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The map label for this gene is yycF [H]

Identifier: 75908099

GI number: 75908099

Start: 2330572

End: 2331300

Strand: Direct

Name: yycF [H]

Synonym: Ava_1878

Alternate gene names: 75908099

Gene position: 2330572-2331300 (Clockwise)

Preceding gene: 75908094

Following gene: 75908100

Centisome position: 36.61

GC content: 43.48

Gene sequence:

>729_bases
TTGGAAAGTCATAAAGAAAAAATCCTGGTAGTAGACGACGAAGCTAGCATTCGCCGAATTTTAGAAACGCGCCTTTCAAT
GATTGGCTACGATGTAGTAACAGCAGGGGATGGCGAAGAAGCTTTAGAAACATTCCGCAAATCTGACCCTGATTTAGTGG
TTTTGGATGTGATGATGCCAAAGCTGGATGGTTATGGTGTTTGTCAAGAATTACGTAAAGAATCGGATGTCCCTATAATT
ATGCTAACAGCCTTAGGGGACGTTGCCGATCGCATCACTGGTTTAGAGTTAGGTGCTGATGACTACGTAGTTAAACCGTT
TTCCCCCAAAGAACTAGAAGCAAGAATTCGCTCAGTATTACGACGGGTAGATAAAACTGGTGCTTCTGGTATTCCCAGTT
CTGGGGTAATTCACGTTGGTAATATCAAAATTGATACCAACAAGCGCCAAGTCTATAAAGGCGATGAGCGTATCCGCTTG
ACAGGTATGGAATTTAGTTTACTAGAGTTGCTAGTCAGCCGTTCTGGAGAAGCTTTTTCCCGTTCGGAAATTTTACAAGA
AGTCTGGGGTTATACTCCAGAACGCCATGTAGACACCCGTGTGGTAGATGTGCATATCTCCCGCTTACGGGCAAAATTAG
AAGATGACCCCAGTAACCCAGAATTAATTCTCACAGCACGGGGTACTGGTTATTTGTTTCAACGCATAATTGAGCCAGGA
GAAGAATAG

Upstream 100 bases:

>100_bases
AGAGTTAGAGCATTTTCCAAATCATTTGAAGGAATGATATCTTAATATTATGGTATTAAAAATTAATCATGAAAATTTTA
GTTAAGGAGCATTGAGAAAC

Downstream 100 bases:

>100_bases
AGGAACAAGCGTTAACCGTTGACTGTTAACTGTTGACTGTTGACTATGGACTAATGACTAATGACCAAACCTGATCCCAA
TCGAGTTTTGCGGCGCTTAC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MESHKEKILVVDDEASIRRILETRLSMIGYDVVTAGDGEEALETFRKSDPDLVVLDVMMPKLDGYGVCQELRKESDVPII
MLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRVDKTGASGIPSSGVIHVGNIKIDTNKRQVYKGDERIRL
TGMEFSLLELLVSRSGEAFSRSEILQEVWGYTPERHVDTRVVDVHISRLRAKLEDDPSNPELILTARGTGYLFQRIIEPG
EE

Sequences:

>Translated_242_residues
MESHKEKILVVDDEASIRRILETRLSMIGYDVVTAGDGEEALETFRKSDPDLVVLDVMMPKLDGYGVCQELRKESDVPII
MLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRVDKTGASGIPSSGVIHVGNIKIDTNKRQVYKGDERIRL
TGMEFSLLELLVSRSGEAFSRSEILQEVWGYTPERHVDTRVVDVHISRLRAKLEDDPSNPELILTARGTGYLFQRIIEPG
EE
>Mature_242_residues
MESHKEKILVVDDEASIRRILETRLSMIGYDVVTAGDGEEALETFRKSDPDLVVLDVMMPKLDGYGVCQELRKESDVPII
MLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVLRRVDKTGASGIPSSGVIHVGNIKIDTNKRQVYKGDERIRL
TGMEFSLLELLVSRSGEAFSRSEILQEVWGYTPERHVDTRVVDVHISRLRAKLEDDPSNPELILTARGTGYLFQRIIEPG
EE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=43.0434782608696, Blast_Score=173, Evalue=8e-45,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=40.4347826086956, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=39.7379912663755, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=40.0881057268723, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=35.6828193832599, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=39.0557939914163, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI2367329, Length=235, Percent_Identity=41.2765957446808, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=34.6153846153846, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=35.3711790393013, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=35.9307359307359, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=32.3144104803493, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=34.9557522123894, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=35.3448275862069, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.7510917030568, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=37.9310344827586, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=36.8421052631579, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=34.3137254901961, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=101, Percent_Identity=34.6534653465347, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788191, Length=127, Percent_Identity=32.2834645669291, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=35.8333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=105, Percent_Identity=37.1428571428571, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788905, Length=106, Percent_Identity=35.8490566037736, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27108; Mature: 27108

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESHKEKILVVDDEASIRRILETRLSMIGYDVVTAGDGEEALETFRKSDPDLVVLDVMMP
CCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCEEEEEEECC
KLDGYGVCQELRKESDVPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVL
CCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCEECCCCEEECCCCHHHHHHHHHHHH
RRVDKTGASGIPSSGVIHVGNIKIDTNKRQVYKGDERIRLTGMEFSLLELLVSRSGEAFS
HHHHHCCCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEEECCHHHHHHHHHHCCCCCHH
RSEILQEVWGYTPERHVDTRVVDVHISRLRAKLEDDPSNPELILTARGTGYLFQRIIEPG
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCC
EE
CC
>Mature Secondary Structure
MESHKEKILVVDDEASIRRILETRLSMIGYDVVTAGDGEEALETFRKSDPDLVVLDVMMP
CCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCEEEEEEECC
KLDGYGVCQELRKESDVPIIMLTALGDVADRITGLELGADDYVVKPFSPKELEARIRSVL
CCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCEECCCCEEECCCCHHHHHHHHHHHH
RRVDKTGASGIPSSGVIHVGNIKIDTNKRQVYKGDERIRLTGMEFSLLELLVSRSGEAFS
HHHHHCCCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEEECCHHHHHHHHHHCCCCCHH
RSEILQEVWGYTPERHVDTRVVDVHISRLRAKLEDDPSNPELILTARGTGYLFQRIIEPG
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCC
EE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]