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The map label for this gene is hemB [H]

Identifier: 75908167

GI number: 75908167

Start: 2420860

End: 2421870

Strand: Direct

Name: hemB [H]

Synonym: Ava_1946

Alternate gene names: 75908167

Gene position: 2420860-2421870 (Clockwise)

Preceding gene: 75908166

Following gene: 75908168

Centisome position: 38.03

GC content: 45.6

Gene sequence:

>1011_bases
ATGTCAGTTGAAAATCCATCTACCGCCAAACCATTGAACCTGCTTCAACGCCCCCGTCGGTTGCGTCGGACTGTAACACT
GAGGCGGATGGTGCGGGAAACTACCCTGACAGTGGATGATTTGATTTATCCGATGTTTGTCATGGAAGGAGAGGGGCAAA
AAGTAGAAATTGCTTCTATGCCTGGATGTTATCGTTACTCCCTAGATTTGTTGCTCAAAGAGATAGCCGAAGTATCACAG
CTAGGAATTAAGGCGATCGCACTTTTCCCTGTCATCTCCGAAAATAAAAAAGATGATATCGGTGCAGAAAGTTACAATCC
AGATGGGTTAGTACAGCAAACAGTCAAAGCCATTAAACAAGCAGTTCCCGACATTGTTATTATCACCGACGTAGCCCTTG
ACCCCTTCACCACACATGGACATGATGGTTTAGTTGCTGAAAACGGCACAATCTTAAATGACCCCACTGTGGAAGTGTTA
GTGAAAATGGCACTTTCCCAAGCCGCCGCCGGTACAGATTTTGTCGCCCCTTCCGACATGATGGATGGCAGAATTGGCGC
AATCCGTCAAGCCTTAGATGCAGAAGGCTACGTTCATGTAGGAATTTTGGCATACTCCGCTAAATACGCCTCTGCCTATT
ACGGCCCCTTTCGAGATGCGTTAGATTCTGCCCCCAAATTTGGCGACAAAAAGACTTATCAAATGGACGCAGCCAACGCT
AGAGAAGCAATTAAAGAAGTAGAACTAGATATTGCCGAAGGTGCAGATATTGTTATGGTAAAACCTGCCCTGGCATATCT
AGATATCATTTATCAAGTCCGTCAAGCCACCCAGTTACCAGTTGCAGCCTACAACGTCAGTGGCGAATATGCCATGATCA
AAGCTGCGGCTCAAATGGGTTGGATTGATGAAAAACAAGTGATTTTGGAATCTTTAACCAGCATGAAACGCGCCGGCGCA
GATTTAATTCTCACCTACTTTGCCAGAGAAGTAGCACTGATGTTGCTTTAA

Upstream 100 bases:

>100_bases
CACCGACTTTTTAAAAAAGTCGGGGTTCTGAGCGTTCATATTTTCCACACAAAACGAACGGCTTCCATTATGATAATGGT
TATCAATCTTGTGAAGACTT

Downstream 100 bases:

>100_bases
AAATGGGAATGGGGAAGTAGAAGGGAGAACTTTTGACAATCACCCATTACTAATGATCAAAAAAATCGTCCCAGCCAGTT
TTATAGTCATTCCCAATTCC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSVENPSTAKPLNLLQRPRRLRRTVTLRRMVRETTLTVDDLIYPMFVMEGEGQKVEIASMPGCYRYSLDLLLKEIAEVSQ
LGIKAIALFPVISENKKDDIGAESYNPDGLVQQTVKAIKQAVPDIVIITDVALDPFTTHGHDGLVAENGTILNDPTVEVL
VKMALSQAAAGTDFVAPSDMMDGRIGAIRQALDAEGYVHVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
REAIKEVELDIAEGADIVMVKPALAYLDIIYQVRQATQLPVAAYNVSGEYAMIKAAAQMGWIDEKQVILESLTSMKRAGA
DLILTYFAREVALMLL

Sequences:

>Translated_336_residues
MSVENPSTAKPLNLLQRPRRLRRTVTLRRMVRETTLTVDDLIYPMFVMEGEGQKVEIASMPGCYRYSLDLLLKEIAEVSQ
LGIKAIALFPVISENKKDDIGAESYNPDGLVQQTVKAIKQAVPDIVIITDVALDPFTTHGHDGLVAENGTILNDPTVEVL
VKMALSQAAAGTDFVAPSDMMDGRIGAIRQALDAEGYVHVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
REAIKEVELDIAEGADIVMVKPALAYLDIIYQVRQATQLPVAAYNVSGEYAMIKAAAQMGWIDEKQVILESLTSMKRAGA
DLILTYFAREVALMLL
>Mature_335_residues
SVENPSTAKPLNLLQRPRRLRRTVTLRRMVRETTLTVDDLIYPMFVMEGEGQKVEIASMPGCYRYSLDLLLKEIAEVSQL
GIKAIALFPVISENKKDDIGAESYNPDGLVQQTVKAIKQAVPDIVIITDVALDPFTTHGHDGLVAENGTILNDPTVEVLV
KMALSQAAAGTDFVAPSDMMDGRIGAIRQALDAEGYVHVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANAR
EAIKEVELDIAEGADIVMVKPALAYLDIIYQVRQATQLPVAAYNVSGEYAMIKAAAQMGWIDEKQVILESLTSMKRAGAD
LILTYFAREVALMLL

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=296, Percent_Identity=41.2162162162162, Blast_Score=249, Evalue=4e-66,
Organism=Escherichia coli, GI87081728, Length=320, Percent_Identity=49.6875, Blast_Score=308, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=40.3908794788274, Blast_Score=221, Evalue=9e-59,
Organism=Drosophila melanogaster, GI21358291, Length=304, Percent_Identity=38.1578947368421, Blast_Score=231, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36796; Mature: 36665

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVENPSTAKPLNLLQRPRRLRRTVTLRRMVRETTLTVDDLIYPMFVMEGEGQKVEIASM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCEEEEECC
PGCYRYSLDLLLKEIAEVSQLGIKAIALFPVISENKKDDIGAESYNPDGLVQQTVKAIKQ
CCHHHHHHHHHHHHHHHHHHHCHHHHHEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AVPDIVIITDVALDPFTTHGHDGLVAENGTILNDPTVEVLVKMALSQAAAGTDFVAPSDM
HCCCEEEEEECCCCCCCCCCCCCEEECCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCHH
MDGRIGAIRQALDAEGYVHVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
CCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECHHHH
REAIKEVELDIAEGADIVMVKPALAYLDIIYQVRQATQLPVAAYNVSGEYAMIKAAAQMG
HHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHC
WIDEKQVILESLTSMKRAGADLILTYFAREVALMLL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVENPSTAKPLNLLQRPRRLRRTVTLRRMVRETTLTVDDLIYPMFVMEGEGQKVEIASM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCEEEEECC
PGCYRYSLDLLLKEIAEVSQLGIKAIALFPVISENKKDDIGAESYNPDGLVQQTVKAIKQ
CCHHHHHHHHHHHHHHHHHHHCHHHHHEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AVPDIVIITDVALDPFTTHGHDGLVAENGTILNDPTVEVLVKMALSQAAAGTDFVAPSDM
HCCCEEEEEECCCCCCCCCCCCCEEECCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCHH
MDGRIGAIRQALDAEGYVHVGILAYSAKYASAYYGPFRDALDSAPKFGDKKTYQMDAANA
CCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECHHHH
REAIKEVELDIAEGADIVMVKPALAYLDIIYQVRQATQLPVAAYNVSGEYAMIKAAAQMG
HHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHC
WIDEKQVILESLTSMKRAGADLILTYFAREVALMLL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]