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The map label for this gene is argF

Identifier: 75908416

GI number: 75908416

Start: 2728483

End: 2729403

Strand: Direct

Name: argF

Synonym: Ava_2197

Alternate gene names: 75908416

Gene position: 2728483-2729403 (Clockwise)

Preceding gene: 75908415

Following gene: 75908417

Centisome position: 42.86

GC content: 42.02

Gene sequence:

>921_bases
ATGGCAGCATTGTTAGGACGAGATTTGTTAAGTCTGGCAGACTTGACTCCTACAGAACTTCAGGAACTTCTGCAATTGGC
AACCCAATTGAAATCACAACAGTTGAAGTTGCGGTGTAATAAGGTATTGGGTTTGTTATTTTCTAAGGCTTCAACTCGGA
CACGAGTCAGTTTTACTGTGGCTATGTACCAACTGGGTGGACAAGTAATTGATCTTAATCCGAATGTGACTCAAGTTAGT
CGAGGAGAACCAGTACAAGATACTGCACGAGTATTAGAGCGATATTTGGATGTTTTGGCAATTCGCACTTTTGAACAGCA
GGAGTTAGCAACTTTTGCTGAGTATGCGAAAATTCCTGTAATTAATGCACTCACTGATTTAGAACATCCTTGCCAAATAT
TAGCGGATTTATTAACTGCACAAGAATGTTTTGACACAATTTCTGGGCTAACTTTGACCTATGTTGGTGATGGCAATAAT
GTCGCTAATTCTTTGATGCTTGGCTGTGCTTTGGCGGGGATGAATGTGAGAATTGCCACACCTAGTGGATATGAACCAAA
TCCGCAGGTTGTCGCACAAGCACAAGCAATAGCTGATGGTAAAACCGAAATTCTCCTCACCAATGACCCAGAATTAGCAA
CCAAAGGTGCATCTGTACTCTACACTGATGTTTGGGCGAGTATGGGACAGGAAGCAGAAGCAAACGATCGCTTTCCTATT
TTCCAACCTTATCAAATTTCTGAGAAGCTATTGAGTCTGGCTGAACCAAACGCAATTGTTTTACATTGCTTACCCGCCCA
TCGTGGTGAAGAAATTACCGAAGAAGTAATCGAAGGTTCTCAATCAAGAGTTTGGCAACAAGCCGAAAATCGATTGCACG
TTCAAAAAGCTTTACTAGCTAGTATCTTGGGGGCAGAGTGA

Upstream 100 bases:

>100_bases
GGTAGGTGAGGGGGTTCTTTTTGTTCGGGGTAACTGTATTTTTTTGCTTGACTGGGTAAAGGAAGAGAGATTTATAATTG
TTATTTAACAGATCACAAGC

Downstream 100 bases:

>100_bases
ACAGTTAAAAGTCAAAAGTAGAAAGGCAAAAGAAAATTAACTTATCTTTCTTTTGCCTTTTAAATTTTTATTTTTATCTT
GTTATTAGAGGTTTTTTGTA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAALLGRDLLSLADLTPTELQELLQLATQLKSQQLKLRCNKVLGLLFSKASTRTRVSFTVAMYQLGGQVIDLNPNVTQVS
RGEPVQDTARVLERYLDVLAIRTFEQQELATFAEYAKIPVINALTDLEHPCQILADLLTAQECFDTISGLTLTYVGDGNN
VANSLMLGCALAGMNVRIATPSGYEPNPQVVAQAQAIADGKTEILLTNDPELATKGASVLYTDVWASMGQEAEANDRFPI
FQPYQISEKLLSLAEPNAIVLHCLPAHRGEEITEEVIEGSQSRVWQQAENRLHVQKALLASILGAE

Sequences:

>Translated_306_residues
MAALLGRDLLSLADLTPTELQELLQLATQLKSQQLKLRCNKVLGLLFSKASTRTRVSFTVAMYQLGGQVIDLNPNVTQVS
RGEPVQDTARVLERYLDVLAIRTFEQQELATFAEYAKIPVINALTDLEHPCQILADLLTAQECFDTISGLTLTYVGDGNN
VANSLMLGCALAGMNVRIATPSGYEPNPQVVAQAQAIADGKTEILLTNDPELATKGASVLYTDVWASMGQEAEANDRFPI
FQPYQISEKLLSLAEPNAIVLHCLPAHRGEEITEEVIEGSQSRVWQQAENRLHVQKALLASILGAE
>Mature_305_residues
AALLGRDLLSLADLTPTELQELLQLATQLKSQQLKLRCNKVLGLLFSKASTRTRVSFTVAMYQLGGQVIDLNPNVTQVSR
GEPVQDTARVLERYLDVLAIRTFEQQELATFAEYAKIPVINALTDLEHPCQILADLLTAQECFDTISGLTLTYVGDGNNV
ANSLMLGCALAGMNVRIATPSGYEPNPQVVAQAQAIADGKTEILLTNDPELATKGASVLYTDVWASMGQEAEANDRFPIF
QPYQISEKLLSLAEPNAIVLHCLPAHRGEEITEEVIEGSQSRVWQQAENRLHVQKALLASILGAE

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=307, Percent_Identity=42.671009771987, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI18105007, Length=317, Percent_Identity=29.6529968454259, Blast_Score=121, Evalue=7e-28,
Organism=Escherichia coli, GI1786469, Length=333, Percent_Identity=38.4384384384384, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1790703, Length=332, Percent_Identity=38.855421686747, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI2367364, Length=315, Percent_Identity=28.2539682539683, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI48994908, Length=354, Percent_Identity=27.1186440677966, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=325, Percent_Identity=28.9230769230769, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322373, Length=309, Percent_Identity=33.3333333333333, Blast_Score=179, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322331, Length=310, Percent_Identity=31.2903225806452, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24642586, Length=319, Percent_Identity=29.153605015674, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_ANAVT (Q3MB19)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322712.1
- HSSP:   P96108
- ProteinModelPortal:   Q3MB19
- SMR:   Q3MB19
- STRING:   Q3MB19
- GeneID:   3679754
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2197
- NMPDR:   fig|240292.3.peg.2349
- eggNOG:   COG0078
- HOGENOM:   HBG579429
- OMA:   FTVAMYQ
- PhylomeDB:   Q3MB19
- ProtClustDB:   PRK00779
- BioCyc:   AVAR240292:AVA_2197-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 33401; Mature: 33269

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 102-102 BINDING 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALLGRDLLSLADLTPTELQELLQLATQLKSQQLKLRCNKVLGLLFSKASTRTRVSFTV
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AMYQLGGQVIDLNPNVTQVSRGEPVQDTARVLERYLDVLAIRTFEQQELATFAEYAKIPV
HHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCH
INALTDLEHPCQILADLLTAQECFDTISGLTLTYVGDGNNVANSLMLGCALAGMNVRIAT
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEC
PSGYEPNPQVVAQAQAIADGKTEILLTNDPELATKGASVLYTDVWASMGQEAEANDRFPI
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
FQPYQISEKLLSLAEPNAIVLHCLPAHRGEEITEEVIEGSQSRVWQQAENRLHVQKALLA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SILGAE
HHHCCC
>Mature Secondary Structure 
AALLGRDLLSLADLTPTELQELLQLATQLKSQQLKLRCNKVLGLLFSKASTRTRVSFTV
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AMYQLGGQVIDLNPNVTQVSRGEPVQDTARVLERYLDVLAIRTFEQQELATFAEYAKIPV
HHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCH
INALTDLEHPCQILADLLTAQECFDTISGLTLTYVGDGNNVANSLMLGCALAGMNVRIAT
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEC
PSGYEPNPQVVAQAQAIADGKTEILLTNDPELATKGASVLYTDVWASMGQEAEANDRFPI
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
FQPYQISEKLLSLAEPNAIVLHCLPAHRGEEITEEVIEGSQSRVWQQAENRLHVQKALLA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SILGAE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA