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The map label for this gene is groEL

Identifier: 161567473

GI number: 161567473

Start: 4686937

End: 4688619

Strand: Direct

Name: groEL

Synonym: Ava_3766

Alternate gene names: 161567473

Gene position: 4686937-4688619 (Clockwise)

Preceding gene: 75909968

Following gene: 75909973

Centisome position: 73.63

GC content: 46.11

Gene sequence:

>1683_bases
ATGGCAAAAATTATTTCGTTTGATGAAGAATCACGGCGTGCTTTAGAGCGGGGTGTCAATGCCCTGGCTGATGCTGTAAA
AATTACCTTGGGTCCCAAGGGTCGCAACGTGCTTTTAGAAAAAAAATATGGCACACCCCAAATTGTGAACGATGGTATTA
CCGTTGCTAAAGAAATTGAATTAGAAGATCCTTTAGAAAATACTGGTGCCAGATTAATTCAAGAGGTAGCAGCTAAAACC
AAGGATGTAGCTGGTGATGGCACAACTACGGCTACCGTTTTAGTGCAAGCCCTAATTAAAGAAGGTTTGAAGAACGTCGC
GGCTGGTAGCAATCCAGTAAGCTTAAAGCGGGGTATCGATAAAACTACTGAGGCGCTAGTAGCGGAAATTGCTAAAGTCG
CCAAGCCTGTAGAAGGTAGTGCGATCGCTCAAGTTGCCACTGTTTCAGCTGGTAACGATGAAGAAGTTGGTGCCATGATT
GCTCAAGCAGTGGAAAAAGTCACCAAAGATGGTGTAATCACTGTGGAAGAATCTAAATCCCTGACAACTGAACTAGACGT
AGTGGAAGGGATGCAGATTGACAGAGGTTATATTTCCCCCTACTTCATCACCAACAACGAGCGCCAAACGGTGGAGTTAG
AAAATGTGCGGATTTTGATTACTGACAAAAAAATCAGCAGTATTCAAGAATTAGTCCCCGTTTTAGAAAAAGTAGCTCGT
TTGGGTCAACCCCTACTGATCATTGCTGAAGATGTAGAAGGAGATGCCCTGGCTACTCTAGTTGTGAACAAAGCACGGGG
TGTACTTTCTGTAGCGGCAATTAAAGCCCCAGGATTTGGCGAACGCCGCAAAGCATTGTTGCAAGACATCGCCATCCTCA
CAGACGGTCAACTAATTTCGGAAGAAATTGGCTTAAGCTTAGATACCGCTTCTCTAGAAGCTTTGGGTACGGCGCAGAAA
ATCACAATTGAAAAAGACAACACCACAATTGTTGCTGGTAACACCACCAAGCCAGAAATTCAAAAGCGGATTGCACAAAT
TCGCAGACAACTGGAAGAGACTGATTCTGAGTACGATAGCGAGAAATTACAAGAACGTATTGCCAAGTTAGCTGGTGGTA
TTGCAGTGATCAAAGTCGGTGCAGCAACTGAAACCGAACTCAAAGACCGCAAGCTCAGAATTGAAGACGCACTCAACGCC
ACCAAAGCGGCTGTTGCGGAAGGTATCGTTCCTGGTGGTGGCAAAACTCTGATTTACTTGGCGAGTAAGGTAGACGAGAT
TAAGAAAAACTTTGACGAAGAAGAAAAAATCGGCGCTGACATCGTTAAACGAGCTTTAGAAGCTCCTTTACGGCAGATTG
CAGATAACGCTGGTGTAGAAGGTTCTGTCATCGTCTCCAGAGTCAAAGACAGCGATTTCAACACCGGTTACAACGCTGCT
ACCGGAGAATTTGAAGACCTGATTGCGGCTGGTATTATCGACCCCGCAAAAGTTGTCCGTTCAGCATTGCAAAACGCCGC
TTCCATTGCCGGTCTAGTTTTAACCACCGAAGCGATCGTTGTGGAAAAACCAGAGAAAAAAGCTGCTGCTCCTGCTGATG
CCGGTATGGGCGGCATGGGTGGCATGGGCGGTATGGGCGGTATGGGTGGCATGGGTGGCATGGGCGGTATGGGTATGTTC
TAA

Upstream 100 bases:

>100_bases
TTTTTTTTACTTCCACACATGATTTAAAGTTTTTCAGGTTCTTAGCACTCTGAGCCTGTGAGTGCTAAATTGTCTAATGG
AAGCGCTAGAGAAAGGAAAC

Downstream 100 bases:

>100_bases
TCCTCCCTGAACCTATAGCGATGCAGTTGAGTTAAATAGACCTAACCCCCAACCCCTTCCCTTGCAGGGAAGGGGAGTAA
GAATCAAAATAGCCAAACAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MAKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIELEDPLENTGARLIQEVAAKT
KDVAGDGTTTATVLVQALIKEGLKNVAAGSNPVSLKRGIDKTTEALVAEIAKVAKPVEGSAIAQVATVSAGNDEEVGAMI
AQAVEKVTKDGVITVEESKSLTTELDVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLISEEIGLSLDTASLEALGTAQK
ITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDSEKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNA
TKAAVAEGIVPGGGKTLIYLASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGVEGSVIVSRVKDSDFNTGYNAA
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKAAAPADAGMGGMGGMGGMGGMGGMGGMGGMGMF

Sequences:

>Translated_560_residues
MAKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIELEDPLENTGARLIQEVAAKT
KDVAGDGTTTATVLVQALIKEGLKNVAAGSNPVSLKRGIDKTTEALVAEIAKVAKPVEGSAIAQVATVSAGNDEEVGAMI
AQAVEKVTKDGVITVEESKSLTTELDVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLISEEIGLSLDTASLEALGTAQK
ITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDSEKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNA
TKAAVAEGIVPGGGKTLIYLASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGVEGSVIVSRVKDSDFNTGYNAA
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKAAAPADAGMGGMGGMGGMGGMGGMGGMGGMGMF
>Mature_559_residues
AKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIELEDPLENTGARLIQEVAAKTK
DVAGDGTTTATVLVQALIKEGLKNVAAGSNPVSLKRGIDKTTEALVAEIAKVAKPVEGSAIAQVATVSAGNDEEVGAMIA
QAVEKVTKDGVITVEESKSLTTELDVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVARL
GQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLISEEIGLSLDTASLEALGTAQKI
TIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDSEKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNAT
KAAVAEGIVPGGGKTLIYLASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGVEGSVIVSRVKDSDFNTGYNAAT
GEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKAAAPADAGMGGMGGMGGMGGMGGMGGMGGMGMF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=47.3484848484849, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=47.3484848484849, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=60.4914933837429, Blast_Score=615, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=534, Percent_Identity=47.565543071161, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI193210679, Length=215, Percent_Identity=46.046511627907, Blast_Score=184, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=50.1901140684411, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=46.969696969697, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=46.969696969697, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=44.952380952381, Blast_Score=467, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=44.952380952381, Blast_Score=467, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=44.952380952381, Blast_Score=467, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17864606, Length=552, Percent_Identity=39.6739130434783, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=37.5471698113208, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=37.5471698113208, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_ANAVT (Q3M6L5)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_324266.2
- HSSP:   P0A6F5
- ProteinModelPortal:   Q3M6L5
- SMR:   Q3M6L5
- STRING:   Q3M6L5
- GeneID:   3678970
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_3766
- NMPDR:   fig|240292.3.peg.3884
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- ProtClustDB:   PRK12849
- BioCyc:   AVAR240292:AVA_3766-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58882; Mature: 58751

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIE
CCCEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCEEEECC
LEDPLENTGARLIQEVAAKTKDVAGDGTTTATVLVQALIKEGLKNVAAGSNPVSLKRGID
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
KTTEALVAEIAKVAKPVEGSAIAQVATVSAGNDEEVGAMIAQAVEKVTKDGVITVEESKS
HHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
LTTELDVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
CHHHHHHHHCCEECCCCCCCEEEECCCCCEEEECCEEEEEECHHHHHHHHHHHHHHHHHH
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLIS
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHH
EEIGLSLDTASLEALGTAQKITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDS
HHHCCEECHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCH
EKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNATKAAVAEGIVPGGGKTLIYL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
ASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGVEGSVIVSRVKDSDFNTGYNAA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKAAAPADAGMGGMG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECEEEEECCCHHCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGMF
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKIISFDEESRRALERGVNALADAVKITLGPKGRNVLLEKKYGTPQIVNDGITVAKEIE
CCEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCEEEECC
LEDPLENTGARLIQEVAAKTKDVAGDGTTTATVLVQALIKEGLKNVAAGSNPVSLKRGID
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
KTTEALVAEIAKVAKPVEGSAIAQVATVSAGNDEEVGAMIAQAVEKVTKDGVITVEESKS
HHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
LTTELDVVEGMQIDRGYISPYFITNNERQTVELENVRILITDKKISSIQELVPVLEKVAR
CHHHHHHHHCCEECCCCCCCEEEECCCCCEEEECCEEEEEECHHHHHHHHHHHHHHHHHH
LGQPLLIIAEDVEGDALATLVVNKARGVLSVAAIKAPGFGERRKALLQDIAILTDGQLIS
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHH
EEIGLSLDTASLEALGTAQKITIEKDNTTIVAGNTTKPEIQKRIAQIRRQLEETDSEYDS
HHHCCEECHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCH
EKLQERIAKLAGGIAVIKVGAATETELKDRKLRIEDALNATKAAVAEGIVPGGGKTLIYL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
ASKVDEIKKNFDEEEKIGADIVKRALEAPLRQIADNAGVEGSVIVSRVKDSDFNTGYNAA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
TGEFEDLIAAGIIDPAKVVRSALQNAASIAGLVLTTEAIVVEKPEKKAAAPADAGMGGMG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECEEEEECCCHHCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGMF
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA