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The map label for this gene is 75909728

Identifier: 75909728

GI number: 75909728

Start: 4373889

End: 4375736

Strand: Direct

Name: 75909728

Synonym: Ava_3522

Alternate gene names: NA

Gene position: 4373889-4375736 (Clockwise)

Preceding gene: 75909724

Following gene: 75909729

Centisome position: 68.71

GC content: 45.08

Gene sequence:

>1848_bases
ATGAGAAGACTTATATTATTGTGCTTGTTTGTCATCGGGCTGATATCTGCTGTATTTGGTTTCCTGAGTTTTCAGGGACT
AGCAGCTAAAGGCGAATTCGAGACAATTTTGTTAGATTTTCGAGAAGATATTCCAGCCGAGGTGATCAAACAGGATTTAC
AAGCGATCGCTCAACAATACAACGTTACACCCCAATTAGATAATAAATTTTCCGAGCAGGATCATGTTTATATTATCAAA
GGCGATCGCCAGCGACTCAAAGCGTTACAAAAATCGTCCTTTGCTAAAGCCACAGAAATTATCGAGCCGAATTATATCTA
TAAGCTAACTCCACCAGCCAAACCAGTTTGGTTAGGAGAAATCTTAGGAAAAGAACAAAGGCAAGAGTTTAACTCCTCCT
TAATTGGCCCCAACGATGAATATTACAGCAAACAGTGGAATCTCCACAAAATTGGTATAGAAGGTGCATGGACTCAAACC
AAAGGTAGCGGCGTAACTGTAGCAGTCATCGACACTGGTGTTACCCAGGTACGTGACTTAAAAGAAACCAAATTTGTTCA
AGGTTACGATTTCGTCAACGATAGAGTAGAAGCCACAGATGACAACGGACACGGTACTCACGTCGCCGGTACAGTCGCCC
AAGCTACCAACAATAAATATGGGGTAGCTGGAGTTGCTTACGAAGCCAGCCTCATGCCCTTAAAAGTCCTGAGTGCTTAC
GGTGGCGGAACCGTTGCTGATATTGCCGAAGCCATTAAATTTGCTGCTGACAAAGGCGCAGATGTGATTAATATGAGCTT
GGGTGGCGGTGGTGAAAGCCAATTACTCAAAGACGCTATCAACTATGCCCATAATAAAGGCGTAGTTATTATCGCGGCTG
CGGGTAATGAAAACGATAGTTCCGCCTCCTACCCCGCCCGTTATCCCCATGTAATTGGTGTTTCCGCCTTTGGCCCCGAT
GGCGAAAAAGCCCCCTATTCTAACTTTGGTGCTGGCGTTGATATTTCTGCCCCTGGTGGAAGTGATGCAGGTGCAATTCT
GCAAGAAACCATCAACGAAGAAGGCGAAGGCGTGTTCCTGGGACTCCAAGGAACAAGCATGGCTGCACCCCACGTTGCTG
GTGTCGCTGCTTTAATTAAAGCTAGTGGCGTAAAAGAACCAGACGCAATTTTAGAAGTACTCAAACAGTCGGCGCGGGTA
ATTCAAGACGATGGCTTGAACTACTACGGTGCGGGACAACTCAACGCCGAAGCCGCAGTTAAATTAGCAGCCCAAGGACA
AATCAGTTTCCAAGATTTCTTCCGTTGGTTGCGAGATAACGGCTATCTCAACCCCCGTTTCTGGTTTGATGGCGGTGCTG
TAGCCCTATTACCCAAAATCTTAATGGTGGTTGGTTCTTACCTATTAGCTTGGTTTTTACGGGTTTACCTCCCCTTCCCT
TGGAGTTGGTCTTTATCCAGTGGCTTGATTTTTGGTAGCTCTGGTCTATTCTTCCTCAAAGGAATCTATATTTTTGACCT
ACCCCAATGGCCATTCCGAGTTTTGGGTAGTTCCATTCCCGAATTGGGTAACACTTTACAGGGAAGCAATGCTTTAAACC
CCGTGTTTGCCAGTGTGTTGATTCCGATTTTGTTAATAGCATTGCTATTAGGTCATCCCAGTTGGAAATGGTTTGCCATC
GGTTCAACTTTAGGCGTAGCGGCTTGTTTAACCGTCAGTGCGGTTTTAGACCCAGCAGTTTGGGGACTAAATGATGTGAA
CTTAGCTCGTATATTCCTAATTATCAATGCTCTACTGTGTTATGCACTAGCTCGTTTAGCATTGAAAAACGAAGAGAAAA
CAGCGTAG

Upstream 100 bases:

>100_bases
TTAACTAAAAACATTTAAGTAGATGACAAAGTACACCAATCAGGGACGCAGATAGGTTATCGTAGTGAGCAATAACTGGC
AAAAAGCGTGATGAATTGAT

Downstream 100 bases:

>100_bases
AAGTGAGTGGGGTAAGAAAGTAGACAAGTATTATCTCTTCTCACCCTCCTCATTTCCCCTATTCCCCAATCCCCAACTTT
TATGAGTATCACAGTCACAG

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MRRLILLCLFVIGLISAVFGFLSFQGLAAKGEFETILLDFREDIPAEVIKQDLQAIAQQYNVTPQLDNKFSEQDHVYIIK
GDRQRLKALQKSSFAKATEIIEPNYIYKLTPPAKPVWLGEILGKEQRQEFNSSLIGPNDEYYSKQWNLHKIGIEGAWTQT
KGSGVTVAVIDTGVTQVRDLKETKFVQGYDFVNDRVEATDDNGHGTHVAGTVAQATNNKYGVAGVAYEASLMPLKVLSAY
GGGTVADIAEAIKFAADKGADVINMSLGGGGESQLLKDAINYAHNKGVVIIAAAGNENDSSASYPARYPHVIGVSAFGPD
GEKAPYSNFGAGVDISAPGGSDAGAILQETINEEGEGVFLGLQGTSMAAPHVAGVAALIKASGVKEPDAILEVLKQSARV
IQDDGLNYYGAGQLNAEAAVKLAAQGQISFQDFFRWLRDNGYLNPRFWFDGGAVALLPKILMVVGSYLLAWFLRVYLPFP
WSWSLSSGLIFGSSGLFFLKGIYIFDLPQWPFRVLGSSIPELGNTLQGSNALNPVFASVLIPILLIALLLGHPSWKWFAI
GSTLGVAACLTVSAVLDPAVWGLNDVNLARIFLIINALLCYALARLALKNEEKTA

Sequences:

>Translated_615_residues
MRRLILLCLFVIGLISAVFGFLSFQGLAAKGEFETILLDFREDIPAEVIKQDLQAIAQQYNVTPQLDNKFSEQDHVYIIK
GDRQRLKALQKSSFAKATEIIEPNYIYKLTPPAKPVWLGEILGKEQRQEFNSSLIGPNDEYYSKQWNLHKIGIEGAWTQT
KGSGVTVAVIDTGVTQVRDLKETKFVQGYDFVNDRVEATDDNGHGTHVAGTVAQATNNKYGVAGVAYEASLMPLKVLSAY
GGGTVADIAEAIKFAADKGADVINMSLGGGGESQLLKDAINYAHNKGVVIIAAAGNENDSSASYPARYPHVIGVSAFGPD
GEKAPYSNFGAGVDISAPGGSDAGAILQETINEEGEGVFLGLQGTSMAAPHVAGVAALIKASGVKEPDAILEVLKQSARV
IQDDGLNYYGAGQLNAEAAVKLAAQGQISFQDFFRWLRDNGYLNPRFWFDGGAVALLPKILMVVGSYLLAWFLRVYLPFP
WSWSLSSGLIFGSSGLFFLKGIYIFDLPQWPFRVLGSSIPELGNTLQGSNALNPVFASVLIPILLIALLLGHPSWKWFAI
GSTLGVAACLTVSAVLDPAVWGLNDVNLARIFLIINALLCYALARLALKNEEKTA
>Mature_615_residues
MRRLILLCLFVIGLISAVFGFLSFQGLAAKGEFETILLDFREDIPAEVIKQDLQAIAQQYNVTPQLDNKFSEQDHVYIIK
GDRQRLKALQKSSFAKATEIIEPNYIYKLTPPAKPVWLGEILGKEQRQEFNSSLIGPNDEYYSKQWNLHKIGIEGAWTQT
KGSGVTVAVIDTGVTQVRDLKETKFVQGYDFVNDRVEATDDNGHGTHVAGTVAQATNNKYGVAGVAYEASLMPLKVLSAY
GGGTVADIAEAIKFAADKGADVINMSLGGGGESQLLKDAINYAHNKGVVIIAAAGNENDSSASYPARYPHVIGVSAFGPD
GEKAPYSNFGAGVDISAPGGSDAGAILQETINEEGEGVFLGLQGTSMAAPHVAGVAALIKASGVKEPDAILEVLKQSARV
IQDDGLNYYGAGQLNAEAAVKLAAQGQISFQDFFRWLRDNGYLNPRFWFDGGAVALLPKILMVVGSYLLAWFLRVYLPFP
WSWSLSSGLIFGSSGLFFLKGIYIFDLPQWPFRVLGSSIPELGNTLQGSNALNPVFASVLIPILLIALLLGHPSWKWFAI
GSTLGVAACLTVSAVLDPAVWGLNDVNLARIFLIINALLCYALARLALKNEEKTA

