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The map label for this gene is mrdA [H]

Identifier: 75908521

GI number: 75908521

Start: 2863716

End: 2865548

Strand: Direct

Name: mrdA [H]

Synonym: Ava_2304

Alternate gene names: 75908521

Gene position: 2863716-2865548 (Clockwise)

Preceding gene: 75908511

Following gene: 75908524

Centisome position: 44.99

GC content: 45.23

Gene sequence:

>1833_bases
ATGGCTTTATTGCAACCATCTCCACTACTGGGTAAAAAAGATAAACGAACTGTTGGCAGGGGTTTTCAGTCTACGTTTTT
GATTATATTTACCCTGCTAATGACGACGGGAATTAGTGCGCGGTTAGTATACTTACAAATTATTGAAGGCTCCCAATTTA
AGCGCAAGGCCGAGTCAAACCGGGTTCGGGTCATCCCTAAACAACCAGAAAGGGGTAATATTTTTGACCGCAATGGCAAA
CTTTTAGCCAGTACACGTTATCCTCGTTCTATTTATCTGTGGCCGATGGCTCACACTAAAGCCTCTTGGTCGGTGGTGGG
GCCACGTCTGGCAAAAATTTTGGAGATTCCCCAAGAGGAAATCGAAAAGAAATTAGAAGAGGCTGGTGCTAACTCTTCTT
CACTCATTCGCATTGCTCGTAATTTGGATGAAGCCCAAATCACCGCTATCAAGGAATATGAAAGTGAACTTAAAGATGTA
GAAATACACACGGAAGCTGTGCGCTACTATCCCCACGGAAGAGAATTGGCTCATGTTTTAGGTTATACGCGAGAGTTGAC
AGCTGAACAGTTAAAAGCTAGGAAGCAAGAAGGCTATCGCCTTGGTGATGTGATTGGTCAAATGGGCGTGGAAAAAGCCT
ATGAGAAATCACTGCGGGGTGAATGGGGTGGTCAACAAGTAGAAGTTGATGGGGCTGGTAGACCGTTGCGGGTTTTAGGC
GAGAAACAAGCTAAAGCTGGTAATGATATACGTTTAACCATAGATTTAGATATGCAGAAAGCAGCAGAGAAAGCATTAGG
CGATCGCAACGGGACAATCATCGCCCTAGACCCGAAAAACGGTGCTGTCCTAGCAATGGTATCTCACCCCACTTTTGACC
CCAACATTTTCTCCAAGCAAAGGCTGACTCAAAAAGACTGGGAATCTGTCCAAGGTGAAGACCATCCTCTGGTCAATCGT
GCTTTGAGTGCTTTTCCACCTGCTAGTACTTTTAAAGTTGTCACGATGACGGCTGGTTTAGAATCAGGTAAATTTTCTCC
CAGCACAATATTACAGACATACGGTTCTCTAACTATCGGTGGAACCCGATTTGGGGAATGGAATCACGCCGGGTTTGGGC
CTTTAGGTTTCGTTGGTGCTATGCAGTGGAGTAGTGATACTTTCTTCTATCAAATTGGTAGAGGAATTGGCGGCCCCACC
TTGATTGAATGGACGCGTAAATATGGGTTTGGTCAGAGAACAGGCTTTGAGTTTGTTTCCGAAGAAGCTAAAGGTGCTGT
ACCAGATGAGACATGGAAACAAAAAGTCTGGAAAATGCCTTGGACTGTTGGCGACACAATTAATATGTCCATTGGTCAAG
GCGCGTTATTAACTACTCCCTTACAAGTTGCGGTTATGTTTGCTGTACCAGCAAATGGTGGCTACCGTGTCCAACCGCAT
TTGCTCAAAGATAATGAAGAAGCTAGAAGCTGGCGAGAGCTTGTACAGATGAAACCGACCACTTTGAAACTTTTGCGCGA
GAGTTTACGTAAGGTAATTTCTGATGGTACCGGGAAAGTTTTACATCAGCCGACAATTCCCCCAGTCGCCGGTAAAAGTG
GGACTGCTGAAGCTTGGAAGGGAAGAGTCAAACAAAATCATGCTTGGTTTGGGGCTTACGCTCCTGCTGATAAGCCGGAA
ATTTTGATTGTCGCCTTTGCCGAACATTCTGGCGGCGGCGGTGGTAGCGTTGCTGCACCAATGATACTTAAAGTGATGGA
AGACTATTTTCAACGCAAATATCCTGGCAAATATCAAAAGCCAGCCACTACAGAAGCAGCAAAAACCAGATAA

Upstream 100 bases:

>100_bases
AGCTAGATTTATTAGGTGCTATCACCCTAAATAGGGTAATAAAAATATAGGACAATTAACTGCATACAAATATTATTATC
TAAGCAATTCTCTAATTATT

Downstream 100 bases:

>100_bases
TACTAATTCCCAATAAAGAAGCTTAGGGGTAAGACCGTTTACCTTACCCCTAAACTTCCTTTTAATTACAAATTACAAAT
TATGAATTAGCCTTAACGTT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MALLQPSPLLGKKDKRTVGRGFQSTFLIIFTLLMTTGISARLVYLQIIEGSQFKRKAESNRVRVIPKQPERGNIFDRNGK
LLASTRYPRSIYLWPMAHTKASWSVVGPRLAKILEIPQEEIEKKLEEAGANSSSLIRIARNLDEAQITAIKEYESELKDV
EIHTEAVRYYPHGRELAHVLGYTRELTAEQLKARKQEGYRLGDVIGQMGVEKAYEKSLRGEWGGQQVEVDGAGRPLRVLG
EKQAKAGNDIRLTIDLDMQKAAEKALGDRNGTIIALDPKNGAVLAMVSHPTFDPNIFSKQRLTQKDWESVQGEDHPLVNR
ALSAFPPASTFKVVTMTAGLESGKFSPSTILQTYGSLTIGGTRFGEWNHAGFGPLGFVGAMQWSSDTFFYQIGRGIGGPT
LIEWTRKYGFGQRTGFEFVSEEAKGAVPDETWKQKVWKMPWTVGDTINMSIGQGALLTTPLQVAVMFAVPANGGYRVQPH
LLKDNEEARSWRELVQMKPTTLKLLRESLRKVISDGTGKVLHQPTIPPVAGKSGTAEAWKGRVKQNHAWFGAYAPADKPE
ILIVAFAEHSGGGGGSVAAPMILKVMEDYFQRKYPGKYQKPATTEAAKTR

Sequences:

>Translated_610_residues
MALLQPSPLLGKKDKRTVGRGFQSTFLIIFTLLMTTGISARLVYLQIIEGSQFKRKAESNRVRVIPKQPERGNIFDRNGK
LLASTRYPRSIYLWPMAHTKASWSVVGPRLAKILEIPQEEIEKKLEEAGANSSSLIRIARNLDEAQITAIKEYESELKDV
EIHTEAVRYYPHGRELAHVLGYTRELTAEQLKARKQEGYRLGDVIGQMGVEKAYEKSLRGEWGGQQVEVDGAGRPLRVLG
EKQAKAGNDIRLTIDLDMQKAAEKALGDRNGTIIALDPKNGAVLAMVSHPTFDPNIFSKQRLTQKDWESVQGEDHPLVNR
ALSAFPPASTFKVVTMTAGLESGKFSPSTILQTYGSLTIGGTRFGEWNHAGFGPLGFVGAMQWSSDTFFYQIGRGIGGPT
LIEWTRKYGFGQRTGFEFVSEEAKGAVPDETWKQKVWKMPWTVGDTINMSIGQGALLTTPLQVAVMFAVPANGGYRVQPH
LLKDNEEARSWRELVQMKPTTLKLLRESLRKVISDGTGKVLHQPTIPPVAGKSGTAEAWKGRVKQNHAWFGAYAPADKPE
ILIVAFAEHSGGGGGSVAAPMILKVMEDYFQRKYPGKYQKPATTEAAKTR
>Mature_609_residues
ALLQPSPLLGKKDKRTVGRGFQSTFLIIFTLLMTTGISARLVYLQIIEGSQFKRKAESNRVRVIPKQPERGNIFDRNGKL
LASTRYPRSIYLWPMAHTKASWSVVGPRLAKILEIPQEEIEKKLEEAGANSSSLIRIARNLDEAQITAIKEYESELKDVE
IHTEAVRYYPHGRELAHVLGYTRELTAEQLKARKQEGYRLGDVIGQMGVEKAYEKSLRGEWGGQQVEVDGAGRPLRVLGE
KQAKAGNDIRLTIDLDMQKAAEKALGDRNGTIIALDPKNGAVLAMVSHPTFDPNIFSKQRLTQKDWESVQGEDHPLVNRA
LSAFPPASTFKVVTMTAGLESGKFSPSTILQTYGSLTIGGTRFGEWNHAGFGPLGFVGAMQWSSDTFFYQIGRGIGGPTL
IEWTRKYGFGQRTGFEFVSEEAKGAVPDETWKQKVWKMPWTVGDTINMSIGQGALLTTPLQVAVMFAVPANGGYRVQPHL
LKDNEEARSWRELVQMKPTTLKLLRESLRKVISDGTGKVLHQPTIPPVAGKSGTAEAWKGRVKQNHAWFGAYAPADKPEI
LIVAFAEHSGGGGGSVAAPMILKVMEDYFQRKYPGKYQKPATTEAAKTR

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=587, Percent_Identity=30.664395229983, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786272, Length=579, Percent_Identity=25.73402417962, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67536; Mature: 67405

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLQPSPLLGKKDKRTVGRGFQSTFLIIFTLLMTTGISARLVYLQIIEGSQFKRKAESN
CCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHCCC
RVRVIPKQPERGNIFDRNGKLLASTRYPRSIYLWPMAHTKASWSVVGPRLAKILEIPQEE
CEEEECCCCCCCCEECCCCCEEEECCCCCEEEEEEECCCCCCCHHCCHHHHHHHHCCHHH
IEKKLEEAGANSSSLIRIARNLDEAQITAIKEYESELKDVEIHTEAVRYYPHGRELAHVL
HHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEHHHHHCCCCHHHHHHHH
GYTRELTAEQLKARKQEGYRLGDVIGQMGVEKAYEKSLRGEWGGQQVEVDGAGRPLRVLG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHC
EKQAKAGNDIRLTIDLDMQKAAEKALGDRNGTIIALDPKNGAVLAMVSHPTFDPNIFSKQ
CHHHCCCCEEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCHH
RLTQKDWESVQGEDHPLVNRALSAFPPASTFKVVTMTAGLESGKFSPSTILQTYGSLTIG
HCCHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEEEC
GTRFGEWNHAGFGPLGFVGAMQWSSDTFFYQIGRGIGGPTLIEWTRKYGFGQRTGFEFVS
CCCCCCCCCCCCCCHHHHEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHH
EEAKGAVPDETWKQKVWKMPWTVGDTINMSIGQGALLTTPLQVAVMFAVPANGGYRVQPH
HHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCEEECCEEEEEEEEEECCCCEEECCE
LLKDNEEARSWRELVQMKPTTLKLLRESLRKVISDGTGKVLHQPTIPPVAGKSGTAEAWK
EECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHH
GRVKQNHAWFGAYAPADKPEILIVAFAEHSGGGGGSVAAPMILKVMEDYFQRKYPGKYQK
CCHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PATTEAAKTR
CCCCHHHCCC
>Mature Secondary Structure 
ALLQPSPLLGKKDKRTVGRGFQSTFLIIFTLLMTTGISARLVYLQIIEGSQFKRKAESN
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHCCC
RVRVIPKQPERGNIFDRNGKLLASTRYPRSIYLWPMAHTKASWSVVGPRLAKILEIPQEE
CEEEECCCCCCCCEECCCCCEEEECCCCCEEEEEEECCCCCCCHHCCHHHHHHHHCCHHH
IEKKLEEAGANSSSLIRIARNLDEAQITAIKEYESELKDVEIHTEAVRYYPHGRELAHVL
HHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEHHHHHCCCCHHHHHHHH
GYTRELTAEQLKARKQEGYRLGDVIGQMGVEKAYEKSLRGEWGGQQVEVDGAGRPLRVLG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHC
EKQAKAGNDIRLTIDLDMQKAAEKALGDRNGTIIALDPKNGAVLAMVSHPTFDPNIFSKQ
CHHHCCCCEEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCHH
RLTQKDWESVQGEDHPLVNRALSAFPPASTFKVVTMTAGLESGKFSPSTILQTYGSLTIG
HCCHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEEEC
GTRFGEWNHAGFGPLGFVGAMQWSSDTFFYQIGRGIGGPTLIEWTRKYGFGQRTGFEFVS
CCCCCCCCCCCCCCHHHHEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHH
EEAKGAVPDETWKQKVWKMPWTVGDTINMSIGQGALLTTPLQVAVMFAVPANGGYRVQPH
HHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCEEECCEEEEEEEEEECCCCEEECCE
LLKDNEEARSWRELVQMKPTTLKLLRESLRKVISDGTGKVLHQPTIPPVAGKSGTAEAWK
EECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHH
GRVKQNHAWFGAYAPADKPEILIVAFAEHSGGGGGSVAAPMILKVMEDYFQRKYPGKYQK
CCHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PATTEAAKTR
CCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]