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The map label for this gene is mtrB [H]

Identifier: 75908166

GI number: 75908166

Start: 2419628

End: 2420743

Strand: Direct

Name: mtrB [H]

Synonym: Ava_1945

Alternate gene names: 75908166

Gene position: 2419628-2420743 (Clockwise)

Preceding gene: 75908165

Following gene: 75908167

Centisome position: 38.01

GC content: 44.09

Gene sequence:

>1116_bases
ATGATCAACAAAGGTTGGCGTTGGACAAAATCCCTACCTTTAGCATCTCGCTTGTTTGTCTCCCATTTAGTGGTGATGAT
AGTGGGATTAATTAGTCTGGTGATTATCAGTAGAGTTTCGTCACCGCGCTTTTTTGTCCTGCACCTAGAAAGATTGGAAA
GTGAAGGGGTAAATTTAATCAATGTTCGTGCAGATTTAGTCCAAGGGTTCGAGATTGCTTGGCGCAGTAGCACTATTTGG
TCAGTTTTAGTCGGTAGCACGGCTGCGGGAGGCTTGAGTTACTGGGTTTCTAAACGGATTATGCAGCGATTAACTGAGAT
GGAACAAATCACTCAACAGTTTGCTGCTGGTCATCTACAAGCGCGACTACCTTTGTCTGACATCCCCGAACTCAATCGCT
TGGGTACGAGTTTTAACCGCATGGCTGCAAGTTTGGAAGGGGTGGAAGCACGCCGACGGGAACTCATAGGAGATATGACT
CATGAACTACGCACACCGTTAACAGTTGTGCGTGGTTATTTAGAAGAACTCGCCGATGGTGAAATTGAACCGTCCCCAGA
GGTTTATCGGCGCTTGGCGAAAGAGACTAAACGTTTAGAACGATTGGTCAATGATTTACAAGAATTATCGAAGGCAGAAG
CTGGTTATTTACCGATTAGAATACAGTCAGTAAATCTATATCCTTTATTAGAGTCTTTAGTAGAAAGATTTAGTGATCAA
TTGTTGGAGGATGGGCCAGTATTACTTGCAGAATTTACACCCCAAATCCCCCTTGTACTAGCAGATATCGATCGCACAGA
ACAAATATTAGTCAACTTGCTAGGTAACGCCATCCGTTATACCGTCAAAGGCTCAATTACCATCCGTACATGGGCTGAAA
ACAGGCAACTCTGGATTGCCGTGATTGATACAGGGATTGGTATTGCCTCAGAGGATATACCTCATGTATTTGAGCGCTTT
TGGCGAGCTGATCAATCACGCGATCGCCATTCCGGTGGCACAGGTATTGGCTTAACTATCACTAAACACCTAGTAGAACT
ACAAGGTGGCGAAATTCACTTAGATAGTGAACTTGGTATTGGCAGCACTTTCCGATTTTGTTTGCCTCTAGCATAA

Upstream 100 bases:

>100_bases
GGCTCAGAAAAAAAATTGAGCCTGATCCCACTAATCCCAGTTTTATTAAAACTGTCGTCGGAGTTGGTTATAAATTTGAA
GACTCTCCCGTAATTTCAGC

Downstream 100 bases:

>100_bases
GCAATAGTTTATAGATCACCGACTTTTTAAAAAAGTCGGGGTTCTGAGCGTTCATATTTTCCACACAAAACGAACGGCTT
CCATTATGATAATGGTTATC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MINKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISRVSSPRFFVLHLERLESEGVNLINVRADLVQGFEIAWRSSTIW
SVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMT
HELRTPLTVVRGYLEELADGEIEPSPEVYRRLAKETKRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
LLEDGPVLLAEFTPQIPLVLADIDRTEQILVNLLGNAIRYTVKGSITIRTWAENRQLWIAVIDTGIGIASEDIPHVFERF
WRADQSRDRHSGGTGIGLTITKHLVELQGGEIHLDSELGIGSTFRFCLPLA

Sequences:

>Translated_371_residues
MINKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISRVSSPRFFVLHLERLESEGVNLINVRADLVQGFEIAWRSSTIW
SVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMT
HELRTPLTVVRGYLEELADGEIEPSPEVYRRLAKETKRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
LLEDGPVLLAEFTPQIPLVLADIDRTEQILVNLLGNAIRYTVKGSITIRTWAENRQLWIAVIDTGIGIASEDIPHVFERF
WRADQSRDRHSGGTGIGLTITKHLVELQGGEIHLDSELGIGSTFRFCLPLA
>Mature_371_residues
MINKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISRVSSPRFFVLHLERLESEGVNLINVRADLVQGFEIAWRSSTIW
SVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMT
HELRTPLTVVRGYLEELADGEIEPSPEVYRRLAKETKRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
LLEDGPVLLAEFTPQIPLVLADIDRTEQILVNLLGNAIRYTVKGSITIRTWAENRQLWIAVIDTGIGIASEDIPHVFERF
WRADQSRDRHSGGTGIGLTITKHLVELQGGEIHLDSELGIGSTFRFCLPLA

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=36.8852459016393, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=33.4763948497854, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787894, Length=270, Percent_Identity=33.7037037037037, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=34.5132743362832, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=29.0836653386454, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI48994928, Length=270, Percent_Identity=30, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=31.9391634980989, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=30.8943089430894, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=29.7397769516729, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082128, Length=245, Percent_Identity=28.1632653061224, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=28.1938325991189, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=30.4721030042918, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=317, Percent_Identity=26.4984227129338, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790861, Length=304, Percent_Identity=27.3026315789474, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=30.672268907563, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=29.1479820627803, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789808, Length=301, Percent_Identity=28.2392026578073, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=27.7372262773723, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789403, Length=253, Percent_Identity=27.6679841897233, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790300, Length=232, Percent_Identity=28.448275862069, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=81, Percent_Identity=43.2098765432099, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41764; Mature: 41764

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISRVSSPRFFVLHLERLESEGVNLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCEE
NVRADLVQGFEIAWRSSTIWSVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQ
EEHHHHHCCHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMTHELRTPLTVVRGYLEELADG
ECCCHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
EIEPSPEVYRRLAKETKRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHH
LLEDGPVLLAEFTPQIPLVLADIDRTEQILVNLLGNAIRYTVKGSITIRTWAENRQLWIA
HHCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHEEEEECCEEEEEECCCCEEEEE
VIDTGIGIASEDIPHVFERFWRADQSRDRHSGGTGIGLTITKHLVELQGGEIHLDSELGI
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCC
GSTFRFCLPLA
CCHHHHHCCCC
>Mature Secondary Structure
MINKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISRVSSPRFFVLHLERLESEGVNLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCEE
NVRADLVQGFEIAWRSSTIWSVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQ
EEHHHHHCCHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMTHELRTPLTVVRGYLEELADG
ECCCHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
EIEPSPEVYRRLAKETKRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHH
LLEDGPVLLAEFTPQIPLVLADIDRTEQILVNLLGNAIRYTVKGSITIRTWAENRQLWIA
HHCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHEEEEECCEEEEEECCCCEEEEE
VIDTGIGIASEDIPHVFERFWRADQSRDRHSGGTGIGLTITKHLVELQGGEIHLDSELGI
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCC
GSTFRFCLPLA
CCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA