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The map label for this gene is groEL [H]

Identifier: 76819196

GI number: 76819196

Start: 2466594

End: 2468234

Strand: Direct

Name: groEL [H]

Synonym: BURPS1710b_A2030

Alternate gene names: 76819196

Gene position: 2466594-2468234 (Clockwise)

Preceding gene: 76817441

Following gene: 76818467

Centisome position: 77.52

GC content: 68.98

Gene sequence:

>1641_bases
ATGGCAGCGAAAGAGATCATTTTCCACGACGGCGCGCGCGCGAAGCTCGTCGAAGGCGTCAATCTGCTCGCGAACGCGGT
GAAGGTCACGCTCGGGCCGAAGGGCCGCAACGTCGTGCTCGAGCGCAGCTTCGGCTCGCCCGTCGTCACGAAGGACGGCG
TGTCGGTCGCGAAGGAAATCGAGCTGGCGGACAAAGTGCAGAACATCGGCGCGCAGCTCGTGAAGGAGGTTGCGTCGAAG
ACGAGCGACGCGGCGGGCGACGGCACGACGACCGCGACCGTGCTCGCGCAGGCGATCGTGCGCGAAGGGCAGAAGTACGT
CGCCGCGGGCCTGAATCCGCTCGATCTGAAGCGCGGCATCGACAAGGCGGTGGCCGCCGCCGTCGACGAGCTGAAGAAGA
TCAGCAAGCCCACGACGACGAGCAAGGAGATCGCGCAGGTCGCGACGATCTCGGCGAACGGCGAGGAATCGATTGGCCAG
CGCATCGCCGAGGCGATCGACCGCGTCGGCAAGGAAGGCGTGATCACCGTCGAGGACGGCAAGTCGCTCGCCGACGAGCT
CGACGTCGTCGAAGGGCTGCAGTTCGATCGCGGCTACCTGTCGCCGTACTTCATCAACCATCCCGAGCGCCAGCTCGCGG
TGCTCGACGAGCCGTTCATCCTGCTGCACGACAAGAAGATCTCGAACATCCGCGATCTGCTGCCGGTGCTCGAGCAGGTC
GCGAAGGCGGGCCGGCCGCTGCTGATCGTCGCCGAGGACGTCGAGGGCGAGGCGCTCGCGACGCTCGTCGTCAACAACAT
CCGCGGCATCCTGAAGACCGTCGCGGTCAAGGCGCCGGGCTTCGGCGACCGCCGCAAGGCGCTGCTCGAGGACATCGCGA
TCCTCACGGGCGGCCAGGTGATCACCGAGGAAACCGGCCTCACGCTCGAGAAGGCGACGCTGCAGGAGCTCGGCCGCGCG
AAGCGCATCGAGGTCGGCAAGGAGAACACGACGCTCATCGACGGCGCGGGCGACAAGCCGAACATCGATGCACGCGTGAA
GCAGATCCGCGCGCAGATCGCCGAGGCGACGTCCGACTACGATCGCGAGAAGCTGCAGGAGCGCGTGGCGAAGCTCGCCG
GCGGCGTGGCGGTGATCAAGGTCGGCGGCGCGACCGAAGTCGAGGTGAAGGAGAAGAAGGACCGCGTCGACGACGCGCTG
CACGCGACGCGCGCGGCCGTCGAGGAAGGCATCGTGCCGGGCGGCGGCGTCGCGCTGATTCGCGTGAAGCAGGCGATCGC
GGCGCTCGCGGGCGCGAACGCCGACCAGAAGGCGGGCATCAGCATCGTGCTGCGCGCGCTCGAGGAGCCGTTGCGCCAGA
TCGTCGCGAACGCGGGCGAGGAGGCGAGCGTCGTCGTCGCGACGGTCGCGGCGGGCCAGGGCAACTACGGCTATAACGCG
GCGACGGGCGAATACGGCGACCTCGTCGAATCGGGCGTGCTCGATCCGACGAAGGTCACGCGCACCGCGCTGCAGAACGC
CGCGTCGATCGCCGGCCTGCTGCTCACGACGGATGCGACGGTGCACGAGGCGCCGAAGGATGCGCCGCCCGCCGCGCCGG
CGGGCGTGCCGGGCGCGGGCGGCCCGGGCTTCGATTTCTGA

Upstream 100 bases:

>100_bases
CGGGCAGTCCGTGAAGGTCGACGGCAACGAACTGCTGGTGCTGCGCGAAGAGGACATCGTCGCAGTCATACATTCCTGAT
CAGGCAAGGAGCACCGTACC

Downstream 100 bases:

>100_bases
GCGCCTCCTCGCGCCGGGGCTGACGCGCGCGGCCGCGCCCGCGCCGCCCGGCCGCACGCGCTCAGCCCGGCGAAGCTTCC
GAAGGCGCGGGCTGCGCCGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKEIIFHDGARAKLVEGVNLLANAVKVTLGPKGRNVVLERSFGSPVVTKDGVSVAKEIELADKVQNIGAQLVKEVASK
TSDAAGDGTTTATVLAQAIVREGQKYVAAGLNPLDLKRGIDKAVAAAVDELKKISKPTTTSKEIAQVATISANGEESIGQ
RIAEAIDRVGKEGVITVEDGKSLADELDVVEGLQFDRGYLSPYFINHPERQLAVLDEPFILLHDKKISNIRDLLPVLEQV
AKAGRPLLIVAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKALLEDIAILTGGQVITEETGLTLEKATLQELGRA
KRIEVGKENTTLIDGAGDKPNIDARVKQIRAQIAEATSDYDREKLQERVAKLAGGVAVIKVGGATEVEVKEKKDRVDDAL
HATRAAVEEGIVPGGGVALIRVKQAIAALAGANADQKAGISIVLRALEEPLRQIVANAGEEASVVVATVAAGQGNYGYNA
ATGEYGDLVESGVLDPTKVTRTALQNAASIAGLLLTTDATVHEAPKDAPPAAPAGVPGAGGPGFDF

Sequences:

>Translated_546_residues
MAAKEIIFHDGARAKLVEGVNLLANAVKVTLGPKGRNVVLERSFGSPVVTKDGVSVAKEIELADKVQNIGAQLVKEVASK
TSDAAGDGTTTATVLAQAIVREGQKYVAAGLNPLDLKRGIDKAVAAAVDELKKISKPTTTSKEIAQVATISANGEESIGQ
RIAEAIDRVGKEGVITVEDGKSLADELDVVEGLQFDRGYLSPYFINHPERQLAVLDEPFILLHDKKISNIRDLLPVLEQV
AKAGRPLLIVAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKALLEDIAILTGGQVITEETGLTLEKATLQELGRA
KRIEVGKENTTLIDGAGDKPNIDARVKQIRAQIAEATSDYDREKLQERVAKLAGGVAVIKVGGATEVEVKEKKDRVDDAL
HATRAAVEEGIVPGGGVALIRVKQAIAALAGANADQKAGISIVLRALEEPLRQIVANAGEEASVVVATVAAGQGNYGYNA
ATGEYGDLVESGVLDPTKVTRTALQNAASIAGLLLTTDATVHEAPKDAPPAAPAGVPGAGGPGFDF
>Mature_545_residues
AAKEIIFHDGARAKLVEGVNLLANAVKVTLGPKGRNVVLERSFGSPVVTKDGVSVAKEIELADKVQNIGAQLVKEVASKT
SDAAGDGTTTATVLAQAIVREGQKYVAAGLNPLDLKRGIDKAVAAAVDELKKISKPTTTSKEIAQVATISANGEESIGQR
IAEAIDRVGKEGVITVEDGKSLADELDVVEGLQFDRGYLSPYFINHPERQLAVLDEPFILLHDKKISNIRDLLPVLEQVA
KAGRPLLIVAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKALLEDIAILTGGQVITEETGLTLEKATLQELGRAK
RIEVGKENTTLIDGAGDKPNIDARVKQIRAQIAEATSDYDREKLQERVAKLAGGVAVIKVGGATEVEVKEKKDRVDDALH
ATRAAVEEGIVPGGGVALIRVKQAIAALAGANADQKAGISIVLRALEEPLRQIVANAGEEASVVVATVAAGQGNYGYNAA
TGEYGDLVESGVLDPTKVTRTALQNAASIAGLLLTTDATVHEAPKDAPPAAPAGVPGAGGPGFDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=53.8899430740038, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=53.8899430740038, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI5453607, Length=554, Percent_Identity=24.0072202166065, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI24307939, Length=443, Percent_Identity=23.2505643340858, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=71.9165085388994, Blast_Score=755, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=527, Percent_Identity=52.1821631878558, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=52.1531100478469, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI25144674, Length=547, Percent_Identity=22.6691042047532, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=522, Percent_Identity=53.2567049808429, Blast_Score=542, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322524, Length=554, Percent_Identity=22.5631768953069, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=540, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=53.041825095057, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=53.041825095057, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=52.0992366412214, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=52.0992366412214, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=52.0992366412214, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI17864606, Length=548, Percent_Identity=44.5255474452555, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=38.7832699619772, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=38.7832699619772, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI17647245, Length=474, Percent_Identity=24.2616033755274, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56975; Mature: 56843

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEIIFHDGARAKLVEGVNLLANAVKVTLGPKGRNVVLERSFGSPVVTKDGVSVAKEI
CCCCCEEEECCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCHHHHHHH
ELADKVQNIGAQLVKEVASKTSDAAGDGTTTATVLAQAIVREGQKYVAAGLNPLDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHH
DKAVAAAVDELKKISKPTTTSKEIAQVATISANGEESIGQRIAEAIDRVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KSLADELDVVEGLQFDRGYLSPYFINHPERQLAVLDEPFILLHDKKISNIRDLLPVLEQV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIVAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKALLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
ITEETGLTLEKATLQELGRAKRIEVGKENTTLIDGAGDKPNIDARVKQIRAQIAEATSDY
EECCCCCEEHHHHHHHHCCHHEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGGATEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVKQAIAALAGANADQKAGISIVLRALEEPLRQIVANAGEEASVVVATVAAGQGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYGDLVESGVLDPTKVTRTALQNAASIAGLLLTTDATVHEAPKDAPPAAPAGVPGAG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHCCCCCCCCCCCCCCCCCC
GPGFDF
CCCCCC
>Mature Secondary Structure 
AAKEIIFHDGARAKLVEGVNLLANAVKVTLGPKGRNVVLERSFGSPVVTKDGVSVAKEI
CCCCEEEECCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCHHHHHHH
ELADKVQNIGAQLVKEVASKTSDAAGDGTTTATVLAQAIVREGQKYVAAGLNPLDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHH
DKAVAAAVDELKKISKPTTTSKEIAQVATISANGEESIGQRIAEAIDRVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KSLADELDVVEGLQFDRGYLSPYFINHPERQLAVLDEPFILLHDKKISNIRDLLPVLEQV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIVAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKALLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
ITEETGLTLEKATLQELGRAKRIEVGKENTTLIDGAGDKPNIDARVKQIRAQIAEATSDY
EECCCCCEEHHHHHHHHCCHHEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGGATEVEVKEKKDRVDDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVKQAIAALAGANADQKAGISIVLRALEEPLRQIVANAGEEASVVVATVAAGQGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYGDLVESGVLDPTKVTRTALQNAASIAGLLLTTDATVHEAPKDAPPAAPAGVPGAG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHCCCCCCCCCCCCCCCCCC
GPGFDF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA