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The map label for this gene is panC

Identifier: 75675894

GI number: 75675894

Start: 1857059

End: 1857910

Strand: Direct

Name: panC

Synonym: Nwi_1702

Alternate gene names: 75675894

Gene position: 1857059-1857910 (Clockwise)

Preceding gene: 75675891

Following gene: 75675899

Centisome position: 54.59

GC content: 62.91

Gene sequence:

>852_bases
ATGCCGCCCGCTCCCGCTATCGTTCGCACCCTGCCATCGCTACGCCGCGCCCTGGAGCGCCTGCGGGCGCGGCGAGGCAC
CATCGCGCTGGTGCCGACCATGGGCGCACTTCACGAAGGACATCTGGCGCTGGTGCGTCAGGCAAAGAGGCGCGCATCGA
GGGTTATCGTCTCGATTTTCGTCAACCCCACCCAGTTTGCGCCGCATGAAGACTTCGGATCCTACCCGCGAACCTGGAAG
GCCGATCTGGCCAAACTCGCCGAGGCGAAGACCGACCTGATATGGCGTCCCGACGTCAGCACGATGTATCCGCGGGACTT
CGCGACCCGGATATCGACTGAAGGACCGGCCATCGCGAGGCTTGAAGATCATTTCCGCCCGCACTTTTTCGGCGGCGTCA
CGACCGTGGTCGGCAAGCTGTTCATCCAGTGCCGGCCTGATGTCGCATTGTTTGGCCAGAAGGATTATCAGCAACTCAAG
GTCGTGACGCGAATGGTGGCCGATCTCGATCTCGGCGTGAAGATCGTTGGTGTCCCCATCGTGCGCGAACCCGACGGGCT
CGCGATGTCGTCACGCAACGTCTACCTGTCGAACGAGCAGCGCGCTCGCGCGCCGACGCTTTATCGCACCCTGAAGGACG
CGGCTGGGCGTTTGCGGAACGGGGATCATCTCGAAGCCGTCATGGCGGATGGCGCGAGGACGATCGAGGACACTGGCTTC
TCGCTGGATTATTTCGAGGCCCGCCACGCCGAAACGCTGTCACCGGTCGGCTCGTTAAAGGATGGCCCGGTCAGGCTCCT
GGTCGCAGCTAAGATCGGGGATACCCGCCTGATCGACAACCTCGGCGTTTAA

Upstream 100 bases:

>100_bases
ACCGATTCAACAAGACGCGAAAATGCTTTAGTAAGGTGCGATCCGCTGCATCCCGCGCATGTAGCAGTCCCGTCCCTGGA
ATTTATCCACCCGAGCAGCA

Downstream 100 bases:

>100_bases
TTCACCCTCTTGCTCACTCGCTCCCGTTTCCAATTACAGCAACCCCAGATCGCGCAACTCGCGGCGCAGCGGCTCGGGCA
TCTCTGCGACGCTCGCGGCG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPPAPAIVRTLPSLRRALERLRARRGTIALVPTMGALHEGHLALVRQAKRRASRVIVSIFVNPTQFAPHEDFGSYPRTWK
ADLAKLAEAKTDLIWRPDVSTMYPRDFATRISTEGPAIARLEDHFRPHFFGGVTTVVGKLFIQCRPDVALFGQKDYQQLK
VVTRMVADLDLGVKIVGVPIVREPDGLAMSSRNVYLSNEQRARAPTLYRTLKDAAGRLRNGDHLEAVMADGARTIEDTGF
SLDYFEARHAETLSPVGSLKDGPVRLLVAAKIGDTRLIDNLGV

Sequences:

>Translated_283_residues
MPPAPAIVRTLPSLRRALERLRARRGTIALVPTMGALHEGHLALVRQAKRRASRVIVSIFVNPTQFAPHEDFGSYPRTWK
ADLAKLAEAKTDLIWRPDVSTMYPRDFATRISTEGPAIARLEDHFRPHFFGGVTTVVGKLFIQCRPDVALFGQKDYQQLK
VVTRMVADLDLGVKIVGVPIVREPDGLAMSSRNVYLSNEQRARAPTLYRTLKDAAGRLRNGDHLEAVMADGARTIEDTGF
SLDYFEARHAETLSPVGSLKDGPVRLLVAAKIGDTRLIDNLGV
>Mature_282_residues
PPAPAIVRTLPSLRRALERLRARRGTIALVPTMGALHEGHLALVRQAKRRASRVIVSIFVNPTQFAPHEDFGSYPRTWKA
DLAKLAEAKTDLIWRPDVSTMYPRDFATRISTEGPAIARLEDHFRPHFFGGVTTVVGKLFIQCRPDVALFGQKDYQQLKV
VTRMVADLDLGVKIVGVPIVREPDGLAMSSRNVYLSNEQRARAPTLYRTLKDAAGRLRNGDHLEAVMADGARTIEDTGFS
LDYFEARHAETLSPVGSLKDGPVRLLVAAKIGDTRLIDNLGV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=276, Percent_Identity=46.7391304347826, Blast_Score=240, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6322046, Length=286, Percent_Identity=37.7622377622378, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_NITWN (Q3SRX8)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_318315.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q3SRX8
- SMR:   Q3SRX8
- STRING:   Q3SRX8
- GeneID:   3675725
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_1702
- NMPDR:   fig|323098.3.peg.1363
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- PhylomeDB:   Q3SRX8
- ProtClustDB:   PRK00380
- BioCyc:   NWIN323098:NWI_1702-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31341; Mature: 31209

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: ACT_SITE 41-41 BINDING 65-65 BINDING 65-65 BINDING 158-158 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPAPAIVRTLPSLRRALERLRARRGTIALVPTMGALHEGHLALVRQAKRRASRVIVSIF
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEE
VNPTQFAPHEDFGSYPRTWKADLAKLAEAKTDLIWRPDVSTMYPRDFATRISTEGPAIAR
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHCCCCCEEHH
LEDHFRPHFFGGVTTVVGKLFIQCRPDVALFGQKDYQQLKVVTRMVADLDLGVKIVGVPI
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEE
VREPDGLAMSSRNVYLSNEQRARAPTLYRTLKDAAGRLRNGDHLEAVMADGARTIEDTGF
EECCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHCCC
SLDYFEARHAETLSPVGSLKDGPVRLLVAAKIGDTRLIDNLGV
CCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHCCCC
>Mature Secondary Structure 
PPAPAIVRTLPSLRRALERLRARRGTIALVPTMGALHEGHLALVRQAKRRASRVIVSIF
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEE
VNPTQFAPHEDFGSYPRTWKADLAKLAEAKTDLIWRPDVSTMYPRDFATRISTEGPAIAR
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHCCCCCEEHH
LEDHFRPHFFGGVTTVVGKLFIQCRPDVALFGQKDYQQLKVVTRMVADLDLGVKIVGVPI
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEE
VREPDGLAMSSRNVYLSNEQRARAPTLYRTLKDAAGRLRNGDHLEAVMADGARTIEDTGF
EECCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHCCC
SLDYFEARHAETLSPVGSLKDGPVRLLVAAKIGDTRLIDNLGV
CCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA