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The map label for this gene is ubiB [C]

Identifier: 75908893

GI number: 75908893

Start: 3315898

End: 3317541

Strand: Direct

Name: ubiB [C]

Synonym: Ava_2681

Alternate gene names: 75908893

Gene position: 3315898-3317541 (Clockwise)

Preceding gene: 75908892

Following gene: 75908894

Centisome position: 52.09

GC content: 43.25

Gene sequence:

>1644_bases
ATGTTCCTCACCCAAACTGTCCCCCGTCAACGAGAAATTATTGAAGTTGTCCTCCGCAATGGCTGGGATTATATGCGGCG
GTTACTTACAGGTGGCAAGGCTGATGAACCCCAATTACCGACACCTGCGGTTTTAAAAAATATTTTGGTGGACTTAGGGC
CGGTTTATGTAAAACTCGGTCAATTGATGTCTACTCGTCCGGATTTACTGAATGCGGCTTACATTGAGGAACTTTCTACC
CTACAGGACGAAGTACCCCCTGTTCCCTGGACAGAAATTGAAATTCTCATCCGCAAACAACTAAAACGACCTCTGGAAGA
AACTTTTAGTAAGATTAATCCCGTACCTGTAGCGGCAGGATCAATTGCCCAGACTCATCGCGCTACATTAATAGATGGTA
GGGAAGTGGCGCTGAAGGTGCAACGACCGGGGATCGATCTGACTATTGCCCAAGATATTGCTTTAATTCAAGGGATTGCT
GATTTGGTGGCGCGTACCGATTTTGGGCAGAACTACGAAATTAAATCAATTGCGGAAGAATTTACCAAAGCTTTAGAGGC
GGAGTTGGATTTTACACGGGAAGCAGGACATACAGATTTACTGCGCCGTAATTTATCTCGTAGTCGCTGGTTTGACCCCA
CACAGCTAGTCGTAGCTGAGATTTATTGGTCTTTAACTACAGAAAAATTGTTGGTGATGGAATGGCTAGACGGTGTACCA
ATACTGTCAGCAAGTTTGAACAATAATAACGGTAAAGACCCAGTAGCCGAACGTAAAGCAGTTACGACGCTGTTATTTCG
GGCTTTCTTTCAGCAATTATATGTTGATGGCTTTTTCCATGCTGATCCTCATCCGGGAAATATCTTTTATCTCAGCGATG
GGCGTGTTGCACTGTTAGATTGTGGCATGGTGGGTAGACTTGATCCCCGGACTCAGCAGATTTTAACAGAAATGCTGTTG
GCGATCGTGGATTTAGATGCAGGGCGATGCGCTCAATTAACATTGCAATTGGCAGATTCCGCCCAACCAGTTATTCTGTC
CCGGTTGGAAAGTGATTATGACCGGATGTTGCGGAAATACTATAACGTTAGTTTGACTGAGATGAATTTTAGTCAAATTT
TTTATGAAATTTTGCAAATTGCGAGAAATAATAAAATTCGTTTACCCAGCAATATGGGTTTGTATGCCAAAACTATAGCG
AATTTGGAAGGGGTAGCACAGACCTTTAATCCAGAGGTAAATTTATTTGATGAAATTCAACCATTAATTACAGATTTGTT
TCGGCGGCAGTTATTGGGGGATAATCCAGTGCGATCGCTCCTGAGAACAGCCTTAGATTTAAAAAGTCTCTCTTTACAAT
CGCCCCGACAGGTGGAACTATTATTAGACCGAGTAACATCGGAAACCTTGCGGTGGAACCTTTCCCTACATGGTTTGGAT
GGGGTACGGCGCACAATGGATGATGCAGCCAATCGCTTATCCTTCAGTATATTAGTAGGTTCACTGATTATGGGAGCAGC
AGTTATATCTACGAAAGCCCAGACAAGTGAATTGTCATTTTTAAGTAGCGTTTTGTTTGCGGTAGCAAGTTTGTTGGGAT
TGTGGCTAATTGTGAGTATATTGCGATCGGGTCGTCTCAAATAA

Upstream 100 bases:

>100_bases
GGTGTAGGGGGCAGAGAGAGAAGAAGAAATGATACTGAAATATTCTCCCCCTCCCTGCTCCCTACCCTAATTCCCATTCC
CTATTCCCAACTCCCCAACA

Downstream 100 bases:

>100_bases
TTTTTTTTAACGCAGAGGGGTGCGGAGGTTAACGCTGAGGGGCGCAGAATGTAGCGAAATAATTTCATTTAGGGTGAAAA
ACATTTAGTATTATTGTTTG

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLGQLMSTRPDLLNAAYIEELST
LQDEVPPVPWTEIEILIRKQLKRPLEETFSKINPVPVAAGSIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIA
DLVARTDFGQNYEIKSIAEEFTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLLVMEWLDGVP
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLDCGMVGRLDPRTQQILTEMLL
AIVDLDAGRCAQLTLQLADSAQPVILSRLESDYDRMLRKYYNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIA
NLEGVAQTFNPEVNLFDEIQPLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQVELLLDRVTSETLRWNLSLHGLD
GVRRTMDDAANRLSFSILVGSLIMGAAVISTKAQTSELSFLSSVLFAVASLLGLWLIVSILRSGRLK

Sequences:

>Translated_547_residues
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLGQLMSTRPDLLNAAYIEELST
LQDEVPPVPWTEIEILIRKQLKRPLEETFSKINPVPVAAGSIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIA
DLVARTDFGQNYEIKSIAEEFTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLLVMEWLDGVP
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLDCGMVGRLDPRTQQILTEMLL
AIVDLDAGRCAQLTLQLADSAQPVILSRLESDYDRMLRKYYNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIA
NLEGVAQTFNPEVNLFDEIQPLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQVELLLDRVTSETLRWNLSLHGLD
GVRRTMDDAANRLSFSILVGSLIMGAAVISTKAQTSELSFLSSVLFAVASLLGLWLIVSILRSGRLK
>Mature_547_residues
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLGQLMSTRPDLLNAAYIEELST
LQDEVPPVPWTEIEILIRKQLKRPLEETFSKINPVPVAAGSIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIA
DLVARTDFGQNYEIKSIAEEFTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLLVMEWLDGVP
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLDCGMVGRLDPRTQQILTEMLL
AIVDLDAGRCAQLTLQLADSAQPVILSRLESDYDRMLRKYYNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIA
NLEGVAQTFNPEVNLFDEIQPLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQVELLLDRVTSETLRWNLSLHGLD
GVRRTMDDAANRLSFSILVGSLIMGAAVISTKAQTSELSFLSSVLFAVASLLGLWLIVSILRSGRLK

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=271, Percent_Identity=30.2583025830258, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI217035081, Length=239, Percent_Identity=30.9623430962343, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI41393593, Length=277, Percent_Identity=28.158844765343, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI27363457, Length=281, Percent_Identity=25.9786476868327, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI217416386, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI34147522, Length=272, Percent_Identity=24.6323529411765, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI2367309, Length=400, Percent_Identity=29.75, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17559152, Length=291, Percent_Identity=26.1168384879725, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323282, Length=303, Percent_Identity=24.7524752475248, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=20.0923787528868, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321319, Length=267, Percent_Identity=26.2172284644195, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24662575, Length=279, Percent_Identity=31.1827956989247, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI22024280, Length=321, Percent_Identity=26.791277258567, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18859849, Length=284, Percent_Identity=26.7605633802817, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61481; Mature: 61481

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLG
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QLMSTRPDLLNAAYIEELSTLQDEVPPVPWTEIEILIRKQLKRPLEETFSKINPVPVAAG
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIADLVARTDFGQNYEIKSIAEE
CHHHHHHHHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLLVMEWLDGVP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLD
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEE
CGMVGRLDPRTQQILTEMLLAIVDLDAGRCAQLTLQLADSAQPVILSRLESDYDRMLRKY
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIANLEGVAQTFNPEVNLFDEIQ
HCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQVELLLDRVTSETLRWNLSLHGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEECCH
GVRRTMDDAANRLSFSILVGSLIMGAAVISTKAQTSELSFLSSVLFAVASLLGLWLIVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSGRLK
HHHCCCC
>Mature Secondary Structure
MFLTQTVPRQREIIEVVLRNGWDYMRRLLTGGKADEPQLPTPAVLKNILVDLGPVYVKLG
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QLMSTRPDLLNAAYIEELSTLQDEVPPVPWTEIEILIRKQLKRPLEETFSKINPVPVAAG
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SIAQTHRATLIDGREVALKVQRPGIDLTIAQDIALIQGIADLVARTDFGQNYEIKSIAEE
CHHHHHHHHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
FTKALEAELDFTREAGHTDLLRRNLSRSRWFDPTQLVVAEIYWSLTTEKLLVMEWLDGVP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILSASLNNNNGKDPVAERKAVTTLLFRAFFQQLYVDGFFHADPHPGNIFYLSDGRVALLD
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEE
CGMVGRLDPRTQQILTEMLLAIVDLDAGRCAQLTLQLADSAQPVILSRLESDYDRMLRKY
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YNVSLTEMNFSQIFYEILQIARNNKIRLPSNMGLYAKTIANLEGVAQTFNPEVNLFDEIQ
HCCEEEECCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
PLITDLFRRQLLGDNPVRSLLRTALDLKSLSLQSPRQVELLLDRVTSETLRWNLSLHGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEECCH
GVRRTMDDAANRLSFSILVGSLIMGAAVISTKAQTSELSFLSSVLFAVASLLGLWLIVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSGRLK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]