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The map label for this gene is nudF [H]

Identifier: 75909719

GI number: 75909719

Start: 4363675

End: 4364229

Strand: Direct

Name: nudF [H]

Synonym: Ava_3513

Alternate gene names: 75909719

Gene position: 4363675-4364229 (Clockwise)

Preceding gene: 75909715

Following gene: 75909720

Centisome position: 68.55

GC content: 34.05

Gene sequence:

>555_bases
ATGAGTAAATTACAAGAATGGCAAATATTAAACTCCAAAATGGTTTTAGATCATCCCTGGTGTCAAGTCAGGCAAGATGA
AGTTAAATTACCAAGCGGTACAATAATAGATGATTATTTTGTCAATGTCAGACCAGATATTGTCCTAGTTTTGCCGATTA
CCGATAATAGAGAAGTTATATTTGTACGTCAATACAGACATGGGGTGGGAGATTTCTTTTTAGAACTGCCAGCCGGGAGA
TTTGATCCAACACAAGAAAGTGCTGAAGATGCAGGGTTGAGAGAATTGCAAGAAGAAACTGGTTATATTGCTCAACAATT
AATCAAAATTGCCATACTATACGATAATCCCAGCAAAGACACTAATCAAATACATTTATTTCTAGCAGAAAATGTGGTTA
AAGTTGGGGAGCAAAATTTAGATATTACAGAGGAAATAGAAATTATTTTAATTCCTCTTGAATCAGTCTTAGAAAAAATT
ACTCAAGGTGAAATTTCGGTAGCGGGAACTATTGCAGCTTTATTTCTAGGGTTGAATTTTATTACTGATAAGTAA

Upstream 100 bases:

>100_bases
CTGTTGCACTGACGCACCCTACATTTTGGATATCTTTTATCTGGAAATTCCTTAATGAGTGGATGTAAATTTAAATATTA
ATTCGTAAATAAATGAATCT

Downstream 100 bases:

>100_bases
TTAACGTAATACCAATTAAAAAATACGACAGATATATACGACTAGTATTTGATTTTTAAAATATAAGTAGGGTGGGCAAT
TCCCACCACAAACATGATAA

Product: NUDIX hydrolase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSKLQEWQILNSKMVLDHPWCQVRQDEVKLPSGTIIDDYFVNVRPDIVLVLPITDNREVIFVRQYRHGVGDFFLELPAGR
FDPTQESAEDAGLRELQEETGYIAQQLIKIAILYDNPSKDTNQIHLFLAENVVKVGEQNLDITEEIEIILIPLESVLEKI
TQGEISVAGTIAALFLGLNFITDK

Sequences:

>Translated_184_residues
MSKLQEWQILNSKMVLDHPWCQVRQDEVKLPSGTIIDDYFVNVRPDIVLVLPITDNREVIFVRQYRHGVGDFFLELPAGR
FDPTQESAEDAGLRELQEETGYIAQQLIKIAILYDNPSKDTNQIHLFLAENVVKVGEQNLDITEEIEIILIPLESVLEKI
TQGEISVAGTIAALFLGLNFITDK
>Mature_183_residues
SKLQEWQILNSKMVLDHPWCQVRQDEVKLPSGTIIDDYFVNVRPDIVLVLPITDNREVIFVRQYRHGVGDFFLELPAGRF
DPTQESAEDAGLRELQEETGYIAQQLIKIAILYDNPSKDTNQIHLFLAENVVKVGEQNLDITEEIEIILIPLESVLEKIT
QGEISVAGTIAALFLGLNFITDK

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17564994, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 20891; Mature: 20760

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLQEWQILNSKMVLDHPWCQVRQDEVKLPSGTIIDDYFVNVRPDIVLVLPITDNREVI
CCCCHHHHHHCCEEEEECCCCCCCCCCEECCCCCEEEEEEEECCCCEEEEEEECCCCCEE
FVRQYRHGVGDFFLELPAGRFDPTQESAEDAGLRELQEETGYIAQQLIKIAILYDNPSKD
EEEHHHCCHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
TNQIHLFLAENVVKVGEQNLDITEEIEIILIPLESVLEKITQGEISVAGTIAALFLGLNF
CCEEEEEEEHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHCCCEEHHHHHHHHHHHHHH
ITDK
HCCC
>Mature Secondary Structure 
SKLQEWQILNSKMVLDHPWCQVRQDEVKLPSGTIIDDYFVNVRPDIVLVLPITDNREVI
CCCHHHHHHCCEEEEECCCCCCCCCCEECCCCCEEEEEEEECCCCEEEEEEECCCCCEE
FVRQYRHGVGDFFLELPAGRFDPTQESAEDAGLRELQEETGYIAQQLIKIAILYDNPSKD
EEEHHHCCHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
TNQIHLFLAENVVKVGEQNLDITEEIEIILIPLESVLEKITQGEISVAGTIAALFLGLNF
CCEEEEEEEHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHCCCEEHHHHHHHHHHHHHH
ITDK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]