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The map label for this gene is pepA

Identifier: 75908939

GI number: 75908939

Start: 3365580

End: 3367055

Strand: Direct

Name: pepA

Synonym: Ava_2727

Alternate gene names: 75908939

Gene position: 3365580-3367055 (Clockwise)

Preceding gene: 75908938

Following gene: 75908940

Centisome position: 52.87

GC content: 45.05

Gene sequence:

>1476_bases
ATGGCAATTCAACTGAGTGATAAGCCTCTACTAGAATGGGCAGGCGATACTTTGGCGATCGCATTATTTGAAGATGCAGT
CGAGTTAACTGGTGAACTAGCGAGTTTAGATGAAAAGTTTGCTGGTATTTTAAAAGAACTAATTGCCGAAGAAGAATTTA
CAGGCAAAGCCAACAGCACGGTTTTTACTCGTGTGAGTGCTAATATCCCAGTCCGGAAAATAATTTTGGTGGGTTTAGGC
AAAACTGAAGCCTTCAACATAGATACCTTAAGACGTGCGGCGGCGGCTGTAGGTAAAGTAGGCAAAAAACAAAAAAGCAA
AGTTATCGGACTGAGTTTTCCCTTGTGGAATAATGACCCTACAGCCTCATCCCAAGCAATTGCTGAAGGTGTGCAGTTAG
CGCTCTATCAAGATAATCGTTTTAAATCAGACCCAGACGATAAAGGTTCCCAAGTCGAAACAGTAGAATTACTTGGTTTT
GCCGGACAAGAAGCAGCAATTAACCGAGCAAATCAAATCGTCTCTGGGGTAATCTTGGCTCGCCAATTGGTAGCAGCACC
AGCCAATAGCGTCACACCAATTACAATGGCAGAAACGGCTCAACAGATTGCCCAAGATTATGGTTTACAAATAGAAATTT
TAGAGCAGGAAGATTGTGAAAAACTAGGCATGGGTGCATTTTTAGGAGTTGCCCTCGCCTCAGATTTACCGCCTAAATTT
ATTCACTTAACCTACAAACCAGAAAGCACACCCAAGCGGAAACTAGCAATTGTTGGTAAAGGTTTAACCTTCGATTCTGG
TGGACTCAATATTAAAGGCGCTGGTAGTGGTATTGAAACCATGAAAATTGATATGGGAGGTGCAGCCGCTACCTTAGGTG
CAGCCAAAGCCATTGCCCAAATCAAGCCAAATGTAGAAGTTCACTTCATCTCAGCCGTAACCGAAAACATGATTAGCGGT
AAGGCTATGCACCCAGGAGACATCCTGACAGCATCCAATGGCAAAACCATCGAAGTGAACAACACCGATGCCGAAGGGCG
CTTAACTCTAGCAGATGCCCTAGTCTATACCGATAAATTGGGATTAGATGCGATCGTTGATTTAGCCACCCTCACCGGTG
CCAATGTCATTGCCTTAGGTGATGACATTGCTGGTTTGTATACTCCCGATGATGCCTTAGCCGGGCAACTAGAGCAAGCG
GCTAGCGAATCTGGTGAAAAGATTTGGCGGATGCCATTAGAAGAAAAATATTTTGAAGGACTAAAATCTGGCATTGCCGA
CATGAAAAACACCGGGCCTCGTCCTGGTGGTTCCATCACGGCTGCTTTGTTCCTCAAGCAGTTTGTCAAAGATACCCCGT
GGGCGCACTTAGACATTGCCGGGCCAGTTTGGGCAGACAAAGAAAACGGCTATAACGGCCCAGGTGCAACTGGTTATGGC
GTAAGGTTGTTGGTTGATTGGGTATTGAGTGAATAG

Upstream 100 bases:

>100_bases
CCTTATCCCCAGTCCCCAATCCCCAACCCCCCTATCCTGAAACAAAATTTTTGAGCAATACTGGTACAGGAAGGCATATA
TACATAGATAAGACCCCAAC

Downstream 100 bases:

>100_bases
GGGTTTAGGGGTTTAGGGGTTTAGGGGTTTAGGGGAAGGAATAAAGATAAATTTCTTTTCCCTCACACCCCTACACCCTC
ACACCCCTACACCCTTACAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAIQLSDKPLLEWAGDTLAIALFEDAVELTGELASLDEKFAGILKELIAEEEFTGKANSTVFTRVSANIPVRKIILVGLG
KTEAFNIDTLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDPTASSQAIAEGVQLALYQDNRFKSDPDDKGSQVETVELLGF
AGQEAAINRANQIVSGVILARQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
IHLTYKPESTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQIKPNVEVHFISAVTENMISG
KAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQA
ASESGEKIWRMPLEEKYFEGLKSGIADMKNTGPRPGGSITAALFLKQFVKDTPWAHLDIAGPVWADKENGYNGPGATGYG
VRLLVDWVLSE

Sequences:

>Translated_491_residues
MAIQLSDKPLLEWAGDTLAIALFEDAVELTGELASLDEKFAGILKELIAEEEFTGKANSTVFTRVSANIPVRKIILVGLG
KTEAFNIDTLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDPTASSQAIAEGVQLALYQDNRFKSDPDDKGSQVETVELLGF
AGQEAAINRANQIVSGVILARQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
IHLTYKPESTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQIKPNVEVHFISAVTENMISG
KAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQA
ASESGEKIWRMPLEEKYFEGLKSGIADMKNTGPRPGGSITAALFLKQFVKDTPWAHLDIAGPVWADKENGYNGPGATGYG
VRLLVDWVLSE
>Mature_490_residues
AIQLSDKPLLEWAGDTLAIALFEDAVELTGELASLDEKFAGILKELIAEEEFTGKANSTVFTRVSANIPVRKIILVGLGK
TEAFNIDTLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDPTASSQAIAEGVQLALYQDNRFKSDPDDKGSQVETVELLGFA
GQEAAINRANQIVSGVILARQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKFI
HLTYKPESTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQIKPNVEVHFISAVTENMISGK
AMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKLGLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQAA
SESGEKIWRMPLEEKYFEGLKSGIADMKNTGPRPGGSITAALFLKQFVKDTPWAHLDIAGPVWADKENGYNGPGATGYGV
RLLVDWVLSE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=481, Percent_Identity=37.4220374220374, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI47155554, Length=385, Percent_Identity=35.3246753246753, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1790710, Length=468, Percent_Identity=34.1880341880342, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082123, Length=315, Percent_Identity=37.7777777777778, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=306, Percent_Identity=37.9084967320261, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=308, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24661038, Length=313, Percent_Identity=33.2268370607029, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21355725, Length=282, Percent_Identity=34.0425531914894, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI221379063, Length=328, Percent_Identity=34.4512195121951, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI221379062, Length=328, Percent_Identity=34.4512195121951, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21357381, Length=328, Percent_Identity=34.4512195121951, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI20129969, Length=444, Percent_Identity=30.6306306306306, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24662227, Length=450, Percent_Identity=28.2222222222222, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21355645, Length=472, Percent_Identity=29.0254237288136, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24662223, Length=472, Percent_Identity=29.0254237288136, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20129963, Length=448, Percent_Identity=30.3571428571429, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI161077148, Length=450, Percent_Identity=28.2222222222222, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI20130057, Length=450, Percent_Identity=28.2222222222222, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19922386, Length=443, Percent_Identity=29.3453724604966, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646701, Length=151, Percent_Identity=33.112582781457, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=151, Percent_Identity=33.112582781457, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=151, Percent_Identity=33.112582781457, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_ANAVT (Q3M9J6)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323235.1
- HSSP:   P00727
- ProteinModelPortal:   Q3M9J6
- SMR:   Q3M9J6
- STRING:   Q3M9J6
- MEROPS:   M17.002
- GeneID:   3682088
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2727
- NMPDR:   fig|240292.3.peg.1131
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHNSG
- PhylomeDB:   Q3M9J6
- ProtClustDB:   PRK00913
- BioCyc:   AVAR240292:AVA_2727-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51903; Mature: 51772

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 272-272 ACT_SITE 347-347

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQLSDKPLLEWAGDTLAIALFEDAVELTGELASLDEKFAGILKELIAEEEFTGKANST
CEEECCCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCE
VFTRVSANIPVRKIILVGLGKTEAFNIDTLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDP
EEEEEECCCCEEEEEEEECCCCCEECHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCCCC
TASSQAIAEGVQLALYQDNRFKSDPDDKGSQVETVELLGFAGQEAAINRANQIVSGVILA
CCHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
RQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHCCHHHHHHHHHCCCCCCE
IHLTYKPESTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQ
EEEEECCCCCCCCEEEEEECCEEECCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHH
IKPNVEVHFISAVTENMISGKAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKL
CCCCCEEEEHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHCC
GLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQAASESGEKIWRMPLEEKYFEG
CHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
LKSGIADMKNTGPRPGGSITAALFLKQFVKDTPWAHLDIAGPVWADKENGYNGPGATGYG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCH
VRLLVDWVLSE
HHHHHHHHHCC
>Mature Secondary Structure 
AIQLSDKPLLEWAGDTLAIALFEDAVELTGELASLDEKFAGILKELIAEEEFTGKANST
EEECCCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCE
VFTRVSANIPVRKIILVGLGKTEAFNIDTLRRAAAAVGKVGKKQKSKVIGLSFPLWNNDP
EEEEEECCCCEEEEEEEECCCCCEECHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCCCC
TASSQAIAEGVQLALYQDNRFKSDPDDKGSQVETVELLGFAGQEAAINRANQIVSGVILA
CCHHHHHHCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
RQLVAAPANSVTPITMAETAQQIAQDYGLQIEILEQEDCEKLGMGAFLGVALASDLPPKF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHCCHHHHHHHHHCCCCCCE
IHLTYKPESTPKRKLAIVGKGLTFDSGGLNIKGAGSGIETMKIDMGGAAATLGAAKAIAQ
EEEEECCCCCCCCEEEEEECCEEECCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHH
IKPNVEVHFISAVTENMISGKAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYTDKL
CCCCCEEEEHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHCC
GLDAIVDLATLTGANVIALGDDIAGLYTPDDALAGQLEQAASESGEKIWRMPLEEKYFEG
CHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
LKSGIADMKNTGPRPGGSITAALFLKQFVKDTPWAHLDIAGPVWADKENGYNGPGATGYG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCH
VRLLVDWVLSE
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA