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The map label for this gene is napA [H]

Identifier: 75909238

GI number: 75909238

Start: 3751480

End: 3752841

Strand: Direct

Name: napA [H]

Synonym: Ava_3029

Alternate gene names: 75909238

Gene position: 3751480-3752841 (Clockwise)

Preceding gene: 75909237

Following gene: 75909240

Centisome position: 58.93

GC content: 49.41

Gene sequence:

>1362_bases
ATGGCTCCGATACCATTCCTGGCGACCGTTGTTGCTGAGGATTCACCCATTATTCTGTCTGGCGTATTGCTGACGCTGGT
GGTGATTTATCTGGCCAGCAAGTTCGGTGCAGAGGTCGCCAGACGCTTGGATTTTCCTCCCGTCCTGGGGGAACTAGTCG
CCGGTGTAATTGTCGGCGTTTCGGCATTGCACCTGGTGATATTTCCCGAAGGGGGGCTGTCTGCCTCTGACTCGGTGATT
ATGACTGCGTTGCAAGGATTGAATCAATTGGCACCAGATGCCCTCACCCGAATCTTTGAGTCGCAAAGTGAAGTGATTTC
AGTTCTAGCTGAAATCGGCGTGATTATTCTGCTGTTTGAAATCGGACTGGAATCCGATCTGCGGCAACTGAAGGAAGTGG
GAATTCAAGCCACGGTTGTCGCCTGTGTCGGAGTCGCGGCACCTTTTGCGGCAGGTACGGCAGGGTTAATGATACTCTTT
CATGTCGCAGCCATTCCAGCGATTTTTGCGGGGGCTGCGTTAACGGCAACGAGTATTGGCATTACCTCTAAAGTGTTGTC
AGAGTTAGGTCAACTCAAATCCAAAGAAGGACAAATCATTGTTGGCGCGGCGGTGATTGATGATGTTCTCGGCATTATTG
TCTTGGCTGTAGTCGCCAGTTTAGCCAAAACCGGTGAAATTGATGTTGCCAATGTCATTTATTTGATTGTCAGTGCTACG
GCATTCTTGATTGGATCAATTTTATTGGGGGGTGTCTTTAACAAAGGTTTTGTGGCGATCGTAGAGCAGCTCAAAACCCG
TGGAAATATCGTCATTCCGGCATTTATCTTCGCTTTCTTTATGGCATTTTTAGGGAACGCCATTCACCTCGAAGCGATTT
TGGGTGCCTTTGCTGCGGGTTTGGTACTCGATGAAACCGATCCCCGGAACGAGTTGGATGAATTAATCAAACCGATCGCC
GATTTACTGGTACCTGTCTTTTTTGTGACGGTGGGAGCGCGTGCCGACCTCGGTGTTTTAAACCCGGCGTTACCAGAGAA
TCGGGCGGGACTATTGATTGCAACGTTTTTGATCGCAGTGGCGATTATCGGCAAGCTGATCACAGGTTGGGCAGTGTTTG
GACAACCCGGCATCAATCGAGTGGCGATCGGGATTGGGATGATTCCACGAGGTGAGGTGGGTCTAGTGTTTGCCGGCATC
GGATCAGCTAGCGGCATTTTGGATAAGCCTCTGGAGGTGTCAATTATTATCATGGTAATTTTGACAACTTTTCTGGCCCC
ACCTTTTTTACGGGTTGCCTTTGGTTCATCCACGAATCCCATCCCAGAATCTACCACGCCTGTAGAAACAGTAAGTGAGT
AA

Upstream 100 bases:

>100_bases
CGCAGTTTTATAACTTCCTCAAACCCTTAACCTTCATTGCTTTAAACTCATGATTTTGTCCAACATTCTGCCTCCTTTCA
TTGGGGGGATGACCACTCTC

Downstream 100 bases:

>100_bases
CGGCTTTAGGGAGTTCCAAGCAATAAAATCCCCAATGTATAAGAATGATAATTATTATAGGGGAAGGGAAGTCAGGGCTG
CCGATGGCAGCCCTGACTTC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAPIPFLATVVAEDSPIILSGVLLTLVVIYLASKFGAEVARRLDFPPVLGELVAGVIVGVSALHLVIFPEGGLSASDSVI
MTALQGLNQLAPDALTRIFESQSEVISVLAEIGVIILLFEIGLESDLRQLKEVGIQATVVACVGVAAPFAAGTAGLMILF
HVAAIPAIFAGAALTATSIGITSKVLSELGQLKSKEGQIIVGAAVIDDVLGIIVLAVVASLAKTGEIDVANVIYLIVSAT
AFLIGSILLGGVFNKGFVAIVEQLKTRGNIVIPAFIFAFFMAFLGNAIHLEAILGAFAAGLVLDETDPRNELDELIKPIA
DLLVPVFFVTVGARADLGVLNPALPENRAGLLIATFLIAVAIIGKLITGWAVFGQPGINRVAIGIGMIPRGEVGLVFAGI
GSASGILDKPLEVSIIIMVILTTFLAPPFLRVAFGSSTNPIPESTTPVETVSE

Sequences:

>Translated_453_residues
MAPIPFLATVVAEDSPIILSGVLLTLVVIYLASKFGAEVARRLDFPPVLGELVAGVIVGVSALHLVIFPEGGLSASDSVI
MTALQGLNQLAPDALTRIFESQSEVISVLAEIGVIILLFEIGLESDLRQLKEVGIQATVVACVGVAAPFAAGTAGLMILF
HVAAIPAIFAGAALTATSIGITSKVLSELGQLKSKEGQIIVGAAVIDDVLGIIVLAVVASLAKTGEIDVANVIYLIVSAT
AFLIGSILLGGVFNKGFVAIVEQLKTRGNIVIPAFIFAFFMAFLGNAIHLEAILGAFAAGLVLDETDPRNELDELIKPIA
DLLVPVFFVTVGARADLGVLNPALPENRAGLLIATFLIAVAIIGKLITGWAVFGQPGINRVAIGIGMIPRGEVGLVFAGI
GSASGILDKPLEVSIIIMVILTTFLAPPFLRVAFGSSTNPIPESTTPVETVSE
>Mature_452_residues
APIPFLATVVAEDSPIILSGVLLTLVVIYLASKFGAEVARRLDFPPVLGELVAGVIVGVSALHLVIFPEGGLSASDSVIM
TALQGLNQLAPDALTRIFESQSEVISVLAEIGVIILLFEIGLESDLRQLKEVGIQATVVACVGVAAPFAAGTAGLMILFH
VAAIPAIFAGAALTATSIGITSKVLSELGQLKSKEGQIIVGAAVIDDVLGIIVLAVVASLAKTGEIDVANVIYLIVSATA
FLIGSILLGGVFNKGFVAIVEQLKTRGNIVIPAFIFAFFMAFLGNAIHLEAILGAFAAGLVLDETDPRNELDELIKPIAD
LLVPVFFVTVGARADLGVLNPALPENRAGLLIATFLIAVAIIGKLITGWAVFGQPGINRVAIGIGMIPRGEVGLVFAGIG
SASGILDKPLEVSIIIMVILTTFLAPPFLRVAFGSSTNPIPESTTPVETVSE

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=308, Percent_Identity=25.974025974026, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789749, Length=255, Percent_Identity=29.8039215686275, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=421, Percent_Identity=25.6532066508314, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46775; Mature: 46644

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPIPFLATVVAEDSPIILSGVLLTLVVIYLASKFGAEVARRLDFPPVLGELVAGVIVGV
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SALHLVIFPEGGLSASDSVIMTALQGLNQLAPDALTRIFESQSEVISVLAEIGVIILLFE
HHHEEEEECCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLESDLRQLKEVGIQATVVACVGVAAPFAAGTAGLMILFHVAAIPAIFAGAALTATSIG
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITSKVLSELGQLKSKEGQIIVGAAVIDDVLGIIVLAVVASLAKTGEIDVANVIYLIVSAT
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AFLIGSILLGGVFNKGFVAIVEQLKTRGNIVIPAFIFAFFMAFLGNAIHLEAILGAFAAG
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LVLDETDPRNELDELIKPIADLLVPVFFVTVGARADLGVLNPALPENRAGLLIATFLIAV
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
AIIGKLITGWAVFGQPGINRVAIGIGMIPRGEVGLVFAGIGSASGILDKPLEVSIIIMVI
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
LTTFLAPPFLRVAFGSSTNPIPESTTPVETVSE
HHHHHCCHHHHHHCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
APIPFLATVVAEDSPIILSGVLLTLVVIYLASKFGAEVARRLDFPPVLGELVAGVIVGV
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SALHLVIFPEGGLSASDSVIMTALQGLNQLAPDALTRIFESQSEVISVLAEIGVIILLFE
HHHEEEEECCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLESDLRQLKEVGIQATVVACVGVAAPFAAGTAGLMILFHVAAIPAIFAGAALTATSIG
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITSKVLSELGQLKSKEGQIIVGAAVIDDVLGIIVLAVVASLAKTGEIDVANVIYLIVSAT
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AFLIGSILLGGVFNKGFVAIVEQLKTRGNIVIPAFIFAFFMAFLGNAIHLEAILGAFAAG
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LVLDETDPRNELDELIKPIADLLVPVFFVTVGARADLGVLNPALPENRAGLLIATFLIAV
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
AIIGKLITGWAVFGQPGINRVAIGIGMIPRGEVGLVFAGIGSASGILDKPLEVSIIIMVI
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
LTTFLAPPFLRVAFGSSTNPIPESTTPVETVSE
HHHHHCCHHHHHHCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]