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The map label for this gene is sul [H]

Identifier: 75676418

GI number: 75676418

Start: 2428648

End: 2429526

Strand: Direct

Name: sul [H]

Synonym: Nwi_2233

Alternate gene names: 75676418

Gene position: 2428648-2429526 (Clockwise)

Preceding gene: 75676417

Following gene: 75676419

Centisome position: 71.39

GC content: 66.33

Gene sequence:

>879_bases
ATGACCTCGGCGGATTCCATGTCCAGAGCTGTGACGGATGATGCACGTCATCCCGCGCTTGAGGCGCTGCTGTCGCGCCC
CTGCCCGGCGGTCATGGGGATCCTGAACATCACCCCCGACTCGTTCTCCGATGGCGGTCAGTTCATGACGCCCGACCGGG
CCGTGGCGCAGGCGCGCCGCATGATCGCGGACGGGGCCGACATCATCGATATCGGCGCGGAGTCAACCCGCCCCTACGGA
GCGCAGCCGATCTCGCGCGACGAGGAAATGCGGCGGCTGGAGCCGGTGCTCGCCGCGGTGGTCGCGCTTGGAATTTCCGT
CTCCATCGACAGCATGAAGTCCCCGGTGGTGGAGTGGGCGCTCGGGAACGCGGCCGCGATCGCCAACGACGTGTGGGGAT
TGCAGCGCGATCCCGACATGGCCCGCGTCGTCGCCGCGCGCAACGCGCCCGTCGTCGTCATGCATAACCGGGACAAGCCC
GATGGTACGCTCGACATCATGCGGGACATCACAGCGTTCTTCGAACGATCGCTGAAGATCGCGGCGCAAGCCGGCATACC
CGCCAGCCGCATCATCCTTGATCCCGGTATCGGATTCGGCAAGACGCCGGAACAGAGCATGATCGCGCTGGCCCGGCTCG
GCGAATTGCAGACCTTCGGATTGCCGGTTCTCGTGGGCGCGTCCCGCAAGCGCTTCATCAGCATGGTGACGCCATCAGAG
CCGCAACAACGGCTCGGCGGCTCGCTCGCCGCGCATCTGATCGCGGCAAGAAGCGGCGCGCGCATCATCCGCACACACGA
TGTGGCCGAGACGGTGCAGGCGCTGCGGGTGGCGCACGCCATCGAGACCGCAACACAGCCGGGATCTTTTGAACCATGA

Upstream 100 bases:

>100_bases
TCAAGATCACCTATTGAGCTTTCCATCGTTGCAAGCCGGGCTTCCCTGAACAAGCTTTTCGCGCCTTGACAGCCTGTCCG
GGACCGCGCAAAGCCACCGC

Downstream 100 bases:

>100_bases
CCGATACGATTTTTATCCGCGGCCTCGTGATTCACGCGCAGCACGGCGTCATGGCGCACGAGACCGAAGTCGGCCAGCGC
TTCGTGATGGACATCGAACT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTSADSMSRAVTDDARHPALEALLSRPCPAVMGILNITPDSFSDGGQFMTPDRAVAQARRMIADGADIIDIGAESTRPYG
AQPISRDEEMRRLEPVLAAVVALGISVSIDSMKSPVVEWALGNAAAIANDVWGLQRDPDMARVVAARNAPVVVMHNRDKP
DGTLDIMRDITAFFERSLKIAAQAGIPASRIILDPGIGFGKTPEQSMIALARLGELQTFGLPVLVGASRKRFISMVTPSE
PQQRLGGSLAAHLIAARSGARIIRTHDVAETVQALRVAHAIETATQPGSFEP

Sequences:

>Translated_292_residues
MTSADSMSRAVTDDARHPALEALLSRPCPAVMGILNITPDSFSDGGQFMTPDRAVAQARRMIADGADIIDIGAESTRPYG
AQPISRDEEMRRLEPVLAAVVALGISVSIDSMKSPVVEWALGNAAAIANDVWGLQRDPDMARVVAARNAPVVVMHNRDKP
DGTLDIMRDITAFFERSLKIAAQAGIPASRIILDPGIGFGKTPEQSMIALARLGELQTFGLPVLVGASRKRFISMVTPSE
PQQRLGGSLAAHLIAARSGARIIRTHDVAETVQALRVAHAIETATQPGSFEP
>Mature_291_residues
TSADSMSRAVTDDARHPALEALLSRPCPAVMGILNITPDSFSDGGQFMTPDRAVAQARRMIADGADIIDIGAESTRPYGA
QPISRDEEMRRLEPVLAAVVALGISVSIDSMKSPVVEWALGNAAAIANDVWGLQRDPDMARVVAARNAPVVVMHNRDKPD
GTLDIMRDITAFFERSLKIAAQAGIPASRIILDPGIGFGKTPEQSMIALARLGELQTFGLPVLVGASRKRFISMVTPSEP
QQRLGGSLAAHLIAARSGARIIRTHDVAETVQALRVAHAIETATQPGSFEP

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=270, Percent_Identity=41.8518518518518, Blast_Score=195, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=27.8125, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31102; Mature: 30971

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSADSMSRAVTDDARHPALEALLSRPCPAVMGILNITPDSFSDGGQFMTPDRAVAQARR
CCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
MIADGADIIDIGAESTRPYGAQPISRDEEMRRLEPVLAAVVALGISVSIDSMKSPVVEWA
HHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGNAAAIANDVWGLQRDPDMARVVAARNAPVVVMHNRDKPDGTLDIMRDITAFFERSLKI
CCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AAQAGIPASRIILDPGIGFGKTPEQSMIALARLGELQTFGLPVLVGASRKRFISMVTPSE
HHHCCCCHHEEEECCCCCCCCCCHHHHHHHHHHCCHHHCCCCEEECCCHHHEEEECCCCC
PQQRLGGSLAAHLIAARSGARIIRTHDVAETVQALRVAHAIETATQPGSFEP
HHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TSADSMSRAVTDDARHPALEALLSRPCPAVMGILNITPDSFSDGGQFMTPDRAVAQARR
CCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
MIADGADIIDIGAESTRPYGAQPISRDEEMRRLEPVLAAVVALGISVSIDSMKSPVVEWA
HHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGNAAAIANDVWGLQRDPDMARVVAARNAPVVVMHNRDKPDGTLDIMRDITAFFERSLKI
CCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AAQAGIPASRIILDPGIGFGKTPEQSMIALARLGELQTFGLPVLVGASRKRFISMVTPSE
HHHCCCCHHEEEECCCCCCCCCCHHHHHHHHHHCCHHHCCCCEEECCCHHHEEEECCCCC
PQQRLGGSLAAHLIAARSGARIIRTHDVAETVQALRVAHAIETATQPGSFEP
HHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]