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The map label for this gene is sppA [C]

Identifier: 75907910

GI number: 75907910

Start: 2118288

End: 2119109

Strand: Direct

Name: sppA [C]

Synonym: Ava_1689

Alternate gene names: 75907910

Gene position: 2118288-2119109 (Clockwise)

Preceding gene: 75907909

Following gene: 75907911

Centisome position: 33.28

GC content: 43.92

Gene sequence:

>822_bases
ATGGTTTGGCCTTTTAAGTCAAAGTTTCGTAAACAAATCGCTCGCATTGAAATCACAGGTGCGATCGCCAGTGGGACGCG
CAAAAGAGTGCTAGAAGCTTTAAAAACTGTTGAAGAAAAAAAGTTTCCCGCATTACTGCTACGCATTGACAGCCCCGGCG
GTACAGTCGGAGACTCCCAAGAAATCTACAGCGCCTTAAAGCGGTTACGGGAAAAAATCAAAATTGTTGCTAGTTTTGGT
AATATCTCTGCTTCTGGTGGTGTTTACATCGGGATGGGAGCAGAACACATCATGGCTAACCCTGGAACAATCACAGGTAG
CATCGGTGTAATTTTGCGTGGGAACAACCTAGAACGCTTGTTAGACAAAGTTGGTGTATCTTTCAAGGTAATTAAATCTG
GGCCTTACAAAGATATCTTGTCATTTGACCGCGAACTAACTGAACCAGAACAAGACATATTGCAGGAGTTGATTGACACA
AGTTACCAGCAGTTTGTCCAAACAGTAGCCGAGGGTAGGTCTTTAGCCGTAGAGAAAGTTAAAAGTTTTGCTGATGGACG
GATTTTTACTGGACAGCAAGCTTTAGAATTAGGAGTAGTAGACCGCTTGGGAACCGAAGAAGAAGCCCGTCGCTGGACAG
CAGAATTAGTCGGTCTTGATCCTGAGAAGACACCTTGCTATACCCTAGAAGAACGAAAACCCCTATTAAGTAGAGTTTTA
CCAGGGAGCCGTAAGGGTTACTCAAGGCTAGGTGCAAGTATAGATTGGCTAGAGTTTGAAATGTCTACCAGTGGTTTACC
ACTGTGGTTATATAGACCTTAA

Upstream 100 bases:

>100_bases
AAGGGTCTCATGGCTGCTTGTTTTTTTTGACAAATCAGAGTTAGGACATCTGACCACTAGACAATTTATATTTAGATCAT
TACGAGGTTTCTATTTGCTC

Downstream 100 bases:

>100_bases
ATTGTCGATAGTCAGTAGTCATTAGTCATTGGCAAAAGTAAGAAGTGACAACTGACAACTGACAACTAACAACTAACAAC
TAACAACTGAACTAATCAAG

Product: signal peptide peptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MVWPFKSKFRKQIARIEITGAIASGTRKRVLEALKTVEEKKFPALLLRIDSPGGTVGDSQEIYSALKRLREKIKIVASFG
NISASGGVYIGMGAEHIMANPGTITGSIGVILRGNNLERLLDKVGVSFKVIKSGPYKDILSFDRELTEPEQDILQELIDT
SYQQFVQTVAEGRSLAVEKVKSFADGRIFTGQQALELGVVDRLGTEEEARRWTAELVGLDPEKTPCYTLEERKPLLSRVL
PGSRKGYSRLGASIDWLEFEMSTSGLPLWLYRP

Sequences:

>Translated_273_residues
MVWPFKSKFRKQIARIEITGAIASGTRKRVLEALKTVEEKKFPALLLRIDSPGGTVGDSQEIYSALKRLREKIKIVASFG
NISASGGVYIGMGAEHIMANPGTITGSIGVILRGNNLERLLDKVGVSFKVIKSGPYKDILSFDRELTEPEQDILQELIDT
SYQQFVQTVAEGRSLAVEKVKSFADGRIFTGQQALELGVVDRLGTEEEARRWTAELVGLDPEKTPCYTLEERKPLLSRVL
PGSRKGYSRLGASIDWLEFEMSTSGLPLWLYRP
>Mature_273_residues
MVWPFKSKFRKQIARIEITGAIASGTRKRVLEALKTVEEKKFPALLLRIDSPGGTVGDSQEIYSALKRLREKIKIVASFG
NISASGGVYIGMGAEHIMANPGTITGSIGVILRGNNLERLLDKVGVSFKVIKSGPYKDILSFDRELTEPEQDILQELIDT
SYQQFVQTVAEGRSLAVEKVKSFADGRIFTGQQALELGVVDRLGTEEEARRWTAELVGLDPEKTPCYTLEERKPLLSRVL
PGSRKGYSRLGASIDWLEFEMSTSGLPLWLYRP

Specific function: Digestion Of The Cleaved Signal Peptides. This Activity Is Necessary To Maintain Proper Secretion Of Mature Proteins Across The Membrane. [C]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=179, Percent_Identity=37.4301675977654, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787527, Length=166, Percent_Identity=34.9397590361446, Blast_Score=88, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 30320; Mature: 30320

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWPFKSKFRKQIARIEITGAIASGTRKRVLEALKTVEEKKFPALLLRIDSPGGTVGDSQ
CCCCCHHHHHHHHHHEEEEHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHH
EIYSALKRLREKIKIVASFGNISASGGVYIGMGAEHIMANPGTITGSIGVILRGNNLERL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHCCCCCEEEECEEEEEECCCHHHH
LDKVGVSFKVIKSGPYKDILSFDRELTEPEQDILQELIDTSYQQFVQTVAEGRSLAVEKV
HHHHCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KSFADGRIFTGQQALELGVVDRLGTEEEARRWTAELVGLDPEKTPCYTLEERKPLLSRVL
HHHHCCCEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHC
PGSRKGYSRLGASIDWLEFEMSTSGLPLWLYRP
CCCCCCHHHHCCCCEEEEEEECCCCCCEEEECC
>Mature Secondary Structure
MVWPFKSKFRKQIARIEITGAIASGTRKRVLEALKTVEEKKFPALLLRIDSPGGTVGDSQ
CCCCCHHHHHHHHHHEEEEHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHH
EIYSALKRLREKIKIVASFGNISASGGVYIGMGAEHIMANPGTITGSIGVILRGNNLERL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHCCCCCEEEECEEEEEECCCHHHH
LDKVGVSFKVIKSGPYKDILSFDRELTEPEQDILQELIDTSYQQFVQTVAEGRSLAVEKV
HHHHCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KSFADGRIFTGQQALELGVVDRLGTEEEARRWTAELVGLDPEKTPCYTLEERKPLLSRVL
HHHHCCCEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHC
PGSRKGYSRLGASIDWLEFEMSTSGLPLWLYRP
CCCCCCHHHHCCCCEEEEEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]