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The map label for this gene is parE [H]

Identifier: 75909542

GI number: 75909542

Start: 4155137

End: 4156093

Strand: Direct

Name: parE [H]

Synonym: Ava_3336

Alternate gene names: 75909542

Gene position: 4155137-4156093 (Clockwise)

Preceding gene: 75909541

Following gene: 75909550

Centisome position: 65.27

GC content: 43.99

Gene sequence:

>957_bases
ATGAAAGGACTCTGGCTAGAAAATAACCAGTTACAACTGCTTACAGATATTCCCATTCCAGAACCAGCGCCAGAAGAAGC
GCTAGTTCGTGTTTTACGCGCAGGAATTTGTAACACTGACTTAGAATTGTTGAGAGGCTATTATCCCTACACAGGGATTC
TAGGACATGAGTTTGTAGGAGTGGTAGAACAAGGGCCAGAAAACCTACTTAATCAAAGAGTAGTGGGGGAAATTAATGCT
GTCTGCGGCTATTGTCGTTTTTGTCGGCGAGGACAACCAACTCACTGTGAAAATCGGACTGTTTTGGGTATTGTAAATCG
TCATGGGGCTTTTGCTGAGTACCTCTGCTTACCAGTCAAAAATCTCCATCCTGTACCCGAAAACGTAGCAACAGAGGTTG
CAACTTTTACCGAACCCTTGGCAGCAGCGCTAGAAATTCAACAACAGGTAATATTGAGTAAAGATGACCGTGTGCTAGTA
GTCGGAGATGGCAAATTGGGACAATTAGTAGCCCAAACACTAGCTTTAACTGGTTGTGAATTATTGGTTGTTGGTCGTCA
CCAAGAAAAACTCGCTAATTTAAAGGTAAGGGGTATTCAAACGGGTTTAGTTGATGCTGTCCAAGATAGAGCTTTTGATA
TTGTAGTTGAGTGTACTGGTAATCCAGAAGGATTTGCGATCGCTCGTCGGGCTTTGCGTCCCCGTGGTACTCTAGTCCTA
AAAAGTACCTATGCTGGTAATCTCAGTCTTGATGCTTCTTCTTTAGTTGTAGACGAAATTACTCTCATCGGTTCTCGTTG
TGGCTCTTTTCCCCCTGCACTGGAACTATTAGCTACAGGAAAAGTTGACGTAGAACCTCTGATTCATGCTCACTACCCAC
TCAGCCAAGGGCTTTTGGCTTTTGAGGAAGCCCAACGCCGAGGCGTGCTAAAGGTATTATTAGAGATTGGTAATTAG

Upstream 100 bases:

>100_bases
TCAAAACTTTAGGAAGTGAGATTGCTGTTCACTCTGATGACTTAGTCATTTGGTTAAGCAAAATTGAGCAGAAGTTTCCC
AGTACTACTGAGATATAAAG

Downstream 100 bases:

>100_bases
TTGTTTCCCCTGCCTACACTAATATAAGTAAGGATTAGTCTTTGCTTGATAATCCATACAGTTGATGGCTTCTTCTGTGT
TAGCACGGGATGGGTGTACA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: DOIA dehydrogenase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKGLWLENNQLQLLTDIPIPEPAPEEALVRVLRAGICNTDLELLRGYYPYTGILGHEFVGVVEQGPENLLNQRVVGEINA
VCGYCRFCRRGQPTHCENRTVLGIVNRHGAFAEYLCLPVKNLHPVPENVATEVATFTEPLAAALEIQQQVILSKDDRVLV
VGDGKLGQLVAQTLALTGCELLVVGRHQEKLANLKVRGIQTGLVDAVQDRAFDIVVECTGNPEGFAIARRALRPRGTLVL
KSTYAGNLSLDASSLVVDEITLIGSRCGSFPPALELLATGKVDVEPLIHAHYPLSQGLLAFEEAQRRGVLKVLLEIGN

Sequences:

>Translated_318_residues
MKGLWLENNQLQLLTDIPIPEPAPEEALVRVLRAGICNTDLELLRGYYPYTGILGHEFVGVVEQGPENLLNQRVVGEINA
VCGYCRFCRRGQPTHCENRTVLGIVNRHGAFAEYLCLPVKNLHPVPENVATEVATFTEPLAAALEIQQQVILSKDDRVLV
VGDGKLGQLVAQTLALTGCELLVVGRHQEKLANLKVRGIQTGLVDAVQDRAFDIVVECTGNPEGFAIARRALRPRGTLVL
KSTYAGNLSLDASSLVVDEITLIGSRCGSFPPALELLATGKVDVEPLIHAHYPLSQGLLAFEEAQRRGVLKVLLEIGN
>Mature_318_residues
MKGLWLENNQLQLLTDIPIPEPAPEEALVRVLRAGICNTDLELLRGYYPYTGILGHEFVGVVEQGPENLLNQRVVGEINA
VCGYCRFCRRGQPTHCENRTVLGIVNRHGAFAEYLCLPVKNLHPVPENVATEVATFTEPLAAALEIQQQVILSKDDRVLV
VGDGKLGQLVAQTLALTGCELLVVGRHQEKLANLKVRGIQTGLVDAVQDRAFDIVVECTGNPEGFAIARRALRPRGTLVL
KSTYAGNLSLDASSLVVDEITLIGSRCGSFPPALELLATGKVDVEPLIHAHYPLSQGLLAFEEAQRRGVLKVLLEIGN

Specific function: Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(+) or NADP(+), forming 3-amino-2,3-dideoxy-scyllo- inosose (amino-DOI) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. DOIA dehydrogenase subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=336, Percent_Identity=25.297619047619, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787863, Length=339, Percent_Identity=29.2035398230088, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=25, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI226510992, Length=300, Percent_Identity=28, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788075, Length=337, Percent_Identity=27.299703264095, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790718, Length=302, Percent_Identity=25.8278145695364, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788407, Length=323, Percent_Identity=26.9349845201238, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788073, Length=327, Percent_Identity=23.5474006116208, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786825, Length=208, Percent_Identity=31.25, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082125, Length=269, Percent_Identity=25.6505576208178, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082401, Length=121, Percent_Identity=34.7107438016529, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=333, Percent_Identity=25.5255255255255, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=329, Percent_Identity=25.531914893617, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=307, Percent_Identity=27.3615635179153, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=303, Percent_Identity=28.3828382838284, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=300, Percent_Identity=26.3333333333333, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=308, Percent_Identity=26.6233766233766, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=296, Percent_Identity=26.3513513513513, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=351, Percent_Identity=23.3618233618234, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=294, Percent_Identity=25.1700680272109, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=283, Percent_Identity=24.3816254416961, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=338, Percent_Identity=22.7810650887574, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=317, Percent_Identity=25.2365930599369, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=317, Percent_Identity=25.2365930599369, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=26.3636363636364, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17137530, Length=328, Percent_Identity=25, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550770, Length=315, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551930, Length=315, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221457811, Length=315, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 34590; Mature: 34590

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLWLENNQLQLLTDIPIPEPAPEEALVRVLRAGICNTDLELLRGYYPYTGILGHEFVG
CCCCEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHH
VVEQGPENLLNQRVVGEINAVCGYCRFCRRGQPTHCENRTVLGIVNRHGAFAEYLCLPVK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHCCC
NLHPVPENVATEVATFTEPLAAALEIQQQVILSKDDRVLVVGDGKLGQLVAQTLALTGCE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCE
LLVVGRHQEKLANLKVRGIQTGLVDAVQDRAFDIVVECTGNPEGFAIARRALRPRGTLVL
EEEECCCHHHHHCEEEECHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEE
KSTYAGNLSLDASSLVVDEITLIGSRCGSFPPALELLATGKVDVEPLIHAHYPLSQGLLA
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHEECCCHHHHHHH
FEEAQRRGVLKVLLEIGN
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGLWLENNQLQLLTDIPIPEPAPEEALVRVLRAGICNTDLELLRGYYPYTGILGHEFVG
CCCCEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHH
VVEQGPENLLNQRVVGEINAVCGYCRFCRRGQPTHCENRTVLGIVNRHGAFAEYLCLPVK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHCCC
NLHPVPENVATEVATFTEPLAAALEIQQQVILSKDDRVLVVGDGKLGQLVAQTLALTGCE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCE
LLVVGRHQEKLANLKVRGIQTGLVDAVQDRAFDIVVECTGNPEGFAIARRALRPRGTLVL
EEEECCCHHHHHCEEEECHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEE
KSTYAGNLSLDASSLVVDEITLIGSRCGSFPPALELLATGKVDVEPLIHAHYPLSQGLLA
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHEECCCHHHHHHH
FEEAQRRGVLKVLLEIGN
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA