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The map label for this gene is folE [H]

Identifier: 75908751

GI number: 75908751

Start: 3137698

End: 3138405

Strand: Direct

Name: folE [H]

Synonym: Ava_2537

Alternate gene names: 75908751

Gene position: 3137698-3138405 (Clockwise)

Preceding gene: 75908750

Following gene: 75908753

Centisome position: 49.29

GC content: 45.62

Gene sequence:

>708_bases
ATGACTATTGCTAGTTCCAACGGTTCCAATCGCGCTCAATCGCCCCTAATTCCCGACTTGGCAGAAGCTATTAATACCAG
ACCTGACCGCAATACCCATAACGGCCGAGAACCAGAATTGCACCAACCTTCAGAACAAGACATGGATTCAATGATGGATG
CAGTCAGGTCAATATTAGTGGGTGTTGGAGAAGACCCAGAAAGAGAAGGTCTATTAAAAACACCAAAGCGCGTGGCAGAA
GCGATGCGGTTCCTGACCAGTGGCTACAACCAATCTTTAGAAGAATTACTCAACGGTGCTGTCTTTGATGAAGGTCATAA
CGAGATGGTACTAGTGCGAGATATCAACTTCTTTAGCTTATGCGAACACCATATGTTACCCTTCATGGGTAGAGCGCACG
TTGCTTATATCCCCAACCAGAAGGTAGTAGGACTAAGTAAGCTAGCCCGGATTGTTGAGATGTATTCCCGGCGCTTGCAA
GTACAAGAAAGGCTAACCCGCCAAATAGCTGAAGCTGTGCAGACCATTTTAGAACCCCAAGGTGTAGCGGTTGTGATGGA
AGCCAGCCATATGTGCATGGTGATGCGTGGTGTACAAAAACCAGGCTCTTGGACTGTAACTAGCGCCATGTTAGGCGTAT
TCCAAGAAGAACAAAAAACTAGAGAAGAATTCTTTAACTTGATTCGTCATCAACCATCATTCTTTTAG

Upstream 100 bases:

>100_bases
AGCTAACTCCTACGTAGTTTGTAGGATTATTTTGAATTCTGAATTTTGAATTCCCCTTATGGGGTTAACCATTGAATAAA
CCATAACCAAGACTGAAATT

Downstream 100 bases:

>100_bases
GGAATGGGGAGTGGGGAATGGGGAATATCCCTTCTTCCACTCCCTAATTCCTACTCCCCAATTTTTCAAAAAGTAGTGCA
ACTTTATCTAAATCTTTGTC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I 1; GTP-CH-I 1 [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTIASSNGSNRAQSPLIPDLAEAINTRPDRNTHNGREPELHQPSEQDMDSMMDAVRSILVGVGEDPEREGLLKTPKRVAE
AMRFLTSGYNQSLEELLNGAVFDEGHNEMVLVRDINFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQ
VQERLTRQIAEAVQTILEPQGVAVVMEASHMCMVMRGVQKPGSWTVTSAMLGVFQEEQKTREEFFNLIRHQPSFF

Sequences:

>Translated_235_residues
MTIASSNGSNRAQSPLIPDLAEAINTRPDRNTHNGREPELHQPSEQDMDSMMDAVRSILVGVGEDPEREGLLKTPKRVAE
AMRFLTSGYNQSLEELLNGAVFDEGHNEMVLVRDINFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQ
VQERLTRQIAEAVQTILEPQGVAVVMEASHMCMVMRGVQKPGSWTVTSAMLGVFQEEQKTREEFFNLIRHQPSFF
>Mature_234_residues
TIASSNGSNRAQSPLIPDLAEAINTRPDRNTHNGREPELHQPSEQDMDSMMDAVRSILVGVGEDPEREGLLKTPKRVAEA
MRFLTSGYNQSLEELLNGAVFDEGHNEMVLVRDINFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQV
QERLTRQIAEAVQTILEPQGVAVVMEASHMCMVMRGVQKPGSWTVTSAMLGVFQEEQKTREEFFNLIRHQPSFF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=212, Percent_Identity=57.0754716981132, Blast_Score=257, Evalue=8e-69,
Organism=Homo sapiens, GI4503949, Length=212, Percent_Identity=57.0754716981132, Blast_Score=257, Evalue=8e-69,
Organism=Homo sapiens, GI66932970, Length=181, Percent_Identity=50.2762430939227, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI66932972, Length=172, Percent_Identity=52.3255813953488, Blast_Score=195, Evalue=2e-50,
Organism=Escherichia coli, GI1788476, Length=175, Percent_Identity=40.5714285714286, Blast_Score=121, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560486, Length=216, Percent_Identity=58.7962962962963, Blast_Score=263, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6321706, Length=176, Percent_Identity=62.5, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24656782, Length=190, Percent_Identity=60.5263157894737, Blast_Score=237, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24656791, Length=190, Percent_Identity=60.5263157894737, Blast_Score=237, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24656796, Length=190, Percent_Identity=60.5263157894737, Blast_Score=237, Evalue=6e-63,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26580; Mature: 26449

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIASSNGSNRAQSPLIPDLAEAINTRPDRNTHNGREPELHQPSEQDMDSMMDAVRSILV
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GVGEDPEREGLLKTPKRVAEAMRFLTSGYNQSLEELLNGAVFDEGHNEMVLVRDINFFSL
CCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHH
CEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQVQERLTRQIAEAVQTILEPQ
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVAVVMEASHMCMVMRGVQKPGSWTVTSAMLGVFQEEQKTREEFFNLIRHQPSFF
CCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TIASSNGSNRAQSPLIPDLAEAINTRPDRNTHNGREPELHQPSEQDMDSMMDAVRSILV
CCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GVGEDPEREGLLKTPKRVAEAMRFLTSGYNQSLEELLNGAVFDEGHNEMVLVRDINFFSL
CCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHH
CEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQVQERLTRQIAEAVQTILEPQ
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVAVVMEASHMCMVMRGVQKPGSWTVTSAMLGVFQEEQKTREEFFNLIRHQPSFF
CCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]