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The map label for this gene is cobH [H]

Identifier: 75910066

GI number: 75910066

Start: 4810316

End: 4811422

Strand: Direct

Name: cobH [H]

Synonym: Ava_3862

Alternate gene names: 75910066

Gene position: 4810316-4811422 (Clockwise)

Preceding gene: 75910065

Following gene: 75910068

Centisome position: 75.57

GC content: 44.81

Gene sequence:

>1107_bases
ATGAATTCTGGTTGTTTAACGATTAAAGAACTTACCCAAGCCGTAGGTGGTGGGATTACTCCCCGGATGGTGCGACATTA
CCATGAACTAGGTTTGTTACCGCAGCCCGTGCGATCGCCTAGCAATTACCGCCTCTACACCCAACAGGATGTCATCCGGT
TGCAGCGAATTGTCGCCTTGAAACAGCAAGGATTCCAACTTAACCACATCCGTCACATTTTGGAGATGGAACCAGAAGCA
GTCACCAACGCCAATTTCATGGCACAGTTACAACAACAATATCGCTCAGTCATGCAGCAAATCGCCCAGCTGCGACAAAC
AGCATCAGCCTTAGAGGGATTATTAGGACGCGATCGCCATTGTCAAATTATGCAGGCGGAAGTATTGGCACAAGTCAAGT
TATTAGAGGTGGAAACGCAAGTTGGATTAGGAGGATTGGAAAAACTTTGGCATGGTTTAGACGCAGAGGTACATACCCAC
CCAGAAGTATTTGCCGAATCTTTGCAACATATCTTACCTGATTTATCCGGGCGATCAGAAATTGAACAACACCTAATTTC
TCAGTTAGTTTTGGCTTGTGGTGATGTGAGTTTGGTATCTTTTATCAGGGTAGATAAAAGAGCGATCGCCGCCAGCCGTC
AAGCCCTTTCCTCTGCTTGCGAGATTGTCGTCGATATCCCCACCATTGCAGCAGCGATAGATCAAACAAGATTAATTCAT
TTAGGCTGTAAAGTCACCACCTTAATTGATAACCCCCATATCACCACAGCCATCGAGGCAGAAAAGGAATTTTGGCAGCA
TCAAGAGTGGCGCGAGAGATTAGCCAAAGCAAGTCAAGGCTGCATATTGGTGATTGGTTACGCACCTTCTGTACTTTTAG
AAGTCTGCACCCTGATTAACCAGCAAAAAATTCAACCTTCATTAGTTATTGGAATGCCCATTGGCTTTAGTCATACTCCC
GCCGCCAAAAGACAATTAATGCAACAAACATCACCTTTTATCACTATTGAGGGAACCATCGGCGGAGGATTGCTGGCTGC
TACTGCCCTCAATGCTTTGGTTGAATCATTAATTGAAAAGCCAAATTGTCATTGTTATTTGAGTTAA

Upstream 100 bases:

>100_bases
AGAATTTCCCCGGATTTTGAGATTATTGGAATAATATTATCTGAAATTGAACAGCAGATACAAATGCAGACAATCAAAAT
ACATCAAGTATTGATAAATT

Downstream 100 bases:

>100_bases
GCGTTGCAATTCCCATTTCACGCAGATTGCCTACTCAAAAAGCTTTCAATAAAGATTAGAGGAATTACTTGGTTGCCACT
CATCCAAAATATCATTAAAT

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNSGCLTIKELTQAVGGGITPRMVRHYHELGLLPQPVRSPSNYRLYTQQDVIRLQRIVALKQQGFQLNHIRHILEMEPEA
VTNANFMAQLQQQYRSVMQQIAQLRQTASALEGLLGRDRHCQIMQAEVLAQVKLLEVETQVGLGGLEKLWHGLDAEVHTH
PEVFAESLQHILPDLSGRSEIEQHLISQLVLACGDVSLVSFIRVDKRAIAASRQALSSACEIVVDIPTIAAAIDQTRLIH
LGCKVTTLIDNPHITTAIEAEKEFWQHQEWRERLAKASQGCILVIGYAPSVLLEVCTLINQQKIQPSLVIGMPIGFSHTP
AAKRQLMQQTSPFITIEGTIGGGLLAATALNALVESLIEKPNCHCYLS

Sequences:

>Translated_368_residues
MNSGCLTIKELTQAVGGGITPRMVRHYHELGLLPQPVRSPSNYRLYTQQDVIRLQRIVALKQQGFQLNHIRHILEMEPEA
VTNANFMAQLQQQYRSVMQQIAQLRQTASALEGLLGRDRHCQIMQAEVLAQVKLLEVETQVGLGGLEKLWHGLDAEVHTH
PEVFAESLQHILPDLSGRSEIEQHLISQLVLACGDVSLVSFIRVDKRAIAASRQALSSACEIVVDIPTIAAAIDQTRLIH
LGCKVTTLIDNPHITTAIEAEKEFWQHQEWRERLAKASQGCILVIGYAPSVLLEVCTLINQQKIQPSLVIGMPIGFSHTP
AAKRQLMQQTSPFITIEGTIGGGLLAATALNALVESLIEKPNCHCYLS
>Mature_368_residues
MNSGCLTIKELTQAVGGGITPRMVRHYHELGLLPQPVRSPSNYRLYTQQDVIRLQRIVALKQQGFQLNHIRHILEMEPEA
VTNANFMAQLQQQYRSVMQQIAQLRQTASALEGLLGRDRHCQIMQAEVLAQVKLLEVETQVGLGGLEKLWHGLDAEVHTH
PEVFAESLQHILPDLSGRSEIEQHLISQLVLACGDVSLVSFIRVDKRAIAASRQALSSACEIVVDIPTIAAAIDQTRLIH
LGCKVTTLIDNPHITTAIEAEKEFWQHQEWRERLAKASQGCILVIGYAPSVLLEVCTLINQQKIQPSLVIGMPIGFSHTP
AAKRQLMQQTSPFITIEGTIGGGLLAATALNALVESLIEKPNCHCYLS

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 40732; Mature: 40732

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGCLTIKELTQAVGGGITPRMVRHYHELGLLPQPVRSPSNYRLYTQQDVIRLQRIVAL
CCCCCEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHH
KQQGFQLNHIRHILEMEPEAVTNANFMAQLQQQYRSVMQQIAQLRQTASALEGLLGRDRH
HHCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CQIMQAEVLAQVKLLEVETQVGLGGLEKLWHGLDAEVHTHPEVFAESLQHILPDLSGRSE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
IEQHLISQLVLACGDVSLVSFIRVDKRAIAASRQALSSACEIVVDIPTIAAAIDQTRLIH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHCCHHEEE
LGCKVTTLIDNPHITTAIEAEKEFWQHQEWRERLAKASQGCILVIGYAPSVLLEVCTLIN
ECCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
QQKIQPSLVIGMPIGFSHTPAAKRQLMQQTSPFITIEGTIGGGLLAATALNALVESLIEK
HHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
PNCHCYLS
CCCEEECC
>Mature Secondary Structure
MNSGCLTIKELTQAVGGGITPRMVRHYHELGLLPQPVRSPSNYRLYTQQDVIRLQRIVAL
CCCCCEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHH
KQQGFQLNHIRHILEMEPEAVTNANFMAQLQQQYRSVMQQIAQLRQTASALEGLLGRDRH
HHCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CQIMQAEVLAQVKLLEVETQVGLGGLEKLWHGLDAEVHTHPEVFAESLQHILPDLSGRSE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
IEQHLISQLVLACGDVSLVSFIRVDKRAIAASRQALSSACEIVVDIPTIAAAIDQTRLIH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHCCHHEEE
LGCKVTTLIDNPHITTAIEAEKEFWQHQEWRERLAKASQGCILVIGYAPSVLLEVCTLIN
ECCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
QQKIQPSLVIGMPIGFSHTPAAKRQLMQQTSPFITIEGTIGGGLLAATALNALVESLIEK
HHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
PNCHCYLS
CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]