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The map label for this gene is aroA

Identifier: 75908476

GI number: 75908476

Start: 2815323

End: 2816603

Strand: Direct

Name: aroA

Synonym: Ava_2259

Alternate gene names: 75908476

Gene position: 2815323-2816603 (Clockwise)

Preceding gene: 75908475

Following gene: 75908477

Centisome position: 44.23

GC content: 45.43

Gene sequence:

>1281_bases
GTGGATACCATCGCCATCCCCGCTCTGAATCGTCCTGTGGATGCCACAGTAGAGATTCCGGGTTCCAAAAGTATCACTAA
TCGGGCGTTGCTTGTTGCTGCTTTAGCACAAGGCGACTCTACTTTAGAAAATGCCTTATTTAGTGAAGATAGTGAATATT
TTGCTAAATGTGTAGAGCAGTTGGGTATTCCCATCACACTCAATCCTCATCTGGCGCAAATCCAAGTTTCAGGTAAGGGA
GGCGACATTCCTGCAAAACAAGCAGATTTGTTCGTGGGTTTAGCTGGTACAGCAGCAAGATTTATCACGGCATTAGTAGC
ACTTGGTAATGGCGAATATCGCTTAGATGGAGTTCCCCGGATGCGAGAACGTCCAATGGGTGACTTGGTAACGGTGCTAC
AAAACAGTGGCATAAAGATTAACTTTGAGGGCAACTCTGGTTTTATGCCCTACACTATTTATGGTCAGCAATTTGCAGGT
GGACATTTTCGCCTCAAAGCTAACCAAACCAGTCAGCAACTCTCCGCTTTGTTGATGATTGCACCCTACGCCCAACAAGA
TACAACCATTGAGGTTGAGGGTACATTGGTTTCCCAATCTTATGTAAAAATGACTTGTCGCCTGATGGCTGATTTTGGTG
TAGATGTCACCCAAACCGACGACAATCAATTTCATATCAAAGCAGGTCAGCGTTACCAAGCTCGACACTATACTATAGAA
CCAGATGCCTCAAATGCGTCTTATTTTTTCGCAGCCGCAGCCGTCACTGGTGGAAGAGTGCGGGTAAACCATTTAACTAA
ACAATCTTGCCAAGGTGATATTTTGTGGCTGAATGTTTTAGAACAGATGGGTTGTCAGGTGCTTGAGGGTGAAGATTACA
CCGAAGTGATAGGGCCAGAACAATTACAGGGTATCGACGTTGATATGAATGATATGTCGGATTTGGTGCAAACATTGGGA
GCGATCGCCCCTTATGCCAACTCACCTGTTATCATCCGTAATGTAGAACATATCCGCTACAAAGAAACCGAACGTATCCG
CGCCGTTGTCACCGAATTACGTCGCTTAGGCGTGAAAGTTGAAGAATTTGCCGACGGGATGAAAATTGAACCAACCCCCA
TCAACCCAGCCGCCATCGAAACCTACCACGACCATAGAATGGCAATGGCTTTTGCAGTTACAGGCTTAAAGACCCCCGGT
ATTGTGATTCAAGACCCAGGTTGTACAGCCAAAACATTCCCCGACTACTTTACTCGATTCTTTAAAATGATTGGGCAATA
G

Upstream 100 bases:

>100_bases
GGTGTATCAAAAAAACACCAAAAAATATGACTGTTCCAGCAACCTTCATCATATGGGAACATATATAAGTTGTAGCTGAC
TACCCAGATAGAGGTTGAAA

Downstream 100 bases:

>100_bases
TCAGTTGTCAATTGATTTAACAAAAATAGACGCATGGCAAAAAACGACAAAATTAACTTCTCAACTCCTAGCGGTTTTCC
TGAATTTCTGCCTAGCGAAA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MDTIAIPALNRPVDATVEIPGSKSITNRALLVAALAQGDSTLENALFSEDSEYFAKCVEQLGIPITLNPHLAQIQVSGKG
GDIPAKQADLFVGLAGTAARFITALVALGNGEYRLDGVPRMRERPMGDLVTVLQNSGIKINFEGNSGFMPYTIYGQQFAG
GHFRLKANQTSQQLSALLMIAPYAQQDTTIEVEGTLVSQSYVKMTCRLMADFGVDVTQTDDNQFHIKAGQRYQARHYTIE
PDASNASYFFAAAAVTGGRVRVNHLTKQSCQGDILWLNVLEQMGCQVLEGEDYTEVIGPEQLQGIDVDMNDMSDLVQTLG
AIAPYANSPVIIRNVEHIRYKETERIRAVVTELRRLGVKVEEFADGMKIEPTPINPAAIETYHDHRMAMAFAVTGLKTPG
IVIQDPGCTAKTFPDYFTRFFKMIGQ

Sequences:

>Translated_426_residues
MDTIAIPALNRPVDATVEIPGSKSITNRALLVAALAQGDSTLENALFSEDSEYFAKCVEQLGIPITLNPHLAQIQVSGKG
GDIPAKQADLFVGLAGTAARFITALVALGNGEYRLDGVPRMRERPMGDLVTVLQNSGIKINFEGNSGFMPYTIYGQQFAG
GHFRLKANQTSQQLSALLMIAPYAQQDTTIEVEGTLVSQSYVKMTCRLMADFGVDVTQTDDNQFHIKAGQRYQARHYTIE
PDASNASYFFAAAAVTGGRVRVNHLTKQSCQGDILWLNVLEQMGCQVLEGEDYTEVIGPEQLQGIDVDMNDMSDLVQTLG
AIAPYANSPVIIRNVEHIRYKETERIRAVVTELRRLGVKVEEFADGMKIEPTPINPAAIETYHDHRMAMAFAVTGLKTPG
IVIQDPGCTAKTFPDYFTRFFKMIGQ
>Mature_426_residues
MDTIAIPALNRPVDATVEIPGSKSITNRALLVAALAQGDSTLENALFSEDSEYFAKCVEQLGIPITLNPHLAQIQVSGKG
GDIPAKQADLFVGLAGTAARFITALVALGNGEYRLDGVPRMRERPMGDLVTVLQNSGIKINFEGNSGFMPYTIYGQQFAG
GHFRLKANQTSQQLSALLMIAPYAQQDTTIEVEGTLVSQSYVKMTCRLMADFGVDVTQTDDNQFHIKAGQRYQARHYTIE
PDASNASYFFAAAAVTGGRVRVNHLTKQSCQGDILWLNVLEQMGCQVLEGEDYTEVIGPEQLQGIDVDMNDMSDLVQTLG
AIAPYANSPVIIRNVEHIRYKETERIRAVVTELRRLGVKVEEFADGMKIEPTPINPAAIETYHDHRMAMAFAVTGLKTPG
IVIQDPGCTAKTFPDYFTRFFKMIGQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=426, Percent_Identity=42.7230046948357, Blast_Score=318, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6320332, Length=470, Percent_Identity=34.468085106383, Blast_Score=231, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_ANAVT (Q3MAV9)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322772.1
- HSSP:   P0A6D3
- STRING:   Q3MAV9
- GeneID:   3679004
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2259
- NMPDR:   fig|240292.3.peg.2526
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   GADIEWG
- PhylomeDB:   Q3MAV9
- ProtClustDB:   PRK02427
- BioCyc:   AVAR240292:AVA_2259-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46691; Mature: 46691

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIAIPALNRPVDATVEIPGSKSITNRALLVAALAQGDSTLENALFSEDSEYFAKCVEQ
CCCEECCCCCCCCCCEEECCCCCCCCHHHEEEEEHHCCCHHHHHHHHCCCHHHHHHHHHH
LGIPITLNPHLAQIQVSGKGGDIPAKQADLFVGLAGTAARFITALVALGNGEYRLDGVPR
CCCCEEECCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEECCCCC
MRERPMGDLVTVLQNSGIKINFEGNSGFMPYTIYGQQFAGGHFRLKANQTSQQLSALLMI
HHHCCHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHEEEEE
APYAQQDTTIEVEGTLVSQSYVKMTCRLMADFGVDVTQTDDNQFHIKAGQRYQARHYTIE
ECCCCCCCEEEEEEEEECHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCEEECEEEEEC
PDASNASYFFAAAAVTGGRVRVNHLTKQSCQGDILWLNVLEQMGCQVLEGEDYTEVIGPE
CCCCCCCEEEEEEEECCCEEEEEEHHHHCCCCCCHHHHHHHHCCCEEECCCCCHHHCCCH
QLQGIDVDMNDMSDLVQTLGAIAPYANSPVIIRNVEHIRYKETERIRAVVTELRRLGVKV
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCH
EEFADGMKIEPTPINPAAIETYHDHRMAMAFAVTGLKTPGIVIQDPGCTAKTFPDYFTRF
HHHHCCCEECCCCCCCHHEEEHHHHHEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHH
FKMIGQ
HHHHCC
>Mature Secondary Structure
MDTIAIPALNRPVDATVEIPGSKSITNRALLVAALAQGDSTLENALFSEDSEYFAKCVEQ
CCCEECCCCCCCCCCEEECCCCCCCCHHHEEEEEHHCCCHHHHHHHHCCCHHHHHHHHHH
LGIPITLNPHLAQIQVSGKGGDIPAKQADLFVGLAGTAARFITALVALGNGEYRLDGVPR
CCCCEEECCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEECCCCC
MRERPMGDLVTVLQNSGIKINFEGNSGFMPYTIYGQQFAGGHFRLKANQTSQQLSALLMI
HHHCCHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHEEEEE
APYAQQDTTIEVEGTLVSQSYVKMTCRLMADFGVDVTQTDDNQFHIKAGQRYQARHYTIE
ECCCCCCCEEEEEEEEECHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCEEECEEEEEC
PDASNASYFFAAAAVTGGRVRVNHLTKQSCQGDILWLNVLEQMGCQVLEGEDYTEVIGPE
CCCCCCCEEEEEEEECCCEEEEEEHHHHCCCCCCHHHHHHHHCCCEEECCCCCHHHCCCH
QLQGIDVDMNDMSDLVQTLGAIAPYANSPVIIRNVEHIRYKETERIRAVVTELRRLGVKV
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCH
EEFADGMKIEPTPINPAAIETYHDHRMAMAFAVTGLKTPGIVIQDPGCTAKTFPDYFTRF
HHHHCCCEECCCCCCCHHEEEHHHHHEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHH
FKMIGQ
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA