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The map label for this gene is apxIIID [H]

Identifier: 75908615

GI number: 75908615

Start: 2982297

End: 2983700

Strand: Direct

Name: apxIIID [H]

Synonym: Ava_2399

Alternate gene names: 75908615

Gene position: 2982297-2983700 (Clockwise)

Preceding gene: 75908614

Following gene: 75908616

Centisome position: 46.85

GC content: 43.66

Gene sequence:

>1404_bases
ATGCTGTATATTCAAAATAAGAAACTTATCCCGCCTCTGCAAGATGATGATGCTTTACCACCAGTTGGTATTTGGACATC
TTTGCTGGGGTTATTTCTTATAGTGTCTGTTGGTTCAGCGATCGCCTTATCCTCATGGATTAAATATAATGTTGTCATCA
AGGCTGGGGCTACTGTTCGTCCTATAGGCGAAACTCGCTTGGTACAGCCGGAAATTGAGGGGACGATTCAGAATCTCTTC
GTAACGGAAAATCAAGTTGTCAAGCGGGGTGATGCGATCGCTACTCTCAATACTGAGCAGTTACAAATCAAGCAAAGTCA
ACTACAAGGTAATATCCAACAAATTAAATTACAGCTTGTGCAAGTTGATGCTCAAATCAGCACTTTCAATAGTCAGATAC
TCGCGGAAACCAAGGTAATCGAGCGTACTGTGGCTTCTGCTCAAGCAGATTTGGCTCGTAATCAACGAGAATATCAAGAA
CGTCAAATCACTACACAAAGTGAATATATCGCCTCTGAAGCTAGTTTGCAAAAAGCTATCGCAGATTTACGTAAATCTCA
AGCTGATTTGAATTTTGCTAACGCAGATCGCGATCGCTATCAGCAATTAGCTGATATTGGTGCGATTGGTAGACGGGAAT
ATGAACAGAAAAAACTCGTGGTAGAACAAGCTAAATCCGCCTTGGAAGCGGGAAAGCGCTCTGTGGAAATCGCTCAAGCC
AAAATGCAATCAGCAAGGGCTGGGGTTAATCCCAGCATGGCAACGGTGGCGATCGCGCAAGAACGTATTGCTCAAGAAAT
TGCTAGGGGTGAAGCTACTATCGCTACGTTACAGAAAGAACAGCAAGCTTTAGTTCAGCGACGTTTAGAAATGCTGTCCC
AACTCAACCAATCCCAAAAAGAATTACAACAAGTAGAAAAGCAACTGCAAAGCAGCGTAATTCGCGCTACCAGTGACGGT
ATTATCCTGAAGTTAAATCTGCGGAACCCTGGTCAAGTAGTACGTACTAGTGAGGCGATCGCAGAAATAGCACCACAAAA
TGCGCCGCTAGTAATTAAAGCAATGATTCCCACCGCAGACATTAAAAAGGTGGAAGTGGGGAAGAAAGTTCAATTGCGTG
TTAATGCTTGTCCTTACCCAGATTATGGTGTTCTCCATGCTGTGGTGAGTGCTGTTTCTCCAGATGCGATCGCACCTCAA
AATAACAATCCAGGGGGAGCATTATCGGCTGCTGCAACTCCTTATTTTGAAGCTACTATCCAACCAGAAAAAATCTCATT
TGGGAATGGCGATCGTCAGTGTCATATCCAGTCAGGTATGCAGGCAGAGGCTCATATTATTTCTCAGGAGGAGACAGCAC
TACGATTCATCCTCAGAAAAGCAAGACTTATCACTGATTTATAG

Upstream 100 bases:

>100_bases
GGACTAGAGGGGATGAGAAAGAGTGCAATTTGAGTAACTTAGTTTTCTCTGTTCCCTATCAATTTTTTCTATTTAAATAC
TGATAATTATTTGGTGAAGT

Downstream 100 bases:

>100_bases
GTTAATCCAGATATAAGTTCCTCATTTTAGTAACTATACGTCCTTGAGTTCAGGGGCTAGAGACTAGGGGTTATACCCAA
CTTAAAACTTAAGAACCCCG

Product: secretion protein HlyD

Products: NA

Alternate protein names: APX-IIID; Cytolysin IIID; CLY-IIID; Toxin RTX-III secretion protein D [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MLYIQNKKLIPPLQDDDALPPVGIWTSLLGLFLIVSVGSAIALSSWIKYNVVIKAGATVRPIGETRLVQPEIEGTIQNLF
VTENQVVKRGDAIATLNTEQLQIKQSQLQGNIQQIKLQLVQVDAQISTFNSQILAETKVIERTVASAQADLARNQREYQE
RQITTQSEYIASEASLQKAIADLRKSQADLNFANADRDRYQQLADIGAIGRREYEQKKLVVEQAKSALEAGKRSVEIAQA
KMQSARAGVNPSMATVAIAQERIAQEIARGEATIATLQKEQQALVQRRLEMLSQLNQSQKELQQVEKQLQSSVIRATSDG
IILKLNLRNPGQVVRTSEAIAEIAPQNAPLVIKAMIPTADIKKVEVGKKVQLRVNACPYPDYGVLHAVVSAVSPDAIAPQ
NNNPGGALSAAATPYFEATIQPEKISFGNGDRQCHIQSGMQAEAHIISQEETALRFILRKARLITDL

Sequences:

>Translated_467_residues
MLYIQNKKLIPPLQDDDALPPVGIWTSLLGLFLIVSVGSAIALSSWIKYNVVIKAGATVRPIGETRLVQPEIEGTIQNLF
VTENQVVKRGDAIATLNTEQLQIKQSQLQGNIQQIKLQLVQVDAQISTFNSQILAETKVIERTVASAQADLARNQREYQE
RQITTQSEYIASEASLQKAIADLRKSQADLNFANADRDRYQQLADIGAIGRREYEQKKLVVEQAKSALEAGKRSVEIAQA
KMQSARAGVNPSMATVAIAQERIAQEIARGEATIATLQKEQQALVQRRLEMLSQLNQSQKELQQVEKQLQSSVIRATSDG
IILKLNLRNPGQVVRTSEAIAEIAPQNAPLVIKAMIPTADIKKVEVGKKVQLRVNACPYPDYGVLHAVVSAVSPDAIAPQ
NNNPGGALSAAATPYFEATIQPEKISFGNGDRQCHIQSGMQAEAHIISQEETALRFILRKARLITDL
>Mature_467_residues
MLYIQNKKLIPPLQDDDALPPVGIWTSLLGLFLIVSVGSAIALSSWIKYNVVIKAGATVRPIGETRLVQPEIEGTIQNLF
VTENQVVKRGDAIATLNTEQLQIKQSQLQGNIQQIKLQLVQVDAQISTFNSQILAETKVIERTVASAQADLARNQREYQE
RQITTQSEYIASEASLQKAIADLRKSQADLNFANADRDRYQQLADIGAIGRREYEQKKLVVEQAKSALEAGKRSVEIAQA
KMQSARAGVNPSMATVAIAQERIAQEIARGEATIATLQKEQQALVQRRLEMLSQLNQSQKELQQVEKQLQSSVIRATSDG
IILKLNLRNPGQVVRTSEAIAEIAPQNAPLVIKAMIPTADIKKVEVGKKVQLRVNACPYPDYGVLHAVVSAVSPDAIAPQ
NNNPGGALSAAATPYFEATIQPEKISFGNGDRQCHIQSGMQAEAHIISQEETALRFILRKARLITDL

Specific function: Involved in the transport of the toxin RTX-III [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 51229; Mature: 51229

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYIQNKKLIPPLQDDDALPPVGIWTSLLGLFLIVSVGSAIALSSWIKYNVVIKAGATVR
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHEEEEEEECCCEEC
PIGETRLVQPEIEGTIQNLFVTENQVVKRGDAIATLNTEQLQIKQSQLQGNIQQIKLQLV
CCCCCEEECHHHHHHHHHHEECCHHHHHCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHH
QVDAQISTFNSQILAETKVIERTVASAQADLARNQREYQERQITTQSEYIASEASLQKAI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ADLRKSQADLNFANADRDRYQQLADIGAIGRREYEQKKLVVEQAKSALEAGKRSVEIAQA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
KMQSARAGVNPSMATVAIAQERIAQEIARGEATIATLQKEQQALVQRRLEMLSQLNQSQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELQQVEKQLQSSVIRATSDGIILKLNLRNPGQVVRTSEAIAEIAPQNAPLVIKAMIPTAD
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
IKKVEVGKKVQLRVNACPYPDYGVLHAVVSAVSPDAIAPQNNNPGGALSAAATPYFEATI
CCEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
QPEKISFGNGDRQCHIQSGMQAEAHIISQEETALRFILRKARLITDL
CCCEECCCCCCCEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYIQNKKLIPPLQDDDALPPVGIWTSLLGLFLIVSVGSAIALSSWIKYNVVIKAGATVR
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHEEEEEEECCCEEC
PIGETRLVQPEIEGTIQNLFVTENQVVKRGDAIATLNTEQLQIKQSQLQGNIQQIKLQLV
CCCCCEEECHHHHHHHHHHEECCHHHHHCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHH
QVDAQISTFNSQILAETKVIERTVASAQADLARNQREYQERQITTQSEYIASEASLQKAI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ADLRKSQADLNFANADRDRYQQLADIGAIGRREYEQKKLVVEQAKSALEAGKRSVEIAQA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
KMQSARAGVNPSMATVAIAQERIAQEIARGEATIATLQKEQQALVQRRLEMLSQLNQSQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELQQVEKQLQSSVIRATSDGIILKLNLRNPGQVVRTSEAIAEIAPQNAPLVIKAMIPTAD
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
IKKVEVGKKVQLRVNACPYPDYGVLHAVVSAVSPDAIAPQNNNPGGALSAAATPYFEATI
CCEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
QPEKISFGNGDRQCHIQSGMQAEAHIISQEETALRFILRKARLITDL
CCCEECCCCCCCEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8494611; 7927703 [H]