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The map label for this gene is ubiE [H]

Identifier: 75908819

GI number: 75908819

Start: 3226387

End: 3227007

Strand: Direct

Name: ubiE [H]

Synonym: Ava_2605

Alternate gene names: 75908819

Gene position: 3226387-3227007 (Clockwise)

Preceding gene: 75908817

Following gene: 75908823

Centisome position: 50.68

GC content: 39.45

Gene sequence:

>621_bases
ATGGGTTTTTATTCGCAAGTCATTTTACCGCGTCTTTTAGACTGGAGCTTGTCTGATCCCACCCTAGCTACATATCGTCA
GGAACTACTAACAGACGTAACAGGAGAAGTACTAGAAATCGGTTTTGGCACTGGATTAAACTTGGCTTACTATCCTTCAC
ATATTCACGAAATCACCACGGTTGACGTGAATCCTGGGATGAATACCCTCGCACAAAAGCGTATTGATGACTCTGGGATT
AAAGTTCAACAACTCCTGCTATCAGGCGAAAATCTTCCTATGGCAGATAATACTTTTGATAGTGTGGTCAGCACTTGGAC
TTTATGCAGTATTGCCAATGTAGAACAAGCCCTACAGGAAGTTTATCGGGTACTAAAACCAGGTGGTAAGTTCTTTTTTC
TAGAACATGGACTGAGTAATAAGCCTAATGTACAAGTCTGGCAGAATCGCCTAACCCCAATTCAGAAAATCTTGGCAGAT
GGGTGTCATCTAAATCGAAATATTCAAAAATTAGTAGAAAAAAGTTTTAACCATGTAGAGCTAAAACGCTTTACACCTGA
GAATTTTCCTGATTTGATGGCACATTTTTACAAAGGATGTGCGACTAAAAAAGCAATATAA

Upstream 100 bases:

>100_bases
TAATTCCCATCTGTTTAAAATAAGACAACAGAGACCACACCCCAATCAATAACTTTGTTAGCCCAACAGCAAAGAATCGA
ATTATGGAGGGATGAAAATT

Downstream 100 bases:

>100_bases
ATTCATGATCAAGGAAATCAATTTTATGAGTTGATTTCCTTGATCTAATTTAAGTCTTAAATATCTCATCTACAGGAATT
TGGTAGCCATTAGCGAGGCG

Product: UbiE/COQ5 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MGFYSQVILPRLLDWSLSDPTLATYRQELLTDVTGEVLEIGFGTGLNLAYYPSHIHEITTVDVNPGMNTLAQKRIDDSGI
KVQQLLLSGENLPMADNTFDSVVSTWTLCSIANVEQALQEVYRVLKPGGKFFFLEHGLSNKPNVQVWQNRLTPIQKILAD
GCHLNRNIQKLVEKSFNHVELKRFTPENFPDLMAHFYKGCATKKAI

Sequences:

>Translated_206_residues
MGFYSQVILPRLLDWSLSDPTLATYRQELLTDVTGEVLEIGFGTGLNLAYYPSHIHEITTVDVNPGMNTLAQKRIDDSGI
KVQQLLLSGENLPMADNTFDSVVSTWTLCSIANVEQALQEVYRVLKPGGKFFFLEHGLSNKPNVQVWQNRLTPIQKILAD
GCHLNRNIQKLVEKSFNHVELKRFTPENFPDLMAHFYKGCATKKAI
>Mature_205_residues
GFYSQVILPRLLDWSLSDPTLATYRQELLTDVTGEVLEIGFGTGLNLAYYPSHIHEITTVDVNPGMNTLAQKRIDDSGIK
VQQLLLSGENLPMADNTFDSVVSTWTLCSIANVEQALQEVYRVLKPGGKFFFLEHGLSNKPNVQVWQNRLTPIQKILADG
CHLNRNIQKLVEKSFNHVELKRFTPENFPDLMAHFYKGCATKKAI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI89145417, Length=196, Percent_Identity=34.1836734693878, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI164663805, Length=164, Percent_Identity=34.7560975609756, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI48994983, Length=104, Percent_Identity=31.7307692307692, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 23251; Mature: 23120

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFYSQVILPRLLDWSLSDPTLATYRQELLTDVTGEVLEIGFGTGLNLAYYPSHIHEITT
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHEEEE
VDVNPGMNTLAQKRIDDSGIKVQQLLLSGENLPMADNTFDSVVSTWTLCSIANVEQALQE
EECCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VYRVLKPGGKFFFLEHGLSNKPNVQVWQNRLTPIQKILADGCHLNRNIQKLVEKSFNHVE
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEE
LKRFTPENFPDLMAHFYKGCATKKAI
EECCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GFYSQVILPRLLDWSLSDPTLATYRQELLTDVTGEVLEIGFGTGLNLAYYPSHIHEITT
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHEEEE
VDVNPGMNTLAQKRIDDSGIKVQQLLLSGENLPMADNTFDSVVSTWTLCSIANVEQALQE
EECCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VYRVLKPGGKFFFLEHGLSNKPNVQVWQNRLTPIQKILADGCHLNRNIQKLVEKSFNHVE
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEE
LKRFTPENFPDLMAHFYKGCATKKAI
EECCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]