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The map label for this gene is menA [H]

Identifier: 75908846

GI number: 75908846

Start: 3258945

End: 3259850

Strand: Direct

Name: menA [H]

Synonym: Ava_2633

Alternate gene names: 75908846

Gene position: 3258945-3259850 (Clockwise)

Preceding gene: 75908844

Following gene: 75908847

Centisome position: 51.2

GC content: 41.61

Gene sequence:

>906_bases
ATGACTACAAAGCAAATTTCTCATACTAAAATTAAGCTATGGATGGCGGCGATCAAACCGCCGATGTATAGTGTTGCCAT
CATGCCTATTTGGGTAGGAAGCGCAGTTGCATTTGCTGAAAATAAAGTTTTTAATTTAGCAGTATTTTCTACTTTTATTT
TTGCAGCAATTTTAATTCTGGCTTGGGAAAATATCAGTAATGATGTATTCGATTCAGAAACAGGAATTGATGTAAATAAA
CATCATTCTTTAGTAAATTTAACTGGCAAGAAGGCTTTGGTGTTTTGGTTAGGAAACTTGTGTTTAGTTTCTGGACTATC
GGGGATATTAGCGATCGCCACTTGGCAACAAGACCCCACAGTTATCGGTATCATCTTGTTATGCTGTGGTTTGGGCTATA
TGTACCAAGGCCCTCCCTTTCGTTTAGGATACCAAGGTTTAGGGGAAATTCTGTGCTTTTTTGCCTTCGGGCCTTTAGGA
GTGTCAGCAGGATACTATAGCCAAACCCAAACTTGGTCAATCACAAGTTTAGCCGCCTCCGTCATTGTCGGGATTGTCAC
CAGCTTAATTTTATTTTGCTCCCACTTCCACCAAGTTGATGATGACATTAAAGCAGGTAAGCGATCGCCCATTGTTCGTT
TAGGTACAGCCAACGGTGCAAAAGTTCTCACTTGGTTTACAGCCAGCATTTACCCCTTTAGCTTGCTGTTTGTAATTTTG
GGATTCTTCCCTGTGTGGACGCTGTTAAGCTGGCTAAGTCTACCTTACGCCTTCAAATTATGTCGCCACGTCCAGCAAAA
CCACAACCAACCAGAAAAAGTCAGCAATTGTAAATTCATTGCCGTAGCGGTGCATTTCTGGAGTTGCTTACTGTTGGGTT
TGGGGTTTGTCATTGCAGGCGTTTAA

Upstream 100 bases:

>100_bases
AGAGATACTTCCAAAAAAGATAGTAGCTTTATTTAACCTGTACTCTACTAGCTAGAGGTATTGTTTGTAATTTTCAATTT
TGAATTGTTTACCACAACTG

Downstream 100 bases:

>100_bases
CGTGAGTTCGACGGAACCTAACCCCAACCCCTTCCCTTGTAGGATACTGTTGGCGAATTATTGAGGGGTTAAGCCCCTCA
AGAGTTTGGAACAGTGGAAA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTTKQISHTKIKLWMAAIKPPMYSVAIMPIWVGSAVAFAENKVFNLAVFSTFIFAAILILAWENISNDVFDSETGIDVNK
HHSLVNLTGKKALVFWLGNLCLVSGLSGILAIATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILCFFAFGPLG
VSAGYYSQTQTWSITSLAASVIVGIVTSLILFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYPFSLLFVIL
GFFPVWTLLSWLSLPYAFKLCRHVQQNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAGV

Sequences:

>Translated_301_residues
MTTKQISHTKIKLWMAAIKPPMYSVAIMPIWVGSAVAFAENKVFNLAVFSTFIFAAILILAWENISNDVFDSETGIDVNK
HHSLVNLTGKKALVFWLGNLCLVSGLSGILAIATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILCFFAFGPLG
VSAGYYSQTQTWSITSLAASVIVGIVTSLILFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYPFSLLFVIL
GFFPVWTLLSWLSLPYAFKLCRHVQQNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAGV
>Mature_300_residues
TTKQISHTKIKLWMAAIKPPMYSVAIMPIWVGSAVAFAENKVFNLAVFSTFIFAAILILAWENISNDVFDSETGIDVNKH
HSLVNLTGKKALVFWLGNLCLVSGLSGILAIATWQQDPTVIGIILLCCGLGYMYQGPPFRLGYQGLGEILCFFAFGPLGV
SAGYYSQTQTWSITSLAASVIVGIVTSLILFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYPFSLLFVILG
FFPVWTLLSWLSLPYAFKLCRHVQQNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAGV

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=288, Percent_Identity=26.0416666666667, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17737429, Length=289, Percent_Identity=25.6055363321799, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33062; Mature: 32931

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKQISHTKIKLWMAAIKPPMYSVAIMPIWVGSAVAFAENKVFNLAVFSTFIFAAILIL
CCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHH
AWENISNDVFDSETGIDVNKHHSLVNLTGKKALVFWLGNLCLVSGLSGILAIATWQQDPT
HHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCH
VIGIILLCCGLGYMYQGPPFRLGYQGLGEILCFFAFGPLGVSAGYYSQTQTWSITSLAAS
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
VIVGIVTSLILFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYPFSLLFVIL
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHH
GFFPVWTLLSWLSLPYAFKLCRHVQQNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHC
V
C
>Mature Secondary Structure 
TTKQISHTKIKLWMAAIKPPMYSVAIMPIWVGSAVAFAENKVFNLAVFSTFIFAAILIL
CCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHH
AWENISNDVFDSETGIDVNKHHSLVNLTGKKALVFWLGNLCLVSGLSGILAIATWQQDPT
HHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCH
VIGIILLCCGLGYMYQGPPFRLGYQGLGEILCFFAFGPLGVSAGYYSQTQTWSITSLAAS
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
VIVGIVTSLILFCSHFHQVDDDIKAGKRSPIVRLGTANGAKVLTWFTASIYPFSLLFVIL
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHH
GFFPVWTLLSWLSLPYAFKLCRHVQQNHNQPEKVSNCKFIAVAVHFWSCLLLGLGFVIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]