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The map label for this gene is hemA

Identifier: 75909903

GI number: 75909903

Start: 4608288

End: 4609574

Strand: Direct

Name: hemA

Synonym: Ava_3699

Alternate gene names: 75909903

Gene position: 4608288-4609574 (Clockwise)

Preceding gene: 75909902

Following gene: 75909906

Centisome position: 72.39

GC content: 43.98

Gene sequence:

>1287_bases
ATGAATATTGCAGTGGTGGGGTTAAGCCATAAAACAGCCCCAGTTGAAATTCGGGAAAAGCTGAGTATTCCAGAACCACA
GACAGAAAGTGCGATCGCACAACTTACCAGCTATCCTCATATTGATGAAGTCGCCATTCTCAGCACCTGTAACCGTCTAG
AAATTTACATCGTTGCTGGTGAAACAGATCACGGTATTCGAGAAGTAACTCAGTTTCTTTCCGAACACAGTAAATTGCCA
GTGCATTCCTTACGTCAACACTTATTTGTGTTGCTACATGAAGACGCAGTTATGCACATCATGCGAGTGGCGGCTGGATT
GGATAGCCTCGTATTAGGCGAAGGTCAAATTCTGGCTCAGGTGAAAAATACTCACAAACTGGGGCAGCAATATAACGGTA
TAAAAACAATTTTGAATCGATTATTTAAACAAGCACTAACAGCAGGTAAGCGAGTCCGCACGGAAACCAGCATTGGTACT
GGTGCAGTTTCCATTAGTTCCGCAGCTGTGGAGTTAGCGCAGATAAAAGCCGAAAATTTAGCAGCTTGCCGAGTCACAAT
TCTTGGTGCTGGTAAAATGTCACGGCTGTTAGTACAACACCTTGTTTCTAAAGGTGCTACACAAATCAGTATTGTCAATC
GTTCACGAGAACGCGCCCAAGAATTAGCGAAGCAATTTTCAGAACACCCCATTCGCACTCATTTGCTTCCAGAAATGATG
ACAGTCATTGCTGAAAGCCATTTGGTGTTTACAAGCACCTCTGCAACAGAGCCAATACTTGATCGGGCTAAGTTAGAAAT
GGTTCTAGCACCAAACCAGCCCCTCATGTTATTTGATATTTCCGTACCACGCAACGTCCATACAGACGTGAATGAACTGG
CAAACGTCCAGGCTTTCAACGTGGATGATTTGAAGGCGGTGGTAGCCCAAAACTACGAAAGCCGTAGGAAGATGGCTCAA
GAGGCGGAACGGCTTTTAGAAGAAGAAATTGAGGCTTTTGATATTTGGTGGCGCAGTTTAGAAACTGTGTCTACAATCAG
CAGTCTGCGGAGTAAAATCGAAACTATCCGCGAACAGGAATTAGAGAAAGCCTTATCAAGATTGGGTTCAGAGTTCGGCG
ACAAACATCAAGAGGTGATTGAAGCCTTAACAAGAGGTATTGTTAATAAAATTTTACATGACCCGATGGTGCAATTGCGC
GCGCAGCAAGATGTTGAAGCCAGAAGGCGTTGTATGCAAACCCTACAAATGTTGTTTAACCTAGATGTGGGTGAGCAGTT
TAGTTAA

Upstream 100 bases:

>100_bases
AATCCCCAGTACCCAATCCCCAATCCCCAATCCCCAATCCCCAGTACCCAATCCCCAATCCCCAATCATTAAATAACCCA
TTACTAATTACCGATAAGAA

Downstream 100 bases:

>100_bases
TTAGGGGTATAGGGGTATAGGGGTGTAAGGGTATAGGGGAAAGAGTAAAACTAAATTCTTCCCTCACACCCTCACACCCT
TCTAAATCTCCTCTGGATTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAGETDHGIREVTQFLSEHSKLP
VHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQVKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGT
GAVSISSAAVELAQIKAENLAACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELANVQAFNVDDLKAVVAQNYESRRKMAQ
EAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQELEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLR
AQQDVEARRRCMQTLQMLFNLDVGEQFS

Sequences:

>Translated_428_residues
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAGETDHGIREVTQFLSEHSKLP
VHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQVKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGT
GAVSISSAAVELAQIKAENLAACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELANVQAFNVDDLKAVVAQNYESRRKMAQ
EAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQELEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLR
AQQDVEARRRCMQTLQMLFNLDVGEQFS
>Mature_428_residues
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAGETDHGIREVTQFLSEHSKLP
VHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQVKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGT
GAVSISSAAVELAQIKAENLAACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELANVQAFNVDDLKAVVAQNYESRRKMAQ
EAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQELEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLR
AQQDVEARRRCMQTLQMLFNLDVGEQFS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=402, Percent_Identity=36.318407960199, Blast_Score=242, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_ANAVT (Q3M6T2)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_324199.1
- ProteinModelPortal:   Q3M6T2
- SMR:   Q3M6T2
- STRING:   Q3M6T2
- GeneID:   3678785
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_3699
- NMPDR:   fig|240292.3.peg.4852
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q3M6T2
- ProtClustDB:   PRK00045
- BioCyc:   AVAR240292:AVA_3699-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47882; Mature: 47882

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAG
CCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEC
ETDHGIREVTQFLSEHSKLPVHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQ
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHH
VKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGTGAVSISSAAVELAQIKAENL
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCH
AACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
HEEEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELANVQAFN
HHHHHCCEEEEECCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
VDDLKAVVAQNYESRRKMAQEAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLRAQQDVEARRRCMQTLQMLFN
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHC
LDVGEQFS
CCCCCCCC
>Mature Secondary Structure
MNIAVVGLSHKTAPVEIREKLSIPEPQTESAIAQLTSYPHIDEVAILSTCNRLEIYIVAG
CCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEC
ETDHGIREVTQFLSEHSKLPVHSLRQHLFVLLHEDAVMHIMRVAAGLDSLVLGEGQILAQ
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHH
VKNTHKLGQQYNGIKTILNRLFKQALTAGKRVRTETSIGTGAVSISSAAVELAQIKAENL
HHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCH
AACRVTILGAGKMSRLLVQHLVSKGATQISIVNRSRERAQELAKQFSEHPIRTHLLPEMM
HEEEEEEECCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVIAESHLVFTSTSATEPILDRAKLEMVLAPNQPLMLFDISVPRNVHTDVNELANVQAFN
HHHHHCCEEEEECCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
VDDLKAVVAQNYESRRKMAQEAERLLEEEIEAFDIWWRSLETVSTISSLRSKIETIREQE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKALSRLGSEFGDKHQEVIEALTRGIVNKILHDPMVQLRAQQDVEARRRCMQTLQMLFN
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHC
LDVGEQFS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA