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The map label for this gene is hyi [C]

Identifier: 76818127

GI number: 76818127

Start: 611864

End: 612640

Strand: Direct

Name: hyi [C]

Synonym: BURPS1710b_A0442

Alternate gene names: 76818127

Gene position: 611864-612640 (Clockwise)

Preceding gene: 76819755

Following gene: 76817720

Centisome position: 19.23

GC content: 68.21

Gene sequence:

>777_bases
ATGCCGCGCTTCGCCGCCAATCTCACGATGATGTACAACGAGCACGCGTTCCTCGAGCGCTTCGCCGCCGCGGCACGCGA
CGGCTTCAAGGCGGTCGAGTACCTGTTCCCGTACGAGTTCCCCGCCGCCGAGCTCAAGGCGCGCCTCGACGCGCATGGCC
TCGTGCAGGCGCTGTTCAACGCGCCGCCCGGCGACTGGGCGGCGGGCGAGCGCGGAATCGCGTCGCTGCCGGGCCGCGAG
GACGAGTTCAGGCGCGCGATCGACACCGCGCTCGACTACGCGCGCGTGATCGGCAACGACACGCTCCACGTGATGGCGGG
CCTGATCGCGCCGACGCAGGATCGCGCGCGGCATCGCGACGTGTATCTGCGCAACCTCGCGCACGCGGCCGAAGCGGCGC
GCGCGCAGAACGTGACGATCGTGATCGAGCCGATCAACCCGCGCGACATGCCGGGCTTCTTCCTGAACCGCCAGGACGAC
GCGCAGGCGATCTGCCGCGAAGTCGGCGCGCCGAACCTGCTGGTGCAGTTCGACTGCTATCACTGCCAGATCGTCGAAGG
CGATCTGGCGATGAAATTGAAGCGCGACATCGCGGGCATCGGCCACATCCAGATCGCGGGCGTGCCGCAGCGTCACGAGC
CGGACGTCGGCGAAATCCACTATCCGTACCTGTTCGAGCTGATCGACGTGCTCGGCTACGACGGCTGGATCGGCTGCGAG
TATCGGCCGAAGGCCGGCACCTCCGAGGGCCTCGGCTGGCTCGCACCGTATCTGTAA

Upstream 100 bases:

>100_bases
GAAGCTCGTCAACCGATAGATAATCGACCGTCGGCGGCGCCGCGCGCGTTCGGGCGCGCCCTCGCCGCCCCTTTCACCCA
CCGGACCTGGAACCGACGCC

Downstream 100 bases:

>100_bases
CCCCACGTTCTCACGAGGCACATTGCGATGAAGGTTCTCATCACCGGCGGCGCCGGCTTTCTCGGCCAGCGTCTCGCGAA
ACAGCTGCTCGCGCGCGGCG

Product: hydroxypyruvate isomerase

Products: 2-hydroxy-3-oxopropanoate

Alternate protein names: ORF4 [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPRFAANLTMMYNEHAFLERFAAAARDGFKAVEYLFPYEFPAAELKARLDAHGLVQALFNAPPGDWAAGERGIASLPGRE
DEFRRAIDTALDYARVIGNDTLHVMAGLIAPTQDRARHRDVYLRNLAHAAEAARAQNVTIVIEPINPRDMPGFFLNRQDD
AQAICREVGAPNLLVQFDCYHCQIVEGDLAMKLKRDIAGIGHIQIAGVPQRHEPDVGEIHYPYLFELIDVLGYDGWIGCE
YRPKAGTSEGLGWLAPYL

Sequences:

>Translated_258_residues
MPRFAANLTMMYNEHAFLERFAAAARDGFKAVEYLFPYEFPAAELKARLDAHGLVQALFNAPPGDWAAGERGIASLPGRE
DEFRRAIDTALDYARVIGNDTLHVMAGLIAPTQDRARHRDVYLRNLAHAAEAARAQNVTIVIEPINPRDMPGFFLNRQDD
AQAICREVGAPNLLVQFDCYHCQIVEGDLAMKLKRDIAGIGHIQIAGVPQRHEPDVGEIHYPYLFELIDVLGYDGWIGCE
YRPKAGTSEGLGWLAPYL
>Mature_257_residues
PRFAANLTMMYNEHAFLERFAAAARDGFKAVEYLFPYEFPAAELKARLDAHGLVQALFNAPPGDWAAGERGIASLPGRED
EFRRAIDTALDYARVIGNDTLHVMAGLIAPTQDRARHRDVYLRNLAHAAEAARAQNVTIVIEPINPRDMPGFFLNRQDDA
QAICREVGAPNLLVQFDCYHCQIVEGDLAMKLKRDIAGIGHIQIAGVPQRHEPDVGEIHYPYLFELIDVLGYDGWIGCEY
RPKAGTSEGLGWLAPYL

Specific function: Unknown

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=262, Percent_Identity=40.4580152671756, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=39.0946502057613, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1789095, Length=255, Percent_Identity=48.2352941176471, Blast_Score=247, Evalue=4e-67,
Organism=Escherichia coli, GI1786718, Length=257, Percent_Identity=43.9688715953307, Blast_Score=235, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=38.75, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17530883, Length=257, Percent_Identity=39.6887159533074, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: 5.3.1.22

Molecular weight: Translated: 28761; Mature: 28630

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFAANLTMMYNEHAFLERFAAAARDGFKAVEYLFPYEFPAAELKARLDAHGLVQALFN
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
APPGDWAAGERGIASLPGREDEFRRAIDTALDYARVIGNDTLHVMAGLIAPTQDRARHRD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHH
VYLRNLAHAAEAARAQNVTIVIEPINPRDMPGFFLNRQDDAQAICREVGAPNLLVQFDCY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECE
HCQIVEGDLAMKLKRDIAGIGHIQIAGVPQRHEPDVGEIHYPYLFELIDVLGYDGWIGCE
EEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCE
YRPKAGTSEGLGWLAPYL
ECCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
PRFAANLTMMYNEHAFLERFAAAARDGFKAVEYLFPYEFPAAELKARLDAHGLVQALFN
CCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
APPGDWAAGERGIASLPGREDEFRRAIDTALDYARVIGNDTLHVMAGLIAPTQDRARHRD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHH
VYLRNLAHAAEAARAQNVTIVIEPINPRDMPGFFLNRQDDAQAICREVGAPNLLVQFDCY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECE
HCQIVEGDLAMKLKRDIAGIGHIQIAGVPQRHEPDVGEIHYPYLFELIDVLGYDGWIGCE
EEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCE
YRPKAGTSEGLGWLAPYL
ECCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxypyruvate

Specific reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate; Other Name(s): hydroxypyruvate ketol-isomerase

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7851418 [H]