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The map label for this gene is todF [H]

Identifier: 75908020

GI number: 75908020

Start: 2242723

End: 2243550

Strand: Direct

Name: todF [H]

Synonym: Ava_1799

Alternate gene names: 75908020

Gene position: 2242723-2243550 (Clockwise)

Preceding gene: 75908019

Following gene: 75908023

Centisome position: 35.23

GC content: 40.1

Gene sequence:

>828_bases
ATGGATACGCTATTACGTAACGCCCGGAGAAAACTATCTCAAGGGCTATTATTCTGGCGTGAAGCTGGTGAGGGGATTCC
TGTAGTTTTGTTACATGGTGCTTGGTATGAAAGTAGCCAATGGGTGGAAGTCATGGAATCACTTTCACAGAATTTTCATT
GCTTTGCACCAGATTTATTAGGTTTTGGAGAATCAGAAAAACCCAATATTCATTACTCAATTGATTTACAAGTAGAGTGC
ATAGCTGAGTTTTTCCAAGCTTTAAAGCTAGAAAAAGTCTATTTATTGGGAGATTCACTAGGTGCTTGGATTGCAGCTAG
TTATGCCTTAAAGTATCCAGAACAAGTGTATGGGTTAGTTTTGTTAGCACCGGAGGGTGTGCAGATAGAGGGGCAATCAC
AAAATTGCCAGAAAATGCGGCGGTTGAGCAAGCGATCGCCATTATTATTTAAAATAATGCGATCGCTCAGTTTTTTAACT
AAGATTTTTGGGCTAGACAAGAAGATAGAGCAAGATTGGCAAACACGGCAAAAATTACTGCAAAATCCTACAGCCGCCCA
GTTATTGTTTCAACGCCAGCAACCAGAAATCGAAGCAGAACTACTGCAAAGCTATCTATCTAAATTAGAAATCCCAGTAC
TAGTTTTGCAAGGTGGCAAAGATAAGCCAGATGCCCTAGCTAGAAGTCAGTTTTATACTAAACTGATTCCTCAAGCAGAA
TTAAAAATTATTGCTCATGGTGAAAGCAATTTACCAGAATCCTGTGTTGGGATTGTAGCTGGAGAAATTCGGGAGTTTAT
AACTAATTCCCCGTCCTATCCCTGCTGA

Upstream 100 bases:

>100_bases
TGATTTTGACTATTGACTACTGACTATTGACAAAAAAGCCAGAAAATTAGTAACACTGCGTAAGTCCTATATTCTAAAGA
AAGATAAACAACACATTAAA

Downstream 100 bases:

>100_bases
ATTTCCAAAGGACACATCGAGTCCATAATGGAAGCGCCACCATCCACATGAATTATTTGACCTGTAATAAAGCTAGCTTC
CTGCATACATAAGAGCATAG

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: HOHH [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MDTLLRNARRKLSQGLLFWREAGEGIPVVLLHGAWYESSQWVEVMESLSQNFHCFAPDLLGFGESEKPNIHYSIDLQVEC
IAEFFQALKLEKVYLLGDSLGAWIAASYALKYPEQVYGLVLLAPEGVQIEGQSQNCQKMRRLSKRSPLLFKIMRSLSFLT
KIFGLDKKIEQDWQTRQKLLQNPTAAQLLFQRQQPEIEAELLQSYLSKLEIPVLVLQGGKDKPDALARSQFYTKLIPQAE
LKIIAHGESNLPESCVGIVAGEIREFITNSPSYPC

Sequences:

>Translated_275_residues
MDTLLRNARRKLSQGLLFWREAGEGIPVVLLHGAWYESSQWVEVMESLSQNFHCFAPDLLGFGESEKPNIHYSIDLQVEC
IAEFFQALKLEKVYLLGDSLGAWIAASYALKYPEQVYGLVLLAPEGVQIEGQSQNCQKMRRLSKRSPLLFKIMRSLSFLT
KIFGLDKKIEQDWQTRQKLLQNPTAAQLLFQRQQPEIEAELLQSYLSKLEIPVLVLQGGKDKPDALARSQFYTKLIPQAE
LKIIAHGESNLPESCVGIVAGEIREFITNSPSYPC
>Mature_275_residues
MDTLLRNARRKLSQGLLFWREAGEGIPVVLLHGAWYESSQWVEVMESLSQNFHCFAPDLLGFGESEKPNIHYSIDLQVEC
IAEFFQALKLEKVYLLGDSLGAWIAASYALKYPEQVYGLVLLAPEGVQIEGQSQNCQKMRRLSKRSPLLFKIMRSLSFLT
KIFGLDKKIEQDWQTRQKLLQNPTAAQLLFQRQQPEIEAELLQSYLSKLEIPVLVLQGGKDKPDALARSQFYTKLIPQAE
LKIIAHGESNLPESCVGIVAGEIREFITNSPSYPC

Specific function: Not Clear. Seems To Be Implicated In The Early Steps Of Biotin Biosynthesis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI189027141, Length=240, Percent_Identity=24.5833333333333, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25146278, Length=133, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558492, Length=106, Percent_Identity=36.7924528301887, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI32566936, Length=137, Percent_Identity=30.6569343065693, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586387, Length=107, Percent_Identity=34.5794392523364, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586391, Length=107, Percent_Identity=34.5794392523364, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586389, Length=107, Percent_Identity=34.5794392523364, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586385, Length=107, Percent_Identity=34.5794392523364, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.-

Molecular weight: Translated: 31188; Mature: 31188

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLLRNARRKLSQGLLFWREAGEGIPVVLLHGAWYESSQWVEVMESLSQNFHCFAPDLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEECHHHH
GFGESEKPNIHYSIDLQVECIAEFFQALKLEKVYLLGDSLGAWIAASYALKYPEQVYGLV
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCHHHHEEE
LLAPEGVQIEGQSQNCQKMRRLSKRSPLLFKIMRSLSFLTKIFGLDKKIEQDWQTRQKLL
EECCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QNPTAAQLLFQRQQPEIEAELLQSYLSKLEIPVLVLQGGKDKPDALARSQFYTKLIPQAE
CCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
LKIIAHGESNLPESCVGIVAGEIREFITNSPSYPC
EEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDTLLRNARRKLSQGLLFWREAGEGIPVVLLHGAWYESSQWVEVMESLSQNFHCFAPDLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEECHHHH
GFGESEKPNIHYSIDLQVECIAEFFQALKLEKVYLLGDSLGAWIAASYALKYPEQVYGLV
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCHHHHEEE
LLAPEGVQIEGQSQNCQKMRRLSKRSPLLFKIMRSLSFLTKIFGLDKKIEQDWQTRQKLL
EECCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QNPTAAQLLFQRQQPEIEAELLQSYLSKLEIPVLVLQGGKDKPDALARSQFYTKLIPQAE
CCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
LKIIAHGESNLPESCVGIVAGEIREFITNSPSYPC
EEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1916282; 2670929 [H]