPVKQLALENN
CCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCC
IQVLQPPTLRNADAQAELAALKPDLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRG
CEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
AAPIQRAVEAGDAESGVTVMRMEAGLDTGPMLLKVVTPISAEDTGGSLHDRLAEMGPPAV
CCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHH
VQAIAGLAAGTLEGEVQNDELATYAHKLNKDEARIDWSRPAVELERLVRAFNPWPITHST
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHCCCCCCCCCC
LNGEALKVLAATLAEGKGAPGTILGASKDGLIVACGEQALCLTRLQLPGGKALNFSDLFN
CCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCEEEEEEEECCCCCCCCHHHHHH
SRREKFATGIVLGAAVDAQ
HHHHHHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA