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The map label for this gene is uvrD [H]

Identifier: 75676545

GI number: 75676545

Start: 2579538

End: 2581988

Strand: Direct

Name: uvrD [H]

Synonym: Nwi_2360

Alternate gene names: 75676545

Gene position: 2579538-2581988 (Clockwise)

Preceding gene: 75676543

Following gene: 75676546

Centisome position: 75.82

GC content: 62.91

Gene sequence:

>2451_bases
ATGACCGAGCCGAACAGACTGATCCATACCAACGTTTCCGGGCACCAGCCCGCCGCCGGCGGCATCGCTGCGCGTGCGCG
AGCCGCGGCAGCGCCACGATATCTGAGCGGGCTCAATCCGGAGCAGCGCGAGGCCGTGGAAACGCTGGACGGACCGGTTC
TGGTGCTGGCCGGCGCGGGCACAGGCAAGACCCGCGTGCTGACGACCCGCATTGCGCATATCCTCAGCCAGGGCCGCGCC
CGCTCCGGCGAAATCCTGTCGGTCACCTTCACCAACAAGGCCGCCCGCGAGATGAAGCATCGTCTCGGACAGATGCTCGG
GCAGGCCGTCGAAGGCATGCCGTGGCTCGGCACCTTTCATTCCATTGCGGGCCGAATCCTGCGCGTTCATGCCGAGCTGG
TGCAGCTCAAATCCAACTTCACGATTCTCGATGTCGACGACCAGATCCGTCTGCTCAAACAGCTTCTGCAGGCCGACAAC
ATCGACGACAAGCGCTGGCCCGCGCGGATGCTGGCCGGGTTGATCGACGGCTGGAAGAACCGCGGACTGACGCCCGCGCA
GGTGCCGTCGGGCGAAGCCTCCGTCTTCGGCAACGGTCGTGGCGGCAAGCTTTACGCCGCCTACCAGGCACGGTTGAAAA
TCCTCAACGCCGCAGACTTCGGCGATCTGCTGCTCGAAAACATCCGGCTGTTCCGCGAGCATCCGGACGTGCTGCGACAA
TACCAGAACCGCTTCAAGTTTATCCTTGTCGACGAATATCAGGACACCAACGTTGCCCAATATCTATGGCTGAGATTGCT
GTCCCAAGCGCCGCCGTCATCCCACGCGCTGTTTCCCGCTCCCGTCGCGGCGGAAGGTCCCGACCCGCGCACGGCTCGAT
CCAGAAACATCTGCTGCGTCGGCGACGACGACCAGTCGATCTACGGCTGGCGCGGCGCCGAGGTGGATAACATCCTGCGG
TTCGACCACGATTTTCCCGGCGCCAAGGTAATCCGGCTGGAACGCAACTATCGCTCGACCGGCCATATCCTCGCCGCCGC
CTCGCACCTGATCGCGCATAACGAAGACCGGCTCGGCAAGACGTTGCGGACCGAGGATGTCGATGGCGAGAAGGTCACCG
TCACCGGCTCCTGGGACTCTGAGGAGGAAGCCCGCGCCATCGGCGAGGAAATCGAGCAGCTCCAGCGTGCCGGCGAAAAG
CTGAACGAAATCGCGATTCTGGTGCGCGCTTCATTCCAGATGCGCGAGTTCGAAGACCGCTTTCTCACGCTTGGCCTACC
CTATCGCGTCATCGGCGGCCCACGCTTCTATGAGCGCGCCGAGATCCGTGACGCGCTCGCCTATCTGCGCCTCATCAACT
CGCCGGCCGATGACCTTGCATTCGAGCGCATCGTCAACGTGCCTAAACGCGGCCTCGGCGACGCTACCGTCAAGATGCTG
CACGAGATCGCGCGAAAGCGTCAGATCCCGCTTAGCGAAGCCGCCCGCGCCGTTGTCGAAACCGACGAGTTGAAACCAAA
AGCGCGCGGATCGCTGCGCGCTCTGCTGGAGAGCTTCGACCGCTGGCGTATCCAGCGGGAGGCCATGCGGCATACCGAGC
TTGCCGAGATCGTGCTGGACGAGAGCGGCTACACCGAGATGTGGCAGAAGGATCGCTCGGCCGACGCCGCAGGACGCCTC
GAAAACCTGAAAGAGCTGATACGCTCGATGGATGAGTTCGAAAACCTGCAAGGCTTTCTCGAGCATATATCCCTGGTGAT
GGACCGCGACGGCGGCGCGGACGAGGATGCCGTCTCGGTGATGACACTGCATTCCGCCAAGGGACTTGAATTCGATACCG
TCTTCCTGCCCGGCTGGGAGGAAGGCCTGTTTCCTCATCAGCGGGCGCTGGACGAGCAGGGACGCTCCGGCCTGGAAGAA
GAGCGCCGCCTCGCGCATGTCGGCCTGACACGGGCGCGCCGTCGCGCGAAACTTTACTTCGCCACCAATCGCCGCATCCA
CGGCTCGTGGTCGACCACGATTCCGTCCCGCTTTCTCGACGAGTTGCCGGCGGAGAATGTGGAGATCACGGAATCGAAGG
GTGGATCGGGCTGGGGCGGAACGGGCGGTTACGGCCCCTCGCGTTTCGACAACATCGATTCCTTCGGCTCGAGCTATGCG
ACTCCAGGCTGGCAACGCGCGCAGGCCAATCGCGGCCGGGGCGGGTTCAATGAGGCCGGAACGCCCTACGATGCAAACCG
ATCGAAGTCGAAGCGCGCGCCGGTGGTCATCGAAGGAGAGTTGATCGCACGATCCACCGGCTCGGATTCCGGCTTCTCAT
TGGGCGACCGTGTTTTTCATCAGAAGTTCGGCTACGGGAAAGTCGCGCGAATCGATGGCAACAAGCTGACCATCACCTTT
GAAAAAGCCGGCGAAAAAAAGGTGGTCGATAGCTTCGTCGCGCGGGTGTAA

Upstream 100 bases:

>100_bases
AGTCGCTACGAAGCACGTTCGCCCTATATATTTCTTCATCCTTGCTGAGAGGGCTCCCCTTCGCTGGCAGGCAGTGCCAT
CGTAGGGAAAGACGATTCGC

Downstream 100 bases:

>100_bases
CCGAATTGCGAACCACCGCCCGTGCTCCTATCTGTTGACCTGCATTCTCCATCGTCCCGCCATTCCGCCGCGATATCATC
TCTCTCCTCGTTCCTCTCCA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MTEPNRLIHTNVSGHQPAAGGIAARARAAAAPRYLSGLNPEQREAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSQGRA
RSGEILSVTFTNKAAREMKHRLGQMLGQAVEGMPWLGTFHSIAGRILRVHAELVQLKSNFTILDVDDQIRLLKQLLQADN
IDDKRWPARMLAGLIDGWKNRGLTPAQVPSGEASVFGNGRGGKLYAAYQARLKILNAADFGDLLLENIRLFREHPDVLRQ
YQNRFKFILVDEYQDTNVAQYLWLRLLSQAPPSSHALFPAPVAAEGPDPRTARSRNICCVGDDDQSIYGWRGAEVDNILR
FDHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEDRLGKTLRTEDVDGEKVTVTGSWDSEEEARAIGEEIEQLQRAGEK
LNEIAILVRASFQMREFEDRFLTLGLPYRVIGGPRFYERAEIRDALAYLRLINSPADDLAFERIVNVPKRGLGDATVKML
HEIARKRQIPLSEAARAVVETDELKPKARGSLRALLESFDRWRIQREAMRHTELAEIVLDESGYTEMWQKDRSADAAGRL
ENLKELIRSMDEFENLQGFLEHISLVMDRDGGADEDAVSVMTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGRSGLEE
ERRLAHVGLTRARRRAKLYFATNRRIHGSWSTTIPSRFLDELPAENVEITESKGGSGWGGTGGYGPSRFDNIDSFGSSYA
TPGWQRAQANRGRGGFNEAGTPYDANRSKSKRAPVVIEGELIARSTGSDSGFSLGDRVFHQKFGYGKVARIDGNKLTITF
EKAGEKKVVDSFVARV

Sequences:

>Translated_816_residues
MTEPNRLIHTNVSGHQPAAGGIAARARAAAAPRYLSGLNPEQREAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSQGRA
RSGEILSVTFTNKAAREMKHRLGQMLGQAVEGMPWLGTFHSIAGRILRVHAELVQLKSNFTILDVDDQIRLLKQLLQADN
IDDKRWPARMLAGLIDGWKNRGLTPAQVPSGEASVFGNGRGGKLYAAYQARLKILNAADFGDLLLENIRLFREHPDVLRQ
YQNRFKFILVDEYQDTNVAQYLWLRLLSQAPPSSHALFPAPVAAEGPDPRTARSRNICCVGDDDQSIYGWRGAEVDNILR
FDHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEDRLGKTLRTEDVDGEKVTVTGSWDSEEEARAIGEEIEQLQRAGEK
LNEIAILVRASFQMREFEDRFLTLGLPYRVIGGPRFYERAEIRDALAYLRLINSPADDLAFERIVNVPKRGLGDATVKML
HEIARKRQIPLSEAARAVVETDELKPKARGSLRALLESFDRWRIQREAMRHTELAEIVLDESGYTEMWQKDRSADAAGRL
ENLKELIRSMDEFENLQGFLEHISLVMDRDGGADEDAVSVMTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGRSGLEE
ERRLAHVGLTRARRRAKLYFATNRRIHGSWSTTIPSRFLDELPAENVEITESKGGSGWGGTGGYGPSRFDNIDSFGSSYA
TPGWQRAQANRGRGGFNEAGTPYDANRSKSKRAPVVIEGELIARSTGSDSGFSLGDRVFHQKFGYGKVARIDGNKLTITF
EKAGEKKVVDSFVARV
>Mature_815_residues
TEPNRLIHTNVSGHQPAAGGIAARARAAAAPRYLSGLNPEQREAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSQGRAR
SGEILSVTFTNKAAREMKHRLGQMLGQAVEGMPWLGTFHSIAGRILRVHAELVQLKSNFTILDVDDQIRLLKQLLQADNI
DDKRWPARMLAGLIDGWKNRGLTPAQVPSGEASVFGNGRGGKLYAAYQARLKILNAADFGDLLLENIRLFREHPDVLRQY
QNRFKFILVDEYQDTNVAQYLWLRLLSQAPPSSHALFPAPVAAEGPDPRTARSRNICCVGDDDQSIYGWRGAEVDNILRF
DHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEDRLGKTLRTEDVDGEKVTVTGSWDSEEEARAIGEEIEQLQRAGEKL
NEIAILVRASFQMREFEDRFLTLGLPYRVIGGPRFYERAEIRDALAYLRLINSPADDLAFERIVNVPKRGLGDATVKMLH
EIARKRQIPLSEAARAVVETDELKPKARGSLRALLESFDRWRIQREAMRHTELAEIVLDESGYTEMWQKDRSADAAGRLE
NLKELIRSMDEFENLQGFLEHISLVMDRDGGADEDAVSVMTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGRSGLEEE
RRLAHVGLTRARRRAKLYFATNRRIHGSWSTTIPSRFLDELPAENVEITESKGGSGWGGTGGYGPSRFDNIDSFGSSYAT
PGWQRAQANRGRGGFNEAGTPYDANRSKSKRAPVVIEGELIARSTGSDSGFSLGDRVFHQKFGYGKVARIDGNKLTITFE
KAGEKKVVDSFVARV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=668, Percent_Identity=44.4610778443114, Blast_Score=520, Evalue=1e-148,
Organism=Escherichia coli, GI48994965, Length=670, Percent_Identity=38.8059701492537, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322369, Length=774, Percent_Identity=27.1317829457364, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 90871; Mature: 90740

