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The map label for this gene is trxA

Identifier: 75908866

GI number: 75908866

Start: 3283615

End: 3283938

Strand: Direct

Name: trxA

Synonym: Ava_2654

Alternate gene names: 75908866

Gene position: 3283615-3283938 (Clockwise)

Preceding gene: 75908865

Following gene: 75908867

Centisome position: 51.58

GC content: 44.75

Gene sequence:

>324_bases
ATGTCAGCAGCCGCACAAGTTACAGATTCTACTTTTAAGCAAGAAGTACTCGACAGCGATGTACCAGTTTTGGTTGATTT
TTGGGCCCCTTGGTGTGGTCCTTGCAGAATGGTCGCTCCTGTTGTCGATGAAATAGCTCAACAGTACGAAGGTAAAATAA
AAGTGGTGAAAGTCAACACTGATGAGAATCCGCAAGTTGCAAGTCAGTACGGCATCCGCAGCATCCCCACACTTATGATT
TTTAAAGGTGGGCAGAAAGTCGATATGGTAGTCGGTGCGGTGCCTAAAACAACATTATCTCAAACCCTAGAAAAGCATCT
GTGA

Upstream 100 bases:

>100_bases
GCTTCTTTGCAAATGTACATCCTTGTGTTTTGGGCAGTTGTTTTTGCTATGGTAGAATTTTCACGAAAGTCAGAAATATA
ATTGGCAAAGGTTTTTAGGC

Downstream 100 bases:

>100_bases
AACTCAATCAATAGTAAGCTCTTGTTGAGTAATCTATTGCCATTAAGTTTAGGTAATATTTGTCCAATACTTTATGAGGT
GCAAATTCTAGCACCTCATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSAAAQVTDSTFKQEVLDSDVPVLVDFWAPWCGPCRMVAPVVDEIAQQYEGKIKVVKVNTDENPQVASQYGIRSIPTLMI
FKGGQKVDMVVGAVPKTTLSQTLEKHL

Sequences:

>Translated_107_residues
MSAAAQVTDSTFKQEVLDSDVPVLVDFWAPWCGPCRMVAPVVDEIAQQYEGKIKVVKVNTDENPQVASQYGIRSIPTLMI
FKGGQKVDMVVGAVPKTTLSQTLEKHL
>Mature_106_residues
SAAAQVTDSTFKQEVLDSDVPVLVDFWAPWCGPCRMVAPVVDEIAQQYEGKIKVVKVNTDENPQVASQYGIRSIPTLMIF
KGGQKVDMVVGAVPKTTLSQTLEKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI5031973, Length=104, Percent_Identity=37.5, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=35.1063829787234, Blast_Score=76, Evalue=5e-15,
Organism=Homo sapiens, GI50592994, Length=102, Percent_Identity=38.2352941176471, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI21361657, Length=98, Percent_Identity=32.6530612244898, Blast_Score=66, Evalue=5e-12,
Organism=Homo sapiens, GI24308127, Length=78, Percent_Identity=35.8974358974359, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=50.9803921568627, Blast_Score=124, Evalue=1e-30,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=53.763440860215, Blast_Score=119, Evalue=3e-29,
Organism=Escherichia coli, GI87081747, Length=96, Percent_Identity=34.375, Blast_Score=71, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=36.5591397849462, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=34.8314606741573, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=41.6666666666667, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=39.5348837209302, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=40.5405405405405, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=40.5405405405405, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=38.8888888888889, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=74, Percent_Identity=40.5405405405405, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=82, Percent_Identity=34.1463414634146, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=82, Percent_Identity=34.1463414634146, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=35.8974358974359, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=82, Percent_Identity=41.4634146341463, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=41.8604651162791, Blast_Score=79, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=41.3793103448276, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=94, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=80, Percent_Identity=30, Blast_Score=63, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24639826, Length=98, Percent_Identity=41.8367346938776, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=35.7142857142857, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664269, Length=82, Percent_Identity=41.4634146341463, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=41.8918918918919, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=41.8918918918919, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=38.2716049382716, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647799, Length=84, Percent_Identity=41.6666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17530795, Length=93, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=37.037037037037, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=26.8817204301075, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24664525, Length=73, Percent_Identity=35.6164383561644, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO1_ANASO (P0A4L2)

Other databases:

- EMBL:   M14736
- ProteinModelPortal:   P0A4L2
- SMR:   P0A4L2
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11721; Mature: 11589

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAAQVTDSTFKQEVLDSDVPVLVDFWAPWCGPCRMVAPVVDEIAQQYEGKIKVVKVNT
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DENPQVASQYGIRSIPTLMIFKGGQKVDMVVGAVPKTTLSQTLEKHL
CCCCHHHHHCCCCCCCEEEEECCCCEEEHEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SAAAQVTDSTFKQEVLDSDVPVLVDFWAPWCGPCRMVAPVVDEIAQQYEGKIKVVKVNT
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
DENPQVASQYGIRSIPTLMIFKGGQKVDMVVGAVPKTTLSQTLEKHL
CCCCHHHHHCCCCCCCEEEEECCCCEEEHEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769