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The map label for this gene is mcl1 [H]

Identifier: 76817316

GI number: 76817316

Start: 1585675

End: 1586580

Strand: Direct

Name: mcl1 [H]

Synonym: BURPS1710b_A1273

Alternate gene names: 76817316

Gene position: 1585675-1586580 (Clockwise)

Preceding gene: 76818764

Following gene: 76817457

Centisome position: 49.84

GC content: 73.73

Gene sequence:

>906_bases
ATGAAAACATCGAACGAGCCGGTCTGGCGCTCGCTGCTCTACGTACCCGCTCACGTGCCGCGCTTCGTCGCGAAGGCGGC
CGGCTGCGATGCCGACGCATTGATTCTCGATCTGGAAGACAGCGTGCCGCCCGAATGGAAGGCCCCCGCGCGCGACGGAC
TCGCCGATACGGTGGCCGGCCTCGCCGCCGTCGGGCACGAGGTGCTCGTGCGCGCGAACGGGCCGCTCGAGCCGCTTGTG
GCCGATCTGCGTGCGGCGCTCGCCGCGGGCGTGCACGGCATCGTGCTGCCGAAGGTGCGCGGCGCGTCGCACATCGAAGC
GATCGACGAACTGCTCGACGCGCTCGAGGCCGAGCACGGCATCGCGGCGGGCCGCACGCGAATCGTCGCGATCATCGAGA
CGCCCGGCGCATTCCAGGCGATGGAGCGCATCGCCCGCGCTTCGCCGCGCATCGCCGCGATGATGCTCGGCGGCGGCGAT
TTCGCGCTGCATTGCGGCGCCGAGGCGCGCGCGGACGTGCTGCGCGTGCCGAAGCAGTTGCTCGTGATCGCCGCGCGCGC
GGCTCGCGTGCAGCCGCTCGGGCTCGTCGGCGGGCTCGACGAGATTCGGGATCTCGACACGTTCGAGCGGCTCGCGCGCG
AATCGGCGGACCTCGGCTACGCCGGCGCGACGTGCATCCATCCCGCGCAGGTCGAAGCGCTGAACCGCGCGTTTCGCCCG
TCCGACGCCGCGGTCCGCGCCGCGCGCGAGATCGTCGCCGCTTACGACGACGCGCGCGCGAACGGCCGCGGCGCGCTGCG
CGTCGGCGACAGGATGGTCGACGCGCCGGGCGTCGCGCACGCGCGCAACGTGCTCGCGCGCGCCGACGCGATCGCGCGCC
GCCCGAGGCGTTGCGCGGCCGCGTGA

Upstream 100 bases:

>100_bases
TTGTTTACCCGACACTCCTATTTATCAGGGTTAACGACAGACTTGACGTTACGCCACAATCGACAAAAATGAAAGTGACT
TTCATTTTTTTAGATTAGAC

Downstream 100 bases:

>100_bases
CGCGCGCCGCCATCCGAGACCGAGACGCGCGCGCCGGGCGCGCGGGCGCCGCGCGCAACCGTTCCGCGACGATGTTCGGG
CGCGATCGCGCTGCCGCTCG

Product: citrate lyase subunit beta

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKTSNEPVWRSLLYVPAHVPRFVAKAAGCDADALILDLEDSVPPEWKAPARDGLADTVAGLAAVGHEVLVRANGPLEPLV
ADLRAALAAGVHGIVLPKVRGASHIEAIDELLDALEAEHGIAAGRTRIVAIIETPGAFQAMERIARASPRIAAMMLGGGD
FALHCGAEARADVLRVPKQLLVIAARAARVQPLGLVGGLDEIRDLDTFERLARESADLGYAGATCIHPAQVEALNRAFRP
SDAAVRAAREIVAAYDDARANGRGALRVGDRMVDAPGVAHARNVLARADAIARRPRRCAAA

Sequences:

>Translated_301_residues
MKTSNEPVWRSLLYVPAHVPRFVAKAAGCDADALILDLEDSVPPEWKAPARDGLADTVAGLAAVGHEVLVRANGPLEPLV
ADLRAALAAGVHGIVLPKVRGASHIEAIDELLDALEAEHGIAAGRTRIVAIIETPGAFQAMERIARASPRIAAMMLGGGD
FALHCGAEARADVLRVPKQLLVIAARAARVQPLGLVGGLDEIRDLDTFERLARESADLGYAGATCIHPAQVEALNRAFRP
SDAAVRAAREIVAAYDDARANGRGALRVGDRMVDAPGVAHARNVLARADAIARRPRRCAAA
>Mature_301_residues
MKTSNEPVWRSLLYVPAHVPRFVAKAAGCDADALILDLEDSVPPEWKAPARDGLADTVAGLAAVGHEVLVRANGPLEPLV
ADLRAALAAGVHGIVLPKVRGASHIEAIDELLDALEAEHGIAAGRTRIVAIIETPGAFQAMERIARASPRIAAMMLGGGD
FALHCGAEARADVLRVPKQLLVIAARAARVQPLGLVGGLDEIRDLDTFERLARESADLGYAGATCIHPAQVEALNRAFRP
SDAAVRAAREIVAAYDDARANGRGALRVGDRMVDAPGVAHARNVLARADAIARRPRRCAAA

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=299, Percent_Identity=27.4247491638796, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI87081764, Length=284, Percent_Identity=31.3380281690141, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17557458, Length=293, Percent_Identity=25.938566552901, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 31642; Mature: 31642

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSNEPVWRSLLYVPAHVPRFVAKAAGCDADALILDLEDSVPPEWKAPARDGLADTVAG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
LAAVGHEVLVRANGPLEPLVADLRAALAAGVHGIVLPKVRGASHIEAIDELLDALEAEHG
HHHHCHHEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
IAAGRTRIVAIIETPGAFQAMERIARASPRIAAMMLGGGDFALHCGAEARADVLRVPKQL
CCCCCEEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHH
LVIAARAARVQPLGLVGGLDEIRDLDTFERLARESADLGYAGATCIHPAQVEALNRAFRP
HHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SDAAVRAAREIVAAYDDARANGRGALRVGDRMVDAPGVAHARNVLARADAIARRPRRCAA
CHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCC
A
C
>Mature Secondary Structure
MKTSNEPVWRSLLYVPAHVPRFVAKAAGCDADALILDLEDSVPPEWKAPARDGLADTVAG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
LAAVGHEVLVRANGPLEPLVADLRAALAAGVHGIVLPKVRGASHIEAIDELLDALEAEHG
HHHHCHHEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
IAAGRTRIVAIIETPGAFQAMERIARASPRIAAMMLGGGDFALHCGAEARADVLRVPKQL
CCCCCEEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHH
LVIAARAARVQPLGLVGGLDEIRDLDTFERLARESADLGYAGATCIHPAQVEALNRAFRP
HHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SDAAVRAAREIVAAYDDARANGRGALRVGDRMVDAPGVAHARNVLARADAIARRPRRCAA
CHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA