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The map label for this gene is lldA [H]

Identifier: 76817331

GI number: 76817331

Start: 1540838

End: 1541980

Strand: Direct

Name: lldA [H]

Synonym: BURPS1710b_A1229

Alternate gene names: 76817331

Gene position: 1540838-1541980 (Clockwise)

Preceding gene: 76818080

Following gene: 76817726

Centisome position: 48.43

GC content: 68.68

Gene sequence:

>1143_bases
ATGTCCGTCCCGATCACCTGCATCGAAGATCTTCGCGTTCTCGCGAAAAAACGCATCCCGCGAATGTTCTATGACTATGT
CGATACGGGCTCCTACACGGAATCGACGTATCGCGCGAATGAGGCCGATTTCCGGAAGATCAGGCTGCGCCAGCGCGTGG
GCGTCGACATCTCGAACCGCAACCTGCGCACGACGATGGCGGGGCAGGATGTGGCGATGCCGGTGGCGCTCGCGCCGACG
GGCCTCGTCGGCATGATGCGCGCGGACGGCGAGATCCTCGCCGCGCGCGCCGCGCGGCATTTCGGCGTGCCGTTCACGCT
GTCGACGATGAGCATCTGCTCGATCGAGGACATCGTCGCGCACGTGGGCGGCCCGTTCTGGTTCCAGTTGTACATGATGC
GCGATCGCGCGTTCATCGAGCGGCTGATCGAGCGCGCGAGCGCGGCGGGCTGCCCCGCGCTCGTGCTGACGATGGACCTG
CAGATCGCCGGCCAGCGCCACAAGGACGTGAAGAACGGCCTGTCGGCACCGCCGCGCATCACGCTGCCGAACCTGCTCGA
CATGATGCGCAAGCCGGGCTGGTGCCTCGGCATGGCGCGCACGCGTCGCCGCCATTTCGGCAACATCGTCGGGCACGTGA
AGGGCGTGACCGACATGTGGTCGCTCGATTCGTGGACCCGCGAGCAGTTCGATCCGACGATCGGCTGGCGCGATGCCGAA
TGGGTCCGGCGGCGGTGGAACGGCAAGCTGATCGTCAAGGGCGTGCTCGATGCGGACGATGCGCTCCGCGCGGCCGATGC
GGGCGCGGACGCGATCGTCGTGTCGAACCACGGCGGCCGCCAGCTCGACGGCGCGATGTCGTCGATCGAGGCGCTGCCCG
CCATCGTCGAGGCGGCCGGCAAGCGCGTCGAAGTGTGGCTCGACGGCGGCGTGCGCACGGGGCAGGACGTGCTGAAGGCG
GTGGCGCTCGGCGCGCGCGGCACGATGATCGGCCGCGCGTTCCTCTACGGCGTCGCCGCGCTCGGCGAGCAAGGCGCGCG
GCGCGCCCTCGAGCTCATCGCGCGCGAGCTCGATACGACGATGGCACTGTGCGGCTGCACCGACATTCGATCGGTGAACG
CCGATGTGCTCGCGCGGCGCTGA

Upstream 100 bases:

>100_bases
CGCGACGGCGCGGAATTTCTTTCGCGCCACGGCTGAAGATATTTCCGGGCGGGCAGCCGGGCGCGGCGGTAGCATCGTCG
CCACCCTCTCGGAGCCGCCC

Downstream 100 bases:

>100_bases
ACCGATCCGAAGCCGCGCGCAAGCGCGCGCGTTTCGCGCGACGACACAGGCGCGCCGCGCGTGCGGCGACGCCGCGACGG
CGGGCGCAATACCGCAAGGG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSVPITCIEDLRVLAKKRIPRMFYDYVDTGSYTESTYRANEADFRKIRLRQRVGVDISNRNLRTTMAGQDVAMPVALAPT
GLVGMMRADGEILAARAARHFGVPFTLSTMSICSIEDIVAHVGGPFWFQLYMMRDRAFIERLIERASAAGCPALVLTMDL
QIAGQRHKDVKNGLSAPPRITLPNLLDMMRKPGWCLGMARTRRRHFGNIVGHVKGVTDMWSLDSWTREQFDPTIGWRDAE
WVRRRWNGKLIVKGVLDADDALRAADAGADAIVVSNHGGRQLDGAMSSIEALPAIVEAAGKRVEVWLDGGVRTGQDVLKA
VALGARGTMIGRAFLYGVAALGEQGARRALELIARELDTTMALCGCTDIRSVNADVLARR

Sequences:

>Translated_380_residues
MSVPITCIEDLRVLAKKRIPRMFYDYVDTGSYTESTYRANEADFRKIRLRQRVGVDISNRNLRTTMAGQDVAMPVALAPT
GLVGMMRADGEILAARAARHFGVPFTLSTMSICSIEDIVAHVGGPFWFQLYMMRDRAFIERLIERASAAGCPALVLTMDL
QIAGQRHKDVKNGLSAPPRITLPNLLDMMRKPGWCLGMARTRRRHFGNIVGHVKGVTDMWSLDSWTREQFDPTIGWRDAE
WVRRRWNGKLIVKGVLDADDALRAADAGADAIVVSNHGGRQLDGAMSSIEALPAIVEAAGKRVEVWLDGGVRTGQDVLKA
VALGARGTMIGRAFLYGVAALGEQGARRALELIARELDTTMALCGCTDIRSVNADVLARR
>Mature_379_residues
SVPITCIEDLRVLAKKRIPRMFYDYVDTGSYTESTYRANEADFRKIRLRQRVGVDISNRNLRTTMAGQDVAMPVALAPTG
LVGMMRADGEILAARAARHFGVPFTLSTMSICSIEDIVAHVGGPFWFQLYMMRDRAFIERLIERASAAGCPALVLTMDLQ
IAGQRHKDVKNGLSAPPRITLPNLLDMMRKPGWCLGMARTRRRHFGNIVGHVKGVTDMWSLDSWTREQFDPTIGWRDAEW
VRRRWNGKLIVKGVLDADDALRAADAGADAIVVSNHGGRQLDGAMSSIEALPAIVEAAGKRVEVWLDGGVRTGQDVLKAV
ALGARGTMIGRAFLYGVAALGEQGARRALELIARELDTTMALCGCTDIRSVNADVLARR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=372, Percent_Identity=35.2150537634409, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=35.0267379679144, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=35.0267379679144, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI1790033, Length=376, Percent_Identity=42.0212765957447, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI193208036, Length=380, Percent_Identity=36.5789473684211, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI32566217, Length=294, Percent_Identity=34.0136054421769, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6323587, Length=384, Percent_Identity=30.2083333333333, Blast_Score=182, Evalue=5e-47,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=36.9973190348526, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281363140, Length=376, Percent_Identity=36.7021276595745, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI78707190, Length=376, Percent_Identity=36.7021276595745, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41837; Mature: 41706

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPITCIEDLRVLAKKRIPRMFYDYVDTGSYTESTYRANEADFRKIRLRQRVGVDISNR
CCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCC
NLRTTMAGQDVAMPVALAPTGLVGMMRADGEILAARAARHFGVPFTLSTMSICSIEDIVA
CEEEEECCCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
HVGGPFWFQLYMMRDRAFIERLIERASAAGCPALVLTMDLQIAGQRHKDVKNGLSAPPRI
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCHHHHHHCCCCCCCCC
TLPNLLDMMRKPGWCLGMARTRRRHFGNIVGHVKGVTDMWSLDSWTREQFDPTIGWRDAE
CCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHCCCCCCCCCHH
WVRRRWNGKLIVKGVLDADDALRAADAGADAIVVSNHGGRQLDGAMSSIEALPAIVEAAG
HHHHHCCCEEEEEEECCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
KRVEVWLDGGVRTGQDVLKAVALGARGTMIGRAFLYGVAALGEQGARRALELIARELDTT
CEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MALCGCTDIRSVNADVLARR
HHHHCCCHHHHCCHHHHCCC
>Mature Secondary Structure 
SVPITCIEDLRVLAKKRIPRMFYDYVDTGSYTESTYRANEADFRKIRLRQRVGVDISNR
CCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCC
NLRTTMAGQDVAMPVALAPTGLVGMMRADGEILAARAARHFGVPFTLSTMSICSIEDIVA
CEEEEECCCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
HVGGPFWFQLYMMRDRAFIERLIERASAAGCPALVLTMDLQIAGQRHKDVKNGLSAPPRI
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCHHHHHHCCCCCCCCC
TLPNLLDMMRKPGWCLGMARTRRRHFGNIVGHVKGVTDMWSLDSWTREQFDPTIGWRDAE
CCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHCCCCCCCCCHH
WVRRRWNGKLIVKGVLDADDALRAADAGADAIVVSNHGGRQLDGAMSSIEALPAIVEAAG
HHHHHCCCEEEEEEECCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
KRVEVWLDGGVRTGQDVLKAVALGARGTMIGRAFLYGVAALGEQGARRALELIARELDTT
CEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MALCGCTDIRSVNADVLARR
HHHHCCCHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA