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The map label for this gene is phoP [H]

Identifier: 75908165

GI number: 75908165

Start: 2418915

End: 2419631

Strand: Direct

Name: phoP [H]

Synonym: Ava_1944

Alternate gene names: 75908165

Gene position: 2418915-2419631 (Clockwise)

Preceding gene: 75908164

Following gene: 75908166

Centisome position: 38.0

GC content: 42.82

Gene sequence:

>717_bases
ATGGACATTCTAATTGTTGAGGATGAATCAGAAATTGCTCAGTTAATTCAACATTCCTTAGAAAAAGAGGGCTTTTCCTG
TCGGACTAGCCGCGATGGAATCAATGCTTTACGAATGTTCCAAGAACAACCACCAGATTTAATCATCCTAGACCTGATGA
TTCCAGGGTTAGATGGGTTGGAAGTTTGCGCGAGAATTCGCCAGAAACCTGGGGCAAAAGACCCATATATACTAATGCTT
ACAGCTAAAGGTGAGGAAATAGACCGGGTAATTGGCTTGTCTACGGGTGCTGATGACTATATGGTCAAACCCTTCAGCCC
TAGAGAGTTGGTAGCGCGAGTGCGGGCGCTTCTAAGGCGCAGTCTACGTCAAGGGGGACAAAATCAGGTAAGTCGAACTC
AACACTTTATAGTAGATGTAGACCAACGGACTGCTAGTCGTCAAATAGATGCCCATCAAGCAGAAGCTTTAGATTTAACT
ACTCTAGAATTTAATTTATTAAGCACTTTTGTCAGCAATCCTGGGCGGGTGTGGAACCGAACCCAACTAATTGACAAATT
GTGGGGAGATAATTTTTTTGGTGATGAGCGTGTTGTGGATACTCATGTAGCTAGGCTCAGAAAAAAAATTGAGCCTGATC
CCACTAATCCCAGTTTTATTAAAACTGTCGTCGGAGTTGGTTATAAATTTGAAGACTCTCCCGTAATTTCAGCATGA

Upstream 100 bases:

>100_bases
AACTAAAAGCGTAAGTGTTAAATTAATTACTATCAGAACTCTTGCAGTTGCTGAAATAAAATAACAAGCCTAGAAATTAC
GCTGCGTACCTTACATCGAA

Downstream 100 bases:

>100_bases
TCAACAAAGGTTGGCGTTGGACAAAATCCCTACCTTTAGCATCTCGCTTGTTTGTCTCCCATTTAGTGGTGATGATAGTG
GGATTAATTAGTCTGGTGAT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALRMFQEQPPDLIILDLMIPGLDGLEVCARIRQKPGAKDPYILML
TAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRRSLRQGGQNQVSRTQHFIVDVDQRTASRQIDAHQAEALDLT
TLEFNLLSTFVSNPGRVWNRTQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA

Sequences:

>Translated_238_residues
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALRMFQEQPPDLIILDLMIPGLDGLEVCARIRQKPGAKDPYILML
TAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRRSLRQGGQNQVSRTQHFIVDVDQRTASRQIDAHQAEALDLT
TLEFNLLSTFVSNPGRVWNRTQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA
>Mature_238_residues
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALRMFQEQPPDLIILDLMIPGLDGLEVCARIRQKPGAKDPYILML
TAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRRSLRQGGQNQVSRTQHFIVDVDQRTASRQIDAHQAEALDLT
TLEFNLLSTFVSNPGRVWNRTQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=43.2314410480349, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=40.7894736842105, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=38.1974248927039, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=40.3508771929825, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=38.0952380952381, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=32.4786324786325, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=34.061135371179, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=35.6521739130435, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.0044052863436, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=36.0869565217391, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=33.7662337662338, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.1896551724138, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=33.4782608695652, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=29.6610169491525, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=34.1463414634146, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=33.0357142857143, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=27.2727272727273, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26857; Mature: 26857

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALRMFQEQPPDLIILDLMIPGLDGL
CCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHH
EVCARIRQKPGAKDPYILMLTAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRR
HHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHH
SLRQGGQNQVSRTQHFIVDVDQRTASRQIDAHQAEALDLTTLEFNLLSTFVSNPGRVWNR
HHHCCCHHHHHHHHHHEEECCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCHHHH
TQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEECCCCCCCC
>Mature Secondary Structure
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALRMFQEQPPDLIILDLMIPGLDGL
CCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHH
EVCARIRQKPGAKDPYILMLTAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRR
HHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHH
SLRQGGQNQVSRTQHFIVDVDQRTASRQIDAHQAEALDLTTLEFNLLSTFVSNPGRVWNR
HHHCCCHHHHHHHHHHEEECCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCHHHH
TQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]