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The map label for this gene is uvrB [H]

Identifier: 76818802

GI number: 76818802

Start: 2335538

End: 2337661

Strand: Direct

Name: uvrB [H]

Synonym: BURPS1710b_A1920

Alternate gene names: 76818802

Gene position: 2335538-2337661 (Clockwise)

Preceding gene: 76819604

Following gene: 76817924

Centisome position: 73.4

GC content: 64.6

Gene sequence:

>2124_bases
TTGCCCGTTTCGGCCCGCCGCCTCCGCATCCACATGTCCGAACACCACTCCGACACCCGTGACGATCTAGACGAATCGAA
ATTCGTGACGTTCGAAGGTTCTCCGTTTCAGCTGTATCAGCCTTATCCGCCGTCGGGCGACCAGCCCACCGCGATCGCGA
CGCTCGTCGAAGGCGTCGAGGATGGCCTGTCGTTCCAGACGCTGCTCGGCGTGACGGGCTCCGGCAAGACCTACACGATG
GCGAACACGATCGCGCGGCTCGGCCGTCCGGCGATCGTGTTCGCGCCGAACAAGACGCTCGCCGCGCAGTTGTACGCGGA
GTTCCGCGAGTTTTTCCCGCGCAACGCGGTCGAGTACTTCGTGTCGTACTACGACTACTACCAGCCGGAAGCGTACGTGC
CGCAGCGCGATCTCTTCATCGAGAAGGATTCGTCGATCAACGAGCACATCGAGCAGATGCGGCTGTCGGCGACGAAGAGC
CTGATGGAGCGGCGCGATGTCGTGATCGTCGCGACGGTGTCGGCGATCTACGGTATCGGCAATCCGTCCGAATACCACCA
GATGATCCTCACGCTGCGCACGGGCGACAAGATCGGCCAGCGCGAGGTGATCGCGCGGCTGATCGCGATGCAGTACACGC
GCAACGAGCAGGACTTCCAGCGCGGCACGTTTCGCGTGCGCGGCGACACGATCGACATCTTCCCGGCCGAGCACGCGGAG
ATGGCGGTGCGCGTCGAGTTGTTCGACGACGAAGTCGATACGCTGCATCTGTTCGATCCGCTGACGGGGCGCGTGCGGCA
GAAGATTCCGCGCTTCACCGTCTATCCGTCGTCGCACTACGTGACGCCGCGCGAGACTGTGATGCGCGCGGTCGAGACGA
TCAAGGACGAATTGCGCGAGCGTCTCGAATTCTTCCATCGCGACGGCAAGCTCGTCGAGGCGCAGCGCCTCGAGCAGCGC
ACCCGGTTCGACCTCGAGATGCTGCAGGAGCTCGGCTTCTGCAAGGGCATCGAGAATTATTCGCGGCACTTCTCCGGCGC
GGCGCCGGGCGAGCCGCCGCCGACCCTCGTCGACTATCTGCCGCCCGACGCGCTGATGCTGCTCGACGAATCGCACGTGC
TGATCGGCCAGTTGAACGGCATGTACAACGGCGATCGCGCGCGCAAGGAAAACCTCGTCGATTACGGGTTCCGGCTGCCG
TCGGCGCTCGATAACCGGCCGCTCAAGTTTCCCGAGTTCGAGCGCAAGATGCGCCAGGTGGTGTTCGTGTCGGCGACGCC
CGCCGACTACGAGCAGCGCGTGTCCGGCCAGACCGCCGAGCAGGTCGTGCGGCCGACCGGGCTCGTCGATCCGCAGATCG
AGGTGCGCCCGGCGAGCACGCAGGTGGACGACGTGCTCTCCGAGATCACCGAGCGGGTGAAGGCGAACGAGCGCGTGCTG
ATCACCGTGCTCACGAAGCGCATGGCCGAGCAATTGACCGAATTCCTCGCCGACCACGGGGTCAAGGTCCGCTATCTGCA
CAGCGACATCGACACCGTCGAGCGCGTCGAGATCATCCGAGACCTGCGGCTCGGCACGTTCGACGTGCTGGTCGGGATCA
ACCTGCTGCGCGAGGGCCTCGACATTCCGGAAGTGTCGCTCGTCGCGATCCTCGATGCGGACAAGGAGGGCTTCCTGCGC
GCCGAGCGCTCGCTGATCCAGACGATCGGCCGCGCGGCGCGCAACGTGAACGGCAAGGCGCTCCTGTACGCGGACCGGAT
CACCGATTCGATGCGCCGCGCGATCGACGAGACCGAGCGCCGCCGCGCAAAGCAGATCGCATACAACGAAAAGATGGGCA
TTACGCCGCGCGGCGTCGTGAAGCGGATCAAGGACATCATCGATGGCGTGTACAACGCCGACGAGGCGCGCGCCGAGCTG
AAGGAGGCGCAGCAGCGCGCGAAATTCGAGGACATGTCCGAGAAGCAGATCGCGAAGGAAATCAAGCGGCTCGAAAAGCA
GATGGCCGATTACGCGAAAAATCTCGAGTTCGAGAAAGCCGCGCAGACGCGCGACCAGCTCGCGCTGCTGCGCGAACGGG
TGTTCGGCGCGAATGTCGGCGATCACGTGAGCGGGGGCGAGTGA

Upstream 100 bases:

>100_bases
AATGTCTCGGCCCCGCACGCGGTTTTTTGCGCATTCGGTCAGCCAATCCCGAGCGCGGCGACGCGGAGCCGGCCGGGCGT
CGAAGCGCTAGAATGATCCT

Downstream 100 bases:

>100_bases
GGGCCCCCGCGGCGCCGCGCCGCAGTCGTTAATCTCGCTGTAAGCCTTGTCGGATCAGGGATTTAGCGGCATCTCCATTT
GTTTCGGAGGACGTTCGGTG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 707; Mature: 706

Protein sequence:

>707_residues
MPVSARRLRIHMSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGVTGSGKTYTM
ANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKS
LMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
MAVRVELFDDEVDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKLVEAQRLEQR
TRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLP
SALDNRPLKFPEFERKMRQVVFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVL
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLR
AERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAEL
KEAQQRAKFEDMSEKQIAKEIKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE

Sequences:

>Translated_707_residues
MPVSARRLRIHMSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGVTGSGKTYTM
ANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKS
LMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
MAVRVELFDDEVDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKLVEAQRLEQR
TRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLP
SALDNRPLKFPEFERKMRQVVFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVL
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLR
AERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAEL
KEAQQRAKFEDMSEKQIAKEIKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE
>Mature_706_residues
PVSARRLRIHMSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGVTGSGKTYTMA
NTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSL
MERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEM
AVRVELFDDEVDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKLVEAQRLEQRT
RFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPS
ALDNRPLKFPEFERKMRQVVFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVLI
TVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRA
ERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAELK
EAQQRAKFEDMSEKQIAKEIKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=66.1698956780924, Blast_Score=876, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.4527687296417, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80747; Mature: 80616

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSARRLRIHMSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVE
CCCCCHHEEEEEHHCCCCCHHCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHH
DGLSFQTLLGVTGSGKTYTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYF
HCCCHHHHHEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHH
VSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIG
HHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCC
NPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
CHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEECCEEEECCCCCCC
MAVRVELFDDEVDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRE
EEEEEEEECCCCCEEEECCCHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RLEFFHRDGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCC
PPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFPEFERKMRQV
CCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHE
VFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVL
EEEECCCCCHHHHHCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEE
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETER
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
RRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDMSEKQIAKE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PVSARRLRIHMSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVE
CCCCHHEEEEEHHCCCCCHHCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHH
DGLSFQTLLGVTGSGKTYTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYF
HCCCHHHHHEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHH
VSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIG
HHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCC
NPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
CHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEECCEEEECCCCCCC
MAVRVELFDDEVDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRE
EEEEEEEECCCCCEEEECCCHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
RLEFFHRDGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCC
PPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFPEFERKMRQV
CCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHE
VFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVL
EEEECCCCCHHHHHCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEE
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETER
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
RRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDMSEKQIAKE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA