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The map label for this gene is eriC [C]

Identifier: 75909331

GI number: 75909331

Start: 3879698

End: 3881488

Strand: Direct

Name: eriC [C]

Synonym: Ava_3124

Alternate gene names: 75909331

Gene position: 3879698-3881488 (Clockwise)

Preceding gene: 75909328

Following gene: 75909333

Centisome position: 60.95

GC content: 44.84

Gene sequence:

>1791_bases
GTGTTGTTTTTAGCCGTACTCATCGGCGGTGGCACCGGTATGGGGGTGGTAACTTTTCACTATTTGATTGAGCTGATTCA
CCACCTGATGCTAGAAAATCTGATGGGTGCAATAGGTGTTTGGGGCGCTTGGACATTAGCTCTTGTCCCCATTTTAGGAG
GGCTAATAGTTGGATTAATGCGCTGGCGCACACAAGACTTTGGCCCTGGATTGTCCTCACTCATTGCCGCTTCTGAGGGT
AGCGAAATCAAAGGACAATTGCGTCCTGTCACGAAAATGTTAGCGGCTGCCGTTTCCTTGGGGAGTGGTGCTTCTTTGGG
CCCAGAGGGCCCAAGTGTGGAAATTGGCGCTAATTTCGGAATGCTGTTGTCCTTAATATTACAAGTCTCACAAGAACGTC
AGCGTTTACTTTTAGGTGCTGGTGCGGCAGCTGGCTTGGCAGCCGGATTTAATGCGCCAATTGCTGGGGTATTTTTTGCC
TTAGAAGTAGTCATGGGGGCTACATCTTTTGCCACTTCCGCCGTGAGTGTAGTGCTGTTGGCGGCGGTCGTAGCAGCTTT
AATTGCACAAATTGGTTTAGGGGCGCAACCTGCCTTTGCTTTACCAGTTTACCAAGTCCGTAGCCCTTTGGAACTGCCTC
TTTATCTGGGGTTGGGGTTGGGTGCTAGTTTGGTTTCTGTAGCTTATAAACAATCTATTAATTGGGGAAAAGCTTGTTTT
GTCGGTTCGATTCCTGGGTTTCAATTTTTAGGTAAAATTCCTCAGCCAATTCACCCTATCATTGGGGGTTTCATGATCGG
CATAGTAGCTTTAAAGTTCCCGCAAATTTTGGGCATCGGTTATGGCACAGTACAAGCGATGCTGCAAGATGTCAAATTTT
CTCTGGATTTGTTATTGATATTATTGGTTTTAAAGTTGCTGATGACAGCCATTAGTGCGGGTAGTGGTTTTGTTGGCGGT
TTGTTTGCGCCGGCGATGTTTTTAGGTGCTTCATTGGGTTCAGCTTATGCTAAGGTTCTCACCCTTATAGCGCCAGGAAT
TGGCGAATATATGGCAGCACCTCCGGCTTACGCAATGGTGGGTATGGCTGCTGTTTTAGCTGGAAGTGTGAGAGCACCAT
TAACCTCAATTTTAATGTTATTTGAACTTACCCGTGATTACCGAATTGTTTTACCTTTAATGGCGGCTGTGGGCTTAAGT
GTATGGCTAGTAGAAAGGATTAAACCCAATACTAATTCTCATACTAATTTACAGCAAATTGGTCTTTCAATTCCGAAAGA
CCAAAAAGTAGAAATTTTGCAGCAAATTTTAGTAGAGGATGCTATGCTTGCTTGCCCAAAAAAGCTACCTGCAACTTTGG
GCATTTTAGAAGCTGCTAGGGAAATGATCAGCGATCGCACACGCAGCGCTCTAGTTATTGATGACGCAGAACAACTAGTT
GGGATTATCTCCCTAGAAGACCTCAACCGTACCCTTTCTCTATGGCAAAATTACCCGAATTCTGCAAGTGAAATCCAAAG
TAATTTAACCAATCAAAGCATCATCGATATCTGTACAAAAGAGATCCTCTATGCTTGGCGTGATGAACCTTTGTCTGAGG
CTTTAGACCGCATGGAGGTTAGAGGTTTACATCAGTTACCTGTGGTAGCACGAGATAACCATGACCATATTCTAGGGTTG
CTAGATAAGGAGCAAATCGCATTAACGTGTAACTTGGCAGTCACACGCCAGACACTTTACCGTTTGGTTAGTAGTCACCA
GTCATTGGTCAGTGAAAAAATCAACAACTGA

Upstream 100 bases:

>100_bases
CACTGAGCTGAGGAAGGTAACAGAACCATCTGCTTTTCCTACACCTTCCGCCCAAGTCACACATCTCATTAACCGATTTC
AACTTTCCCCAGAAACTATC

Downstream 100 bases:

>100_bases
CAACTGACAACTGACAACTAACTATTAATTATGCTGTAGCTTCTGCGATTTCCAGGATTTCTCTTTCTTCGCCATCTACT
TGTCTAAGACGGATGTGCTT

Product: voltage gated Cl- channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGLMRWRTQDFGPGLSSLIAASEG
SEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFGMLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFA
LEVVMGATSFATSAVSVVLLAAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
VGSIPGFQFLGKIPQPIHPIIGGFMIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLILLVLKLLMTAISAGSGFVGG
LFAPAMFLGASLGSAYAKVLTLIAPGIGEYMAAPPAYAMVGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLS
VWLVERIKPNTNSHTNLQQIGLSIPKDQKVEILQQILVEDAMLACPKKLPATLGILEAAREMISDRTRSALVIDDAEQLV
GIISLEDLNRTLSLWQNYPNSASEIQSNLTNQSIIDICTKEILYAWRDEPLSEALDRMEVRGLHQLPVVARDNHDHILGL
LDKEQIALTCNLAVTRQTLYRLVSSHQSLVSEKINN

Sequences:

>Translated_596_residues
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGLMRWRTQDFGPGLSSLIAASEG
SEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFGMLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFA
LEVVMGATSFATSAVSVVLLAAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
VGSIPGFQFLGKIPQPIHPIIGGFMIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLILLVLKLLMTAISAGSGFVGG
LFAPAMFLGASLGSAYAKVLTLIAPGIGEYMAAPPAYAMVGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLS
VWLVERIKPNTNSHTNLQQIGLSIPKDQKVEILQQILVEDAMLACPKKLPATLGILEAAREMISDRTRSALVIDDAEQLV
GIISLEDLNRTLSLWQNYPNSASEIQSNLTNQSIIDICTKEILYAWRDEPLSEALDRMEVRGLHQLPVVARDNHDHILGL
LDKEQIALTCNLAVTRQTLYRLVSSHQSLVSEKINN
>Mature_596_residues
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGLMRWRTQDFGPGLSSLIAASEG
SEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFGMLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFA
LEVVMGATSFATSAVSVVLLAAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
VGSIPGFQFLGKIPQPIHPIIGGFMIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLILLVLKLLMTAISAGSGFVGG
LFAPAMFLGASLGSAYAKVLTLIAPGIGEYMAAPPAYAMVGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLS
VWLVERIKPNTNSHTNLQQIGLSIPKDQKVEILQQILVEDAMLACPKKLPATLGILEAAREMISDRTRSALVIDDAEQLV
GIISLEDLNRTLSLWQNYPNSASEIQSNLTNQSIIDICTKEILYAWRDEPLSEALDRMEVRGLHQLPVVARDNHDHILGL
LDKEQIALTCNLAVTRQTLYRLVSSHQSLVSEKINN

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=473, Percent_Identity=24.9471458773784, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI55770840, Length=473, Percent_Identity=24.9471458773784, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1786350, Length=292, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081943, Length=329, Percent_Identity=30.3951367781155, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322500, Length=408, Percent_Identity=26.4705882352941, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24665008, Length=467, Percent_Identity=25.2676659528908, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 63219; Mature: 63219

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGLM
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWRTQDFGPGLSSLIAASEGSEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFG
HHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHH
MLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSVVLL
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
HHHHHHHHHHHCCCCCCCHHCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEE
VGSIPGFQFLGKIPQPIHPIIGGFMIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLI
EECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLVLKLLMTAISAGSGFVGGLFAPAMFLGASLGSAYAKVLTLIAPGIGEYMAAPPAYAMV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHH
GMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLSVWLVERIKPNTNSHTNLQQI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GLSIPKDQKVEILQQILVEDAMLACPKKLPATLGILEAAREMISDRTRSALVIDDAEQLV
CCCCCCCHHHHHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
GIISLEDLNRTLSLWQNYPNSASEIQSNLTNQSIIDICTKEILYAWRDEPLSEALDRMEV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RGLHQLPVVARDNHDHILGLLDKEQIALTCNLAVTRQTLYRLVSSHQSLVSEKINN
CCHHHCCCEEECCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGLM
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWRTQDFGPGLSSLIAASEGSEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFG
HHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHH
MLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSVVLL
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
HHHHHHHHHHHCCCCCCCHHCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEE
VGSIPGFQFLGKIPQPIHPIIGGFMIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLI
EECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLVLKLLMTAISAGSGFVGGLFAPAMFLGASLGSAYAKVLTLIAPGIGEYMAAPPAYAMV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHH
GMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLSVWLVERIKPNTNSHTNLQQI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GLSIPKDQKVEILQQILVEDAMLACPKKLPATLGILEAAREMISDRTRSALVIDDAEQLV
CCCCCCCHHHHHHHHHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
GIISLEDLNRTLSLWQNYPNSASEIQSNLTNQSIIDICTKEILYAWRDEPLSEALDRMEV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RGLHQLPVVARDNHDHILGLLDKEQIALTCNLAVTRQTLYRLVSSHQSLVSEKINN
CCHHHCCCEEECCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]