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPNRLIHTNVSGHQPAAGGIAARARAAAAPRYLSGLNPEQREAVETLDGPVLVLAGAG
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCEEEEEECC
TGKTRVLTTRIAHILSQGRARSGEILSVTFTNKAAREMKHRLGQMLGQAVEGMPWLGTFH
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SIAGRILRVHAELVQLKSNFTILDVDDQIRLLKQLLQADNIDDKRWPARMLAGLIDGWKN
HHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
RGLTPAQVPSGEASVFGNGRGGKLYAAYQARLKILNAADFGDLLLENIRLFREHPDVLRQ
CCCCCCCCCCCCCEEEECCCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
YQNRFKFILVDEYQDTNVAQYLWLRLLSQAPPSSHALFPAPVAAEGPDPRTARSRNICCV
HHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEDRLGK
CCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHCC
TLRTEDVDGEKVTVTGSWDSEEEARAIGEEIEQLQRAGEKLNEIAILVRASFQMREFEDR
HHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FLTLGLPYRVIGGPRFYERAEIRDALAYLRLINSPADDLAFERIVNVPKRGLGDATVKML
EEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
HEIARKRQIPLSEAARAVVETDELKPKARGSLRALLESFDRWRIQREAMRHTELAEIVLD
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESGYTEMWQKDRSADAAGRLENLKELIRSMDEFENLQGFLEHISLVMDRDGGADEDAVSV
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEE
MTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGRSGLEEERRLAHVGLTRARRRAKLYF
EEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEE
ATNRRIHGSWSTTIPSRFLDELPAENVEITESKGGSGWGGTGGYGPSRFDNIDSFGSSYA
EECCEECCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHCCHHHHCCCCC
TPGWQRAQANRGRGGFNEAGTPYDANRSKSKRAPVVIEGELIARSTGSDSGFSLGDRVFH
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEECCCCCCCCCHHHHHHH
QKFGYGKVARIDGNKLTITFEKAGEKKVVDSFVARV
HHCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
TEPNRLIHTNVSGHQPAAGGIAARARAAAAPRYLSGLNPEQREAVETLDGPVLVLAGAG
CCCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCEEEEEECC
TGKTRVLTTRIAHILSQGRARSGEILSVTFTNKAAREMKHRLGQMLGQAVEGMPWLGTFH
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SIAGRILRVHAELVQLKSNFTILDVDDQIRLLKQLLQADNIDDKRWPARMLAGLIDGWKN
HHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
RGLTPAQVPSGEASVFGNGRGGKLYAAYQARLKILNAADFGDLLLENIRLFREHPDVLRQ
CCCCCCCCCCCCCEEEECCCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
YQNRFKFILVDEYQDTNVAQYLWLRLLSQAPPSSHALFPAPVAAEGPDPRTARSRNICCV
HHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEDRLGK
CCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHCC
TLRTEDVDGEKVTVTGSWDSEEEARAIGEEIEQLQRAGEKLNEIAILVRASFQMREFEDR
HHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FLTLGLPYRVIGGPRFYERAEIRDALAYLRLINSPADDLAFERIVNVPKRGLGDATVKML
EEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
HEIARKRQIPLSEAARAVVETDELKPKARGSLRALLESFDRWRIQREAMRHTELAEIVLD
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESGYTEMWQKDRSADAAGRLENLKELIRSMDEFENLQGFLEHISLVMDRDGGADEDAVSV
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEE
MTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGRSGLEEERRLAHVGLTRARRRAKLYF
EEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEE
ATNRRIHGSWSTTIPSRFLDELPAENVEITESKGGSGWGGTGGYGPSRFDNIDSFGSSYA
EECCEECCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHCCHHHHCCCCC
TPGWQRAQANRGRGGFNEAGTPYDANRSKSKRAPVVIEGELIARSTGSDSGFSLGDRVFH
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEECCCCCCCCCHHHHHHH
QKFGYGKVARIDGNKLTITFEKAGEKKVVDSFVARV
HHCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA