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The map label for this gene is purL [H]

Identifier: 75909841

GI number: 75909841

Start: 4532770

End: 4535103

Strand: Direct

Name: purL [H]

Synonym: Ava_3636

Alternate gene names: 75909841

Gene position: 4532770-4535103 (Clockwise)

Preceding gene: 75909840

Following gene: 75909842

Centisome position: 71.21

GC content: 47.77

Gene sequence:

>2334_bases
ATGACCGCCACATCTCCTGCTCCCTTTTCCCCCCAAGAAATTGCTGCTGAAGGCATCAAACCAGAAGAATACGCAGAAAT
TGTCCGACGATTAGGCCGTCATCCCAATAAAGCTGAACTGGGAATGTTTGGGGTGATGTGGTCAGAACACTGCTGTTACA
AAAATTCCCGCCCCTTACTCAAACAGTTCCCCACCACAGGCCCCCGCATTCTGGTAGGCCCAGGGGAAAATGCTGGAGTT
GTAGATTTAGGTGAAGGATTGCAACTGGCATTTAAGATTGAATCTCACAACCACCCTTCAGCCGTTGAACCCTTTCAAGG
AGCCGCCACTGGTGTGGGTGGCATCCTCAGAGATATTTTTACAATGGGTGCGCGTCCCATAGCTTTGTTAAATTCTCTCC
GCTTTGGTTCTCTGGAAGACCCCAAAACCCAAAGATTATTCTCCGGCGTAGTTGCTGGAATTTCCCACTATGGTAACTGT
GTCGGTGTTCCTACTGTCGGTGGCGAAGTTTATTTTGATCCCGCCTATTCAGGAAATCCCCTGGTAAATGTCATGGCGCT
AGGATTAATGGAAACACCAGAAATTGTCAAATCTGGGGCATCTGGTATAGGTAATCCTGTGTTGTACGTGGGTTCCACTA
CGGGACGGGATGGTATGGGAGGGGCGAGTTTTGCCAGCGCGGAATTAAGTGATGAGTCCATTGATGACCGGCCAGCAGTG
CAGGTGGGCGATCCTTTTTTGGAGAAATCACTAATTGAAGCCTGTTTAGAAGCATTTAAAACAGGTGCAGTGGTTGCAGC
GCAAGATATGGGTGCGGCGGGAATCACTTGTTCTACATCCGAGATGGCGGCTAAAGGTGGCGTAGGGATTGAACTAGATT
TAGATAAAATTCCTGTGCGGGAAACAGGGATGATTCCCTATGAATATCTCCTATCGGAGTCTCAAGAAAGAATGTTATTT
GTTGCCCACAAAGGACGGGAACAAGAATTAATTGATATTTTCCATCGTTGGGGACTACAGGCGGTTGTTGCTGGTACAGT
AATCGCCGAACCTATTGTGCGTATTCTCTTTCAAGGTGCAATTGCTGCGGAAATTCCGGCTGATGCCTTAGCTGAGAATA
CCCCACTGTACGAGCGTGAGTTACTGGCAGAACCCCCAGAATATGCCCGTCAAGCATGGGAATGGTCATCTGACTCTTTA
CCTACTTGTACAACTGCTGGTATTGAGATTCAAGGAAATCTGCAAAGTTGGCAGGAGATTTTGTTAACTTTGCTCAATAC
TCCCACGATCGCCTCGAAAAATTGGGTGTATCGTCAATATGACCACCAAGTCCAAAATAATACGGTTTTTCTCCCCGGTG
GTGCAGATGCGGCAGTCGTGCGCTTACGTCCCCTAGAAGGGCAGGGGAAAATTACTAATACCCTCAGTGGTGTTGCGGCT
ACGGTGGACTGCAATCCTCGGTATGTTTACCTTGATCCCTATGAGGGAGCTAAGGCAGTGGTGGCAGAAGCAGCCCGGAA
TCTTAGCTGTGTAGGGGCAGAACCTCTGGCGGTGACAGATAACTTAAATTTTGGTAGCCCAGAAAAACCCATTGGTTATT
GGCAATTGTCGGAGGCTTGTCGGGGTTTAGCGGAAGGTTGCCGAGAATTAGCAACCCCGGTCACTGGTGGTAATGTCTCT
CTATATAACGAAACCCTTGATCCTCAAGGCAACCCCCAACCAATTTACCCAACGCCAGTTGTGGGGATGGTGGGATTGAT
TACTGATTTAACCAAGATTTGCGGTCAAGGTTGGCAAACCCCAGGTGATGTGATTTATCTTTTAGGCGCATCTATCACCA
CTTTAGGCGCATCTGAATATTTAGCGACGATTCACGACACTGTGGCAGGTAGACCCCCACGGGTAGATTTTGACTTAGAA
CGCCGTGTGCAGAAAGTTTGTCGTGAGGGGATTTATGCTGATTGGGTACGTTCAGCCCATGATTGTGCTGAGGGGGGTTT
AGTCGTTGCGCTCGCAGAATCTTGTCTTGCTGGTAACCTGGGGGCAGAAATTCACCTAGACGCATCTGGAAGTCAGTTAC
AACGCCTGGATGAAGTGCTATTTGGTGAGGGTGGAGCCAGAATTTTAGTATCTGTAGCATCAACACAACAGGAAAATTGG
GAATCCTATTTACAGGAGCATCTAGGACAAAATTGGCAAAAATTGGGCATAGTTGGAAATACCGATGCAGATTTGGCGGT
TTTAACTACCGATAACCAAAGCTTAATCCGAGTTAGTATCGAAGAAATGAACGATCGCTATCAAAATGCGATCGCCAGAA
GGTTAGCCCTGTGA

Upstream 100 bases:

>100_bases
CTCAGCAGCAAAAACTTATCCAGTAAAACAACTAACAACTGACACGCATAGCGCACTAAATCGATACAATAATGCTCTGT
CCTGTTGGTGCATTATTTCC

Downstream 100 bases:

>100_bases
ATAAGTAGATAGTAGGGGGCGTAATTAACAACCCCTAACTAGTGACAACTAACCAATGACAACTGACAACTGACAAATTC
CCCAAATCAATAGCATCTTT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MTATSPAPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQFPTTGPRILVGPGENAGV
VDLGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNC
VGVPTVGGEVYFDPAYSGNPLVNVMALGLMETPEIVKSGASGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAV
QVGDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRETGMIPYEYLLSESQERMLF
VAHKGREQELIDIFHRWGLQAVVAGTVIAEPIVRILFQGAIAAEIPADALAENTPLYERELLAEPPEYARQAWEWSSDSL
PTCTTAGIEIQGNLQSWQEILLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGKITNTLSGVAA
TVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEACRGLAEGCRELATPVTGGNVS
LYNETLDPQGNPQPIYPTPVVGMVGLITDLTKICGQGWQTPGDVIYLLGASITTLGASEYLATIHDTVAGRPPRVDFDLE
RRVQKVCREGIYADWVRSAHDCAEGGLVVALAESCLAGNLGAEIHLDASGSQLQRLDEVLFGEGGARILVSVASTQQENW
ESYLQEHLGQNWQKLGIVGNTDADLAVLTTDNQSLIRVSIEEMNDRYQNAIARRLAL

Sequences:

>Translated_777_residues
MTATSPAPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQFPTTGPRILVGPGENAGV
VDLGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNC
VGVPTVGGEVYFDPAYSGNPLVNVMALGLMETPEIVKSGASGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAV
QVGDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRETGMIPYEYLLSESQERMLF
VAHKGREQELIDIFHRWGLQAVVAGTVIAEPIVRILFQGAIAAEIPADALAENTPLYERELLAEPPEYARQAWEWSSDSL
PTCTTAGIEIQGNLQSWQEILLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGKITNTLSGVAA
TVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEACRGLAEGCRELATPVTGGNVS
LYNETLDPQGNPQPIYPTPVVGMVGLITDLTKICGQGWQTPGDVIYLLGASITTLGASEYLATIHDTVAGRPPRVDFDLE
RRVQKVCREGIYADWVRSAHDCAEGGLVVALAESCLAGNLGAEIHLDASGSQLQRLDEVLFGEGGARILVSVASTQQENW
ESYLQEHLGQNWQKLGIVGNTDADLAVLTTDNQSLIRVSIEEMNDRYQNAIARRLAL
>Mature_776_residues
TATSPAPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQFPTTGPRILVGPGENAGVV
DLGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCV
GVPTVGGEVYFDPAYSGNPLVNVMALGLMETPEIVKSGASGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAVQ
VGDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVRETGMIPYEYLLSESQERMLFV
AHKGREQELIDIFHRWGLQAVVAGTVIAEPIVRILFQGAIAAEIPADALAENTPLYERELLAEPPEYARQAWEWSSDSLP
TCTTAGIEIQGNLQSWQEILLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGKITNTLSGVAAT
VDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEACRGLAEGCRELATPVTGGNVSL
YNETLDPQGNPQPIYPTPVVGMVGLITDLTKICGQGWQTPGDVIYLLGASITTLGASEYLATIHDTVAGRPPRVDFDLER
RVQKVCREGIYADWVRSAHDCAEGGLVVALAESCLAGNLGAEIHLDASGSQLQRLDEVLFGEGGARILVSVASTQQENWE
SYLQEHLGQNWQKLGIVGNTDADLAVLTTDNQSLIRVSIEEMNDRYQNAIARRLAL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=784, Percent_Identity=24.1071428571429, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17553022, Length=700, Percent_Identity=24.2857142857143, Blast_Score=100, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=809, Percent_Identity=23.4857849196539, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24582111, Length=666, Percent_Identity=23.8738738738739, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24582109, Length=666, Percent_Identity=23.8738738738739, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17137292, Length=666, Percent_Identity=23.8738738738739, Blast_Score=90, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 83321; Mature: 83190

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATSPAPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCCCHH
KQFPTTGPRILVGPGENAGVVDLGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIF
HHCCCCCCEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
TMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCVGVPTVGGEVYFDPAYSGNP
HCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCC
LVNVMALGLMETPEIVKSGASGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAV
HHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCE
QVGDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVR
ECCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECCHHHHHCCCCEEEEECCCCCCC
ETGMIPYEYLLSESQERMLFVAHKGREQELIDIFHRWGLQAVVAGTVIAEPIVRILFQGA
CCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCC
IAAEIPADALAENTPLYERELLAEPPEYARQAWEWSSDSLPTCTTAGIEIQGNLQSWQEI
HHHCCCHHHHHCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCEEEECCHHHHHHH
LLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGKITNTLSGVAA
HHHHHCCCCCCCCCCEEHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCHHHHHCCEEE
TVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEAC
EEECCCEEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCHHHHHHHH
RGLAEGCRELATPVTGGNVSLYNETLDPQGNPQPIYPTPVVGMVGLITDLTKICGQGWQT
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
PGDVIYLLGASITTLGASEYLATIHDTVAGRPPRVDFDLERRVQKVCREGIYADWVRSAH
CCCEEEEECCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
DCAEGGLVVALAESCLAGNLGAEIHLDASGSQLQRLDEVLFGEGGARILVSVASTQQENW
HHHCCCEEEEEHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHCCHHHH
ESYLQEHLGQNWQKLGIVGNTDADLAVLTTDNQSLIRVSIEEMNDRYQNAIARRLAL
HHHHHHHHCCCCEEECEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TATSPAPFSPQEIAAEGIKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLL
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCCCHH
KQFPTTGPRILVGPGENAGVVDLGEGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIF
HHCCCCCCEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
TMGARPIALLNSLRFGSLEDPKTQRLFSGVVAGISHYGNCVGVPTVGGEVYFDPAYSGNP
HCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCC
LVNVMALGLMETPEIVKSGASGIGNPVLYVGSTTGRDGMGGASFASAELSDESIDDRPAV
HHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCE
QVGDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPVR
ECCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECCHHHHHCCCCEEEEECCCCCCC
ETGMIPYEYLLSESQERMLFVAHKGREQELIDIFHRWGLQAVVAGTVIAEPIVRILFQGA
CCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCC
IAAEIPADALAENTPLYERELLAEPPEYARQAWEWSSDSLPTCTTAGIEIQGNLQSWQEI
HHHCCCHHHHHCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCEEEECCHHHHHHH
LLTLLNTPTIASKNWVYRQYDHQVQNNTVFLPGGADAAVVRLRPLEGQGKITNTLSGVAA
HHHHHCCCCCCCCCCEEHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCHHHHHCCEEE
TVDCNPRYVYLDPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLSEAC
EEECCCEEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCHHHHHHHH
RGLAEGCRELATPVTGGNVSLYNETLDPQGNPQPIYPTPVVGMVGLITDLTKICGQGWQT
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
PGDVIYLLGASITTLGASEYLATIHDTVAGRPPRVDFDLERRVQKVCREGIYADWVRSAH
CCCEEEEECCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
DCAEGGLVVALAESCLAGNLGAEIHLDASGSQLQRLDEVLFGEGGARILVSVASTQQENW
HHHCCCEEEEEHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHCCHHHH
ESYLQEHLGQNWQKLGIVGNTDADLAVLTTDNQSLIRVSIEEMNDRYQNAIARRLAL
HHHHHHHHCCCCEEECEEECCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]