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The map label for this gene is luxQ [H]

Identifier: 75907937

GI number: 75907937

Start: 2152803

End: 2154689

Strand: Direct

Name: luxQ [H]

Synonym: Ava_1716

Alternate gene names: 75907937

Gene position: 2152803-2154689 (Clockwise)

Preceding gene: 75907933

Following gene: 75907938

Centisome position: 33.82

GC content: 44.46

Gene sequence:

>1887_bases
ATGGCAGCAGGCTTAGGGTTAGGGGTGGTAGGAATTACGAAAGCTGATATAGAAGGTAAAACCATTTGGGAAGCACTCCC
CCCAGAAACTTCTTCTGAGGTTGAGTTACCTTATCGCCAAGCATTTGCCGGGATCAGCTCTCGTTTTGAAGCACCCTATG
GACACCGCGTTTATGAAGTCCATGTTTTACCTGTGAGGAACGATGATGGTGAGATTTTTGCTGGAATGACCATTACCCAA
GAAATCACAGAGCGTAAACAATCTGAATTAGCTTTGCAAGATGCCCTACAACTGTTAAATCTACACATAGATACTACTCC
TTTGGCAGTGGTGCAATGGGATTGCCACCTATGCGTTACCCGTTGGTCATCTACTGCCGAAAAAATCTTTGGCTGGCGGA
CAGAGGAAGTAATCGGAAAATACTTTCAAGATTTGCACATGGTCTATGAGGAAGATATGACAGCAGTTGCAGAGGCGAGC
AATCGCCTCCTCAGTGGCCAAGAATCGCAAATTATCCAATACAATCGCAACTATACTAAAGACTCTAGAGTTATTTATTG
CGAGTGGTACAACTCTAGCATTACTAATGAAGCAGGTAGTGTCACCTCTGTACTGTCACTAGTATTAGATGTAACAGAGC
GCATACAAGCAGAAAAAGCATTACGCCAAAGCGAATTAATGGTAATTGAAGAGCGGGCGCAAGCTTTAGAAAGAGAACGG
GCAGCTCGTATAGAACTGGAAAGAGCCAGTCGCATGAAAGATGAATTTTTAGCGATAGTTTCCCATGAATTGCGATCGCC
CCTCAATGGTATTTTAGGTTGGTCGCGCCTGCTCCGCACCCGCAAACTGTCACCAGAAAAGATTGAACAAGCTTTAGAAT
CAATTGAGCGCAATGCTCAAGCCCAAACTCAATTAATTGAAGACTTACTCGATATTTCGCGGATTATTCGCGGTAACATT
CGCTTACTTGTACGCCCCACAAAATTGATTCCCGTAATTCAAGCAGCACTAGATACTGTTCGCCCAATTGCCAATACCAA
ATCAATCCAAATTATATCTCGCCTGAATTTTGATATTGGTTTAGTTTCTGCCGACCCAGAACGTTTACAGCAAGTGATTT
GGAACTTACTTTCCAATGCAGTCAAGTTTACTCCTGAAGGCGGACGGGTAGAAATTTGCCTAGAACAAGTAGAGACTAAT
GTGCAGATTCGGGTAACTGACACAGGTAAAGGCATTAGTCCTGAGTTTTTACCTTATGTATTTGACCGTTTCCGCCAAGC
AGATGCTACCACAACCAGAAATCAAGGGGGACTAGGTTTAGGTCTGGCGATCGTGCGTAATCTCGTTGAGCTTCACAATG
GTACAGTTTCAGTTGCTAGCCCAGGAGAAGGACAAGGAGCGACATTTACGGTCCAACTACCACTCTTACCAAGTTACTCC
ACAGTCACCCCAGAAGAACCCTTGCTTCAACGACAGACAACCTGGGATGCTAAAGTCCAAATCAGAGGACTAAAAATTTT
AGCAGTTGATGATGAACCAGATACTAGAGAATTTCTCAAAACTGCCTTAGAACAATACGGAGCAATTGTGACAACCGCAG
CCTCCACCAGTGAAGCCTTAAAACTGTTGCAATTAGTGAAGCCTGATGTGCTACTAAGTGATATTGGGATGCCAAATGAA
GATGGCTACGCTCTAATTCGGCAAATTCGAGCGCTATCATCAGAACAAGGGGGAAATGTCCCAGCTGCCGCCCTGACCGC
TTACACCAGACAAAGCGATCGCCTCCTTGCCCTAACCGCCGGATTTCAAATTCATATATCCAAACCAATTGAGCCAATCC
AGTTATTAAAAATTGTTGCCACCCTGGCTGGCAACAACTCGAATTGA

Upstream 100 bases:

>100_bases
TTCAAAGTTTGATGTTGTGATTGGTGAGAAAGCCCAAAATTGCGTTAACTCTTTCTCGATTTATGGTTCAAAATTTTTCT
CATATTATGATTCAAAGGAC

Downstream 100 bases:

>100_bases
AAGAAAGCCGCAGAGGAATTAAAATTCCTCACCCACAAAGGGATGAGAAATCTGGTAATGGGTAATAGTCCTATTACTTA
TTACCTATTACCTATTACCT

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MAAGLGLGVVGITKADIEGKTIWEALPPETSSEVELPYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFAGMTITQ
EITERKQSELALQDALQLLNLHIDTTPLAVVQWDCHLCVTRWSSTAEKIFGWRTEEVIGKYFQDLHMVYEEDMTAVAEAS
NRLLSGQESQIIQYNRNYTKDSRVIYCEWYNSSITNEAGSVTSVLSLVLDVTERIQAEKALRQSELMVIEERAQALERER
AARIELERASRMKDEFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISRIIRGNI
RLLVRPTKLIPVIQAALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETN
VQIRVTDTGKGISPEFLPYVFDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGTVSVASPGEGQGATFTVQLPLLPSYS
TVTPEEPLLQRQTTWDAKVQIRGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTSEALKLLQLVKPDVLLSDIGMPNE
DGYALIRQIRALSSEQGGNVPAAALTAYTRQSDRLLALTAGFQIHISKPIEPIQLLKIVATLAGNNSN

Sequences:

>Translated_628_residues
MAAGLGLGVVGITKADIEGKTIWEALPPETSSEVELPYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFAGMTITQ
EITERKQSELALQDALQLLNLHIDTTPLAVVQWDCHLCVTRWSSTAEKIFGWRTEEVIGKYFQDLHMVYEEDMTAVAEAS
NRLLSGQESQIIQYNRNYTKDSRVIYCEWYNSSITNEAGSVTSVLSLVLDVTERIQAEKALRQSELMVIEERAQALERER
AARIELERASRMKDEFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISRIIRGNI
RLLVRPTKLIPVIQAALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETN
VQIRVTDTGKGISPEFLPYVFDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGTVSVASPGEGQGATFTVQLPLLPSYS
TVTPEEPLLQRQTTWDAKVQIRGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTSEALKLLQLVKPDVLLSDIGMPNE
DGYALIRQIRALSSEQGGNVPAAALTAYTRQSDRLLALTAGFQIHISKPIEPIQLLKIVATLAGNNSN
>Mature_627_residues
AAGLGLGVVGITKADIEGKTIWEALPPETSSEVELPYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFAGMTITQE
ITERKQSELALQDALQLLNLHIDTTPLAVVQWDCHLCVTRWSSTAEKIFGWRTEEVIGKYFQDLHMVYEEDMTAVAEASN
RLLSGQESQIIQYNRNYTKDSRVIYCEWYNSSITNEAGSVTSVLSLVLDVTERIQAEKALRQSELMVIEERAQALERERA
ARIELERASRMKDEFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISRIIRGNIR
LLVRPTKLIPVIQAALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETNV
QIRVTDTGKGISPEFLPYVFDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGTVSVASPGEGQGATFTVQLPLLPSYST
VTPEEPLLQRQTTWDAKVQIRGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTSEALKLLQLVKPDVLLSDIGMPNED
GYALIRQIRALSSEQGGNVPAAALTAYTRQSDRLLALTAGFQIHISKPIEPIQLLKIVATLAGNNSN

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=382, Percent_Identity=33.2460732984293, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789149, Length=271, Percent_Identity=35.7933579335793, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI145693157, Length=391, Percent_Identity=29.6675191815857, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI87081816, Length=366, Percent_Identity=32.2404371584699, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI48994928, Length=549, Percent_Identity=26.0473588342441, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=33.1896551724138, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=33.4862385321101, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=32.9059829059829, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=28.8288288288288, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=34.5238095238095, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788549, Length=401, Percent_Identity=26.1845386533666, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1790861, Length=241, Percent_Identity=33.195020746888, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=31.8965517241379, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=246, Percent_Identity=27.2357723577236, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790300, Length=315, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=27.8969957081545, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=258, Percent_Identity=30.2325581395349, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786911, Length=106, Percent_Identity=37.7358490566038, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=209, Percent_Identity=27.7511961722488, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=91, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69779; Mature: 69647

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAGLGLGVVGITKADIEGKTIWEALPPETSSEVELPYRQAFAGISSRFEAPYGHRVYEV
CCCCCCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
HVLPVRNDDGEIFAGMTITQEITERKQSELALQDALQLLNLHIDTTPLAVVQWDCHLCVT
EEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHEEH
RWSSTAEKIFGWRTEEVIGKYFQDLHMVYEEDMTAVAEASNRLLSGQESQIIQYNRNYTK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCC
DSRVIYCEWYNSSITNEAGSVTSVLSLVLDVTERIQAEKALRQSELMVIEERAQALERER
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARIELERASRMKDEFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHH
AQTQLIEDLLDISRIIRGNIRLLVRPTKLIPVIQAALDTVRPIANTKSIQIISRLNFDIG
HHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEE
LVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETNVQIRVTDTGKGISPEFLPYV
EECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEEHHHCCEEEEEEECCCCCCHHHHHHH
FDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGTVSVASPGEGQGATFTVQLPLLPSYS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCC
TVTPEEPLLQRQTTWDAKVQIRGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTSEAL
CCCCCCHHHHCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHH
KLLQLVKPDVLLSDIGMPNEDGYALIRQIRALSSEQGGNVPAAALTAYTRQSDRLLALTA
HHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEC
GFQIHISKPIEPIQLLKIVATLAGNNSN
CEEEEECCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AAGLGLGVVGITKADIEGKTIWEALPPETSSEVELPYRQAFAGISSRFEAPYGHRVYEV
CCCCCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
HVLPVRNDDGEIFAGMTITQEITERKQSELALQDALQLLNLHIDTTPLAVVQWDCHLCVT
EEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHEEH
RWSSTAEKIFGWRTEEVIGKYFQDLHMVYEEDMTAVAEASNRLLSGQESQIIQYNRNYTK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCC
DSRVIYCEWYNSSITNEAGSVTSVLSLVLDVTERIQAEKALRQSELMVIEERAQALERER
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARIELERASRMKDEFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHH
AQTQLIEDLLDISRIIRGNIRLLVRPTKLIPVIQAALDTVRPIANTKSIQIISRLNFDIG
HHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEE
LVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETNVQIRVTDTGKGISPEFLPYV
EECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEEHHHCCEEEEEEECCCCCCHHHHHHH
FDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGTVSVASPGEGQGATFTVQLPLLPSYS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCC
TVTPEEPLLQRQTTWDAKVQIRGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTSEAL
CCCCCCHHHHCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHH
KLLQLVKPDVLLSDIGMPNEDGYALIRQIRALSSEQGGNVPAAALTAYTRQSDRLLALTA
HHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEC
GFQIHISKPIEPIQLLKIVATLAGNNSN
CEEEEECCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]