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The map label for this gene is rnd [H]

Identifier: 75675781

GI number: 75675781

Start: 1736709

End: 1737857

Strand: Direct

Name: rnd [H]

Synonym: Nwi_1589

Alternate gene names: 75675781

Gene position: 1736709-1737857 (Clockwise)

Preceding gene: 75675778

Following gene: 75675783

Centisome position: 51.05

GC content: 63.79

Gene sequence:

>1149_bases
ATGGATCTGATTACCACCTCCGCGGAGCTGGCCTCCGTCTGCGCCCGCCTCGCCAGGCACCCGGTCATTACCGTCGACAC
CGAGTTCCTCCGCGAAACCACCTACTATCCCCTGCTCTGCGTCATTCAGCTGGCAAGTCCCGATGAAGCCGTGGTGGTCG
ATGCTCTCGCCGGGGGAATCGACCTGAAGCCGTTTTTCGCTCTGATGTCGAACGAAAGCGTCCTCAAGGTCTTCCACGCT
GCACGGCAGGATATCGAGATTATCTGGCACCAGGCCGGGCTTATCCCCCATCCTGTCTTCGACACCCAGGTTGCCGCCAT
GGTGCTGGGACACGGCGATTCCATTGCCTATGACGCGCTGGTCGAGCGTATTACCGGACACCGTCCGGACAAGACCCACC
GATTCACCGACTGGTCGCGCCGTCCGCTGACCGCGGAACAACTCGAATACGCCGTGGCGGATGTCACTCACCTCCGCGAC
GTCTTTGCCGCCCTCGACGCCGATCTCAGCAAGCGCGGACGCAGCGATTGGGTCAGCGAGGAGATGGAGGTCCTGACGTC
GCCGAAGACCTACGACTTTCATCCCGAACGTGCATGGGAACGATTGAAGAGCCGGGTCCGCAAGCCGAAGGACCTTGCCG
TCCTGATGGAAGTGGCGGCCTGGCGCGAACAGGAAGCCCAGAGCCGCAATATTCCACGGTCCCGTGTTCTGAAGGACGAC
GCCGTCGGCGATATCGCGATCCATGCGCCGAGTAGCCCGGAACGGTTGGCGACGCTGCGTTCGCTGCCCAAGGGTTTTGA
ACGGTCGCAATGGGGCGCTGATATCGTCGCGGCGGTCCAGCGCGGGCTTGCACGAGACCCGCGCACGCTGCCCCGGATCG
AGAAGCCCCGCAACAATTCGAACGGCGCCGCCACGGTGGAGCTTCTCAAGGTTTTGCTGCGCATGACGTCCGAGCGCCAT
GCTGTCGCCAGCAAGGTGATCGCGACGGTGGATGACCTGGAACGGATCGTCGCCGATGACGAGGCCGATGTCGGTGCGCT
GCACGGGTGGCGGCGTGAACTGTTTGGCGAGGCCGCCCTCGCCCTGAAGCATGGCCGGCTGGCTCTGGCGATCGAAAAGG
GCCGCGTGGTGCGCGTGGAGCGAGCGTAG

Upstream 100 bases:

>100_bases
CGGATGATCATTCTTGACCGGAAAAGTCTGAAGAAAACAAGCGCGGCGTGCTGCAAAAAAGCAGGGCGACAGGGCAAAAA
AGACGAGCTATGGAGCGTTC

Downstream 100 bases:

>100_bases
AGCTTTTTCGCTTCTGATGTGATCTGGAGCGAGGCTTTCCGATTCCTGAAGCACGCCCGCGATTCAGCGATGCACGTCAT
TCGACGGACCTCGACGCGAT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDLITTSAELASVCARLARHPVITVDTEFLRETTYYPLLCVIQLASPDEAVVVDALAGGIDLKPFFALMSNESVLKVFHA
ARQDIEIIWHQAGLIPHPVFDTQVAAMVLGHGDSIAYDALVERITGHRPDKTHRFTDWSRRPLTAEQLEYAVADVTHLRD
VFAALDADLSKRGRSDWVSEEMEVLTSPKTYDFHPERAWERLKSRVRKPKDLAVLMEVAAWREQEAQSRNIPRSRVLKDD
AVGDIAIHAPSSPERLATLRSLPKGFERSQWGADIVAAVQRGLARDPRTLPRIEKPRNNSNGAATVELLKVLLRMTSERH
AVASKVIATVDDLERIVADDEADVGALHGWRRELFGEAALALKHGRLALAIEKGRVVRVERA

Sequences:

>Translated_382_residues
MDLITTSAELASVCARLARHPVITVDTEFLRETTYYPLLCVIQLASPDEAVVVDALAGGIDLKPFFALMSNESVLKVFHA
ARQDIEIIWHQAGLIPHPVFDTQVAAMVLGHGDSIAYDALVERITGHRPDKTHRFTDWSRRPLTAEQLEYAVADVTHLRD
VFAALDADLSKRGRSDWVSEEMEVLTSPKTYDFHPERAWERLKSRVRKPKDLAVLMEVAAWREQEAQSRNIPRSRVLKDD
AVGDIAIHAPSSPERLATLRSLPKGFERSQWGADIVAAVQRGLARDPRTLPRIEKPRNNSNGAATVELLKVLLRMTSERH
AVASKVIATVDDLERIVADDEADVGALHGWRRELFGEAALALKHGRLALAIEKGRVVRVERA
>Mature_382_residues
MDLITTSAELASVCARLARHPVITVDTEFLRETTYYPLLCVIQLASPDEAVVVDALAGGIDLKPFFALMSNESVLKVFHA
ARQDIEIIWHQAGLIPHPVFDTQVAAMVLGHGDSIAYDALVERITGHRPDKTHRFTDWSRRPLTAEQLEYAVADVTHLRD
VFAALDADLSKRGRSDWVSEEMEVLTSPKTYDFHPERAWERLKSRVRKPKDLAVLMEVAAWREQEAQSRNIPRSRVLKDD
AVGDIAIHAPSSPERLATLRSLPKGFERSQWGADIVAAVQRGLARDPRTLPRIEKPRNNSNGAATVELLKVLLRMTSERH
AVASKVIATVDDLERIVADDEADVGALHGWRRELFGEAALALKHGRLALAIEKGRVVRVERA

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=262, Percent_Identity=23.6641221374046, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI50301240, Length=262, Percent_Identity=23.6641221374046, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788105, Length=370, Percent_Identity=30, Blast_Score=148, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324574, Length=165, Percent_Identity=32.7272727272727, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42632; Mature: 42632

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLITTSAELASVCARLARHPVITVDTEFLRETTYYPLLCVIQLASPDEAVVVDALAGGI
CCCCCCHHHHHHHHHHHHHCCEEEECHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHCCC
DLKPFFALMSNESVLKVFHAARQDIEIIWHQAGLIPHPVFDTQVAAMVLGHGDSIAYDAL
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
VERITGHRPDKTHRFTDWSRRPLTAEQLEYAVADVTHLRDVFAALDADLSKRGRSDWVSE
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EMEVLTSPKTYDFHPERAWERLKSRVRKPKDLAVLMEVAAWREQEAQSRNIPRSRVLKDD
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
AVGDIAIHAPSSPERLATLRSLPKGFERSQWGADIVAAVQRGLARDPRTLPRIEKPRNNS
CCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NGAATVELLKVLLRMTSERHAVASKVIATVDDLERIVADDEADVGALHGWRRELFGEAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ALKHGRLALAIEKGRVVRVERA
HHHCCCEEEEEECCCEEEEECC
>Mature Secondary Structure
MDLITTSAELASVCARLARHPVITVDTEFLRETTYYPLLCVIQLASPDEAVVVDALAGGI
CCCCCCHHHHHHHHHHHHHCCEEEECHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHCCC
DLKPFFALMSNESVLKVFHAARQDIEIIWHQAGLIPHPVFDTQVAAMVLGHGDSIAYDAL
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
VERITGHRPDKTHRFTDWSRRPLTAEQLEYAVADVTHLRDVFAALDADLSKRGRSDWVSE
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EMEVLTSPKTYDFHPERAWERLKSRVRKPKDLAVLMEVAAWREQEAQSRNIPRSRVLKDD
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
AVGDIAIHAPSSPERLATLRSLPKGFERSQWGADIVAAVQRGLARDPRTLPRIEKPRNNS
CCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NGAATVELLKVLLRMTSERHAVASKVIATVDDLERIVADDEADVGALHGWRRELFGEAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ALKHGRLALAIEKGRVVRVERA
HHHCCCEEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]