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The map label for this gene is 75909399

Identifier: 75909399

GI number: 75909399

Start: 3966194

End: 3967111

Strand: Direct

Name: 75909399

Synonym: Ava_3192

Alternate gene names: NA

Gene position: 3966194-3967111 (Clockwise)

Preceding gene: 75909395

Following gene: 75909400

Centisome position: 62.31

GC content: 43.36

Gene sequence:

>918_bases
ATGGAATTGCCAATTATTTATCACCCACATTATGTTGCACCATTGCCTGAAGGACATCGCTTCCCGATGGCAAAATTCAA
AAAACTCTATGAATTGCTCTTAAGTGATGATGTAGCACAAACAGAGCAATTTTATACCCCAATCCTGCCACACCCAGAGT
TAATCGAGTTAGTTCATACCCCAGACTATGTGCGGTCTTACTGCGAAGGTACACTAGATACTAAAGCACAACGTCGAATC
GGTTTACCTTGGAGTCCAGCACTAGCAAATCGTACCTGTATAGCTGTGGGTGGAACAATACTCACAGCACAGCTAGCACT
CAATCAAGGTTTAGCTTGTAATACTGCTGGTGGTACTCATCATGCTTTTCCTAGTTATGGTTCTGGTTTTTGTATTTTCA
ACGATATAGCGATCGCCTCTCGCGTTCTCCAACAACAGCAACTAGTCAAAAAAATCCTCATTGTCGATTTGGATGTCCAT
CAAGGAGACGGTACAGCGTTTATATTCCAAGATGATGACAGTGTTTTCACATTCTCCATGCACTGCGAAGTTAATTTCCC
AGGAACCAAGCAACACAGTGATTTAGATGTTCCCTTACCAGTAGGAATGGAGGATGATGCTTACCTACAAACCTTGGCGA
GTTACCTACCAGATTTGTTATCTGAGATCAAACCAGACTTAGTATTTTACGATGCTGGTGTTGATCCCCACATAGGCGAT
CGCTTAGGTAAACTAGCCTTAAGTGACACTGGCTTATTCCGTCGAGAAATGCAGGTTTTAACTACCTGTATCAGCGCTGG
TTATCCAGTCGCCTGCGTAATTGGTGGTGGTTACGCTGATGATATGACATCCCTAGTTTGGCGACATTCCCTATTGCATC
GTGCCGCTAGTGAGGTTTACCGTCAATACAAGCTTTAA

Upstream 100 bases:

>100_bases
CCAAACAACCTCTCATATATTAGGCGCGATCGCCTACAATTTCTCTGCTCACCATAAGATTTTTAAGCATATTCAGCTTC
AGTCTGGGAAAATAAATAAC

Downstream 100 bases:

>100_bases
TAGATTATGAAATAATTAGACATTTCATGAGAATATAGATGACATCAGAATTTCTCACCTAAATCAAAAATTAGTATTAA
GCCATCAATAGTTAATTGTG

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MELPIIYHPHYVAPLPEGHRFPMAKFKKLYELLLSDDVAQTEQFYTPILPHPELIELVHTPDYVRSYCEGTLDTKAQRRI
GLPWSPALANRTCIAVGGTILTAQLALNQGLACNTAGGTHHAFPSYGSGFCIFNDIAIASRVLQQQQLVKKILIVDLDVH
QGDGTAFIFQDDDSVFTFSMHCEVNFPGTKQHSDLDVPLPVGMEDDAYLQTLASYLPDLLSEIKPDLVFYDAGVDPHIGD
RLGKLALSDTGLFRREMQVLTTCISAGYPVACVIGGGYADDMTSLVWRHSLLHRAASEVYRQYKL

Sequences:

>Translated_305_residues
MELPIIYHPHYVAPLPEGHRFPMAKFKKLYELLLSDDVAQTEQFYTPILPHPELIELVHTPDYVRSYCEGTLDTKAQRRI
GLPWSPALANRTCIAVGGTILTAQLALNQGLACNTAGGTHHAFPSYGSGFCIFNDIAIASRVLQQQQLVKKILIVDLDVH
QGDGTAFIFQDDDSVFTFSMHCEVNFPGTKQHSDLDVPLPVGMEDDAYLQTLASYLPDLLSEIKPDLVFYDAGVDPHIGD
RLGKLALSDTGLFRREMQVLTTCISAGYPVACVIGGGYADDMTSLVWRHSLLHRAASEVYRQYKL
>Mature_305_residues
MELPIIYHPHYVAPLPEGHRFPMAKFKKLYELLLSDDVAQTEQFYTPILPHPELIELVHTPDYVRSYCEGTLDTKAQRRI
GLPWSPALANRTCIAVGGTILTAQLALNQGLACNTAGGTHHAFPSYGSGFCIFNDIAIASRVLQQQQLVKKILIVDLDVH
QGDGTAFIFQDDDSVFTFSMHCEVNFPGTKQHSDLDVPLPVGMEDDAYLQTLASYLPDLLSEIKPDLVFYDAGVDPHIGD
RLGKLALSDTGLFRREMQVLTTCISAGYPVACVIGGGYADDMTSLVWRHSLLHRAASEVYRQYKL

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI217272877, Length=299, Percent_Identity=31.1036789297659, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI209862883, Length=272, Percent_Identity=30.5147058823529, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI13128860, Length=294, Percent_Identity=27.5510204081633, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI13128864, Length=272, Percent_Identity=30.8823529411765, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI20070354, Length=254, Percent_Identity=31.1023622047244, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI293336691, Length=258, Percent_Identity=28.2945736434109, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI8923769, Length=308, Percent_Identity=27.5974025974026, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI13128862, Length=224, Percent_Identity=30.3571428571429, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17158039, Length=163, Percent_Identity=36.1963190184049, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI30795204, Length=163, Percent_Identity=36.1963190184049, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI30795202, Length=163, Percent_Identity=36.1963190184049, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI169234807, Length=150, Percent_Identity=38, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI148539870, Length=150, Percent_Identity=38, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI153085395, Length=146, Percent_Identity=36.3013698630137, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI262073092, Length=234, Percent_Identity=29.4871794871795, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI62750347, Length=187, Percent_Identity=32.0855614973262, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI62750349, Length=187, Percent_Identity=32.0855614973262, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI226529806, Length=141, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI262073088, Length=184, Percent_Identity=28.804347826087, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193207430, Length=308, Percent_Identity=29.5454545454545, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17534739, Length=271, Percent_Identity=29.520295202952, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17508561, Length=208, Percent_Identity=33.6538461538462, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=209, Percent_Identity=32.5358851674641, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540332, Length=182, Percent_Identity=31.8681318681319, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI193206283, Length=182, Percent_Identity=31.8681318681319, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17540334, Length=182, Percent_Identity=31.8681318681319, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17537347, Length=210, Percent_Identity=30.952380952381, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193209491, Length=162, Percent_Identity=33.9506172839506, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=211, Percent_Identity=27.0142180094787, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=211, Percent_Identity=27.4881516587678, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321244, Length=319, Percent_Identity=30.0940438871473, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323999, Length=209, Percent_Identity=32.5358851674641, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=187, Percent_Identity=34.7593582887701, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=143, Percent_Identity=32.8671328671329, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24649807, Length=309, Percent_Identity=31.7152103559871, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24657891, Length=294, Percent_Identity=27.891156462585, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24644244, Length=218, Percent_Identity=31.1926605504587, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24642142, Length=184, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24642144, Length=184, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24642146, Length=184, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281360899, Length=184, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641720, Length=201, Percent_Identity=29.8507462686567, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281360799, Length=201, Percent_Identity=29.8507462686567, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281360801, Length=201, Percent_Identity=29.8507462686567, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33838; Mature: 33838

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPIIYHPHYVAPLPEGHRFPMAKFKKLYELLLSDDVAQTEQFYTPILPHPELIELVHT
CCCCEEECCCEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHCC
PDYVRSYCEGTLDTKAQRRIGLPWSPALANRTCIAVGGTILTAQLALNQGLACNTAGGTH
HHHHHHHHCCCCCCHHHHHCCCCCCCHHCCCEEEEECCHHHHHHHHHCCCCEEECCCCCC
HAFPSYGSGFCIFNDIAIASRVLQQQQLVKKILIVDLDVHQGDGTAFIFQDDDSVFTFSM
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCEEEEEE
HCEVNFPGTKQHSDLDVPLPVGMEDDAYLQTLASYLPDLLSEIKPDLVFYDAGVDPHIGD
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
RLGKLALSDTGLFRREMQVLTTCISAGYPVACVIGGGYADDMTSLVWRHSLLHRAASEVY
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RQYKL
HHHCC
>Mature Secondary Structure
MELPIIYHPHYVAPLPEGHRFPMAKFKKLYELLLSDDVAQTEQFYTPILPHPELIELVHT
CCCCEEECCCEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHCC
PDYVRSYCEGTLDTKAQRRIGLPWSPALANRTCIAVGGTILTAQLALNQGLACNTAGGTH
HHHHHHHHCCCCCCHHHHHCCCCCCCHHCCCEEEEECCHHHHHHHHHCCCCEEECCCCCC
HAFPSYGSGFCIFNDIAIASRVLQQQQLVKKILIVDLDVHQGDGTAFIFQDDDSVFTFSM
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCEEEEEE
HCEVNFPGTKQHSDLDVPLPVGMEDDAYLQTLASYLPDLLSEIKPDLVFYDAGVDPHIGD
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
RLGKLALSDTGLFRREMQVLTTCISAGYPVACVIGGGYADDMTSLVWRHSLLHRAASEVY
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RQYKL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7678591 [H]