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The map label for this gene is pip [H]

Identifier: 76818974

GI number: 76818974

Start: 2107168

End: 2108478

Strand: Direct

Name: pip [H]

Synonym: BURPS1710b_A1728

Alternate gene names: 76818974

Gene position: 2107168-2108478 (Clockwise)

Preceding gene: 76818064

Following gene: 76818507

Centisome position: 66.23

GC content: 70.4

Gene sequence:

>1311_bases
GTGCGCGCGGCGTTCGCCACGCATGCGCGCGCGCGTCGAGCCGGCGCCCGCGCGCGCAAGCATTCATGCATGCATCCATG
CGGCGATGCATTCGTGCGCGCCTTCGGCAGTCGACGCGCCACGCCGCGCCGCGACGAACGGCGCGCGAGGCGGCCGGGCG
GCGGCTCGGCCACCTCCGTGCAAGCGCGTCCCCGCGTTTTCCGGCGACTCGGCATAATGAAGCGTCGCTTTCGTCGCCGG
CGCCGCATCGGCGCGAGCCAACGCGGCCGGCGCATCGCATGGGGCGCACGCATGCGCCGCGCGGCCGTTCCATTCATCGC
GTTCGGCGAGGCACCCCCAGTCGTCTTCTTCCATTCAACCGGAGCGTCTCTCTTGTATCCACCGATCGAACCTTATGCAC
ACGGCTTCCTCGATACCGGCGACGGCCATCGCGTGTACTGGGAGCTGTGCGGCAACCCCAACGGCAAGCCGGCCGTCTTC
CTGCACGGCGGCCCCGGCAGCGGCTGCAGCGCCGATCACCGTCGCCTCTTCGATCCCGCGCGCTACAACGTGCTGCTGTT
CGACCAGCGCGGCTGCGGCCGCTCGACGCCGCACGCGAGCCTCGAGAACAACACGACATGGCATCTCGTCGACGACATCG
AGCGGCTGCGCGCGATGATCGGCGTCGAGCGCTGGCTCGTGTTCGGCGGCTCGTGGGGCAGCGCGCTCGCGCTCGCATAT
GCGCAAACGCACCCGGCGCGCGTGGCCGAGCTCGTCGTGCGCGGCATCTTCACGGTGCGCCGGTCCGAGCTGCTCTGGTA
CTACCAGGAAGGCGCGTCGTGGCTGTTCCCGGATCTGTGGGAAGACTTCATCGCGCCCATTCCGAGCGCCGAGCGCGCGG
ATCTGATCGCCGCGTATCGCCGCCGGCTGACGGGCGACGACGAGGCGGCCAAGCGCGAGGCCGCGCGCGCGTGGAGCGTC
TGGGAGGGCCGGACGATCGCGCTGCTGCCGAACGCCGCGCACGAAACGTATTTCGGCGACGCGCATTTCGCGCTCGCGTT
CGCCCGCATCGAAAACCACTACTTCGTTCATCAAGGCTTCATGGAAGACGGGCAGTTGCTGCGCGATGCGCATCGTCTCG
CGGACATCCCGGGCGTGATCGTTCAGGGGCGCTACGACGTCGCGACGCCGGCGCGCACCGCGTGGGAACTCGCGAAGGCG
TGGCCGCGCGCGTCGCTCGAGATCGTGCCCGACGCGGGGCACGCATACGACGAGCCGGGCATTCTGCGCGCGCTGATCGC
GGCGACCGACCGCTTCGCGCGCGAGCGCTGA

Upstream 100 bases:

>100_bases
GAATACTGGCCGATGGCGTTCAGCGATCGCGCTGTGGACGCGCTCGCGCACGACACGCTGATACTGGAGCCGGCGCCCGC
GCAGTGAGCGGCGTCATCCG

Downstream 100 bases:

>100_bases
TCGGCCTTCCCGTGCGAACCTCGTTCGCCGTTCGCGGCGCGTCGCGCGCCGCCCGTCGTTGCCGGTGCGCGAAGCGGTGC
GCGCGCACCGCTTCGAATAA

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MRAAFATHARARRAGARARKHSCMHPCGDAFVRAFGSRRATPRRDERRARRPGGGSATSVQARPRVFRRLGIMKRRFRRR
RRIGASQRGRRIAWGARMRRAAVPFIAFGEAPPVVFFHSTGASLLYPPIEPYAHGFLDTGDGHRVYWELCGNPNGKPAVF
LHGGPGSGCSADHRRLFDPARYNVLLFDQRGCGRSTPHASLENNTTWHLVDDIERLRAMIGVERWLVFGGSWGSALALAY
AQTHPARVAELVVRGIFTVRRSELLWYYQEGASWLFPDLWEDFIAPIPSAERADLIAAYRRRLTGDDEAAKREAARAWSV
WEGRTIALLPNAAHETYFGDAHFALAFARIENHYFVHQGFMEDGQLLRDAHRLADIPGVIVQGRYDVATPARTAWELAKA
WPRASLEIVPDAGHAYDEPGILRALIAATDRFARER

Sequences:

>Translated_436_residues
MRAAFATHARARRAGARARKHSCMHPCGDAFVRAFGSRRATPRRDERRARRPGGGSATSVQARPRVFRRLGIMKRRFRRR
RRIGASQRGRRIAWGARMRRAAVPFIAFGEAPPVVFFHSTGASLLYPPIEPYAHGFLDTGDGHRVYWELCGNPNGKPAVF
LHGGPGSGCSADHRRLFDPARYNVLLFDQRGCGRSTPHASLENNTTWHLVDDIERLRAMIGVERWLVFGGSWGSALALAY
AQTHPARVAELVVRGIFTVRRSELLWYYQEGASWLFPDLWEDFIAPIPSAERADLIAAYRRRLTGDDEAAKREAARAWSV
WEGRTIALLPNAAHETYFGDAHFALAFARIENHYFVHQGFMEDGQLLRDAHRLADIPGVIVQGRYDVATPARTAWELAKA
WPRASLEIVPDAGHAYDEPGILRALIAATDRFARER
>Mature_436_residues
MRAAFATHARARRAGARARKHSCMHPCGDAFVRAFGSRRATPRRDERRARRPGGGSATSVQARPRVFRRLGIMKRRFRRR
RRIGASQRGRRIAWGARMRRAAVPFIAFGEAPPVVFFHSTGASLLYPPIEPYAHGFLDTGDGHRVYWELCGNPNGKPAVF
LHGGPGSGCSADHRRLFDPARYNVLLFDQRGCGRSTPHASLENNTTWHLVDDIERLRAMIGVERWLVFGGSWGSALALAY
AQTHPARVAELVVRGIFTVRRSELLWYYQEGASWLFPDLWEDFIAPIPSAERADLIAAYRRRLTGDDEAAKREAARAWSV
WEGRTIALLPNAAHETYFGDAHFALAFARIENHYFVHQGFMEDGQLLRDAHRLADIPGVIVQGRYDVATPARTAWELAKA
WPRASLEIVPDAGHAYDEPGILRALIAATDRFARER

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 49062; Mature: 49062

Theoretical pI: Translated: 11.14; Mature: 11.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAFATHARARRAGARARKHSCMHPCGDAFVRAFGSRRATPRRDERRARRPGGGSATSV
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCC
QARPRVFRRLGIMKRRFRRRRRIGASQRGRRIAWGARMRRAAVPFIAFGEAPPVVFFHST
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCEEEECCCCCEEEEECC
GASLLYPPIEPYAHGFLDTGDGHRVYWELCGNPNGKPAVFLHGGPGSGCSADHRRLFDPA
CCCEECCCCCHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHCCCCC
RYNVLLFDQRGCGRSTPHASLENNTTWHLVDDIERLRAMIGVERWLVFGGSWGSALALAY
CCCEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCHHHHHHHH
AQTHPARVAELVVRGIFTVRRSELLWYYQEGASWLFPDLWEDFIAPIPSAERADLIAAYR
HHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
RRLTGDDEAAKREAARAWSVWEGRTIALLPNAAHETYFGDAHFALAFARIENHYFVHQGF
HHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCEEEEECCC
MEDGQLLRDAHRLADIPGVIVQGRYDVATPARTAWELAKAWPRASLEIVPDAGHAYDEPG
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCH
ILRALIAATDRFARER
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRAAFATHARARRAGARARKHSCMHPCGDAFVRAFGSRRATPRRDERRARRPGGGSATSV
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCC
QARPRVFRRLGIMKRRFRRRRRIGASQRGRRIAWGARMRRAAVPFIAFGEAPPVVFFHST
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCEEEECCCCCEEEEECC
GASLLYPPIEPYAHGFLDTGDGHRVYWELCGNPNGKPAVFLHGGPGSGCSADHRRLFDPA
CCCEECCCCCHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHCCCCC
RYNVLLFDQRGCGRSTPHASLENNTTWHLVDDIERLRAMIGVERWLVFGGSWGSALALAY
CCCEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCHHHHHHHH
AQTHPARVAELVVRGIFTVRRSELLWYYQEGASWLFPDLWEDFIAPIPSAERADLIAAYR
HHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
RRLTGDDEAAKREAARAWSVWEGRTIALLPNAAHETYFGDAHFALAFARIENHYFVHQGF
HHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCEEEEECCC
MEDGQLLRDAHRLADIPGVIVQGRYDVATPARTAWELAKAWPRASLEIVPDAGHAYDEPG
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCH
ILRALIAATDRFARER
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]