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI27894285, Length=317, Percent_Identity=26.4984227129338, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI20336190, Length=317, Percent_Identity=26.4984227129338, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI20336188, Length=317, Percent_Identity=26.4984227129338, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI20336180, Length=317, Percent_Identity=26.4984227129338, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI4505577, Length=317, Percent_Identity=26.4984227129338, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI20336186, Length=317, Percent_Identity=26.4984227129338, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI20336184, Length=317, Percent_Identity=26.4984227129338, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI20336182, Length=317, Percent_Identity=26.4984227129338, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31317307, Length=253, Percent_Identity=32.4110671936759, Blast_Score=70, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320775, Length=234, Percent_Identity=38.034188034188, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319893, Length=246, Percent_Identity=32.520325203252, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324576, Length=254, Percent_Identity=33.0708661417323, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45550681, Length=286, Percent_Identity=26.5734265734266, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007280
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 66242; Mature: 66242

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLILLCLFVIGLISAVFGFLSFQGLAAKGEFETILLDFREDIPAEVIKQDLQAIAQQY
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHC
NVTPQLDNKFSEQDHVYIIKGDRQRLKALQKSSFAKATEIIEPNYIYKLTPPAKPVWLGE
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
ILGKEQRQEFNSSLIGPNDEYYSKQWNLHKIGIEGAWTQTKGSGVTVAVIDTGVTQVRDL
HHCHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCCEECCCCCCEEEEEEECCHHHHHHH
KETKFVQGYDFVNDRVEATDDNGHGTHVAGTVAQATNNKYGVAGVAYEASLMPLKVLSAY
HHHHHHCCCHHHCCCEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHC
GGGTVADIAEAIKFAADKGADVINMSLGGGGESQLLKDAINYAHNKGVVIIAAAGNENDS
CCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCC
SASYPARYPHVIGVSAFGPDGEKAPYSNFGAGVDISAPGGSDAGAILQETINEEGEGVFL
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEE
GLQGTSMAAPHVAGVAALIKASGVKEPDAILEVLKQSARVIQDDGLNYYGAGQLNAEAAV
EECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHE
KLAAQGQISFQDFFRWLRDNGYLNPRFWFDGGAVALLPKILMVVGSYLLAWFLRVYLPFP
EEECCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WSWSLSSGLIFGSSGLFFLKGIYIFDLPQWPFRVLGSSIPELGNTLQGSNALNPVFASVL
CCCCCCCCEEECCCCCEECCCEEEEECCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHH
IPILLIALLLGHPSWKWFAIGSTLGVAACLTVSAVLDPAVWGLNDVNLARIFLIINALLC
HHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
YALARLALKNEEKTA
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MRRLILLCLFVIGLISAVFGFLSFQGLAAKGEFETILLDFREDIPAEVIKQDLQAIAQQY
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHC
NVTPQLDNKFSEQDHVYIIKGDRQRLKALQKSSFAKATEIIEPNYIYKLTPPAKPVWLGE
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
ILGKEQRQEFNSSLIGPNDEYYSKQWNLHKIGIEGAWTQTKGSGVTVAVIDTGVTQVRDL
HHCHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCCEECCCCCCEEEEEEECCHHHHHHH
KETKFVQGYDFVNDRVEATDDNGHGTHVAGTVAQATNNKYGVAGVAYEASLMPLKVLSAY
HHHHHHCCCHHHCCCEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHC
GGGTVADIAEAIKFAADKGADVINMSLGGGGESQLLKDAINYAHNKGVVIIAAAGNENDS
CCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCC
SASYPARYPHVIGVSAFGPDGEKAPYSNFGAGVDISAPGGSDAGAILQETINEEGEGVFL
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEE
GLQGTSMAAPHVAGVAALIKASGVKEPDAILEVLKQSARVIQDDGLNYYGAGQLNAEAAV
EECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHE
KLAAQGQISFQDFFRWLRDNGYLNPRFWFDGGAVALLPKILMVVGSYLLAWFLRVYLPFP
EEECCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WSWSLSSGLIFGSSGLFFLKGIYIFDLPQWPFRVLGSSIPELGNTLQGSNALNPVFASVL
CCCCCCCCEEECCCCCEECCCEEEEECCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHH
IPILLIALLLGHPSWKWFAIGSTLGVAACLTVSAVLDPAVWGLNDVNLARIFLIINALLC
HHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
YALARLALKNEEKTA
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2187155; 12024217 [H]